S100 Family: 3.60.20.10.9.1.1.1

Representative domain: 1rypD00

Classification Lineage (3.60.20.10.9.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.60	4-Layer Sandwich
3.60.20	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
3.60.20.10	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Gene3D
3.60.20.10.9
3.60.20.10.9.1
3.60.20.10.9.1.1
3.60.20.10.9.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	40

Non-Redundant Representatives (40)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.60.20.10.9.1.1.1 (40)

CATH code	Domain ID	Keywords
3.60.20.10.9.1.1.1.1	1rypD00	protein binding, ubiquitin-dependent protein catabolic process, mitochondrion, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome
3.60.20.10.9.1.1.1.2	1rypR00	proteasome core complex, alpha-subunit complex, Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome, protein binding, ubiquitin-dependent protein catabolic process, mitochondrion, Proteasome endopeptidase complex.
3.60.20.10.9.1.1.1.3	1g65C00	ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex., mitochondrion, proteasome core complex, alpha-subunit complex, Proteasome, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome component PRE6, proteasome storage granule
3.60.20.10.9.1.1.1.4	1g65Q00	mitochondrion, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process, Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.9.1.1.1.5	1g0uC00	mitochondrion, Proteasome endopeptidase complex., ubiquitin-dependent protein catabolic process, protein binding, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome component PRE6, proteasome storage granule, Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.9.1.1.1.6	1g0uQ00	mitochondrion, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process, Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.9.1.1.1.7	3gptC00	Proteasome, Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., mitochondrion, protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.9.1.1.1.8	3gptQ00	Proteasome endopeptidase complex., mitochondrion, protein binding, ubiquitin-dependent protein catabolic process, Proteasome, Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex
3.60.20.10.9.1.1.1.9	3gpwC00	Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex, mitochondrion, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.9.1.1.1.10	3gpwQ00	Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex, mitochondrion, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.9.1.1.1.11	3hyeC00	Proteasome, Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., mitochondrion, protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.9.1.1.1.12	3hyeQ00	Proteasome endopeptidase complex., mitochondrion, ubiquitin-dependent protein catabolic process, protein binding, Proteasome, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome component PRE6, proteasome storage granule, proteasome core complex, alpha-subunit complex
3.60.20.10.9.1.1.1.13	3d29C00	Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex, mitochondrion, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.9.1.1.1.14	3d29Q00	protein binding, ubiquitin-dependent protein catabolic process, mitochondrion, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome
3.60.20.10.9.1.1.1.15	3bdmC00	mitochondrion, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process, Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.9.1.1.1.16	3bdmQ00	Proteasome endopeptidase complex., mitochondrion, protein binding, ubiquitin-dependent protein catabolic process, Proteasome, Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex
3.60.20.10.9.1.1.1.17	3gpjC00	mitochondrion, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process, Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.9.1.1.1.18	3gpjQ00	mitochondrion, Proteasome endopeptidase complex., ubiquitin-dependent protein catabolic process, protein binding, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome component PRE6, proteasome storage granule, Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.9.1.1.1.19	2f16C00	mitochondrion, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process, Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.9.1.1.1.20	2f16Q00	mitochondrion, Proteasome endopeptidase complex., ubiquitin-dependent protein catabolic process, protein binding, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome component PRE6, proteasome storage granule, Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.9.1.1.1.21	2fakC00	proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome component PRE6, proteasome storage granule, Proteasome, ubiquitin-dependent protein catabolic process, protein binding, mitochondrion, Proteasome endopeptidase complex.
3.60.20.10.9.1.1.1.22	2fakQ00	proteasome core complex, alpha-subunit complex, Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome, protein binding, ubiquitin-dependent protein catabolic process, mitochondrion, Proteasome endopeptidase complex.
3.60.20.10.9.1.1.1.23	3dy4C00	Proteasome endopeptidase complex., mitochondrion, ubiquitin-dependent protein catabolic process, protein binding, Proteasome, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome component PRE6, proteasome storage granule, proteasome core complex, alpha-subunit complex
3.60.20.10.9.1.1.1.24	3dy4Q00	Proteasome, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome component PRE6, proteasome storage granule, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., mitochondrion, ubiquitin-dependent protein catabolic process, protein binding
3.60.20.10.9.1.1.1.25	2gplC00	Proteasome, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome component PRE6, proteasome storage granule, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., mitochondrion, ubiquitin-dependent protein catabolic process, protein binding
3.60.20.10.9.1.1.1.26	2gplQ00	proteasome core complex, alpha-subunit complex, Proteasome, Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, protein binding, ubiquitin-dependent protein catabolic process, Proteasome endopeptidase complex., mitochondrion
3.60.20.10.9.1.1.1.27	3dy3C00	Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex, mitochondrion, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.9.1.1.1.28	3dy3Q00	mitochondrion, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process, Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.9.1.1.1.29	2zcyC00	Proteasome, Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., mitochondrion, protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.9.1.1.1.30	2zcyQ00	proteasome core complex, alpha-subunit complex, Proteasome, Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, protein binding, ubiquitin-dependent protein catabolic process, Proteasome endopeptidase complex., mitochondrion
3.60.20.10.9.1.1.1.31	1jd2C00	Proteasome, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome component PRE6, proteasome storage granule, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., mitochondrion, ubiquitin-dependent protein catabolic process, protein binding
3.60.20.10.9.1.1.1.32	1jd2X00	Proteasome endopeptidase complex., mitochondrion, ubiquitin-dependent protein catabolic process, protein binding, Proteasome, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome component PRE6, proteasome storage granule, proteasome core complex, alpha-subunit complex
3.60.20.10.9.1.1.1.33	3e47C00	Proteasome endopeptidase complex., mitochondrion, ubiquitin-dependent protein catabolic process, protein binding, Proteasome, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome component PRE6, proteasome storage granule, proteasome core complex, alpha-subunit complex
3.60.20.10.9.1.1.1.34	3e47Q00	proteasome core complex, alpha-subunit complex, Proteasome, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome component PRE6, proteasome storage granule, ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex., mitochondrion
3.60.20.10.9.1.1.1.35	1fntD00	ubiquitin-dependent protein catabolic process, protein binding, mitochondrion, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome component PRE6, proteasome storage granule, Proteasome
3.60.20.10.9.1.1.1.36	1fntR00	proteasome core complex, alpha-subunit complex, Proteasome, Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, protein binding, ubiquitin-dependent protein catabolic process, Proteasome endopeptidase complex., mitochondrion
3.60.20.10.9.1.1.1.37	1z7qD00	Proteasome component PRE6, proteasome storage granule, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex, mitochondrion, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.9.1.1.1.38	1z7qR00	Proteasome endopeptidase complex., mitochondrion, ubiquitin-dependent protein catabolic process, protein binding, Proteasome, 20S proteasome subunit alpha 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome component PRE6, proteasome storage granule, proteasome core complex, alpha-subunit complex
3.60.20.10.9.1.1.1.39	2fnyC00
3.60.20.10.9.1.1.1.40	2fnyQ00

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.60.20.10.9.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.60.20.10.9.1.1.1

Classification Lineage (3.60.20.10.9.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.60.20.10.9.1.1.1 (40)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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