S100 Family: 3.70.10.10.5.1.1.1

Representative domain: 1u7bA00

Classification Lineage (3.70.10.10.5.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.70	Box
3.70.10	Proliferating Cell Nuclear Antigen
3.70.10.10		Gene3D
3.70.10.10.5
3.70.10.10.5.1
3.70.10.10.5.1.1
3.70.10.10.5.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	33

Non-Redundant Representatives (33)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.70.10.10.5.1.1.1 (33)

CATH code	Domain ID	Keywords
3.70.10.10.5.1.1.1.1	1u7bA00	Nucleotide excision repair, DNA replication factor C complex, Homo sapiens, mismatch repair, Base excision repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, purine-specific mismatch base pair DNA N-glycosylase activity, Mismatch repair, cell proliferation, proliferating cell nuclear antigen, DNA replication, dinucleotide insertion or deletion binding
3.70.10.10.5.1.1.1.2	2zvmB00	Base excision repair, mismatch repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, Nucleotide excision repair, Homo sapiens, DNA replication factor C complex, DNA replication, dinucleotide insertion or deletion binding, cell proliferation, Mismatch repair, purine-specific mismatch base pair DNA N-glycosylase activity, proliferating cell nuclear antigen
3.70.10.10.5.1.1.1.3	2zvmA00	Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, mismatch repair, Base excision repair, Homo sapiens, DNA replication factor C complex, Nucleotide excision repair, dinucleotide insertion or deletion binding, DNA replication, proliferating cell nuclear antigen, purine-specific mismatch base pair DNA N-glycosylase activity, Mismatch repair, cell proliferation
3.70.10.10.5.1.1.1.4	2zvmC00	Base excision repair, mismatch repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, Nucleotide excision repair, Homo sapiens, DNA replication factor C complex, DNA replication, dinucleotide insertion or deletion binding, Mismatch repair, cell proliferation, purine-specific mismatch base pair DNA N-glycosylase activity, proliferating cell nuclear antigen
3.70.10.10.5.1.1.1.5	1vymA00	proliferating cell nuclear antigen, purine-specific mismatch base pair DNA N-glycosylase activity, cell proliferation, Mismatch repair, dinucleotide insertion or deletion binding, DNA replication, DNA replication factor C complex, Homo sapiens, Nucleotide excision repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, mismatch repair, Base excision repair
3.70.10.10.5.1.1.1.6	1vymB00	proliferating cell nuclear antigen, Mismatch repair, cell proliferation, purine-specific mismatch base pair DNA N-glycosylase activity, dinucleotide insertion or deletion binding, DNA replication, DNA replication factor C complex, Homo sapiens, Nucleotide excision repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, Base excision repair, mismatch repair
3.70.10.10.5.1.1.1.7	1vymC00	Homo sapiens, DNA replication factor C complex, Nucleotide excision repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, Base excision repair, mismatch repair, proliferating cell nuclear antigen, cell proliferation, Mismatch repair, purine-specific mismatch base pair DNA N-glycosylase activity, dinucleotide insertion or deletion binding, DNA replication
3.70.10.10.5.1.1.1.8	2zvlB00	dinucleotide insertion or deletion binding, DNA replication, proliferating cell nuclear antigen, cell proliferation, Mismatch repair, purine-specific mismatch base pair DNA N-glycosylase activity, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, Base excision repair, mismatch repair, DNA replication factor C complex, Homo sapiens, Nucleotide excision repair
3.70.10.10.5.1.1.1.9	2zvlC00	DNA replication, dinucleotide insertion or deletion binding, purine-specific mismatch base pair DNA N-glycosylase activity, cell proliferation, Mismatch repair, proliferating cell nuclear antigen, mismatch repair, Base excision repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, Nucleotide excision repair, DNA replication factor C complex, Homo sapiens
3.70.10.10.5.1.1.1.10	2zvlD00	DNA replication, dinucleotide insertion or deletion binding, Mismatch repair, cell proliferation, purine-specific mismatch base pair DNA N-glycosylase activity, proliferating cell nuclear antigen, Base excision repair, mismatch repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, Nucleotide excision repair, Homo sapiens, DNA replication factor C complex
3.70.10.10.5.1.1.1.11	2zvlA00	dinucleotide insertion or deletion binding, DNA replication, proliferating cell nuclear antigen, purine-specific mismatch base pair DNA N-glycosylase activity, cell proliferation, Mismatch repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, mismatch repair, Base excision repair, DNA replication factor C complex, Homo sapiens, Nucleotide excision repair
3.70.10.10.5.1.1.1.12	2zvlE00	Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, Base excision repair, mismatch repair, Homo sapiens, DNA replication factor C complex, Nucleotide excision repair, dinucleotide insertion or deletion binding, DNA replication, proliferating cell nuclear antigen, Mismatch repair, cell proliferation, purine-specific mismatch base pair DNA N-glycosylase activity
3.70.10.10.5.1.1.1.13	2zvlF00	cell proliferation, Mismatch repair, purine-specific mismatch base pair DNA N-glycosylase activity, proliferating cell nuclear antigen, DNA replication, dinucleotide insertion or deletion binding, Nucleotide excision repair, Homo sapiens, DNA replication factor C complex, Base excision repair, mismatch repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding
3.70.10.10.5.1.1.1.14	1axcC00	cell proliferation, Mismatch repair, purine-specific mismatch base pair DNA N-glycosylase activity, proliferating cell nuclear antigen, DNA replication, dinucleotide insertion or deletion binding, Nucleotide excision repair, Homo sapiens, DNA replication factor C complex, Base excision repair, mismatch repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding
3.70.10.10.5.1.1.1.15	1axcA00	Nucleotide excision repair, DNA replication factor C complex, Homo sapiens, mismatch repair, Base excision repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, purine-specific mismatch base pair DNA N-glycosylase activity, Mismatch repair, cell proliferation, proliferating cell nuclear antigen, DNA replication, dinucleotide insertion or deletion binding
3.70.10.10.5.1.1.1.16	1u76C00	dinucleotide insertion or deletion binding, DNA replication, proliferating cell nuclear antigen, purine-specific mismatch base pair DNA N-glycosylase activity, Mismatch repair, cell proliferation, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, mismatch repair, Base excision repair, Homo sapiens, DNA replication factor C complex, Nucleotide excision repair
3.70.10.10.5.1.1.1.17	1axcE00	Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, Base excision repair, mismatch repair, DNA replication factor C complex, Homo sapiens, Nucleotide excision repair, dinucleotide insertion or deletion binding, DNA replication, proliferating cell nuclear antigen, Mismatch repair, cell proliferation, purine-specific mismatch base pair DNA N-glycosylase activity
3.70.10.10.5.1.1.1.18	1u76A00	Nucleotide excision repair, Homo sapiens, DNA replication factor C complex, mismatch repair, Base excision repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, purine-specific mismatch base pair DNA N-glycosylase activity, Mismatch repair, cell proliferation, proliferating cell nuclear antigen, DNA replication, dinucleotide insertion or deletion binding
3.70.10.10.5.1.1.1.19	1u76E00	dinucleotide insertion or deletion binding, DNA replication, proliferating cell nuclear antigen, purine-specific mismatch base pair DNA N-glycosylase activity, cell proliferation, Mismatch repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, mismatch repair, Base excision repair, DNA replication factor C complex, Homo sapiens, Nucleotide excision repair
3.70.10.10.5.1.1.1.20	2zvkC00	purine-specific mismatch base pair DNA N-glycosylase activity, cell proliferation, Mismatch repair, proliferating cell nuclear antigen, DNA replication, dinucleotide insertion or deletion binding, Nucleotide excision repair, DNA replication factor C complex, Homo sapiens, mismatch repair, Base excision repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding
3.70.10.10.5.1.1.1.21	2zvkA00	DNA replication factor C complex, Homo sapiens, Nucleotide excision repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, Base excision repair, mismatch repair, proliferating cell nuclear antigen, Mismatch repair, cell proliferation, purine-specific mismatch base pair DNA N-glycosylase activity, dinucleotide insertion or deletion binding, DNA replication
3.70.10.10.5.1.1.1.22	2zvkB00	Nucleotide excision repair, DNA replication factor C complex, Homo sapiens, mismatch repair, Base excision repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, purine-specific mismatch base pair DNA N-glycosylase activity, cell proliferation, Mismatch repair, proliferating cell nuclear antigen, DNA replication, dinucleotide insertion or deletion binding
3.70.10.10.5.1.1.1.23	1vyjA00	DNA replication factor C complex, Homo sapiens, Nucleotide excision repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, mismatch repair, Base excision repair, proliferating cell nuclear antigen, purine-specific mismatch base pair DNA N-glycosylase activity, Mismatch repair, cell proliferation, dinucleotide insertion or deletion binding, DNA replication
3.70.10.10.5.1.1.1.24	1vyjC00	DNA replication, dinucleotide insertion or deletion binding, Mismatch repair, cell proliferation, purine-specific mismatch base pair DNA N-glycosylase activity, proliferating cell nuclear antigen, Base excision repair, mismatch repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, Nucleotide excision repair, Homo sapiens, DNA replication factor C complex
3.70.10.10.5.1.1.1.25	1vyjE00	dinucleotide insertion or deletion binding, DNA replication, proliferating cell nuclear antigen, purine-specific mismatch base pair DNA N-glycosylase activity, Mismatch repair, cell proliferation, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, mismatch repair, Base excision repair, Homo sapiens, DNA replication factor C complex, Nucleotide excision repair
3.70.10.10.5.1.1.1.26	1vyjI00	Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, Base excision repair, mismatch repair, DNA replication factor C complex, Homo sapiens, Nucleotide excision repair, dinucleotide insertion or deletion binding, DNA replication, proliferating cell nuclear antigen, Mismatch repair, cell proliferation, purine-specific mismatch base pair DNA N-glycosylase activity
3.70.10.10.5.1.1.1.27	1vyjK00	proliferating cell nuclear antigen, purine-specific mismatch base pair DNA N-glycosylase activity, cell proliferation, Mismatch repair, dinucleotide insertion or deletion binding, DNA replication, Homo sapiens, DNA replication factor C complex, Nucleotide excision repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, mismatch repair, Base excision repair
3.70.10.10.5.1.1.1.28	1vyjG00	DNA replication, dinucleotide insertion or deletion binding, cell proliferation, Mismatch repair, purine-specific mismatch base pair DNA N-glycosylase activity, proliferating cell nuclear antigen, Base excision repair, mismatch repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, Nucleotide excision repair, DNA replication factor C complex, Homo sapiens
3.70.10.10.5.1.1.1.29	1ul1C00	dinucleotide insertion or deletion binding, DNA replication, proliferating cell nuclear antigen, Mismatch repair, cell proliferation, purine-specific mismatch base pair DNA N-glycosylase activity, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, Base excision repair, mismatch repair, DNA replication factor C complex, Homo sapiens, Nucleotide excision repair
3.70.10.10.5.1.1.1.30	1ul1A00	Homo sapiens, DNA replication factor C complex, Nucleotide excision repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, Base excision repair, mismatch repair, proliferating cell nuclear antigen, cell proliferation, Mismatch repair, purine-specific mismatch base pair DNA N-glycosylase activity, dinucleotide insertion or deletion binding, DNA replication
3.70.10.10.5.1.1.1.31	1ul1B00	DNA replication factor C complex, Homo sapiens, Nucleotide excision repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, mismatch repair, Base excision repair, proliferating cell nuclear antigen, purine-specific mismatch base pair DNA N-glycosylase activity, cell proliferation, Mismatch repair, dinucleotide insertion or deletion binding, DNA replication
3.70.10.10.5.1.1.1.32	1w60A00	proliferating cell nuclear antigen, purine-specific mismatch base pair DNA N-glycosylase activity, Mismatch repair, cell proliferation, dinucleotide insertion or deletion binding, DNA replication, DNA replication factor C complex, Homo sapiens, Nucleotide excision repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding, mismatch repair, Base excision repair
3.70.10.10.5.1.1.1.33	1w60B00	purine-specific mismatch base pair DNA N-glycosylase activity, Mismatch repair, cell proliferation, proliferating cell nuclear antigen, DNA replication, dinucleotide insertion or deletion binding, Nucleotide excision repair, DNA replication factor C complex, Homo sapiens, mismatch repair, Base excision repair, Cell cycle, Proliferating cell nuclear antigen, MutLalpha complex binding

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.70.10.10.5.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.70.10.10.5.1.1.1

Classification Lineage (3.70.10.10.5.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.70.10.10.5.1.1.1 (33)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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