S100 Family: 3.60.20.10.2.1.1.1

Representative domain: 1ryp100

Classification Lineage (3.60.20.10.2.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.60	4-Layer Sandwich
3.60.20	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
3.60.20.10	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Gene3D
3.60.20.10.2
3.60.20.10.2.1
3.60.20.10.2.1.1
3.60.20.10.2.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	44

Non-Redundant Representatives (44)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.60.20.10.2.1.1.1 (44)

CATH code	Domain ID	Keywords
3.60.20.10.2.1.1.1.1	1ryp100	Proteasome, Saccharomyces cerevisiae, Proteasome endopeptidase complex., proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1], protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C5
3.60.20.10.2.1.1.1.2	1rypM00	Proteasome, Saccharomyces cerevisiae, Proteasome endopeptidase complex., proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1], protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C5
3.60.20.10.2.1.1.1.3	1g65L00	ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C5, Proteasome endopeptidase complex., 20S proteasome subunit beta 6 [EC:3.4.25.1], proteasome core complex, beta-subunit complex, Proteasome, Saccharomyces cerevisiae
3.60.20.10.2.1.1.1.4	1g65Z00	Proteasome, Saccharomyces cerevisiae, ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C5, Proteasome endopeptidase complex., 20S proteasome subunit beta 6 [EC:3.4.25.1], proteasome core complex, beta-subunit complex
3.60.20.10.2.1.1.1.5	1g0uL00	Proteasome, Saccharomyces cerevisiae, Proteasome endopeptidase complex., proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1], protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C5
3.60.20.10.2.1.1.1.6	1g0uZ00	Saccharomyces cerevisiae, Proteasome, proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1], Proteasome endopeptidase complex., Proteasome component C5, protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.2.1.1.1.7	3gptL00	Proteasome component C5, protein binding, ubiquitin-dependent protein catabolic process, proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1], Proteasome endopeptidase complex., Saccharomyces cerevisiae, Proteasome
3.60.20.10.2.1.1.1.8	3gptZ00	Proteasome, Saccharomyces cerevisiae, ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C5, Proteasome endopeptidase complex., 20S proteasome subunit beta 6 [EC:3.4.25.1], proteasome core complex, beta-subunit complex
3.60.20.10.2.1.1.1.9	3gpwL00	Proteasome, Saccharomyces cerevisiae, protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C5, Proteasome endopeptidase complex., proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1]
3.60.20.10.2.1.1.1.10	3gpwZ00	Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit beta 6 [EC:3.4.25.1], proteasome core complex, beta-subunit complex, Proteasome endopeptidase complex., Proteasome component C5, ubiquitin-dependent protein catabolic process, protein binding
3.60.20.10.2.1.1.1.11	3hyeL00	Proteasome, Saccharomyces cerevisiae, ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C5, Proteasome endopeptidase complex., 20S proteasome subunit beta 6 [EC:3.4.25.1], proteasome core complex, beta-subunit complex
3.60.20.10.2.1.1.1.12	3hyeZ00	Saccharomyces cerevisiae, Proteasome, Proteasome component C5, ubiquitin-dependent protein catabolic process, protein binding, 20S proteasome subunit beta 6 [EC:3.4.25.1], proteasome core complex, beta-subunit complex, Proteasome endopeptidase complex.
3.60.20.10.2.1.1.1.13	3d29L00	20S proteasome subunit beta 6 [EC:3.4.25.1], proteasome core complex, beta-subunit complex, Proteasome endopeptidase complex., Proteasome component C5, ubiquitin-dependent protein catabolic process, protein binding, Saccharomyces cerevisiae, Proteasome
3.60.20.10.2.1.1.1.14	3d29Z00	proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1], Proteasome endopeptidase complex., Proteasome component C5, protein binding, ubiquitin-dependent protein catabolic process, Saccharomyces cerevisiae, Proteasome
3.60.20.10.2.1.1.1.15	3bdmL00	Proteasome endopeptidase complex., 20S proteasome subunit beta 6 [EC:3.4.25.1], proteasome core complex, beta-subunit complex, ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C5, Proteasome, Saccharomyces cerevisiae
3.60.20.10.2.1.1.1.16	3bdmZ00	ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C5, Proteasome endopeptidase complex., 20S proteasome subunit beta 6 [EC:3.4.25.1], proteasome core complex, beta-subunit complex, Proteasome, Saccharomyces cerevisiae
3.60.20.10.2.1.1.1.17	3gpjL00	proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1], Proteasome endopeptidase complex., Proteasome component C5, protein binding, ubiquitin-dependent protein catabolic process, Saccharomyces cerevisiae, Proteasome
3.60.20.10.2.1.1.1.18	3gpjZ00	Proteasome, Saccharomyces cerevisiae, Proteasome endopeptidase complex., 20S proteasome subunit beta 6 [EC:3.4.25.1], proteasome core complex, beta-subunit complex, ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C5
3.60.20.10.2.1.1.1.19	2f16L00	Proteasome endopeptidase complex., proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1], protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C5, Proteasome, Saccharomyces cerevisiae
3.60.20.10.2.1.1.1.20	2f16Z00	Proteasome, Saccharomyces cerevisiae, Proteasome endopeptidase complex., 20S proteasome subunit beta 6 [EC:3.4.25.1], proteasome core complex, beta-subunit complex, ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C5
3.60.20.10.2.1.1.1.21	2fakL00	Proteasome endopeptidase complex., 20S proteasome subunit beta 6 [EC:3.4.25.1], proteasome core complex, beta-subunit complex, ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C5, Proteasome, Saccharomyces cerevisiae
3.60.20.10.2.1.1.1.22	2fakZ00	Saccharomyces cerevisiae, Proteasome, Proteasome component C5, protein binding, ubiquitin-dependent protein catabolic process, proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1], Proteasome endopeptidase complex.
3.60.20.10.2.1.1.1.23	3dy4L00	ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C5, Proteasome endopeptidase complex., 20S proteasome subunit beta 6 [EC:3.4.25.1], proteasome core complex, beta-subunit complex, Proteasome, Saccharomyces cerevisiae
3.60.20.10.2.1.1.1.24	3dy4Z00	Saccharomyces cerevisiae, Proteasome, Proteasome component C5, protein binding, ubiquitin-dependent protein catabolic process, proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1], Proteasome endopeptidase complex.
3.60.20.10.2.1.1.1.25	2gplL00	Saccharomyces cerevisiae, Proteasome, proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1], Proteasome endopeptidase complex., Proteasome component C5, protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.2.1.1.1.26	2gplZ00	protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C5, Proteasome endopeptidase complex., proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae
3.60.20.10.2.1.1.1.27	3dy3L00	20S proteasome subunit beta 6 [EC:3.4.25.1], proteasome core complex, beta-subunit complex, Proteasome endopeptidase complex., Proteasome component C5, ubiquitin-dependent protein catabolic process, protein binding, Saccharomyces cerevisiae, Proteasome
3.60.20.10.2.1.1.1.28	3dy3Z00	Proteasome endopeptidase complex., proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1], protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C5, Proteasome, Saccharomyces cerevisiae
3.60.20.10.2.1.1.1.29	2zcyL00	Saccharomyces cerevisiae, Proteasome, proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1], Proteasome endopeptidase complex., Proteasome component C5, protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.2.1.1.1.30	2zcyZ00	proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1], Proteasome endopeptidase complex., Proteasome component C5, protein binding, ubiquitin-dependent protein catabolic process, Saccharomyces cerevisiae, Proteasome
3.60.20.10.2.1.1.1.31	1jd2L00	Proteasome, Saccharomyces cerevisiae, protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C5, Proteasome endopeptidase complex., proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1]
3.60.20.10.2.1.1.1.32	1jd2S00	Saccharomyces cerevisiae, Proteasome, proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1], Proteasome endopeptidase complex., Proteasome component C5, protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.2.1.1.1.33	1vsy100	Proteasome, Saccharomyces cerevisiae, ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C5, Proteasome endopeptidase complex., 20S proteasome subunit beta 6 [EC:3.4.25.1], proteasome core complex, beta-subunit complex
3.60.20.10.2.1.1.1.34	1vsyM00	Proteasome component C5, protein binding, ubiquitin-dependent protein catabolic process, proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1], Proteasome endopeptidase complex., Saccharomyces cerevisiae, Proteasome
3.60.20.10.2.1.1.1.35	3e47L00	ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C5, Proteasome endopeptidase complex., 20S proteasome subunit beta 6 [EC:3.4.25.1], proteasome core complex, beta-subunit complex, Proteasome, Saccharomyces cerevisiae
3.60.20.10.2.1.1.1.36	3e47Z00	Saccharomyces cerevisiae, Proteasome, Proteasome component C5, ubiquitin-dependent protein catabolic process, protein binding, 20S proteasome subunit beta 6 [EC:3.4.25.1], proteasome core complex, beta-subunit complex, Proteasome endopeptidase complex.
3.60.20.10.2.1.1.1.37	3l5q300	protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C5, Proteasome endopeptidase complex., proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae
3.60.20.10.2.1.1.1.38	3l5qQ00	Proteasome endopeptidase complex., 20S proteasome subunit beta 6 [EC:3.4.25.1], proteasome core complex, beta-subunit complex, ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C5, Proteasome, Saccharomyces cerevisiae
3.60.20.10.2.1.1.1.39	1fntM00	Proteasome component C5, ubiquitin-dependent protein catabolic process, protein binding, 20S proteasome subunit beta 6 [EC:3.4.25.1], proteasome core complex, beta-subunit complex, Proteasome endopeptidase complex., Saccharomyces cerevisiae, Proteasome
3.60.20.10.2.1.1.1.40	1fnta00	Saccharomyces cerevisiae, Proteasome, proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1], Proteasome endopeptidase complex., Proteasome component C5, protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.2.1.1.1.41	1z7qM00	Proteasome, Saccharomyces cerevisiae, ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C5, Proteasome endopeptidase complex., 20S proteasome subunit beta 6 [EC:3.4.25.1], proteasome core complex, beta-subunit complex
3.60.20.10.2.1.1.1.42	1z7qa00	Proteasome endopeptidase complex., proteasome core complex, beta-subunit complex, 20S proteasome subunit beta 6 [EC:3.4.25.1], protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C5, Proteasome, Saccharomyces cerevisiae
3.60.20.10.2.1.1.1.43	2fnyL00
3.60.20.10.2.1.1.1.44	2fnyZ00

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.60.20.10.2.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.60.20.10.2.1.1.1

Classification Lineage (3.60.20.10.2.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.60.20.10.2.1.1.1 (44)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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