S100 Family: 3.40.50.620.5.1.1.1

Representative domain: 3covA01

Classification Lineage (3.40.50.620.5.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.40	3-Layer(aba) Sandwich
3.40.50	Rossmann fold
3.40.50.620	Tyrosyl-Transfer RNA Synthetase , subunit E, domain 1	Gene3D
3.40.50.620.5
3.40.50.620.5.1
3.40.50.620.5.1.1
3.40.50.620.5.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	54

Non-Redundant Representatives (54)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.40.50.620.5.1.1.1 (54)

CATH code	Domain ID	Keywords
3.40.50.620.5.1.1.1.1	3covA01	Metabolic pathways, Mycobacterium tuberculosis, pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Pantoate--beta-alanine ligase., Pantothenate synthetase, Pantothenate and CoA biosynthesis
3.40.50.620.5.1.1.1.2	3iubA01	Pantothenate synthetase, Pantothenate and CoA biosynthesis, Pantoate--beta-alanine ligase., Mycobacterium tuberculosis, Metabolic pathways, pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism
3.40.50.620.5.1.1.1.3	1mopA01	Pantoate--beta-alanine ligase., Pantothenate synthetase, Pantothenate and CoA biosynthesis, pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Metabolic pathways, Mycobacterium tuberculosis
3.40.50.620.5.1.1.1.4	1n2eA01	Pantothenate synthetase, Pantothenate and CoA biosynthesis, Pantoate--beta-alanine ligase., Metabolic pathways, Mycobacterium tuberculosis, pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism
3.40.50.620.5.1.1.1.5	3imcA01	beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1], Metabolic pathways, Mycobacterium tuberculosis, Pantoate--beta-alanine ligase., Pantothenate and CoA biosynthesis, Pantothenate synthetase
3.40.50.620.5.1.1.1.6	3iubB01	Metabolic pathways, Mycobacterium tuberculosis, pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Pantothenate synthetase, Pantothenate and CoA biosynthesis, Pantoate--beta-alanine ligase.
3.40.50.620.5.1.1.1.7	1mopB01	Pantothenate and CoA biosynthesis, Pantothenate synthetase, Pantoate--beta-alanine ligase., Mycobacterium tuberculosis, Metabolic pathways, beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1]
3.40.50.620.5.1.1.1.8	3covB01	pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Mycobacterium tuberculosis, Metabolic pathways, Pantothenate synthetase, Pantothenate and CoA biosynthesis, Pantoate--beta-alanine ligase.
3.40.50.620.5.1.1.1.9	1n2bA01	Pantothenate and CoA biosynthesis, Pantothenate synthetase, Pantoate--beta-alanine ligase., beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1], Metabolic pathways, Mycobacterium tuberculosis
3.40.50.620.5.1.1.1.10	1n2iA01	Metabolic pathways, Mycobacterium tuberculosis, beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1], Pantoate--beta-alanine ligase., Pantothenate and CoA biosynthesis, Pantothenate synthetase
3.40.50.620.5.1.1.1.11	1n2iB01	Pantoate--beta-alanine ligase., Pantothenate and CoA biosynthesis, Pantothenate synthetase, beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1], Metabolic pathways, Mycobacterium tuberculosis
3.40.50.620.5.1.1.1.12	3le8A01	Metabolic pathways, Mycobacterium tuberculosis, beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1], Pantothenate and CoA biosynthesis, Pantothenate synthetase, Pantoate--beta-alanine ligase.
3.40.50.620.5.1.1.1.13	1n2eB01	Pantothenate and CoA biosynthesis, Pantothenate synthetase, Pantoate--beta-alanine ligase., beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1], Mycobacterium tuberculosis, Metabolic pathways
3.40.50.620.5.1.1.1.14	2a84A01	Pantothenate synthetase, Pantothenate and CoA biosynthesis, Pantoate--beta-alanine ligase., Metabolic pathways, Mycobacterium tuberculosis, pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism
3.40.50.620.5.1.1.1.15	3iueA01	Pantoate--beta-alanine ligase., Pantothenate and CoA biosynthesis, Pantothenate synthetase, Mycobacterium tuberculosis, Metabolic pathways, beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1]
3.40.50.620.5.1.1.1.16	3ivxA01	Pantothenate synthetase, Pantothenate and CoA biosynthesis, Pantoate--beta-alanine ligase., Mycobacterium tuberculosis, Metabolic pathways, pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism
3.40.50.620.5.1.1.1.17	3imcB01	Pantothenate synthetase, Pantothenate and CoA biosynthesis, Pantoate--beta-alanine ligase., pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Mycobacterium tuberculosis, Metabolic pathways
3.40.50.620.5.1.1.1.18	1n2jA01	pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Metabolic pathways, Mycobacterium tuberculosis, Pantoate--beta-alanine ligase., Pantothenate synthetase, Pantothenate and CoA biosynthesis
3.40.50.620.5.1.1.1.19	1n2jB01	beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1], Mycobacterium tuberculosis, Metabolic pathways, Pantothenate and CoA biosynthesis, Pantothenate synthetase, Pantoate--beta-alanine ligase.
3.40.50.620.5.1.1.1.20	3cowA01	Pantothenate and CoA biosynthesis, Pantothenate synthetase, Pantoate--beta-alanine ligase., beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1], Metabolic pathways, Mycobacterium tuberculosis
3.40.50.620.5.1.1.1.21	3imgA01	Pantothenate synthetase, Pantothenate and CoA biosynthesis, Pantoate--beta-alanine ligase., pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Metabolic pathways, Mycobacterium tuberculosis
3.40.50.620.5.1.1.1.22	3iobA01	Pantothenate synthetase, Pantothenate and CoA biosynthesis, Pantoate--beta-alanine ligase., Mycobacterium tuberculosis, Metabolic pathways, pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism
3.40.50.620.5.1.1.1.23	2a86A01	Pantothenate synthetase, Pantothenate and CoA biosynthesis, Pantoate--beta-alanine ligase., pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Metabolic pathways, Mycobacterium tuberculosis
3.40.50.620.5.1.1.1.24	3iodA01	Pantoate--beta-alanine ligase., Pantothenate and CoA biosynthesis, Pantothenate synthetase, beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1], Mycobacterium tuberculosis, Metabolic pathways
3.40.50.620.5.1.1.1.25	2a7xA01	beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1], Mycobacterium tuberculosis, Metabolic pathways, Pantothenate and CoA biosynthesis, Pantothenate synthetase, Pantoate--beta-alanine ligase.
3.40.50.620.5.1.1.1.26	3iueB01	pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Metabolic pathways, Mycobacterium tuberculosis, Pantothenate synthetase, Pantothenate and CoA biosynthesis, Pantoate--beta-alanine ligase.
3.40.50.620.5.1.1.1.27	3le8B01	Metabolic pathways, Mycobacterium tuberculosis, pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Pantothenate synthetase, Pantothenate and CoA biosynthesis, Pantoate--beta-alanine ligase.
3.40.50.620.5.1.1.1.28	2a88A01	Pantoate--beta-alanine ligase., Pantothenate synthetase, Pantothenate and CoA biosynthesis, pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Mycobacterium tuberculosis, Metabolic pathways
3.40.50.620.5.1.1.1.29	3ivxB01	Metabolic pathways, Mycobacterium tuberculosis, pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Pantoate--beta-alanine ligase., Pantothenate synthetase, Pantothenate and CoA biosynthesis
3.40.50.620.5.1.1.1.30	3cowB01	Pantoate--beta-alanine ligase., Pantothenate synthetase, Pantothenate and CoA biosynthesis, pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Metabolic pathways, Mycobacterium tuberculosis
3.40.50.620.5.1.1.1.31	3ivgA01	Pantothenate synthetase, Pantothenate and CoA biosynthesis, Pantoate--beta-alanine ligase., Mycobacterium tuberculosis, Metabolic pathways, pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism
3.40.50.620.5.1.1.1.32	3ioeA01	Metabolic pathways, Mycobacterium tuberculosis, beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1], Pantothenate and CoA biosynthesis, Pantothenate synthetase, Pantoate--beta-alanine ligase.
3.40.50.620.5.1.1.1.33	3iobB01	Pantothenate synthetase, Pantothenate and CoA biosynthesis, Pantoate--beta-alanine ligase., pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Metabolic pathways, Mycobacterium tuberculosis
3.40.50.620.5.1.1.1.34	3iodB01	Mycobacterium tuberculosis, Metabolic pathways, pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Pantoate--beta-alanine ligase., Pantothenate synthetase, Pantothenate and CoA biosynthesis
3.40.50.620.5.1.1.1.35	1n2hA01	beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1], Mycobacterium tuberculosis, Metabolic pathways, Pantothenate and CoA biosynthesis, Pantothenate synthetase, Pantoate--beta-alanine ligase.
3.40.50.620.5.1.1.1.36	1n2hB01	Pantoate--beta-alanine ligase., Pantothenate and CoA biosynthesis, Pantothenate synthetase, beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1], Metabolic pathways, Mycobacterium tuberculosis
3.40.50.620.5.1.1.1.37	3cozA01	Metabolic pathways, Mycobacterium tuberculosis, pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Pantothenate synthetase, Pantothenate and CoA biosynthesis, Pantoate--beta-alanine ligase.
3.40.50.620.5.1.1.1.38	2a86B01	Pantothenate synthetase, Pantothenate and CoA biosynthesis, Pantoate--beta-alanine ligase., pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Mycobacterium tuberculosis, Metabolic pathways
3.40.50.620.5.1.1.1.39	3imgB01	pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Mycobacterium tuberculosis, Metabolic pathways, Pantothenate synthetase, Pantothenate and CoA biosynthesis, Pantoate--beta-alanine ligase.
3.40.50.620.5.1.1.1.40	3ioeB01	Pantothenate and CoA biosynthesis, Pantothenate synthetase, Pantoate--beta-alanine ligase., Metabolic pathways, Mycobacterium tuberculosis, beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1]
3.40.50.620.5.1.1.1.41	3ivcA01	pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Mycobacterium tuberculosis, Metabolic pathways, Pantoate--beta-alanine ligase., Pantothenate synthetase, Pantothenate and CoA biosynthesis
3.40.50.620.5.1.1.1.42	3coyA01	Mycobacterium tuberculosis, Metabolic pathways, beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1], Pantoate--beta-alanine ligase., Pantothenate and CoA biosynthesis, Pantothenate synthetase
3.40.50.620.5.1.1.1.43	3cozB01	Pantothenate and CoA biosynthesis, Pantothenate synthetase, Pantoate--beta-alanine ligase., Metabolic pathways, Mycobacterium tuberculosis, beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1]
3.40.50.620.5.1.1.1.44	3ivgB01	beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1], Mycobacterium tuberculosis, Metabolic pathways, Pantoate--beta-alanine ligase., Pantothenate and CoA biosynthesis, Pantothenate synthetase
3.40.50.620.5.1.1.1.45	3coyB01	Pantothenate and CoA biosynthesis, Pantothenate synthetase, Pantoate--beta-alanine ligase., beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1], Metabolic pathways, Mycobacterium tuberculosis
3.40.50.620.5.1.1.1.46	3isjA01	pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Mycobacterium tuberculosis, Metabolic pathways, Pantoate--beta-alanine ligase., Pantothenate synthetase, Pantothenate and CoA biosynthesis
3.40.50.620.5.1.1.1.47	1n2oA01	Mycobacterium tuberculosis, Metabolic pathways, beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1], Pantoate--beta-alanine ligase., Pantothenate and CoA biosynthesis, Pantothenate synthetase
3.40.50.620.5.1.1.1.48	1n2oB01	Pantothenate synthetase, Pantothenate and CoA biosynthesis, Pantoate--beta-alanine ligase., pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Mycobacterium tuberculosis, Metabolic pathways
3.40.50.620.5.1.1.1.49	3ivcB01	Pantoate--beta-alanine ligase., Pantothenate and CoA biosynthesis, Pantothenate synthetase, beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1], Mycobacterium tuberculosis, Metabolic pathways
3.40.50.620.5.1.1.1.50	3isjB01	pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Mycobacterium tuberculosis, Metabolic pathways, Pantoate--beta-alanine ligase., Pantothenate synthetase, Pantothenate and CoA biosynthesis
3.40.50.620.5.1.1.1.51	3imeA01	pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism, Metabolic pathways, Mycobacterium tuberculosis, Pantothenate synthetase, Pantothenate and CoA biosynthesis, Pantoate--beta-alanine ligase.
3.40.50.620.5.1.1.1.52	3imeB01	Metabolic pathways, Mycobacterium tuberculosis, beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1], Pantothenate and CoA biosynthesis, Pantothenate synthetase, Pantoate--beta-alanine ligase.
3.40.50.620.5.1.1.1.53	3iocB01	Pantoate--beta-alanine ligase., Pantothenate synthetase, Pantothenate and CoA biosynthesis, Mycobacterium tuberculosis, Metabolic pathways, pantoate--beta-alanine ligase [EC:6.3.2.1], beta-Alanine metabolism
3.40.50.620.5.1.1.1.54	3iocA01	Metabolic pathways, Mycobacterium tuberculosis, beta-Alanine metabolism, pantoate--beta-alanine ligase [EC:6.3.2.1], Pantothenate and CoA biosynthesis, Pantothenate synthetase, Pantoate--beta-alanine ligase.

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.40.50.620.5.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.40.50.620.5.1.1.1

Classification Lineage (3.40.50.620.5.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.40.50.620.5.1.1.1 (54)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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