S100 Family: 3.60.20.10.17.1.1.1

Representative domain: 1rypB00

Classification Lineage (3.60.20.10.17.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.60	4-Layer Sandwich
3.60.20	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
3.60.20.10	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Gene3D
3.60.20.10.17
3.60.20.10.17.1
3.60.20.10.17.1.1
3.60.20.10.17.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	40

Non-Redundant Representatives (40)
Functional Families
Help

What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.60.20.10.17.1.1.1 (40)

CATH code	Domain ID	Keywords
3.60.20.10.17.1.1.1.1	1rypB00	proteasome storage granule, Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., Proteasome component Y7, 20S proteasome subunit alpha 2 [EC:3.4.25.1], protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.17.1.1.1.2	1rypP00	20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome component Y7, ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, Saccharomyces cerevisiae, proteasome storage granule, Proteasome
3.60.20.10.17.1.1.1.3	1g65A00	20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome component Y7, protein binding, ubiquitin-dependent protein catabolic process, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, proteasome storage granule, Saccharomyces cerevisiae, Proteasome
3.60.20.10.17.1.1.1.4	1g65O00	proteasome core complex, alpha-subunit complex, Proteasome, Saccharomyces cerevisiae, proteasome storage granule, ubiquitin-dependent protein catabolic process, protein binding, Proteasome component Y7, 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome endopeptidase complex.
3.60.20.10.17.1.1.1.5	1g0uA00	protein binding, ubiquitin-dependent protein catabolic process, 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome component Y7, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, Proteasome, proteasome storage granule, Saccharomyces cerevisiae
3.60.20.10.17.1.1.1.6	1g0uO00	protein binding, ubiquitin-dependent protein catabolic process, Proteasome component Y7, 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, Proteasome, proteasome storage granule, Saccharomyces cerevisiae
3.60.20.10.17.1.1.1.7	3gptA00	Saccharomyces cerevisiae, proteasome storage granule, Proteasome, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., Proteasome component Y7, 20S proteasome subunit alpha 2 [EC:3.4.25.1], ubiquitin-dependent protein catabolic process, protein binding
3.60.20.10.17.1.1.1.8	3gptO00	Proteasome endopeptidase complex., Proteasome component Y7, 20S proteasome subunit alpha 2 [EC:3.4.25.1], protein binding, ubiquitin-dependent protein catabolic process, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.17.1.1.1.9	3gpwA00	Proteasome endopeptidase complex., 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome component Y7, protein binding, ubiquitin-dependent protein catabolic process, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.17.1.1.1.10	3gpwO00	20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome component Y7, ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, Saccharomyces cerevisiae, proteasome storage granule, Proteasome
3.60.20.10.17.1.1.1.11	3hyeA00	proteasome core complex, alpha-subunit complex, Proteasome, Saccharomyces cerevisiae, proteasome storage granule, ubiquitin-dependent protein catabolic process, protein binding, Proteasome component Y7, 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome endopeptidase complex.
3.60.20.10.17.1.1.1.12	3hyeO00	protein binding, ubiquitin-dependent protein catabolic process, 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome component Y7, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, Proteasome, proteasome storage granule, Saccharomyces cerevisiae
3.60.20.10.17.1.1.1.13	3d29A00	Proteasome component Y7, 20S proteasome subunit alpha 2 [EC:3.4.25.1], protein binding, ubiquitin-dependent protein catabolic process, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, proteasome storage granule, Saccharomyces cerevisiae, Proteasome
3.60.20.10.17.1.1.1.14	3d29O00	ubiquitin-dependent protein catabolic process, protein binding, 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome component Y7, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, Proteasome, Saccharomyces cerevisiae, proteasome storage granule
3.60.20.10.17.1.1.1.15	3bdmA00	Proteasome component Y7, 20S proteasome subunit alpha 2 [EC:3.4.25.1], protein binding, ubiquitin-dependent protein catabolic process, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, proteasome storage granule, Saccharomyces cerevisiae, Proteasome
3.60.20.10.17.1.1.1.16	3bdmO00	Proteasome endopeptidase complex., ubiquitin-dependent protein catabolic process, protein binding, 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome component Y7, Proteasome, Saccharomyces cerevisiae, proteasome storage granule, proteasome core complex, alpha-subunit complex
3.60.20.10.17.1.1.1.17	3gpjA00	proteasome core complex, alpha-subunit complex, Proteasome, Saccharomyces cerevisiae, proteasome storage granule, ubiquitin-dependent protein catabolic process, protein binding, 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome component Y7, Proteasome endopeptidase complex.
3.60.20.10.17.1.1.1.18	3gpjO00	proteasome storage granule, Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome component Y7, protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.17.1.1.1.19	2f16A00	Proteasome, Saccharomyces cerevisiae, proteasome storage granule, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., ubiquitin-dependent protein catabolic process, protein binding, 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome component Y7
3.60.20.10.17.1.1.1.20	2f16O00	proteasome core complex, alpha-subunit complex, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome component Y7, protein binding, ubiquitin-dependent protein catabolic process, Proteasome endopeptidase complex.
3.60.20.10.17.1.1.1.21	2fakA00	proteasome core complex, alpha-subunit complex, Saccharomyces cerevisiae, proteasome storage granule, Proteasome, Proteasome component Y7, 20S proteasome subunit alpha 2 [EC:3.4.25.1], ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex.
3.60.20.10.17.1.1.1.22	2fakO00	proteasome core complex, alpha-subunit complex, Proteasome, Saccharomyces cerevisiae, proteasome storage granule, ubiquitin-dependent protein catabolic process, protein binding, Proteasome component Y7, 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome endopeptidase complex.
3.60.20.10.17.1.1.1.23	3dy4A00	Proteasome endopeptidase complex., Proteasome component Y7, 20S proteasome subunit alpha 2 [EC:3.4.25.1], ubiquitin-dependent protein catabolic process, protein binding, Saccharomyces cerevisiae, proteasome storage granule, Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.17.1.1.1.24	3dy4O00	proteasome storage granule, Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome component Y7, protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.17.1.1.1.25	2gplA00	proteasome storage granule, Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., Proteasome component Y7, 20S proteasome subunit alpha 2 [EC:3.4.25.1], protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.17.1.1.1.26	2gplO00	Saccharomyces cerevisiae, proteasome storage granule, Proteasome, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., Proteasome component Y7, 20S proteasome subunit alpha 2 [EC:3.4.25.1], ubiquitin-dependent protein catabolic process, protein binding
3.60.20.10.17.1.1.1.27	3dy3A00	Proteasome, proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process, 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome component Y7
3.60.20.10.17.1.1.1.28	3dy3O00	proteasome core complex, alpha-subunit complex, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome component Y7, protein binding, ubiquitin-dependent protein catabolic process, Proteasome endopeptidase complex.
3.60.20.10.17.1.1.1.29	2zcyA00	Proteasome endopeptidase complex., 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome component Y7, protein binding, ubiquitin-dependent protein catabolic process, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.17.1.1.1.30	2zcyO00	proteasome core complex, alpha-subunit complex, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome component Y7, protein binding, ubiquitin-dependent protein catabolic process, Proteasome endopeptidase complex.
3.60.20.10.17.1.1.1.31	1jd2A00	Proteasome, proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process, 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome component Y7
3.60.20.10.17.1.1.1.32	1jd2V00	Saccharomyces cerevisiae, proteasome storage granule, Proteasome, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., Proteasome component Y7, 20S proteasome subunit alpha 2 [EC:3.4.25.1], ubiquitin-dependent protein catabolic process, protein binding
3.60.20.10.17.1.1.1.33	3e47A00	Proteasome endopeptidase complex., ubiquitin-dependent protein catabolic process, protein binding, Proteasome component Y7, 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, proteasome core complex, alpha-subunit complex
3.60.20.10.17.1.1.1.34	3e47O00	Proteasome endopeptidase complex., Proteasome component Y7, 20S proteasome subunit alpha 2 [EC:3.4.25.1], protein binding, ubiquitin-dependent protein catabolic process, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.17.1.1.1.35	1fntB00	proteasome storage granule, Saccharomyces cerevisiae, Proteasome, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., Proteasome component Y7, 20S proteasome subunit alpha 2 [EC:3.4.25.1], protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.17.1.1.1.36	1fntP00	proteasome core complex, alpha-subunit complex, Saccharomyces cerevisiae, proteasome storage granule, Proteasome, 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome component Y7, ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex.
3.60.20.10.17.1.1.1.37	1z7qB00	Proteasome endopeptidase complex., ubiquitin-dependent protein catabolic process, protein binding, Proteasome component Y7, 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, proteasome core complex, alpha-subunit complex
3.60.20.10.17.1.1.1.38	1z7qP00	Proteasome, proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process, 20S proteasome subunit alpha 2 [EC:3.4.25.1], Proteasome component Y7
3.60.20.10.17.1.1.1.39	2fnyA00
3.60.20.10.17.1.1.1.40	2fnyO00

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.60.20.10.17.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.60.20.10.17.1.1.1

Classification Lineage (3.60.20.10.17.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.60.20.10.17.1.1.1 (40)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

CATH Shortcuts