S100 Family: 3.60.20.10.7.1.1.1

Representative domain: 1rypF00

Classification Lineage (3.60.20.10.7.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.60	4-Layer Sandwich
3.60.20	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
3.60.20.10	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Gene3D
3.60.20.10.7
3.60.20.10.7.1
3.60.20.10.7.1.1
3.60.20.10.7.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	42

Non-Redundant Representatives (42)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.60.20.10.7.1.1.1 (42)

CATH code	Domain ID	Keywords
3.60.20.10.7.1.1.1.1	1rypF00	proteasome core complex, alpha-subunit complex, Proteasome, proteasome storage granule, Saccharomyces cerevisiae, Proteasome component PRE5, ubiquitin-dependent protein catabolic process, 20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome endopeptidase complex.
3.60.20.10.7.1.1.1.2	1rypT00	Proteasome endopeptidase complex., Proteasome component PRE5, ubiquitin-dependent protein catabolic process, 20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome, proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex
3.60.20.10.7.1.1.1.3	1g65E00	Proteasome endopeptidase complex., Proteasome component PRE5, ubiquitin-dependent protein catabolic process, 20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, proteasome core complex, alpha-subunit complex
3.60.20.10.7.1.1.1.4	1g65S00	20S proteasome subunit alpha 6 [EC:3.4.25.1], ubiquitin-dependent protein catabolic process, Proteasome component PRE5, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, Saccharomyces cerevisiae, proteasome storage granule, Proteasome
3.60.20.10.7.1.1.1.5	3gptE00	Proteasome, Saccharomyces cerevisiae, proteasome storage granule, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., Proteasome component PRE5, ubiquitin-dependent protein catabolic process, 20S proteasome subunit alpha 6 [EC:3.4.25.1]
3.60.20.10.7.1.1.1.6	3gptS00	20S proteasome subunit alpha 6 [EC:3.4.25.1], ubiquitin-dependent protein catabolic process, Proteasome component PRE5, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, proteasome storage granule, Saccharomyces cerevisiae, Proteasome
3.60.20.10.7.1.1.1.7	3gpwE00	proteasome storage granule, Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., 20S proteasome subunit alpha 6 [EC:3.4.25.1], ubiquitin-dependent protein catabolic process, Proteasome component PRE5
3.60.20.10.7.1.1.1.8	3gpwS00	20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome component PRE5, ubiquitin-dependent protein catabolic process, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, proteasome storage granule, Saccharomyces cerevisiae, Proteasome
3.60.20.10.7.1.1.1.9	3hyeE00	Proteasome endopeptidase complex., 20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome component PRE5, ubiquitin-dependent protein catabolic process, Saccharomyces cerevisiae, proteasome storage granule, Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.7.1.1.1.10	3hyeS00	proteasome core complex, alpha-subunit complex, Proteasome, proteasome storage granule, Saccharomyces cerevisiae, ubiquitin-dependent protein catabolic process, Proteasome component PRE5, 20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome endopeptidase complex.
3.60.20.10.7.1.1.1.11	3d29E00	Proteasome endopeptidase complex., Proteasome component PRE5, ubiquitin-dependent protein catabolic process, 20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome, proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex
3.60.20.10.7.1.1.1.12	3d29S00	proteasome core complex, alpha-subunit complex, Proteasome, Saccharomyces cerevisiae, proteasome storage granule, ubiquitin-dependent protein catabolic process, Proteasome component PRE5, 20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome endopeptidase complex.
3.60.20.10.7.1.1.1.13	3bdmE00	proteasome core complex, alpha-subunit complex, Proteasome, Saccharomyces cerevisiae, proteasome storage granule, Proteasome component PRE5, ubiquitin-dependent protein catabolic process, 20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome endopeptidase complex.
3.60.20.10.7.1.1.1.14	3bdmS00	Saccharomyces cerevisiae, proteasome storage granule, Proteasome, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., 20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome component PRE5, ubiquitin-dependent protein catabolic process
3.60.20.10.7.1.1.1.15	3gpjE00	ubiquitin-dependent protein catabolic process, Proteasome component PRE5, 20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, Proteasome, proteasome storage granule, Saccharomyces cerevisiae
3.60.20.10.7.1.1.1.16	3gpjS00	Proteasome endopeptidase complex., 20S proteasome subunit alpha 6 [EC:3.4.25.1], ubiquitin-dependent protein catabolic process, Proteasome component PRE5, Saccharomyces cerevisiae, proteasome storage granule, Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.7.1.1.1.17	2f16E00	proteasome core complex, alpha-subunit complex, Proteasome, Saccharomyces cerevisiae, proteasome storage granule, ubiquitin-dependent protein catabolic process, Proteasome component PRE5, 20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome endopeptidase complex.
3.60.20.10.7.1.1.1.18	2f16S00	Saccharomyces cerevisiae, proteasome storage granule, Proteasome, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., 20S proteasome subunit alpha 6 [EC:3.4.25.1], ubiquitin-dependent protein catabolic process, Proteasome component PRE5
3.60.20.10.7.1.1.1.19	2fakE00	Proteasome component PRE5, ubiquitin-dependent protein catabolic process, 20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, Proteasome, Saccharomyces cerevisiae, proteasome storage granule
3.60.20.10.7.1.1.1.20	2fakS00	20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome component PRE5, ubiquitin-dependent protein catabolic process, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, Saccharomyces cerevisiae, proteasome storage granule, Proteasome
3.60.20.10.7.1.1.1.21	3dy4E00	Saccharomyces cerevisiae, proteasome storage granule, Proteasome, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., 20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome component PRE5, ubiquitin-dependent protein catabolic process
3.60.20.10.7.1.1.1.22	3dy4S00	20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome component PRE5, ubiquitin-dependent protein catabolic process, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, proteasome storage granule, Saccharomyces cerevisiae, Proteasome
3.60.20.10.7.1.1.1.23	2gplE00	Proteasome, Saccharomyces cerevisiae, proteasome storage granule, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., Proteasome component PRE5, ubiquitin-dependent protein catabolic process, 20S proteasome subunit alpha 6 [EC:3.4.25.1]
3.60.20.10.7.1.1.1.24	2gplS00	ubiquitin-dependent protein catabolic process, Proteasome component PRE5, 20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, Proteasome, proteasome storage granule, Saccharomyces cerevisiae
3.60.20.10.7.1.1.1.25	3dy3E00	proteasome storage granule, Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., 20S proteasome subunit alpha 6 [EC:3.4.25.1], ubiquitin-dependent protein catabolic process, Proteasome component PRE5
3.60.20.10.7.1.1.1.26	3dy3S00	Proteasome endopeptidase complex., Proteasome component PRE5, ubiquitin-dependent protein catabolic process, 20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome, proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex
3.60.20.10.7.1.1.1.27	2zcyE00	20S proteasome subunit alpha 6 [EC:3.4.25.1], ubiquitin-dependent protein catabolic process, Proteasome component PRE5, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, Saccharomyces cerevisiae, proteasome storage granule, Proteasome
3.60.20.10.7.1.1.1.28	2zcyS00	20S proteasome subunit alpha 6 [EC:3.4.25.1], ubiquitin-dependent protein catabolic process, Proteasome component PRE5, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, proteasome storage granule, Saccharomyces cerevisiae, Proteasome
3.60.20.10.7.1.1.1.29	1jd2E00	proteasome core complex, alpha-subunit complex, Proteasome, Saccharomyces cerevisiae, proteasome storage granule, ubiquitin-dependent protein catabolic process, Proteasome component PRE5, 20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome endopeptidase complex.
3.60.20.10.7.1.1.1.30	1jd2Z00	20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome component PRE5, ubiquitin-dependent protein catabolic process, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, Saccharomyces cerevisiae, proteasome storage granule, Proteasome
3.60.20.10.7.1.1.1.31	3e47E00	Proteasome endopeptidase complex., 20S proteasome subunit alpha 6 [EC:3.4.25.1], ubiquitin-dependent protein catabolic process, Proteasome component PRE5, Saccharomyces cerevisiae, proteasome storage granule, Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.7.1.1.1.32	3e47S00	Proteasome, proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., Proteasome component PRE5, ubiquitin-dependent protein catabolic process, 20S proteasome subunit alpha 6 [EC:3.4.25.1]
3.60.20.10.7.1.1.1.33	1vsyF00	Proteasome endopeptidase complex., 20S proteasome subunit alpha 6 [EC:3.4.25.1], ubiquitin-dependent protein catabolic process, Proteasome component PRE5, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.7.1.1.1.34	1vsyT00	proteasome core complex, alpha-subunit complex, Proteasome, proteasome storage granule, Saccharomyces cerevisiae, ubiquitin-dependent protein catabolic process, Proteasome component PRE5, 20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome endopeptidase complex.
3.60.20.10.7.1.1.1.35	3l5qK00	ubiquitin-dependent protein catabolic process, Proteasome component PRE5, 20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, Proteasome, proteasome storage granule, Saccharomyces cerevisiae
3.60.20.10.7.1.1.1.36	3l5qW00	proteasome core complex, alpha-subunit complex, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome component PRE5, ubiquitin-dependent protein catabolic process, Proteasome endopeptidase complex.
3.60.20.10.7.1.1.1.37	1fntF00	proteasome storage granule, Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., 20S proteasome subunit alpha 6 [EC:3.4.25.1], ubiquitin-dependent protein catabolic process, Proteasome component PRE5
3.60.20.10.7.1.1.1.38	1fntT00	Proteasome endopeptidase complex., 20S proteasome subunit alpha 6 [EC:3.4.25.1], ubiquitin-dependent protein catabolic process, Proteasome component PRE5, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.7.1.1.1.39	1z7qF00	Proteasome endopeptidase complex., ubiquitin-dependent protein catabolic process, Proteasome component PRE5, 20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome, proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex
3.60.20.10.7.1.1.1.40	1z7qT00	ubiquitin-dependent protein catabolic process, Proteasome component PRE5, 20S proteasome subunit alpha 6 [EC:3.4.25.1], Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, Proteasome, Saccharomyces cerevisiae, proteasome storage granule
3.60.20.10.7.1.1.1.41	2fnyE00
3.60.20.10.7.1.1.1.42	2fnyS00

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.60.20.10.7.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.60.20.10.7.1.1.1

Classification Lineage (3.60.20.10.7.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.60.20.10.7.1.1.1 (42)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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