S100 Family: 3.40.50.960.2.1.1.1

Representative domain: 2c92A00

Classification Lineage (3.40.50.960.2.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.40	3-Layer(aba) Sandwich
3.40.50	Rossmann fold
3.40.50.960		Gene3D
3.40.50.960.2
3.40.50.960.2.1
3.40.50.960.2.1.1
3.40.50.960.2.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	55

Non-Redundant Representatives (55)
Functional Families
Help

What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.40.50.960.2.1.1.1 (55)

CATH code	Domain ID	Keywords
3.40.50.960.2.1.1.1.1	2c92A00	6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-], Riboflavin synthase., Metabolic pathways, Riboflavin metabolism, Mycobacterium tuberculosis
3.40.50.960.2.1.1.1.2	2c92B00	Riboflavin metabolism, Mycobacterium tuberculosis, Metabolic pathways, Riboflavin synthase., 6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-]
3.40.50.960.2.1.1.1.3	2c92C00	riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase, Riboflavin metabolism, Mycobacterium tuberculosis, Metabolic pathways, Riboflavin synthase.
3.40.50.960.2.1.1.1.4	2c92D00	Metabolic pathways, Mycobacterium tuberculosis, Riboflavin metabolism, Riboflavin synthase., 6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-]
3.40.50.960.2.1.1.1.5	2c92E00	6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-], Metabolic pathways, Mycobacterium tuberculosis, Riboflavin metabolism, Riboflavin synthase.
3.40.50.960.2.1.1.1.6	2c94A00	riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase, Riboflavin synthase., Riboflavin metabolism, Mycobacterium tuberculosis, Metabolic pathways
3.40.50.960.2.1.1.1.7	2c94B00	Riboflavin synthase., Mycobacterium tuberculosis, Riboflavin metabolism, Metabolic pathways, 6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-]
3.40.50.960.2.1.1.1.8	2c94C00	Riboflavin synthase., Mycobacterium tuberculosis, Riboflavin metabolism, Metabolic pathways, riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase
3.40.50.960.2.1.1.1.9	2c94D00	riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase, Riboflavin synthase., Mycobacterium tuberculosis, Riboflavin metabolism, Metabolic pathways
3.40.50.960.2.1.1.1.10	2c94E00	Metabolic pathways, Riboflavin metabolism, Mycobacterium tuberculosis, Riboflavin synthase., riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase
3.40.50.960.2.1.1.1.11	1w19A00	Mycobacterium tuberculosis, Riboflavin metabolism, Metabolic pathways, Riboflavin synthase., riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase
3.40.50.960.2.1.1.1.12	1w19B00	6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-], Metabolic pathways, Mycobacterium tuberculosis, Riboflavin metabolism, Riboflavin synthase.
3.40.50.960.2.1.1.1.13	1w19D00	riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase, Mycobacterium tuberculosis, Riboflavin metabolism, Metabolic pathways, Riboflavin synthase.
3.40.50.960.2.1.1.1.14	2c97A00	6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-], Riboflavin synthase., Metabolic pathways, Mycobacterium tuberculosis, Riboflavin metabolism
3.40.50.960.2.1.1.1.15	2c97B00	riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase, Riboflavin synthase., Metabolic pathways, Riboflavin metabolism, Mycobacterium tuberculosis
3.40.50.960.2.1.1.1.16	2c97D00	Riboflavin metabolism, Mycobacterium tuberculosis, Metabolic pathways, Riboflavin synthase., 6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-]
3.40.50.960.2.1.1.1.17	1w19C00	Riboflavin synthase., Mycobacterium tuberculosis, Riboflavin metabolism, Metabolic pathways, riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase
3.40.50.960.2.1.1.1.18	1w19E00	Riboflavin synthase., Mycobacterium tuberculosis, Riboflavin metabolism, Metabolic pathways, 6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-]
3.40.50.960.2.1.1.1.19	2c97C00	Mycobacterium tuberculosis, Riboflavin metabolism, Metabolic pathways, Riboflavin synthase., riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase
3.40.50.960.2.1.1.1.20	2c97E00	Metabolic pathways, Mycobacterium tuberculosis, Riboflavin metabolism, Riboflavin synthase., riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase
3.40.50.960.2.1.1.1.21	2vi5E00	riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase, Mycobacterium tuberculosis, Riboflavin metabolism, Metabolic pathways, Riboflavin synthase.
3.40.50.960.2.1.1.1.22	2vi5A00	Riboflavin synthase., Mycobacterium tuberculosis, Riboflavin metabolism, Metabolic pathways, 6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-]
3.40.50.960.2.1.1.1.23	2vi5I00	6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-], Riboflavin synthase., Riboflavin metabolism, Mycobacterium tuberculosis, Metabolic pathways
3.40.50.960.2.1.1.1.24	2vi5D00	6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-], Riboflavin synthase., Metabolic pathways, Riboflavin metabolism, Mycobacterium tuberculosis
3.40.50.960.2.1.1.1.25	2vi5H00	6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-], Riboflavin synthase., Metabolic pathways, Mycobacterium tuberculosis, Riboflavin metabolism
3.40.50.960.2.1.1.1.26	1w29B00	Metabolic pathways, Riboflavin metabolism, Mycobacterium tuberculosis, Riboflavin synthase., riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase
3.40.50.960.2.1.1.1.27	2vi5B00	Riboflavin synthase., Metabolic pathways, Mycobacterium tuberculosis, Riboflavin metabolism, riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase
3.40.50.960.2.1.1.1.28	2vi5F00	6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-], Riboflavin synthase., Metabolic pathways, Riboflavin metabolism, Mycobacterium tuberculosis
3.40.50.960.2.1.1.1.29	2vi5G00	riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase, Metabolic pathways, Riboflavin metabolism, Mycobacterium tuberculosis, Riboflavin synthase.
3.40.50.960.2.1.1.1.30	1w29A00	riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase, Riboflavin synthase., Riboflavin metabolism, Mycobacterium tuberculosis, Metabolic pathways
3.40.50.960.2.1.1.1.31	1w29C00	Riboflavin synthase., Metabolic pathways, Riboflavin metabolism, Mycobacterium tuberculosis, 6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-]
3.40.50.960.2.1.1.1.32	1w29D00	Riboflavin synthase., Metabolic pathways, Riboflavin metabolism, Mycobacterium tuberculosis, riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase
3.40.50.960.2.1.1.1.33	1w29E00	riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase, Riboflavin synthase., Riboflavin metabolism, Mycobacterium tuberculosis, Metabolic pathways
3.40.50.960.2.1.1.1.34	2vi5C00	riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase, Riboflavin metabolism, Mycobacterium tuberculosis, Metabolic pathways, Riboflavin synthase.
3.40.50.960.2.1.1.1.35	2vi5J00	6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-], Mycobacterium tuberculosis, Riboflavin metabolism, Metabolic pathways, Riboflavin synthase.
3.40.50.960.2.1.1.1.36	2c9bA00	6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-], Riboflavin metabolism, Mycobacterium tuberculosis, Metabolic pathways, Riboflavin synthase.
3.40.50.960.2.1.1.1.37	2c9bB00	riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase, Riboflavin synthase., Metabolic pathways, Riboflavin metabolism, Mycobacterium tuberculosis
3.40.50.960.2.1.1.1.38	2c9bD00	Riboflavin metabolism, Mycobacterium tuberculosis, Metabolic pathways, Riboflavin synthase., 6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-]
3.40.50.960.2.1.1.1.39	2c9bF00	Riboflavin synthase., Metabolic pathways, Mycobacterium tuberculosis, Riboflavin metabolism, 6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-]
3.40.50.960.2.1.1.1.40	2c9bG00	riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase, Riboflavin synthase., Riboflavin metabolism, Mycobacterium tuberculosis, Metabolic pathways
3.40.50.960.2.1.1.1.41	2c9bI00	Mycobacterium tuberculosis, Riboflavin metabolism, Metabolic pathways, Riboflavin synthase., riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase
3.40.50.960.2.1.1.1.42	2c9bC00	Riboflavin synthase., Metabolic pathways, Mycobacterium tuberculosis, Riboflavin metabolism, 6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-]
3.40.50.960.2.1.1.1.43	2c9bE00	6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-], Riboflavin synthase., Riboflavin metabolism, Mycobacterium tuberculosis, Metabolic pathways
3.40.50.960.2.1.1.1.44	2c9bH00	Mycobacterium tuberculosis, Riboflavin metabolism, Metabolic pathways, Riboflavin synthase., 6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-]
3.40.50.960.2.1.1.1.45	2c9bJ00	6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-], Riboflavin synthase., Metabolic pathways, Riboflavin metabolism, Mycobacterium tuberculosis
3.40.50.960.2.1.1.1.46	2c9dA00	Riboflavin synthase., Metabolic pathways, Riboflavin metabolism, Mycobacterium tuberculosis, riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase
3.40.50.960.2.1.1.1.47	2c9dB00	Riboflavin synthase., Metabolic pathways, Mycobacterium tuberculosis, Riboflavin metabolism, riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase
3.40.50.960.2.1.1.1.48	2c9dD00	6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-], Riboflavin synthase., Mycobacterium tuberculosis, Riboflavin metabolism, Metabolic pathways
3.40.50.960.2.1.1.1.49	2c9dF00	Riboflavin synthase., Metabolic pathways, Mycobacterium tuberculosis, Riboflavin metabolism, 6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-]
3.40.50.960.2.1.1.1.50	2c9dG00	Mycobacterium tuberculosis, Riboflavin metabolism, Metabolic pathways, Riboflavin synthase., 6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-]
3.40.50.960.2.1.1.1.51	2c9dI00	Riboflavin synthase., Mycobacterium tuberculosis, Riboflavin metabolism, Metabolic pathways, riboflavin synthase beta chain [EC:2.5.1.-], 6,7-dimethyl-8-ribityllumazine synthase
3.40.50.960.2.1.1.1.52	2c9dC00	Metabolic pathways, Mycobacterium tuberculosis, Riboflavin metabolism, Riboflavin synthase., 6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-]
3.40.50.960.2.1.1.1.53	2c9dE00	Riboflavin synthase., Metabolic pathways, Mycobacterium tuberculosis, Riboflavin metabolism, 6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-]
3.40.50.960.2.1.1.1.54	2c9dH00	Riboflavin synthase., Riboflavin metabolism, Mycobacterium tuberculosis, Metabolic pathways, 6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-]
3.40.50.960.2.1.1.1.55	2c9dJ00	Riboflavin synthase., Riboflavin metabolism, Mycobacterium tuberculosis, Metabolic pathways, 6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta chain [EC:2.5.1.-]

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.40.50.960.2.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.40.50.960.2.1.1.1

Classification Lineage (3.40.50.960.2.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.40.50.960.2.1.1.1 (55)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

CATH Shortcuts