CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.1.1.80
Isopropanol dehydrogenase (NADP(+)).
based on mapping to UniProt P14941
Propan-2-ol + NADP(+) = acetone + NADPH.
-!- Also acts on other short-chain secondary alcohols and, slowly, on primary alcohols.
1.1.1.80
Isopropanol dehydrogenase (NADP(+)).
based on mapping to UniProt P35630
Propan-2-ol + NADP(+) = acetone + NADPH.
-!- Also acts on other short-chain secondary alcohols and, slowly, on primary alcohols.

UniProtKB Entries (2)

P14941
ADH_THEBR
Thermoanaerobacter brockii
NADP-dependent isopropanol dehydrogenase
P35630
ADH1_ENTHI
Entamoeba histolytica
NADP-dependent isopropanol dehydrogenase

PDB Structure

PDB 3FPC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Biochemical and structural properties of chimeras constructed by exchange of cofactor-binding domains in alcohol dehydrogenases from thermophilic and mesophilic microorganisms
Goihberg, E., Peretz, M., Tel-Or, S., Dym, O., Shimon, L., Frolow, F., Burstein, Y.
Biochemistry