S100 Family: 3.90.226.10.13.1.1.1

Representative domain: 1yg6A00

Classification Lineage (3.90.226.10.13.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.90	Alpha-Beta Complex
3.90.226	2-enoyl-CoA Hydratase; Chain A, domain 1
3.90.226.10	2-enoyl-CoA Hydratase; Chain A, domain 1	Gene3D
3.90.226.10.13
3.90.226.10.13.1
3.90.226.10.13.1.1
3.90.226.10.13.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	42

Non-Redundant Representatives (42)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.90.226.10.13.1.1.1 (42)

CATH code	Domain ID	Keywords
3.90.226.10.13.1.1.1.1	1yg6A00	ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Escherichia coli K-12, Endopeptidase Clp., membrane, response to heat, cytosol, ATP-dependent Clp protease proteolytic subunit, misfolded or incompletely synthesized protein catabolic process
3.90.226.10.13.1.1.1.2	1yg6D00	membrane, Endopeptidase Clp., ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Escherichia coli K-12, ATP-dependent Clp protease proteolytic subunit, misfolded or incompletely synthesized protein catabolic process, cytosol, response to heat
3.90.226.10.13.1.1.1.3	1yg6E00	response to heat, ATP-dependent Clp protease proteolytic subunit, misfolded or incompletely synthesized protein catabolic process, cytosol, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Escherichia coli K-12, membrane, Endopeptidase Clp.
3.90.226.10.13.1.1.1.4	1yg6F00	cytosol, misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, response to heat, Endopeptidase Clp., membrane, Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
3.90.226.10.13.1.1.1.5	1yg6B00	Endopeptidase Clp., membrane, Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], cytosol, misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, response to heat
3.90.226.10.13.1.1.1.6	1yg6G00	response to heat, cytosol, ATP-dependent Clp protease proteolytic subunit, misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Escherichia coli K-12, Endopeptidase Clp., membrane
3.90.226.10.13.1.1.1.7	2fzsB00	cytosol, misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, response to heat, Endopeptidase Clp., membrane, Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
3.90.226.10.13.1.1.1.8	1yg6C00	misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, cytosol, response to heat, membrane, Endopeptidase Clp., Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
3.90.226.10.13.1.1.1.9	2fzsE00	misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, cytosol, response to heat, membrane, Endopeptidase Clp., Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
3.90.226.10.13.1.1.1.10	1yg6H00	membrane, Endopeptidase Clp., Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, cytosol, response to heat
3.90.226.10.13.1.1.1.11	2fzsA00	Endopeptidase Clp., membrane, Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], cytosol, misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, response to heat
3.90.226.10.13.1.1.1.12	2fzsK00	response to heat, ATP-dependent Clp protease proteolytic subunit, misfolded or incompletely synthesized protein catabolic process, cytosol, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Escherichia coli K-12, membrane, Endopeptidase Clp.
3.90.226.10.13.1.1.1.13	2fzsM00	Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], membrane, Endopeptidase Clp., response to heat, misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, cytosol
3.90.226.10.13.1.1.1.14	2fzsD00	Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], membrane, Endopeptidase Clp., response to heat, misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, cytosol
3.90.226.10.13.1.1.1.15	2fzsF00	Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Endopeptidase Clp., membrane, response to heat, cytosol, misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit
3.90.226.10.13.1.1.1.16	2fzsJ00	membrane, Endopeptidase Clp., Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, cytosol, response to heat
3.90.226.10.13.1.1.1.17	1yg6I00	Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Endopeptidase Clp., membrane, response to heat, cytosol, misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit
3.90.226.10.13.1.1.1.18	1yg6J00	Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Endopeptidase Clp., membrane, response to heat, cytosol, misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit
3.90.226.10.13.1.1.1.19	2fzsC00	Endopeptidase Clp., membrane, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Escherichia coli K-12, cytosol, ATP-dependent Clp protease proteolytic subunit, misfolded or incompletely synthesized protein catabolic process, response to heat
3.90.226.10.13.1.1.1.20	2fzsG00	membrane, Endopeptidase Clp., ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Escherichia coli K-12, ATP-dependent Clp protease proteolytic subunit, misfolded or incompletely synthesized protein catabolic process, cytosol, response to heat
3.90.226.10.13.1.1.1.21	2fzsH00	cytosol, misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, response to heat, Endopeptidase Clp., membrane, Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
3.90.226.10.13.1.1.1.22	2fzsI00	membrane, Endopeptidase Clp., ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Escherichia coli K-12, ATP-dependent Clp protease proteolytic subunit, misfolded or incompletely synthesized protein catabolic process, cytosol, response to heat
3.90.226.10.13.1.1.1.23	2fzsL00	cytosol, ATP-dependent Clp protease proteolytic subunit, misfolded or incompletely synthesized protein catabolic process, response to heat, Endopeptidase Clp., membrane, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Escherichia coli K-12
3.90.226.10.13.1.1.1.24	2fzsN00	ATP-dependent Clp protease proteolytic subunit, misfolded or incompletely synthesized protein catabolic process, cytosol, response to heat, membrane, Endopeptidase Clp., ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Escherichia coli K-12
3.90.226.10.13.1.1.1.25	1yg6L00	response to heat, cytosol, misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Endopeptidase Clp., membrane
3.90.226.10.13.1.1.1.26	1yg6M00	membrane, Endopeptidase Clp., Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, cytosol, response to heat
3.90.226.10.13.1.1.1.27	1yg6K00	misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, cytosol, response to heat, membrane, Endopeptidase Clp., Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
3.90.226.10.13.1.1.1.28	1yg6N00	membrane, Endopeptidase Clp., ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Escherichia coli K-12, ATP-dependent Clp protease proteolytic subunit, misfolded or incompletely synthesized protein catabolic process, cytosol, response to heat
3.90.226.10.13.1.1.1.29	1tyfA00	response to heat, misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, cytosol, Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], membrane, Endopeptidase Clp.
3.90.226.10.13.1.1.1.30	1tyfB00	cytosol, misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, response to heat, Endopeptidase Clp., membrane, Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
3.90.226.10.13.1.1.1.31	1tyfC00	membrane, Endopeptidase Clp., ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Escherichia coli K-12, ATP-dependent Clp protease proteolytic subunit, misfolded or incompletely synthesized protein catabolic process, cytosol, response to heat
3.90.226.10.13.1.1.1.32	1tyfD00	ATP-dependent Clp protease proteolytic subunit, misfolded or incompletely synthesized protein catabolic process, cytosol, response to heat, membrane, Endopeptidase Clp., ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Escherichia coli K-12
3.90.226.10.13.1.1.1.33	1tyfE00	Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], membrane, Endopeptidase Clp., response to heat, misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, cytosol
3.90.226.10.13.1.1.1.34	1tyfF00	membrane, Endopeptidase Clp., Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, cytosol, response to heat
3.90.226.10.13.1.1.1.35	1tyfG00	membrane, Endopeptidase Clp., Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, cytosol, response to heat
3.90.226.10.13.1.1.1.36	1tyfH00	membrane, Endopeptidase Clp., ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Escherichia coli K-12, ATP-dependent Clp protease proteolytic subunit, misfolded or incompletely synthesized protein catabolic process, cytosol, response to heat
3.90.226.10.13.1.1.1.37	1tyfI00	Endopeptidase Clp., membrane, Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], cytosol, misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, response to heat
3.90.226.10.13.1.1.1.38	1tyfJ00	Endopeptidase Clp., membrane, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Escherichia coli K-12, cytosol, ATP-dependent Clp protease proteolytic subunit, misfolded or incompletely synthesized protein catabolic process, response to heat
3.90.226.10.13.1.1.1.39	1tyfK00	membrane, Endopeptidase Clp., Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, cytosol, response to heat
3.90.226.10.13.1.1.1.40	1tyfL00	response to heat, cytosol, ATP-dependent Clp protease proteolytic subunit, misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Escherichia coli K-12, Endopeptidase Clp., membrane
3.90.226.10.13.1.1.1.41	1tyfM00	response to heat, cytosol, misfolded or incompletely synthesized protein catabolic process, ATP-dependent Clp protease proteolytic subunit, Escherichia coli K-12, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Endopeptidase Clp., membrane
3.90.226.10.13.1.1.1.42	1tyfN00	Endopeptidase Clp., membrane, ATP-dependent Clp protease, protease subunit [EC:3.4.21.92], Escherichia coli K-12, cytosol, ATP-dependent Clp protease proteolytic subunit, misfolded or incompletely synthesized protein catabolic process, response to heat

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.90.226.10.13.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.90.226.10.13.1.1.1

Classification Lineage (3.90.226.10.13.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.90.226.10.13.1.1.1 (42)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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