S100 Family: 3.60.20.10.18.1.1.1

Representative domain: 1rypK00

Classification Lineage (3.60.20.10.18.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.60	4-Layer Sandwich
3.60.20	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
3.60.20.10	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Gene3D
3.60.20.10.18
3.60.20.10.18.1
3.60.20.10.18.1.1
3.60.20.10.18.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	44

Non-Redundant Representatives (44)
Functional Families
Help

What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.60.20.10.18.1.1.1 (44)

CATH code	Domain ID	Keywords
3.60.20.10.18.1.1.1.1	1rypK00	Proteasome, Saccharomyces cerevisiae, 20S proteasome subunit beta 4 [EC:3.4.25.1], nucleus, Proteasome component C11, response to stress, Proteasome endopeptidase complex., ascospore formation, proteasome core complex, beta-subunit complex, ubiquitin-dependent protein catabolic process, protein binding
3.60.20.10.18.1.1.1.2	1rypY00	protein binding, ubiquitin-dependent protein catabolic process, proteasome core complex, beta-subunit complex, ascospore formation, Proteasome endopeptidase complex., response to stress, Proteasome component C11, nucleus, 20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome
3.60.20.10.18.1.1.1.3	1g65J00	protein binding, ubiquitin-dependent protein catabolic process, proteasome core complex, beta-subunit complex, ascospore formation, Proteasome endopeptidase complex., response to stress, Proteasome component C11, nucleus, 20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome
3.60.20.10.18.1.1.1.4	1g65X00	protein binding, ubiquitin-dependent protein catabolic process, proteasome core complex, beta-subunit complex, ascospore formation, Proteasome endopeptidase complex., response to stress, Proteasome component C11, nucleus, 20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome
3.60.20.10.18.1.1.1.5	1g0uJ00	Proteasome endopeptidase complex., ascospore formation, proteasome core complex, beta-subunit complex, ubiquitin-dependent protein catabolic process, protein binding, Proteasome, Saccharomyces cerevisiae, 20S proteasome subunit beta 4 [EC:3.4.25.1], nucleus, Proteasome component C11, response to stress
3.60.20.10.18.1.1.1.6	1g0uX00	20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome, response to stress, Proteasome component C11, nucleus, proteasome core complex, beta-subunit complex, ascospore formation, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.18.1.1.1.7	3gptJ00	ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex., ascospore formation, proteasome core complex, beta-subunit complex, nucleus, Proteasome component C11, response to stress, Proteasome, Saccharomyces cerevisiae, 20S proteasome subunit beta 4 [EC:3.4.25.1]
3.60.20.10.18.1.1.1.8	3gptX00	ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex., ascospore formation, proteasome core complex, beta-subunit complex, nucleus, Proteasome component C11, response to stress, Proteasome, Saccharomyces cerevisiae, 20S proteasome subunit beta 4 [EC:3.4.25.1]
3.60.20.10.18.1.1.1.9	3gpwJ00	nucleus, Proteasome component C11, response to stress, Proteasome, Saccharomyces cerevisiae, 20S proteasome subunit beta 4 [EC:3.4.25.1], ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex., ascospore formation, proteasome core complex, beta-subunit complex
3.60.20.10.18.1.1.1.10	3gpwX00	Proteasome, Saccharomyces cerevisiae, 20S proteasome subunit beta 4 [EC:3.4.25.1], nucleus, Proteasome component C11, response to stress, Proteasome endopeptidase complex., ascospore formation, proteasome core complex, beta-subunit complex, ubiquitin-dependent protein catabolic process, protein binding
3.60.20.10.18.1.1.1.11	3hyeJ00	protein binding, ubiquitin-dependent protein catabolic process, ascospore formation, Proteasome endopeptidase complex., proteasome core complex, beta-subunit complex, nucleus, response to stress, Proteasome component C11, Proteasome, 20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae
3.60.20.10.18.1.1.1.12	3hyeX00	nucleus, response to stress, Proteasome component C11, Proteasome, 20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae, protein binding, ubiquitin-dependent protein catabolic process, ascospore formation, Proteasome endopeptidase complex., proteasome core complex, beta-subunit complex
3.60.20.10.18.1.1.1.13	3d29J00	protein binding, ubiquitin-dependent protein catabolic process, proteasome core complex, beta-subunit complex, ascospore formation, Proteasome endopeptidase complex., response to stress, Proteasome component C11, nucleus, 20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome
3.60.20.10.18.1.1.1.14	3d29X00	proteasome core complex, beta-subunit complex, ascospore formation, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process, 20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome, response to stress, Proteasome component C11, nucleus
3.60.20.10.18.1.1.1.15	3bdmJ00	Proteasome component C11, response to stress, nucleus, Saccharomyces cerevisiae, 20S proteasome subunit beta 4 [EC:3.4.25.1], Proteasome, ubiquitin-dependent protein catabolic process, protein binding, proteasome core complex, beta-subunit complex, Proteasome endopeptidase complex., ascospore formation
3.60.20.10.18.1.1.1.16	3bdmX00	ascospore formation, Proteasome endopeptidase complex., proteasome core complex, beta-subunit complex, protein binding, ubiquitin-dependent protein catabolic process, Proteasome, 20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae, nucleus, response to stress, Proteasome component C11
3.60.20.10.18.1.1.1.17	3gpjJ00	ascospore formation, Proteasome endopeptidase complex., proteasome core complex, beta-subunit complex, protein binding, ubiquitin-dependent protein catabolic process, Proteasome, 20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae, nucleus, response to stress, Proteasome component C11
3.60.20.10.18.1.1.1.18	3gpjX00	Proteasome, Saccharomyces cerevisiae, 20S proteasome subunit beta 4 [EC:3.4.25.1], nucleus, Proteasome component C11, response to stress, Proteasome endopeptidase complex., ascospore formation, proteasome core complex, beta-subunit complex, ubiquitin-dependent protein catabolic process, protein binding
3.60.20.10.18.1.1.1.19	2f16J00	protein binding, ubiquitin-dependent protein catabolic process, proteasome core complex, beta-subunit complex, ascospore formation, Proteasome endopeptidase complex., response to stress, Proteasome component C11, nucleus, 20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome
3.60.20.10.18.1.1.1.20	2f16X00	ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex., ascospore formation, proteasome core complex, beta-subunit complex, nucleus, Proteasome component C11, response to stress, Proteasome, Saccharomyces cerevisiae, 20S proteasome subunit beta 4 [EC:3.4.25.1]
3.60.20.10.18.1.1.1.21	2fakJ00	ubiquitin-dependent protein catabolic process, protein binding, proteasome core complex, beta-subunit complex, Proteasome endopeptidase complex., ascospore formation, Proteasome component C11, response to stress, nucleus, Saccharomyces cerevisiae, 20S proteasome subunit beta 4 [EC:3.4.25.1], Proteasome
3.60.20.10.18.1.1.1.22	2fakX00	20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome, response to stress, Proteasome component C11, nucleus, proteasome core complex, beta-subunit complex, ascospore formation, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.18.1.1.1.23	3dy4J00	Proteasome, 20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae, nucleus, response to stress, Proteasome component C11, ascospore formation, Proteasome endopeptidase complex., proteasome core complex, beta-subunit complex, protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.18.1.1.1.24	3dy4X00	Saccharomyces cerevisiae, 20S proteasome subunit beta 4 [EC:3.4.25.1], Proteasome, Proteasome component C11, response to stress, nucleus, proteasome core complex, beta-subunit complex, Proteasome endopeptidase complex., ascospore formation, ubiquitin-dependent protein catabolic process, protein binding
3.60.20.10.18.1.1.1.25	2gplJ00	Proteasome endopeptidase complex., ascospore formation, proteasome core complex, beta-subunit complex, ubiquitin-dependent protein catabolic process, protein binding, Proteasome, Saccharomyces cerevisiae, 20S proteasome subunit beta 4 [EC:3.4.25.1], nucleus, Proteasome component C11, response to stress
3.60.20.10.18.1.1.1.26	2gplX00	response to stress, Proteasome component C11, nucleus, 20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome, protein binding, ubiquitin-dependent protein catabolic process, proteasome core complex, beta-subunit complex, ascospore formation, Proteasome endopeptidase complex.
3.60.20.10.18.1.1.1.27	3dy3J00	protein binding, ubiquitin-dependent protein catabolic process, proteasome core complex, beta-subunit complex, ascospore formation, Proteasome endopeptidase complex., response to stress, Proteasome component C11, nucleus, 20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome
3.60.20.10.18.1.1.1.28	3dy3X00	Proteasome endopeptidase complex., ascospore formation, proteasome core complex, beta-subunit complex, ubiquitin-dependent protein catabolic process, protein binding, Proteasome, Saccharomyces cerevisiae, 20S proteasome subunit beta 4 [EC:3.4.25.1], nucleus, Proteasome component C11, response to stress
3.60.20.10.18.1.1.1.29	2zcyJ00	ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex., ascospore formation, proteasome core complex, beta-subunit complex, nucleus, Proteasome component C11, response to stress, Proteasome, Saccharomyces cerevisiae, 20S proteasome subunit beta 4 [EC:3.4.25.1]
3.60.20.10.18.1.1.1.30	2zcyX00	protein binding, ubiquitin-dependent protein catabolic process, proteasome core complex, beta-subunit complex, ascospore formation, Proteasome endopeptidase complex., response to stress, Proteasome component C11, nucleus, 20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome
3.60.20.10.18.1.1.1.31	1jd2J00	Proteasome endopeptidase complex., ascospore formation, proteasome core complex, beta-subunit complex, ubiquitin-dependent protein catabolic process, protein binding, Proteasome, Saccharomyces cerevisiae, 20S proteasome subunit beta 4 [EC:3.4.25.1], nucleus, Proteasome component C11, response to stress
3.60.20.10.18.1.1.1.32	1jd2Q00	Proteasome, 20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae, nucleus, response to stress, Proteasome component C11, ascospore formation, Proteasome endopeptidase complex., proteasome core complex, beta-subunit complex, protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.18.1.1.1.33	1vsyK00	Proteasome endopeptidase complex., ascospore formation, proteasome core complex, beta-subunit complex, ubiquitin-dependent protein catabolic process, protein binding, Proteasome, Saccharomyces cerevisiae, 20S proteasome subunit beta 4 [EC:3.4.25.1], nucleus, Proteasome component C11, response to stress
3.60.20.10.18.1.1.1.34	1vsyY00	Proteasome, 20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae, nucleus, response to stress, Proteasome component C11, ascospore formation, Proteasome endopeptidase complex., proteasome core complex, beta-subunit complex, protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.18.1.1.1.35	3e47J00	nucleus, Proteasome component C11, response to stress, Proteasome, Saccharomyces cerevisiae, 20S proteasome subunit beta 4 [EC:3.4.25.1], ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex., ascospore formation, proteasome core complex, beta-subunit complex
3.60.20.10.18.1.1.1.36	3e47X00	Proteasome component C11, response to stress, nucleus, Saccharomyces cerevisiae, 20S proteasome subunit beta 4 [EC:3.4.25.1], Proteasome, ubiquitin-dependent protein catabolic process, protein binding, proteasome core complex, beta-subunit complex, Proteasome endopeptidase complex., ascospore formation
3.60.20.10.18.1.1.1.37	3l5q100	ascospore formation, Proteasome endopeptidase complex., proteasome core complex, beta-subunit complex, protein binding, ubiquitin-dependent protein catabolic process, Proteasome, 20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae, nucleus, response to stress, Proteasome component C11
3.60.20.10.18.1.1.1.38	3l5qO00	Proteasome component C11, response to stress, nucleus, Saccharomyces cerevisiae, 20S proteasome subunit beta 4 [EC:3.4.25.1], Proteasome, ubiquitin-dependent protein catabolic process, protein binding, proteasome core complex, beta-subunit complex, Proteasome endopeptidase complex., ascospore formation
3.60.20.10.18.1.1.1.39	1fntK00	Proteasome component C11, response to stress, nucleus, Saccharomyces cerevisiae, 20S proteasome subunit beta 4 [EC:3.4.25.1], Proteasome, ubiquitin-dependent protein catabolic process, protein binding, proteasome core complex, beta-subunit complex, Proteasome endopeptidase complex., ascospore formation
3.60.20.10.18.1.1.1.40	1fntY00	Proteasome, 20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae, nucleus, response to stress, Proteasome component C11, ascospore formation, Proteasome endopeptidase complex., proteasome core complex, beta-subunit complex, protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.18.1.1.1.41	1z7qK00	response to stress, Proteasome component C11, nucleus, 20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae, Proteasome, protein binding, ubiquitin-dependent protein catabolic process, proteasome core complex, beta-subunit complex, ascospore formation, Proteasome endopeptidase complex.
3.60.20.10.18.1.1.1.42	1z7qY00	protein binding, ubiquitin-dependent protein catabolic process, ascospore formation, Proteasome endopeptidase complex., proteasome core complex, beta-subunit complex, nucleus, response to stress, Proteasome component C11, Proteasome, 20S proteasome subunit beta 4 [EC:3.4.25.1], Saccharomyces cerevisiae
3.60.20.10.18.1.1.1.43	2fnyJ00
3.60.20.10.18.1.1.1.44	2fnyX00

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.60.20.10.18.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.60.20.10.18.1.1.1

Classification Lineage (3.60.20.10.18.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.60.20.10.18.1.1.1 (44)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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