S100 Family: 3.90.770.10.1.1.1.1

Representative domain: 2r4fA02

Classification Lineage (3.90.770.10.1.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.90	Alpha-Beta Complex
3.90.770	3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
3.90.770.10	3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2	Gene3D
3.90.770.10.1
3.90.770.10.1.1
3.90.770.10.1.1.1
3.90.770.10.1.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	88

Non-Redundant Representatives (88)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.90.770.10.1.1.1.1 (88)

CATH code	Domain ID	Keywords
3.90.770.10.1.1.1.1.1	2r4fA02	gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
3.90.770.10.1.1.1.1.2	2r4fB02	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
3.90.770.10.1.1.1.1.3	2r4fC02	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
3.90.770.10.1.1.1.1.4	2r4fD02	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Homo sapiens, gonad development
3.90.770.10.1.1.1.1.5	3cczA02	Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Homo sapiens, gonad development, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis
3.90.770.10.1.1.1.1.6	3cczB02	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Homo sapiens, gonad development, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH).
3.90.770.10.1.1.1.1.7	3cczC02	gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
3.90.770.10.1.1.1.1.8	3cczD02	Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration
3.90.770.10.1.1.1.1.9	1dqaB02	Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration
3.90.770.10.1.1.1.1.10	2q6bD02	Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration
3.90.770.10.1.1.1.1.11	2q6bA02	Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., gonad development, Homo sapiens, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34]
3.90.770.10.1.1.1.1.12	1dqaA02	Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., gonad development, Homo sapiens, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34]
3.90.770.10.1.1.1.1.13	1dqaC02	gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
3.90.770.10.1.1.1.1.14	1dqaD02	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
3.90.770.10.1.1.1.1.15	2q6bB02	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens
3.90.770.10.1.1.1.1.16	2q6bC02	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH).
3.90.770.10.1.1.1.1.17	2q6cA02	Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Homo sapiens, gonad development, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis
3.90.770.10.1.1.1.1.18	2q6cD02	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens
3.90.770.10.1.1.1.1.19	2q6cB02	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens
3.90.770.10.1.1.1.1.20	2q6cC02	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
3.90.770.10.1.1.1.1.21	1dq8B02	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
3.90.770.10.1.1.1.1.22	1dq8C02	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH).
3.90.770.10.1.1.1.1.23	2q1lA02	Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration
3.90.770.10.1.1.1.1.24	2q1lB02	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Homo sapiens, gonad development
3.90.770.10.1.1.1.1.25	3cd7A02	Homo sapiens, gonad development, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
3.90.770.10.1.1.1.1.26	3cd7B02	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., gonad development, Homo sapiens
3.90.770.10.1.1.1.1.27	1dq8D02	Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34]
3.90.770.10.1.1.1.1.28	3cdaA02	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
3.90.770.10.1.1.1.1.29	2q1lC02	gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration
3.90.770.10.1.1.1.1.30	3cd7C02	Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Homo sapiens, gonad development, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis
3.90.770.10.1.1.1.1.31	3cdaB02	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens
3.90.770.10.1.1.1.1.32	2q1lD02	gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration
3.90.770.10.1.1.1.1.33	3cd7D02	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens
3.90.770.10.1.1.1.1.34	1dq8A02	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Homo sapiens, gonad development
3.90.770.10.1.1.1.1.35	3cdaC02	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
3.90.770.10.1.1.1.1.36	3ccwA02	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Homo sapiens, gonad development
3.90.770.10.1.1.1.1.37	3ccwB02	gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration
3.90.770.10.1.1.1.1.38	3cdaD02	Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., gonad development, Homo sapiens, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34]
3.90.770.10.1.1.1.1.39	1hw8C02	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
3.90.770.10.1.1.1.1.40	1hwlB02	gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration
3.90.770.10.1.1.1.1.41	1hwlC02	Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34]
3.90.770.10.1.1.1.1.42	1hwlD02	Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., gonad development, Homo sapiens, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34]
3.90.770.10.1.1.1.1.43	3ccwC02	Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Homo sapiens, gonad development, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis
3.90.770.10.1.1.1.1.44	3cctA02	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Homo sapiens, gonad development
3.90.770.10.1.1.1.1.45	3cctB02	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
3.90.770.10.1.1.1.1.46	1hw8A02	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH).
3.90.770.10.1.1.1.1.47	1hw8B02	Homo sapiens, gonad development, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
3.90.770.10.1.1.1.1.48	1hw8D02	Homo sapiens, gonad development, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
3.90.770.10.1.1.1.1.49	1hwlA02	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
3.90.770.10.1.1.1.1.50	3ccwD02	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Homo sapiens, gonad development, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH).
3.90.770.10.1.1.1.1.51	3cctC02	Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34]
3.90.770.10.1.1.1.1.52	3cctD02	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH).
3.90.770.10.1.1.1.1.53	3bglA02	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Homo sapiens, gonad development
3.90.770.10.1.1.1.1.54	3bglB02	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
3.90.770.10.1.1.1.1.55	1hwkA02	Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34]
3.90.770.10.1.1.1.1.56	1hwkC02	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH).
3.90.770.10.1.1.1.1.57	3bglC02	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Homo sapiens, gonad development
3.90.770.10.1.1.1.1.58	1hwkB02	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., gonad development, Homo sapiens
3.90.770.10.1.1.1.1.59	1hwkD02	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Homo sapiens, gonad development, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH).
3.90.770.10.1.1.1.1.60	3bglD02	gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
3.90.770.10.1.1.1.1.61	1hwjA02	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
3.90.770.10.1.1.1.1.62	1hwjB02	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens
3.90.770.10.1.1.1.1.63	1hwiC02	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
3.90.770.10.1.1.1.1.64	1hwjC02	Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Homo sapiens, gonad development, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis
3.90.770.10.1.1.1.1.65	1hwjD02	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Homo sapiens, gonad development
3.90.770.10.1.1.1.1.66	1hwiA02	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens
3.90.770.10.1.1.1.1.67	3cdbA02	Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., gonad development, Homo sapiens, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34]
3.90.770.10.1.1.1.1.68	3cdbB02	gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
3.90.770.10.1.1.1.1.69	3cdbC02	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens
3.90.770.10.1.1.1.1.70	3cdbD02	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
3.90.770.10.1.1.1.1.71	1hwiB02	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
3.90.770.10.1.1.1.1.72	1hwiD02	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
3.90.770.10.1.1.1.1.73	3cd5A02	Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Homo sapiens, gonad development, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis
3.90.770.10.1.1.1.1.74	3cd5B02	Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., gonad development, Homo sapiens, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34]
3.90.770.10.1.1.1.1.75	3cd5C02	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Homo sapiens, gonad development
3.90.770.10.1.1.1.1.76	3cd5D02	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens
3.90.770.10.1.1.1.1.77	1hw9B02	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Homo sapiens, gonad development
3.90.770.10.1.1.1.1.78	1hw9A02	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
3.90.770.10.1.1.1.1.79	1hw9C02	Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., gonad development, Homo sapiens, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34]
3.90.770.10.1.1.1.1.80	1hw9D02	Homo sapiens, gonad development, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
3.90.770.10.1.1.1.1.81	3cd0A02	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., gonad development, Homo sapiens
3.90.770.10.1.1.1.1.82	3cd0B02	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
3.90.770.10.1.1.1.1.83	3cd0D02	Homo sapiens, gonad development, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
3.90.770.10.1.1.1.1.84	3cd0C02	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
3.90.770.10.1.1.1.1.85	1dq9C02	Homo sapiens, gonad development, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
3.90.770.10.1.1.1.1.86	1dq9A02	Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34]
3.90.770.10.1.1.1.1.87	1dq9D02	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Homo sapiens, gonad development, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH).
3.90.770.10.1.1.1.1.88	1dq9B02	Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.90.770.10.1.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.90.770.10.1.1.1.1

Classification Lineage (3.90.770.10.1.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.90.770.10.1.1.1.1 (88)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

CATH Shortcuts