S100 Family: 3.60.20.10.12.1.1.1

Representative domain: 1rypG00

Classification Lineage (3.60.20.10.12.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.60	4-Layer Sandwich
3.60.20	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
3.60.20.10	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Gene3D
3.60.20.10.12
3.60.20.10.12.1
3.60.20.10.12.1.1
3.60.20.10.12.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	44

Non-Redundant Representatives (44)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.60.20.10.12.1.1.1 (44)

CATH code	Domain ID	Keywords
3.60.20.10.12.1.1.1.1	1rypG00	Proteasome endopeptidase complex., Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding, Saccharomyces cerevisiae, proteasome storage granule, 20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.12.1.1.1.2	1rypU00	Proteasome endopeptidase complex., Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding, Saccharomyces cerevisiae, proteasome storage granule, 20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.12.1.1.1.3	1g65F00	protein binding, Proteasome component C1, ubiquitin-dependent protein catabolic process, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 7 [EC:3.4.25.1]
3.60.20.10.12.1.1.1.4	1g65T00	proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 7 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., protein binding, Proteasome component C1, ubiquitin-dependent protein catabolic process
3.60.20.10.12.1.1.1.5	1g0uF00	proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex.
3.60.20.10.12.1.1.1.6	1g0uT00	proteasome core complex, alpha-subunit complex, Saccharomyces cerevisiae, proteasome storage granule, 20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome, Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex.
3.60.20.10.12.1.1.1.7	3gptF00	Proteasome endopeptidase complex., protein binding, Proteasome component C1, ubiquitin-dependent protein catabolic process, Proteasome, 20S proteasome subunit alpha 7 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex
3.60.20.10.12.1.1.1.8	3gptT00	Proteasome, 20S proteasome subunit alpha 7 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., protein binding, Proteasome component C1, ubiquitin-dependent protein catabolic process
3.60.20.10.12.1.1.1.9	3gpwF00	Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, Saccharomyces cerevisiae, proteasome storage granule, 20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome
3.60.20.10.12.1.1.1.10	3gpwT00	Proteasome endopeptidase complex., protein binding, Proteasome component C1, ubiquitin-dependent protein catabolic process, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 7 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex
3.60.20.10.12.1.1.1.11	3hyeF00	Proteasome endopeptidase complex., protein binding, Proteasome component C1, ubiquitin-dependent protein catabolic process, Proteasome, 20S proteasome subunit alpha 7 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex
3.60.20.10.12.1.1.1.12	3hyeT00	Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, Saccharomyces cerevisiae, proteasome storage granule, 20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome
3.60.20.10.12.1.1.1.13	3d29F00	Proteasome endopeptidase complex., Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding, 20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, proteasome core complex, alpha-subunit complex
3.60.20.10.12.1.1.1.14	3d29T00	Proteasome, 20S proteasome subunit alpha 7 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., protein binding, Proteasome component C1, ubiquitin-dependent protein catabolic process
3.60.20.10.12.1.1.1.15	3bdmF00	proteasome core complex, alpha-subunit complex, Saccharomyces cerevisiae, proteasome storage granule, 20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome, Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex.
3.60.20.10.12.1.1.1.16	3bdmT00	proteasome core complex, alpha-subunit complex, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 7 [EC:3.4.25.1], protein binding, Proteasome component C1, ubiquitin-dependent protein catabolic process, Proteasome endopeptidase complex.
3.60.20.10.12.1.1.1.17	3gpjF00	proteasome core complex, alpha-subunit complex, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 7 [EC:3.4.25.1], protein binding, Proteasome component C1, ubiquitin-dependent protein catabolic process, Proteasome endopeptidase complex.
3.60.20.10.12.1.1.1.18	3gpjT00	proteasome core complex, alpha-subunit complex, Saccharomyces cerevisiae, proteasome storage granule, 20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome, Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex.
3.60.20.10.12.1.1.1.19	2f16F00	Proteasome endopeptidase complex., protein binding, Proteasome component C1, ubiquitin-dependent protein catabolic process, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 7 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex
3.60.20.10.12.1.1.1.20	2f16T00	Proteasome, 20S proteasome subunit alpha 7 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., protein binding, Proteasome component C1, ubiquitin-dependent protein catabolic process
3.60.20.10.12.1.1.1.21	2fakF00	20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding
3.60.20.10.12.1.1.1.22	2fakT00	proteasome core complex, alpha-subunit complex, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 7 [EC:3.4.25.1], protein binding, Proteasome component C1, ubiquitin-dependent protein catabolic process, Proteasome endopeptidase complex.
3.60.20.10.12.1.1.1.23	3dy4F00	proteasome core complex, alpha-subunit complex, Saccharomyces cerevisiae, proteasome storage granule, 20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome, Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex.
3.60.20.10.12.1.1.1.24	3dy4T00	Proteasome endopeptidase complex., Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding, Saccharomyces cerevisiae, proteasome storage granule, 20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.12.1.1.1.25	2gplF00	Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule
3.60.20.10.12.1.1.1.26	2gplT00	Proteasome endopeptidase complex., Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding, 20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, proteasome core complex, alpha-subunit complex
3.60.20.10.12.1.1.1.27	3dy3F00	Proteasome endopeptidase complex., Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding, Saccharomyces cerevisiae, proteasome storage granule, 20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.12.1.1.1.28	3dy3T00	proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex.
3.60.20.10.12.1.1.1.29	2zcyF00	Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, Saccharomyces cerevisiae, proteasome storage granule, 20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome
3.60.20.10.12.1.1.1.30	2zcyT00	proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex.
3.60.20.10.12.1.1.1.31	1jd2100	Proteasome, 20S proteasome subunit alpha 7 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., protein binding, Proteasome component C1, ubiquitin-dependent protein catabolic process
3.60.20.10.12.1.1.1.32	1jd2F00	Proteasome, 20S proteasome subunit alpha 7 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., protein binding, Proteasome component C1, ubiquitin-dependent protein catabolic process
3.60.20.10.12.1.1.1.33	1vsyG00	proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex.
3.60.20.10.12.1.1.1.34	1vsyU00	Proteasome endopeptidase complex., Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding, Saccharomyces cerevisiae, proteasome storage granule, 20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome, proteasome core complex, alpha-subunit complex
3.60.20.10.12.1.1.1.35	3e47F00	Proteasome, 20S proteasome subunit alpha 7 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., protein binding, Proteasome component C1, ubiquitin-dependent protein catabolic process
3.60.20.10.12.1.1.1.36	3e47T00	proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 7 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., protein binding, Proteasome component C1, ubiquitin-dependent protein catabolic process
3.60.20.10.12.1.1.1.37	3l5qL00	protein binding, Proteasome component C1, ubiquitin-dependent protein catabolic process, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, Proteasome, 20S proteasome subunit alpha 7 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae
3.60.20.10.12.1.1.1.38	3l5qX00	Proteasome endopeptidase complex., protein binding, Proteasome component C1, ubiquitin-dependent protein catabolic process, Proteasome, 20S proteasome subunit alpha 7 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex
3.60.20.10.12.1.1.1.39	1fntG00	protein binding, Proteasome component C1, ubiquitin-dependent protein catabolic process, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 7 [EC:3.4.25.1]
3.60.20.10.12.1.1.1.40	1fntU00	proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex.
3.60.20.10.12.1.1.1.41	1z7qG00	20S proteasome subunit alpha 7 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., Proteasome component C1, ubiquitin-dependent protein catabolic process, protein binding
3.60.20.10.12.1.1.1.42	1z7qU00	proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 7 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., protein binding, Proteasome component C1, ubiquitin-dependent protein catabolic process
3.60.20.10.12.1.1.1.43	2fnyF00
3.60.20.10.12.1.1.1.44	2fnyT00

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.60.20.10.12.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.60.20.10.12.1.1.1

Classification Lineage (3.60.20.10.12.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.60.20.10.12.1.1.1 (44)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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