S100 Family: 3.60.20.10.11.1.1.1

Representative domain: 1rypC00

Classification Lineage (3.60.20.10.11.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.60	4-Layer Sandwich
3.60.20	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
3.60.20.10	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Gene3D
3.60.20.10.11
3.60.20.10.11.1
3.60.20.10.11.1.1
3.60.20.10.11.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	40

Non-Redundant Representatives (40)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.60.20.10.11.1.1.1 (40)

CATH code	Domain ID	Keywords
3.60.20.10.11.1.1.1.1	1rypC00	proteasome core complex, alpha-subunit complex, filamentous growth, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 3 [EC:3.4.25.1], protein binding, ubiquitin-dependent protein catabolic process, Proteasome component Y13, Proteasome endopeptidase complex.
3.60.20.10.11.1.1.1.2	1rypQ00	Proteasome component Y13, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 3 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, filamentous growth
3.60.20.10.11.1.1.1.3	1g65B00	filamentous growth, proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 3 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex., Proteasome component Y13
3.60.20.10.11.1.1.1.4	1g65P00	20S proteasome subunit alpha 3 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, filamentous growth, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., Proteasome component Y13, ubiquitin-dependent protein catabolic process, protein binding
3.60.20.10.11.1.1.1.5	1g0uB00	Proteasome endopeptidase complex., Proteasome component Y13, ubiquitin-dependent protein catabolic process, protein binding, Saccharomyces cerevisiae, proteasome storage granule, 20S proteasome subunit alpha 3 [EC:3.4.25.1], Proteasome, filamentous growth, proteasome core complex, alpha-subunit complex
3.60.20.10.11.1.1.1.6	1g0uP00	Proteasome endopeptidase complex., Proteasome component Y13, ubiquitin-dependent protein catabolic process, protein binding, 20S proteasome subunit alpha 3 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, filamentous growth, proteasome core complex, alpha-subunit complex
3.60.20.10.11.1.1.1.7	3gptB00	Proteasome component Y13, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 3 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, filamentous growth
3.60.20.10.11.1.1.1.8	3gptP00	Proteasome endopeptidase complex., Proteasome component Y13, ubiquitin-dependent protein catabolic process, protein binding, 20S proteasome subunit alpha 3 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, filamentous growth, proteasome core complex, alpha-subunit complex
3.60.20.10.11.1.1.1.9	3gpwB00	ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex., Proteasome component Y13, filamentous growth, proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 3 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule
3.60.20.10.11.1.1.1.10	3gpwP00	Proteasome component Y13, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process, Proteasome, 20S proteasome subunit alpha 3 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, filamentous growth
3.60.20.10.11.1.1.1.11	3hyeB00	Proteasome component Y13, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process, Proteasome, 20S proteasome subunit alpha 3 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, filamentous growth
3.60.20.10.11.1.1.1.12	3hyeP00	proteasome core complex, alpha-subunit complex, filamentous growth, Proteasome, 20S proteasome subunit alpha 3 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae, protein binding, ubiquitin-dependent protein catabolic process, Proteasome component Y13, Proteasome endopeptidase complex.
3.60.20.10.11.1.1.1.13	3d29B00	Proteasome endopeptidase complex., Proteasome component Y13, ubiquitin-dependent protein catabolic process, protein binding, 20S proteasome subunit alpha 3 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, filamentous growth, proteasome core complex, alpha-subunit complex
3.60.20.10.11.1.1.1.14	3d29P00	20S proteasome subunit alpha 3 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, filamentous growth, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., Proteasome component Y13, ubiquitin-dependent protein catabolic process, protein binding
3.60.20.10.11.1.1.1.15	3bdmB00	filamentous growth, proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 3 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex., Proteasome component Y13
3.60.20.10.11.1.1.1.16	3bdmP00	Proteasome, 20S proteasome subunit alpha 3 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, filamentous growth, Proteasome component Y13, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.11.1.1.1.17	3gpjB00	20S proteasome subunit alpha 3 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, filamentous growth, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., Proteasome component Y13, ubiquitin-dependent protein catabolic process, protein binding
3.60.20.10.11.1.1.1.18	3gpjP00	proteasome core complex, alpha-subunit complex, filamentous growth, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 3 [EC:3.4.25.1], protein binding, ubiquitin-dependent protein catabolic process, Proteasome component Y13, Proteasome endopeptidase complex.
3.60.20.10.11.1.1.1.19	2f16B00	proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 3 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, filamentous growth, Proteasome component Y13, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.11.1.1.1.20	2f16P00	protein binding, ubiquitin-dependent protein catabolic process, Proteasome component Y13, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, filamentous growth, Proteasome, 20S proteasome subunit alpha 3 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae
3.60.20.10.11.1.1.1.21	2fakB00	Proteasome component Y13, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 3 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, filamentous growth
3.60.20.10.11.1.1.1.22	2fakP00	proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 3 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, filamentous growth, Proteasome component Y13, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.11.1.1.1.23	3dy4B00	Proteasome endopeptidase complex., Proteasome component Y13, ubiquitin-dependent protein catabolic process, protein binding, 20S proteasome subunit alpha 3 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, filamentous growth, proteasome core complex, alpha-subunit complex
3.60.20.10.11.1.1.1.24	3dy4P00	proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 3 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, filamentous growth, Proteasome component Y13, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.11.1.1.1.25	2gplB00	ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex., Proteasome component Y13, filamentous growth, proteasome core complex, alpha-subunit complex, Saccharomyces cerevisiae, proteasome storage granule, 20S proteasome subunit alpha 3 [EC:3.4.25.1], Proteasome
3.60.20.10.11.1.1.1.26	2gplP00	proteasome core complex, alpha-subunit complex, filamentous growth, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 3 [EC:3.4.25.1], protein binding, ubiquitin-dependent protein catabolic process, Proteasome component Y13, Proteasome endopeptidase complex.
3.60.20.10.11.1.1.1.27	3dy3B00	proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 3 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, filamentous growth, Proteasome component Y13, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.11.1.1.1.28	3dy3P00	Proteasome endopeptidase complex., Proteasome component Y13, ubiquitin-dependent protein catabolic process, protein binding, Saccharomyces cerevisiae, proteasome storage granule, 20S proteasome subunit alpha 3 [EC:3.4.25.1], Proteasome, filamentous growth, proteasome core complex, alpha-subunit complex
3.60.20.10.11.1.1.1.29	2zcyB00	Proteasome endopeptidase complex., Proteasome component Y13, ubiquitin-dependent protein catabolic process, protein binding, 20S proteasome subunit alpha 3 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, filamentous growth, proteasome core complex, alpha-subunit complex
3.60.20.10.11.1.1.1.30	2zcyP00	Proteasome endopeptidase complex., Proteasome component Y13, ubiquitin-dependent protein catabolic process, protein binding, 20S proteasome subunit alpha 3 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, filamentous growth, proteasome core complex, alpha-subunit complex
3.60.20.10.11.1.1.1.31	1jd2B00	proteasome core complex, alpha-subunit complex, filamentous growth, Proteasome, 20S proteasome subunit alpha 3 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae, protein binding, ubiquitin-dependent protein catabolic process, Proteasome component Y13, Proteasome endopeptidase complex.
3.60.20.10.11.1.1.1.32	1jd2W00	ubiquitin-dependent protein catabolic process, protein binding, Proteasome endopeptidase complex., Proteasome component Y13, filamentous growth, proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 3 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule
3.60.20.10.11.1.1.1.33	3e47B00	protein binding, ubiquitin-dependent protein catabolic process, Proteasome component Y13, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, filamentous growth, Proteasome, 20S proteasome subunit alpha 3 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae
3.60.20.10.11.1.1.1.34	3e47P00	proteasome core complex, alpha-subunit complex, filamentous growth, proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 3 [EC:3.4.25.1], protein binding, ubiquitin-dependent protein catabolic process, Proteasome component Y13, Proteasome endopeptidase complex.
3.60.20.10.11.1.1.1.35	1fntC00	20S proteasome subunit alpha 3 [EC:3.4.25.1], Proteasome, Saccharomyces cerevisiae, proteasome storage granule, filamentous growth, proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., Proteasome component Y13, ubiquitin-dependent protein catabolic process, protein binding
3.60.20.10.11.1.1.1.36	1fntQ00	proteasome core complex, alpha-subunit complex, filamentous growth, Proteasome, 20S proteasome subunit alpha 3 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae, protein binding, ubiquitin-dependent protein catabolic process, Proteasome component Y13, Proteasome endopeptidase complex.
3.60.20.10.11.1.1.1.37	1z7qC00	proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 20S proteasome subunit alpha 3 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, filamentous growth, Proteasome component Y13, Proteasome endopeptidase complex., protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.11.1.1.1.38	1z7qQ00	proteasome core complex, alpha-subunit complex, filamentous growth, Proteasome, 20S proteasome subunit alpha 3 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae, protein binding, ubiquitin-dependent protein catabolic process, Proteasome component Y13, Proteasome endopeptidase complex.
3.60.20.10.11.1.1.1.39	2fnyB00
3.60.20.10.11.1.1.1.40	2fnyP00

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.60.20.10.11.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.60.20.10.11.1.1.1

Classification Lineage (3.60.20.10.11.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.60.20.10.11.1.1.1 (40)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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