S100 Family: 3.60.20.10.15.1.1.1

Representative domain: 1yarH00

Classification Lineage (3.60.20.10.15.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.60	4-Layer Sandwich
3.60.20	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
3.60.20.10	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Gene3D
3.60.20.10.15
3.60.20.10.15.1
3.60.20.10.15.1.1
3.60.20.10.15.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	63

Non-Redundant Representatives (63)
Functional Families
Help

What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.60.20.10.15.1.1.1 (63)

CATH code	Domain ID	Keywords
3.60.20.10.15.1.1.1.1	1yarH00	Proteasome endopeptidase complex., Proteasome subunit beta, Proteasome, Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1]
3.60.20.10.15.1.1.1.2	1yarI00	proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome, Proteasome subunit beta, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.3	1yarJ00	Proteasome, Proteasome subunit beta, proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.4	1yarK00	Proteasome subunit beta, Proteasome, Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1], Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.5	1yarL00	Proteasome endopeptidase complex., Proteasome, Proteasome subunit beta, proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum
3.60.20.10.15.1.1.1.6	1yarM00	Proteasome, Proteasome subunit beta, proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.7	1yarN00	Proteasome endopeptidase complex., Proteasome, Proteasome subunit beta, proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum
3.60.20.10.15.1.1.1.8	1ya7H00	Proteasome endopeptidase complex., Proteasome subunit beta, Proteasome, Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1]
3.60.20.10.15.1.1.1.9	1ya7I00	proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome, Proteasome subunit beta, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.10	1ya7J00	Proteasome endopeptidase complex., Proteasome, Proteasome subunit beta, proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum
3.60.20.10.15.1.1.1.11	1ya7K00	Proteasome endopeptidase complex., Proteasome, Proteasome subunit beta, proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum
3.60.20.10.15.1.1.1.12	1ya7L00	proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome, Proteasome subunit beta, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.13	1ya7M00	Proteasome endopeptidase complex., Proteasome, Proteasome subunit beta, proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum
3.60.20.10.15.1.1.1.14	1ya7N00	Proteasome endopeptidase complex., proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome, Proteasome subunit beta
3.60.20.10.15.1.1.1.15	1yauH00	Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1], Proteasome subunit beta, Proteasome, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.16	1yauI00	Proteasome subunit beta, Proteasome, Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1], Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.17	1yauJ00	Proteasome endopeptidase complex., proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome, Proteasome subunit beta
3.60.20.10.15.1.1.1.18	1yauK00	proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome, Proteasome subunit beta, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.19	1yauL00	Proteasome, Proteasome subunit beta, proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.20	1yauM00	Proteasome endopeptidase complex., Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1], Proteasome subunit beta, Proteasome
3.60.20.10.15.1.1.1.21	1yauN00	Proteasome endopeptidase complex., Proteasome subunit beta, Proteasome, Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1]
3.60.20.10.15.1.1.1.22	3jrmH00	Proteasome endopeptidase complex., proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome, Proteasome subunit beta
3.60.20.10.15.1.1.1.23	3jrmI00	proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome, Proteasome subunit beta, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.24	3jrmJ00	Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1], Proteasome subunit beta, Proteasome, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.25	3jrmK00	Proteasome endopeptidase complex., Proteasome, Proteasome subunit beta, proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum
3.60.20.10.15.1.1.1.26	3jrmL00	Proteasome, Proteasome subunit beta, proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.27	3jrmM00	Proteasome endopeptidase complex., Proteasome subunit beta, Proteasome, Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1]
3.60.20.10.15.1.1.1.28	3jrmN00	Proteasome endopeptidase complex., Proteasome, Proteasome subunit beta, proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum
3.60.20.10.15.1.1.1.29	3jseH00	Proteasome endopeptidase complex., Proteasome, Proteasome subunit beta, proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum
3.60.20.10.15.1.1.1.30	3jseI00	Proteasome endopeptidase complex., proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome, Proteasome subunit beta
3.60.20.10.15.1.1.1.31	3jseJ00	Proteasome endopeptidase complex., proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome, Proteasome subunit beta
3.60.20.10.15.1.1.1.32	3jseK00	proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome, Proteasome subunit beta, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.33	3jseL00	Proteasome subunit beta, Proteasome, Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1], Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.34	3jseM00	Proteasome endopeptidase complex., Proteasome subunit beta, Proteasome, Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1]
3.60.20.10.15.1.1.1.35	3jseN00	Proteasome endopeptidase complex., Proteasome subunit beta, Proteasome, Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1]
3.60.20.10.15.1.1.1.36	3jtlH00	proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome, Proteasome subunit beta, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.37	3jtlI00	Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1], Proteasome subunit beta, Proteasome, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.38	3jtlJ00	Proteasome endopeptidase complex., Proteasome subunit beta, Proteasome, Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1]
3.60.20.10.15.1.1.1.39	3jtlK00	Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1], Proteasome subunit beta, Proteasome, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.40	3jtlL00	Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1], Proteasome subunit beta, Proteasome, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.41	3jtlM00	Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1], Proteasome subunit beta, Proteasome, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.42	3jtlN00	Proteasome endopeptidase complex., proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome, Proteasome subunit beta
3.60.20.10.15.1.1.1.43	1pma100	Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1], Proteasome subunit beta, Proteasome, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.44	1pma200	Proteasome endopeptidase complex., Proteasome, Proteasome subunit beta, proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum
3.60.20.10.15.1.1.1.45	1pmaB00	Proteasome endopeptidase complex., proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome, Proteasome subunit beta
3.60.20.10.15.1.1.1.46	1pmaP00	Proteasome endopeptidase complex., proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome, Proteasome subunit beta
3.60.20.10.15.1.1.1.47	1pmaQ00	Proteasome subunit beta, Proteasome, Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1], Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.48	1pmaR00	Proteasome endopeptidase complex., Proteasome subunit beta, Proteasome, Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1]
3.60.20.10.15.1.1.1.49	1pmaS00	Proteasome endopeptidase complex., Proteasome subunit beta, Proteasome, Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1]
3.60.20.10.15.1.1.1.50	1pmaT00	Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1], Proteasome subunit beta, Proteasome, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.51	1pmaU00	Proteasome endopeptidase complex., Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1], Proteasome subunit beta, Proteasome
3.60.20.10.15.1.1.1.52	1pmaV00	Proteasome endopeptidase complex., Proteasome, Proteasome subunit beta, proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum
3.60.20.10.15.1.1.1.53	1pmaW00	Proteasome, Proteasome subunit beta, proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.54	1pmaX00	Proteasome endopeptidase complex., Proteasome subunit beta, Proteasome, Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1]
3.60.20.10.15.1.1.1.55	1pmaY00	Proteasome endopeptidase complex., proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome, Proteasome subunit beta
3.60.20.10.15.1.1.1.56	1pmaZ00	Proteasome endopeptidase complex., Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1], Proteasome subunit beta, Proteasome
3.60.20.10.15.1.1.1.57	3ipmH00	proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome, Proteasome subunit beta, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.58	3ipmI00	Proteasome, Proteasome subunit beta, proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.59	3ipmJ00	Proteasome endopeptidase complex., Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1], Proteasome subunit beta, Proteasome
3.60.20.10.15.1.1.1.60	3ipmK00	Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1], Proteasome subunit beta, Proteasome, Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.61	3ipmL00	Proteasome endopeptidase complex., proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome, Proteasome subunit beta
3.60.20.10.15.1.1.1.62	3ipmM00	Proteasome subunit beta, Proteasome, Thermoplasma acidophilum, proteasome beta subunit [EC:3.4.25.1], Proteasome endopeptidase complex.
3.60.20.10.15.1.1.1.63	3ipmN00	Proteasome, Proteasome subunit beta, proteasome beta subunit [EC:3.4.25.1], Thermoplasma acidophilum, Proteasome endopeptidase complex.

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.60.20.10.15.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.60.20.10.15.1.1.1

Classification Lineage (3.60.20.10.15.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.60.20.10.15.1.1.1 (63)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

CATH Shortcuts