S100 Family: 3.90.25.10.13.1.1.1

Representative domain: 1eq2D02

Classification Lineage (3.90.25.10.13.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.90	Alpha-Beta Complex
3.90.25	UDP-galactose 4-epimerase; domain 1
3.90.25.10	UDP-galactose 4-epimerase, domain 1	Gene3D
3.90.25.10.13
3.90.25.10.13.1
3.90.25.10.13.1.1
3.90.25.10.13.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	40

Non-Redundant Representatives (40)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.90.25.10.13.1.1.1 (40)

CATH code	Domain ID	Keywords
3.90.25.10.13.1.1.1.1	1eq2D02	ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Lipopolysaccharide biosynthesis, cytosol, Metabolic pathways, ADP-L-glycero-D-manno-heptose-6-epimerase, Escherichia coli K-12, ADP-glyceromanno-heptose 6-epimerase., protein binding, membrane
3.90.25.10.13.1.1.1.2	1eq2F02	Metabolic pathways, ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase., Escherichia coli K-12, protein binding, membrane, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Lipopolysaccharide biosynthesis, cytosol
3.90.25.10.13.1.1.1.3	1eq2G02	membrane, protein binding, ADP-glyceromanno-heptose 6-epimerase., Escherichia coli K-12, Metabolic pathways, ADP-L-glycero-D-manno-heptose-6-epimerase, cytosol, Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20]
3.90.25.10.13.1.1.1.4	1eq2I02	ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Lipopolysaccharide biosynthesis, cytosol, ADP-L-glycero-D-manno-heptose-6-epimerase, Metabolic pathways, Escherichia coli K-12, ADP-glyceromanno-heptose 6-epimerase., protein binding, membrane
3.90.25.10.13.1.1.1.5	1eq2B02	protein binding, ADP-glyceromanno-heptose 6-epimerase., Escherichia coli K-12, ADP-L-glycero-D-manno-heptose-6-epimerase, Metabolic pathways, membrane, Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], cytosol
3.90.25.10.13.1.1.1.6	1eq2E02	Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], cytosol, Escherichia coli K-12, ADP-glyceromanno-heptose 6-epimerase., protein binding, ADP-L-glycero-D-manno-heptose-6-epimerase, Metabolic pathways, membrane
3.90.25.10.13.1.1.1.7	1eq2J02	cytosol, Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], membrane, ADP-glyceromanno-heptose 6-epimerase., Escherichia coli K-12, protein binding, Metabolic pathways, ADP-L-glycero-D-manno-heptose-6-epimerase
3.90.25.10.13.1.1.1.8	1eq2H02	cytosol, Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], membrane, protein binding, Escherichia coli K-12, ADP-glyceromanno-heptose 6-epimerase., ADP-L-glycero-D-manno-heptose-6-epimerase, Metabolic pathways
3.90.25.10.13.1.1.1.9	2x6tA02	ADP-glyceromanno-heptose 6-epimerase., Escherichia coli K-12, protein binding, Metabolic pathways, ADP-L-glycero-D-manno-heptose-6-epimerase, membrane, Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], cytosol
3.90.25.10.13.1.1.1.10	2x6tB02	membrane, Metabolic pathways, ADP-L-glycero-D-manno-heptose-6-epimerase, protein binding, ADP-glyceromanno-heptose 6-epimerase., Escherichia coli K-12, cytosol, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Lipopolysaccharide biosynthesis
3.90.25.10.13.1.1.1.11	2x6tC02	Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], cytosol, ADP-glyceromanno-heptose 6-epimerase., Escherichia coli K-12, protein binding, Metabolic pathways, ADP-L-glycero-D-manno-heptose-6-epimerase, membrane
3.90.25.10.13.1.1.1.12	2x6tD02	membrane, Escherichia coli K-12, ADP-glyceromanno-heptose 6-epimerase., protein binding, ADP-L-glycero-D-manno-heptose-6-epimerase, Metabolic pathways, cytosol, Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20]
3.90.25.10.13.1.1.1.13	2x6tE02	cytosol, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Lipopolysaccharide biosynthesis, membrane, ADP-L-glycero-D-manno-heptose-6-epimerase, Metabolic pathways, ADP-glyceromanno-heptose 6-epimerase., Escherichia coli K-12, protein binding
3.90.25.10.13.1.1.1.14	2x6tF02	ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Lipopolysaccharide biosynthesis, cytosol, ADP-L-glycero-D-manno-heptose-6-epimerase, Metabolic pathways, Escherichia coli K-12, ADP-glyceromanno-heptose 6-epimerase., protein binding, membrane
3.90.25.10.13.1.1.1.15	2x6tG02	cytosol, Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], membrane, ADP-glyceromanno-heptose 6-epimerase., Escherichia coli K-12, protein binding, ADP-L-glycero-D-manno-heptose-6-epimerase, Metabolic pathways
3.90.25.10.13.1.1.1.16	2x6tH02	ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Lipopolysaccharide biosynthesis, cytosol, ADP-L-glycero-D-manno-heptose-6-epimerase, Metabolic pathways, protein binding, Escherichia coli K-12, ADP-glyceromanno-heptose 6-epimerase., membrane
3.90.25.10.13.1.1.1.17	2x6tI02	ADP-L-glycero-D-manno-heptose-6-epimerase, Metabolic pathways, protein binding, Escherichia coli K-12, ADP-glyceromanno-heptose 6-epimerase., membrane, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Lipopolysaccharide biosynthesis, cytosol
3.90.25.10.13.1.1.1.18	2x6tJ02	membrane, Metabolic pathways, ADP-L-glycero-D-manno-heptose-6-epimerase, protein binding, Escherichia coli K-12, ADP-glyceromanno-heptose 6-epimerase., cytosol, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Lipopolysaccharide biosynthesis
3.90.25.10.13.1.1.1.19	2x86A02	ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Lipopolysaccharide biosynthesis, Escherichia coli O157:H7, ADP-L-glycero-D-manno-heptose-6-epimerase, Metabolic pathways, ADP-glyceromanno-heptose 6-epimerase.
3.90.25.10.13.1.1.1.20	2x86B02	Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], ADP-glyceromanno-heptose 6-epimerase., ADP-L-glycero-D-manno-heptose-6-epimerase, Metabolic pathways, Escherichia coli O157:H7
3.90.25.10.13.1.1.1.21	2x86C02	ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose-6-epimerase, Metabolic pathways, ADP-glyceromanno-heptose 6-epimerase., Escherichia coli O157:H7
3.90.25.10.13.1.1.1.22	2x86D02	ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Lipopolysaccharide biosynthesis, Metabolic pathways, ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase., Escherichia coli O157:H7
3.90.25.10.13.1.1.1.23	2x86E02	Escherichia coli O157:H7, ADP-glyceromanno-heptose 6-epimerase., ADP-L-glycero-D-manno-heptose-6-epimerase, Metabolic pathways, Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20]
3.90.25.10.13.1.1.1.24	2x86F02	Escherichia coli O157:H7, Metabolic pathways, ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase., ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Lipopolysaccharide biosynthesis
3.90.25.10.13.1.1.1.25	2x86G02	ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Lipopolysaccharide biosynthesis, Escherichia coli O157:H7, Metabolic pathways, ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase.
3.90.25.10.13.1.1.1.26	2x86H02	Escherichia coli O157:H7, ADP-glyceromanno-heptose 6-epimerase., ADP-L-glycero-D-manno-heptose-6-epimerase, Metabolic pathways, Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20]
3.90.25.10.13.1.1.1.27	2x86I02	Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Escherichia coli O157:H7, ADP-glyceromanno-heptose 6-epimerase., ADP-L-glycero-D-manno-heptose-6-epimerase, Metabolic pathways
3.90.25.10.13.1.1.1.28	2x86J02	ADP-glyceromanno-heptose 6-epimerase., Metabolic pathways, ADP-L-glycero-D-manno-heptose-6-epimerase, Escherichia coli O157:H7, Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20]
3.90.25.10.13.1.1.1.29	2x86K02	Metabolic pathways, ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase., Escherichia coli O157:H7, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Lipopolysaccharide biosynthesis
3.90.25.10.13.1.1.1.30	2x86L02	Escherichia coli O157:H7, Metabolic pathways, ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase., ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Lipopolysaccharide biosynthesis
3.90.25.10.13.1.1.1.31	2x86M02	Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], ADP-glyceromanno-heptose 6-epimerase., ADP-L-glycero-D-manno-heptose-6-epimerase, Metabolic pathways, Escherichia coli O157:H7
3.90.25.10.13.1.1.1.32	2x86N02	Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], ADP-glyceromanno-heptose 6-epimerase., Metabolic pathways, ADP-L-glycero-D-manno-heptose-6-epimerase, Escherichia coli O157:H7
3.90.25.10.13.1.1.1.33	2x86O02	Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Escherichia coli O157:H7, ADP-glyceromanno-heptose 6-epimerase., Metabolic pathways, ADP-L-glycero-D-manno-heptose-6-epimerase
3.90.25.10.13.1.1.1.34	2x86P02	ADP-glyceromanno-heptose 6-epimerase., Metabolic pathways, ADP-L-glycero-D-manno-heptose-6-epimerase, Escherichia coli O157:H7, Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20]
3.90.25.10.13.1.1.1.35	2x86Q02	ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose-6-epimerase, Metabolic pathways, ADP-glyceromanno-heptose 6-epimerase., Escherichia coli O157:H7
3.90.25.10.13.1.1.1.36	2x86R02	ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Lipopolysaccharide biosynthesis, Escherichia coli O157:H7, Metabolic pathways, ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase.
3.90.25.10.13.1.1.1.37	2x86S02	ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Lipopolysaccharide biosynthesis, Escherichia coli O157:H7, Metabolic pathways, ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase.
3.90.25.10.13.1.1.1.38	2x86T02	ADP-glyceromanno-heptose 6-epimerase., ADP-L-glycero-D-manno-heptose-6-epimerase, Metabolic pathways, Escherichia coli O157:H7, Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20]
3.90.25.10.13.1.1.1.39	1eq2A02	cytosol, Lipopolysaccharide biosynthesis, ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], membrane, Escherichia coli K-12, ADP-glyceromanno-heptose 6-epimerase., protein binding, Metabolic pathways, ADP-L-glycero-D-manno-heptose-6-epimerase
3.90.25.10.13.1.1.1.40	1eq2C02	ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20], Lipopolysaccharide biosynthesis, cytosol, ADP-L-glycero-D-manno-heptose-6-epimerase, Metabolic pathways, Escherichia coli K-12, ADP-glyceromanno-heptose 6-epimerase., protein binding, membrane

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.90.25.10.13.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.90.25.10.13.1.1.1

Classification Lineage (3.90.25.10.13.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.90.25.10.13.1.1.1 (40)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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