S100 Family: 3.90.550.10.2.1.1.1

Representative domain: 2fy7A00

Classification Lineage (3.90.550.10.2.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.90	Alpha-Beta Complex
3.90.550	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
3.90.550.10	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A	Gene3D
3.90.550.10.2
3.90.550.10.2.1
3.90.550.10.2.1.1
3.90.550.10.2.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	21

Non-Redundant Representatives (21)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.90.550.10.2.1.1.1 (21)

CATH code	Domain ID	Keywords
3.90.550.10.2.1.1.1.1	2fy7A00	Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase., N-acetyllactosamine synthase activity, basolateral plasma membrane, Hexosyltransferases., external side of plasma membrane, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, alpha-tubulin binding, Glycosaminoglycan biosynthesis - keratan sulfate, glycocalyx, Metabolic pathways, Glycosphingolipid biosynthesis - lacto and neolacto series, Golgi trans cisterna, protein homodimerization activity, Galactose metabolism, Beta-1,4-galactosyltransferase 1, brush border membrane, Lactose synthase., N-acetyllactosamine synthase., desmosome, beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-], beta-tubulin binding, Homo sapiens, lactose synthase activity
3.90.550.10.2.1.1.1.2	2fyaA00	beta-tubulin binding, beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-], lactose synthase activity, Homo sapiens, Beta-1,4-galactosyltransferase 1, Galactose metabolism, N-acetyllactosamine synthase., desmosome, Lactose synthase., brush border membrane, protein homodimerization activity, Glycosphingolipid biosynthesis - lacto and neolacto series, Golgi trans cisterna, Metabolic pathways, glycocalyx, Glycosaminoglycan biosynthesis - keratan sulfate, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, alpha-tubulin binding, Hexosyltransferases., external side of plasma membrane, N-acetyllactosamine synthase activity, basolateral plasma membrane, Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase.
3.90.550.10.2.1.1.1.3	2fybA00	glycocalyx, Glycosaminoglycan biosynthesis - keratan sulfate, protein homodimerization activity, Metabolic pathways, Glycosphingolipid biosynthesis - lacto and neolacto series, Golgi trans cisterna, N-acetyllactosamine synthase., desmosome, brush border membrane, Lactose synthase., Galactose metabolism, Beta-1,4-galactosyltransferase 1, lactose synthase activity, Homo sapiens, beta-tubulin binding, beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-], Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase., basolateral plasma membrane, N-acetyllactosamine synthase activity, external side of plasma membrane, Hexosyltransferases., alpha-tubulin binding, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
3.90.550.10.2.1.1.1.4	2agdA00	alpha-tubulin binding, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, external side of plasma membrane, Hexosyltransferases., basolateral plasma membrane, N-acetyllactosamine synthase activity, Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase., lactose synthase activity, Homo sapiens, beta-tubulin binding, beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-], N-acetyllactosamine synthase., desmosome, brush border membrane, Lactose synthase., Galactose metabolism, Beta-1,4-galactosyltransferase 1, protein homodimerization activity, Metabolic pathways, Glycosphingolipid biosynthesis - lacto and neolacto series, Golgi trans cisterna, glycocalyx, Glycosaminoglycan biosynthesis - keratan sulfate
3.90.550.10.2.1.1.1.5	2agdB00	external side of plasma membrane, Hexosyltransferases., alpha-tubulin binding, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase., basolateral plasma membrane, N-acetyllactosamine synthase activity, Lactose synthase., brush border membrane, N-acetyllactosamine synthase., desmosome, Beta-1,4-galactosyltransferase 1, Galactose metabolism, Homo sapiens, lactose synthase activity, beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-], beta-tubulin binding, Glycosaminoglycan biosynthesis - keratan sulfate, glycocalyx, Glycosphingolipid biosynthesis - lacto and neolacto series, Golgi trans cisterna, Metabolic pathways, protein homodimerization activity
3.90.550.10.2.1.1.1.6	2agdC00	Galactose metabolism, Beta-1,4-galactosyltransferase 1, N-acetyllactosamine synthase., desmosome, brush border membrane, Lactose synthase., beta-tubulin binding, beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-], lactose synthase activity, Homo sapiens, glycocalyx, Glycosaminoglycan biosynthesis - keratan sulfate, protein homodimerization activity, Metabolic pathways, Glycosphingolipid biosynthesis - lacto and neolacto series, Golgi trans cisterna, Hexosyltransferases., external side of plasma membrane, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, alpha-tubulin binding, Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase., N-acetyllactosamine synthase activity, basolateral plasma membrane
3.90.550.10.2.1.1.1.7	2ae7A00	Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase., basolateral plasma membrane, N-acetyllactosamine synthase activity, external side of plasma membrane, Hexosyltransferases., alpha-tubulin binding, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, glycocalyx, Glycosaminoglycan biosynthesis - keratan sulfate, protein homodimerization activity, Metabolic pathways, Glycosphingolipid biosynthesis - lacto and neolacto series, Golgi trans cisterna, N-acetyllactosamine synthase., desmosome, brush border membrane, Lactose synthase., Galactose metabolism, Beta-1,4-galactosyltransferase 1, lactose synthase activity, Homo sapiens, beta-tubulin binding, beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]
3.90.550.10.2.1.1.1.8	2ae7B00	N-acetyllactosamine synthase activity, basolateral plasma membrane, Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase., beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, alpha-tubulin binding, Hexosyltransferases., external side of plasma membrane, protein homodimerization activity, Metabolic pathways, Glycosphingolipid biosynthesis - lacto and neolacto series, Golgi trans cisterna, glycocalyx, Glycosaminoglycan biosynthesis - keratan sulfate, beta-tubulin binding, beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-], lactose synthase activity, Homo sapiens, Galactose metabolism, Beta-1,4-galactosyltransferase 1, N-acetyllactosamine synthase., desmosome, brush border membrane, Lactose synthase.
3.90.550.10.2.1.1.1.9	2ae7C00	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, alpha-tubulin binding, Hexosyltransferases., external side of plasma membrane, N-acetyllactosamine synthase activity, basolateral plasma membrane, Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase., beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-], beta-tubulin binding, Homo sapiens, lactose synthase activity, Galactose metabolism, Beta-1,4-galactosyltransferase 1, brush border membrane, Lactose synthase., N-acetyllactosamine synthase., desmosome, Metabolic pathways, Glycosphingolipid biosynthesis - lacto and neolacto series, Golgi trans cisterna, protein homodimerization activity, Glycosaminoglycan biosynthesis - keratan sulfate, glycocalyx
3.90.550.10.2.1.1.1.10	2aecA00	Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase., basolateral plasma membrane, N-acetyllactosamine synthase activity, external side of plasma membrane, Hexosyltransferases., alpha-tubulin binding, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, Glycosaminoglycan biosynthesis - keratan sulfate, glycocalyx, Glycosphingolipid biosynthesis - lacto and neolacto series, Golgi trans cisterna, Metabolic pathways, protein homodimerization activity, Lactose synthase., brush border membrane, N-acetyllactosamine synthase., desmosome, Beta-1,4-galactosyltransferase 1, Galactose metabolism, Homo sapiens, lactose synthase activity, beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-], beta-tubulin binding
3.90.550.10.2.1.1.1.11	2aecB00	protein homodimerization activity, Metabolic pathways, Glycosphingolipid biosynthesis - lacto and neolacto series, Golgi trans cisterna, glycocalyx, Glycosaminoglycan biosynthesis - keratan sulfate, lactose synthase activity, Homo sapiens, beta-tubulin binding, beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-], N-acetyllactosamine synthase., desmosome, brush border membrane, Lactose synthase., Galactose metabolism, Beta-1,4-galactosyltransferase 1, basolateral plasma membrane, N-acetyllactosamine synthase activity, Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase., alpha-tubulin binding, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, external side of plasma membrane, Hexosyltransferases.
3.90.550.10.2.1.1.1.12	2aecC00	protein homodimerization activity, Glycosphingolipid biosynthesis - lacto and neolacto series, Golgi trans cisterna, Metabolic pathways, glycocalyx, Glycosaminoglycan biosynthesis - keratan sulfate, lactose synthase activity, Homo sapiens, beta-tubulin binding, beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-], N-acetyllactosamine synthase., desmosome, Lactose synthase., brush border membrane, Beta-1,4-galactosyltransferase 1, Galactose metabolism, basolateral plasma membrane, N-acetyllactosamine synthase activity, Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase., alpha-tubulin binding, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, external side of plasma membrane, Hexosyltransferases.
3.90.550.10.2.1.1.1.13	2aesA00	protein homodimerization activity, Glycosphingolipid biosynthesis - lacto and neolacto series, Golgi trans cisterna, Metabolic pathways, glycocalyx, Glycosaminoglycan biosynthesis - keratan sulfate, lactose synthase activity, Homo sapiens, beta-tubulin binding, beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-], N-acetyllactosamine synthase., desmosome, Lactose synthase., brush border membrane, Beta-1,4-galactosyltransferase 1, Galactose metabolism, basolateral plasma membrane, N-acetyllactosamine synthase activity, Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase., alpha-tubulin binding, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, external side of plasma membrane, Hexosyltransferases.
3.90.550.10.2.1.1.1.14	2aesB00	Glycosaminoglycan biosynthesis - keratan sulfate, glycocalyx, Glycosphingolipid biosynthesis - lacto and neolacto series, Golgi trans cisterna, Metabolic pathways, protein homodimerization activity, Beta-1,4-galactosyltransferase 1, Galactose metabolism, Lactose synthase., brush border membrane, N-acetyllactosamine synthase., desmosome, beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-], beta-tubulin binding, Homo sapiens, lactose synthase activity, Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase., N-acetyllactosamine synthase activity, basolateral plasma membrane, Hexosyltransferases., external side of plasma membrane, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, alpha-tubulin binding
3.90.550.10.2.1.1.1.15	2aesC00	beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-], beta-tubulin binding, Homo sapiens, lactose synthase activity, Galactose metabolism, Beta-1,4-galactosyltransferase 1, brush border membrane, Lactose synthase., N-acetyllactosamine synthase., desmosome, Metabolic pathways, Glycosphingolipid biosynthesis - lacto and neolacto series, Golgi trans cisterna, protein homodimerization activity, Glycosaminoglycan biosynthesis - keratan sulfate, glycocalyx, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, alpha-tubulin binding, Hexosyltransferases., external side of plasma membrane, N-acetyllactosamine synthase activity, basolateral plasma membrane, Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase.
3.90.550.10.2.1.1.1.16	2ah9A00	Beta-1,4-galactosyltransferase 1, Galactose metabolism, Lactose synthase., brush border membrane, N-acetyllactosamine synthase., desmosome, beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-], beta-tubulin binding, Homo sapiens, lactose synthase activity, Glycosaminoglycan biosynthesis - keratan sulfate, glycocalyx, Glycosphingolipid biosynthesis - lacto and neolacto series, Golgi trans cisterna, Metabolic pathways, protein homodimerization activity, Hexosyltransferases., external side of plasma membrane, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, alpha-tubulin binding, Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase., N-acetyllactosamine synthase activity, basolateral plasma membrane
3.90.550.10.2.1.1.1.17	2ah9B00	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, alpha-tubulin binding, Hexosyltransferases., external side of plasma membrane, N-acetyllactosamine synthase activity, basolateral plasma membrane, Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase., beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-], beta-tubulin binding, Homo sapiens, lactose synthase activity, Beta-1,4-galactosyltransferase 1, Galactose metabolism, Lactose synthase., brush border membrane, N-acetyllactosamine synthase., desmosome, Glycosphingolipid biosynthesis - lacto and neolacto series, Golgi trans cisterna, Metabolic pathways, protein homodimerization activity, Glycosaminoglycan biosynthesis - keratan sulfate, glycocalyx
3.90.550.10.2.1.1.1.18	2ah9C00	Galactose metabolism, Beta-1,4-galactosyltransferase 1, brush border membrane, Lactose synthase., N-acetyllactosamine synthase., desmosome, beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-], beta-tubulin binding, Homo sapiens, lactose synthase activity, Glycosaminoglycan biosynthesis - keratan sulfate, glycocalyx, Metabolic pathways, Glycosphingolipid biosynthesis - lacto and neolacto series, Golgi trans cisterna, protein homodimerization activity, Hexosyltransferases., external side of plasma membrane, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, alpha-tubulin binding, Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase., N-acetyllactosamine synthase activity, basolateral plasma membrane
3.90.550.10.2.1.1.1.19	3ee5A00	N-acetyllactosamine synthase., desmosome, brush border membrane, Lactose synthase., Galactose metabolism, Beta-1,4-galactosyltransferase 1, lactose synthase activity, Homo sapiens, beta-tubulin binding, beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-], glycocalyx, Glycosaminoglycan biosynthesis - keratan sulfate, protein homodimerization activity, Metabolic pathways, Glycosphingolipid biosynthesis - lacto and neolacto series, Golgi trans cisterna, external side of plasma membrane, Hexosyltransferases., alpha-tubulin binding, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase., basolateral plasma membrane, N-acetyllactosamine synthase activity
3.90.550.10.2.1.1.1.20	3ee5B00	Hexosyltransferases., external side of plasma membrane, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, alpha-tubulin binding, Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase., N-acetyllactosamine synthase activity, basolateral plasma membrane, Beta-1,4-galactosyltransferase 1, Galactose metabolism, N-acetyllactosamine synthase., desmosome, Lactose synthase., brush border membrane, beta-tubulin binding, beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-], lactose synthase activity, Homo sapiens, glycocalyx, Glycosaminoglycan biosynthesis - keratan sulfate, protein homodimerization activity, Glycosphingolipid biosynthesis - lacto and neolacto series, Golgi trans cisterna, Metabolic pathways
3.90.550.10.2.1.1.1.21	3ee5C00	Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase., N-acetyllactosamine synthase activity, basolateral plasma membrane, Hexosyltransferases., external side of plasma membrane, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, alpha-tubulin binding, Glycosaminoglycan biosynthesis - keratan sulfate, glycocalyx, Metabolic pathways, Glycosphingolipid biosynthesis - lacto and neolacto series, Golgi trans cisterna, protein homodimerization activity, Galactose metabolism, Beta-1,4-galactosyltransferase 1, brush border membrane, Lactose synthase., N-acetyllactosamine synthase., desmosome, beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-], beta-tubulin binding, Homo sapiens, lactose synthase activity

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.90.550.10.2.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.90.550.10.2.1.1.1

Classification Lineage (3.90.550.10.2.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.90.550.10.2.1.1.1 (21)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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