S100 Family: 3.60.20.10.10.1.1.1

Representative domain: 1rypA00

Classification Lineage (3.60.20.10.10.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.60	4-Layer Sandwich
3.60.20	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
3.60.20.10	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Gene3D
3.60.20.10.10
3.60.20.10.10.1
3.60.20.10.10.1.1
3.60.20.10.10.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	44

Non-Redundant Representatives (44)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.60.20.10.10.1.1.1 (44)

CATH code	Domain ID	Keywords
3.60.20.10.10.1.1.1.1	1rypA00	mitochondrion, Proteasome endopeptidase complex., Proteasome component C7-alpha, ubiquitin-dependent protein catabolic process, protein binding, Saccharomyces cerevisiae, proteasome storage granule, 90S preribosome, Proteasome, 20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex
3.60.20.10.10.1.1.1.2	1rypO00	proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1], Proteasome, 90S preribosome, proteasome storage granule, Saccharomyces cerevisiae, protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C7-alpha, Proteasome endopeptidase complex., mitochondrion
3.60.20.10.10.1.1.1.3	1g65G00	mitochondrion, Proteasome endopeptidase complex., Proteasome component C7-alpha, protein binding, ubiquitin-dependent protein catabolic process, proteasome storage granule, Saccharomyces cerevisiae, 90S preribosome, Proteasome, proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1]
3.60.20.10.10.1.1.1.4	1g65U00	Proteasome component C7-alpha, ubiquitin-dependent protein catabolic process, protein binding, mitochondrion, Proteasome endopeptidase complex., 20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, Saccharomyces cerevisiae, proteasome storage granule, Proteasome, 90S preribosome
3.60.20.10.10.1.1.1.5	1g0uG00	Proteasome component C7-alpha, ubiquitin-dependent protein catabolic process, protein binding, mitochondrion, Proteasome endopeptidase complex., 20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, Saccharomyces cerevisiae, proteasome storage granule, 90S preribosome, Proteasome
3.60.20.10.10.1.1.1.6	1g0uU00	Proteasome endopeptidase complex., mitochondrion, protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C7-alpha, 90S preribosome, Proteasome, proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1]
3.60.20.10.10.1.1.1.7	3gptG00	protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C7-alpha, Proteasome endopeptidase complex., mitochondrion, proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1], Proteasome, 90S preribosome, proteasome storage granule, Saccharomyces cerevisiae
3.60.20.10.10.1.1.1.8	3gptU00	Proteasome component C7-alpha, protein binding, ubiquitin-dependent protein catabolic process, mitochondrion, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 90S preribosome
3.60.20.10.10.1.1.1.9	3gpwG00	20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, Proteasome, 90S preribosome, Saccharomyces cerevisiae, proteasome storage granule, ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C7-alpha, Proteasome endopeptidase complex., mitochondrion
3.60.20.10.10.1.1.1.10	3gpwU00	20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, 90S preribosome, Proteasome, Saccharomyces cerevisiae, proteasome storage granule, ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C7-alpha, Proteasome endopeptidase complex., mitochondrion
3.60.20.10.10.1.1.1.11	3hyeG00	proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1], 90S preribosome, Proteasome, proteasome storage granule, Saccharomyces cerevisiae, protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C7-alpha, Proteasome endopeptidase complex., mitochondrion
3.60.20.10.10.1.1.1.12	3hyeU00	proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 90S preribosome, proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1], mitochondrion, Proteasome endopeptidase complex., Proteasome component C7-alpha, protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.10.1.1.1.13	3d29G00	protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C7-alpha, Proteasome endopeptidase complex., mitochondrion, proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1], 90S preribosome, Proteasome, proteasome storage granule, Saccharomyces cerevisiae
3.60.20.10.10.1.1.1.14	3d29U00	mitochondrion, Proteasome endopeptidase complex., Proteasome component C7-alpha, ubiquitin-dependent protein catabolic process, protein binding, Saccharomyces cerevisiae, proteasome storage granule, Proteasome, 90S preribosome, 20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex
3.60.20.10.10.1.1.1.15	3bdmG00	Proteasome component C7-alpha, protein binding, ubiquitin-dependent protein catabolic process, mitochondrion, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae, 90S preribosome, Proteasome
3.60.20.10.10.1.1.1.16	3bdmU00	protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C7-alpha, Proteasome endopeptidase complex., mitochondrion, proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1], Proteasome, 90S preribosome, proteasome storage granule, Saccharomyces cerevisiae
3.60.20.10.10.1.1.1.17	3gpjG00	Proteasome component C7-alpha, ubiquitin-dependent protein catabolic process, protein binding, mitochondrion, Proteasome endopeptidase complex., 20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, Saccharomyces cerevisiae, proteasome storage granule, Proteasome, 90S preribosome
3.60.20.10.10.1.1.1.18	3gpjU00	ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C7-alpha, Proteasome endopeptidase complex., mitochondrion, 20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, 90S preribosome, Proteasome, Saccharomyces cerevisiae, proteasome storage granule
3.60.20.10.10.1.1.1.19	2f16G00	proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1], 90S preribosome, Proteasome, proteasome storage granule, Saccharomyces cerevisiae, protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C7-alpha, Proteasome endopeptidase complex., mitochondrion
3.60.20.10.10.1.1.1.20	2f16U00	protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C7-alpha, Proteasome endopeptidase complex., mitochondrion, proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1], 90S preribosome, Proteasome, proteasome storage granule, Saccharomyces cerevisiae
3.60.20.10.10.1.1.1.21	2fakG00	ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C7-alpha, Proteasome endopeptidase complex., mitochondrion, 20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, Proteasome, 90S preribosome, Saccharomyces cerevisiae, proteasome storage granule
3.60.20.10.10.1.1.1.22	2fakU00	20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, Proteasome, 90S preribosome, Saccharomyces cerevisiae, proteasome storage granule, ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C7-alpha, Proteasome endopeptidase complex., mitochondrion
3.60.20.10.10.1.1.1.23	3dy4G00	mitochondrion, Proteasome endopeptidase complex., Proteasome component C7-alpha, protein binding, ubiquitin-dependent protein catabolic process, proteasome storage granule, Saccharomyces cerevisiae, 90S preribosome, Proteasome, proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1]
3.60.20.10.10.1.1.1.24	3dy4U00	proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1], Proteasome, 90S preribosome, proteasome storage granule, Saccharomyces cerevisiae, protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C7-alpha, Proteasome endopeptidase complex., mitochondrion
3.60.20.10.10.1.1.1.25	2gplG00	Saccharomyces cerevisiae, proteasome storage granule, Proteasome, 90S preribosome, 20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, mitochondrion, Proteasome endopeptidase complex., Proteasome component C7-alpha, ubiquitin-dependent protein catabolic process, protein binding
3.60.20.10.10.1.1.1.26	2gplU00	ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C7-alpha, Proteasome endopeptidase complex., mitochondrion, 20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, 90S preribosome, Proteasome, Saccharomyces cerevisiae, proteasome storage granule
3.60.20.10.10.1.1.1.27	3dy3G00	Proteasome component C7-alpha, ubiquitin-dependent protein catabolic process, protein binding, mitochondrion, Proteasome endopeptidase complex., 20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, Saccharomyces cerevisiae, proteasome storage granule, Proteasome, 90S preribosome
3.60.20.10.10.1.1.1.28	3dy3U00	Proteasome endopeptidase complex., mitochondrion, protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C7-alpha, 90S preribosome, Proteasome, proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1]
3.60.20.10.10.1.1.1.29	2zcyG00	Proteasome, 90S preribosome, Saccharomyces cerevisiae, proteasome storage granule, 20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., mitochondrion, ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C7-alpha
3.60.20.10.10.1.1.1.30	2zcyU00	proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 90S preribosome, proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1], mitochondrion, Proteasome endopeptidase complex., Proteasome component C7-alpha, protein binding, ubiquitin-dependent protein catabolic process
3.60.20.10.10.1.1.1.31	1jd2200	90S preribosome, Proteasome, proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1], Proteasome endopeptidase complex., mitochondrion, protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C7-alpha
3.60.20.10.10.1.1.1.32	1jd2G00	Proteasome endopeptidase complex., mitochondrion, protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C7-alpha, Proteasome, 90S preribosome, proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1]
3.60.20.10.10.1.1.1.33	1vsyA00	mitochondrion, Proteasome endopeptidase complex., Proteasome component C7-alpha, ubiquitin-dependent protein catabolic process, protein binding, Saccharomyces cerevisiae, proteasome storage granule, Proteasome, 90S preribosome, 20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex
3.60.20.10.10.1.1.1.34	1vsyO00	ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C7-alpha, Proteasome endopeptidase complex., mitochondrion, 20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, 90S preribosome, Proteasome, Saccharomyces cerevisiae, proteasome storage granule
3.60.20.10.10.1.1.1.35	3e47G00	Proteasome, 90S preribosome, proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1], Proteasome endopeptidase complex., mitochondrion, protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C7-alpha
3.60.20.10.10.1.1.1.36	3e47U00	protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C7-alpha, Proteasome endopeptidase complex., mitochondrion, proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1], Proteasome, 90S preribosome, proteasome storage granule, Saccharomyces cerevisiae
3.60.20.10.10.1.1.1.37	3l5qA00	proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1], Proteasome, 90S preribosome, proteasome storage granule, Saccharomyces cerevisiae, protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C7-alpha, Proteasome endopeptidase complex., mitochondrion
3.60.20.10.10.1.1.1.38	3l5qC00	Proteasome endopeptidase complex., mitochondrion, protein binding, ubiquitin-dependent protein catabolic process, Proteasome component C7-alpha, Proteasome, 90S preribosome, proteasome storage granule, Saccharomyces cerevisiae, proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1]
3.60.20.10.10.1.1.1.39	1fntA00	90S preribosome, Proteasome, Saccharomyces cerevisiae, proteasome storage granule, 20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., mitochondrion, ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C7-alpha
3.60.20.10.10.1.1.1.40	1fntO00	90S preribosome, Proteasome, Saccharomyces cerevisiae, proteasome storage granule, 20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, Proteasome endopeptidase complex., mitochondrion, ubiquitin-dependent protein catabolic process, protein binding, Proteasome component C7-alpha
3.60.20.10.10.1.1.1.41	1z7qA00	Proteasome component C7-alpha, protein binding, ubiquitin-dependent protein catabolic process, mitochondrion, Proteasome endopeptidase complex., proteasome core complex, alpha-subunit complex, 20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome storage granule, Saccharomyces cerevisiae, Proteasome, 90S preribosome
3.60.20.10.10.1.1.1.42	1z7qO00	Proteasome component C7-alpha, ubiquitin-dependent protein catabolic process, protein binding, mitochondrion, Proteasome endopeptidase complex., 20S proteasome subunit alpha 1 [EC:3.4.25.1], proteasome core complex, alpha-subunit complex, Saccharomyces cerevisiae, proteasome storage granule, Proteasome, 90S preribosome
3.60.20.10.10.1.1.1.43	2fnyG00
3.60.20.10.10.1.1.1.44	2fnyU00

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.60.20.10.10.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.60.20.10.10.1.1.1

Classification Lineage (3.60.20.10.10.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.60.20.10.10.1.1.1 (44)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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