S100 Family: 3.40.50.620.2.1.1.1

Representative domain: 1r6xA02

Classification Lineage (3.40.50.620.2.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.40	3-Layer(aba) Sandwich
3.40.50	Rossmann fold
3.40.50.620	Tyrosyl-Transfer RNA Synthetase , subunit E, domain 1	Gene3D
3.40.50.620.2
3.40.50.620.2.1
3.40.50.620.2.1.1
3.40.50.620.2.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	14

Non-Redundant Representatives (14)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.40.50.620.2.1.1.1 (14)

CATH code	Domain ID	Keywords
3.40.50.620.2.1.1.1.1	1r6xA02	sulfate adenylyltransferase [EC:2.7.7.4], Saccharomyces cerevisiae, Sulfur metabolism, Purine metabolism, identical protein binding, sulfate adenylyltransferase (ATP) activity, Sulfate adenylyltransferase., mitochondrion, Metabolic pathways, sulfate assimilation, Selenoamino acid metabolism, Sulfate adenylyltransferase
3.40.50.620.2.1.1.1.2	1g8fA01	Sulfate adenylyltransferase., sulfate adenylyltransferase (ATP) activity, Purine metabolism, identical protein binding, sulfate adenylyltransferase [EC:2.7.7.4], Saccharomyces cerevisiae, Sulfur metabolism, sulfate assimilation, Selenoamino acid metabolism, Sulfate adenylyltransferase, Metabolic pathways, mitochondrion
3.40.50.620.2.1.1.1.3	1j70A01	Selenoamino acid metabolism, Sulfate adenylyltransferase, sulfate assimilation, Metabolic pathways, mitochondrion, Sulfate adenylyltransferase., sulfate adenylyltransferase (ATP) activity, identical protein binding, Purine metabolism, Sulfur metabolism, sulfate adenylyltransferase [EC:2.7.7.4], Saccharomyces cerevisiae
3.40.50.620.2.1.1.1.4	1j70B01	Metabolic pathways, Selenoamino acid metabolism, Sulfate adenylyltransferase, sulfate assimilation, mitochondrion, Sulfate adenylyltransferase., Sulfur metabolism, sulfate adenylyltransferase [EC:2.7.7.4], Saccharomyces cerevisiae, identical protein binding, Purine metabolism, sulfate adenylyltransferase (ATP) activity
3.40.50.620.2.1.1.1.5	1j70C01	mitochondrion, Selenoamino acid metabolism, Sulfate adenylyltransferase, sulfate assimilation, Metabolic pathways, sulfate adenylyltransferase (ATP) activity, identical protein binding, Purine metabolism, Sulfur metabolism, sulfate adenylyltransferase [EC:2.7.7.4], Saccharomyces cerevisiae, Sulfate adenylyltransferase.
3.40.50.620.2.1.1.1.6	1jecA01	Metabolic pathways, sulfate assimilation, Selenoamino acid metabolism, Sulfate adenylyltransferase, mitochondrion, Sulfate adenylyltransferase., Purine metabolism, identical protein binding, sulfate adenylyltransferase [EC:2.7.7.4], Saccharomyces cerevisiae, Sulfur metabolism, sulfate adenylyltransferase (ATP) activity
3.40.50.620.2.1.1.1.7	1g8gA01	sulfate adenylyltransferase (ATP) activity, sulfate adenylyltransferase [EC:2.7.7.4], Saccharomyces cerevisiae, Sulfur metabolism, Purine metabolism, identical protein binding, Sulfate adenylyltransferase., mitochondrion, sulfate assimilation, Selenoamino acid metabolism, Sulfate adenylyltransferase, Metabolic pathways
3.40.50.620.2.1.1.1.8	1g8gB01	sulfate adenylyltransferase (ATP) activity, sulfate adenylyltransferase [EC:2.7.7.4], Saccharomyces cerevisiae, Sulfur metabolism, Purine metabolism, identical protein binding, Sulfate adenylyltransferase., mitochondrion, sulfate assimilation, Selenoamino acid metabolism, Sulfate adenylyltransferase, Metabolic pathways
3.40.50.620.2.1.1.1.9	1g8hA01	Sulfate adenylyltransferase., sulfate adenylyltransferase (ATP) activity, sulfate adenylyltransferase [EC:2.7.7.4], Saccharomyces cerevisiae, Sulfur metabolism, Purine metabolism, identical protein binding, sulfate assimilation, Selenoamino acid metabolism, Sulfate adenylyltransferase, Metabolic pathways, mitochondrion
3.40.50.620.2.1.1.1.10	1g8hB01	mitochondrion, sulfate assimilation, Selenoamino acid metabolism, Sulfate adenylyltransferase, Metabolic pathways, sulfate adenylyltransferase (ATP) activity, sulfate adenylyltransferase [EC:2.7.7.4], Saccharomyces cerevisiae, Sulfur metabolism, Purine metabolism, identical protein binding, Sulfate adenylyltransferase.
3.40.50.620.2.1.1.1.11	1jeeA01	sulfate assimilation, Selenoamino acid metabolism, Sulfate adenylyltransferase, Metabolic pathways, mitochondrion, Sulfate adenylyltransferase., sulfate adenylyltransferase (ATP) activity, Purine metabolism, identical protein binding, sulfate adenylyltransferase [EC:2.7.7.4], Saccharomyces cerevisiae, Sulfur metabolism
3.40.50.620.2.1.1.1.12	1jeeB01	Selenoamino acid metabolism, Sulfate adenylyltransferase, sulfate assimilation, Metabolic pathways, mitochondrion, Sulfate adenylyltransferase., sulfate adenylyltransferase (ATP) activity, Sulfur metabolism, sulfate adenylyltransferase [EC:2.7.7.4], Saccharomyces cerevisiae, identical protein binding, Purine metabolism
3.40.50.620.2.1.1.1.13	1jedA01	sulfate assimilation, Selenoamino acid metabolism, Sulfate adenylyltransferase, Metabolic pathways, mitochondrion, Sulfate adenylyltransferase., sulfate adenylyltransferase (ATP) activity, sulfate adenylyltransferase [EC:2.7.7.4], Saccharomyces cerevisiae, Sulfur metabolism, Purine metabolism, identical protein binding
3.40.50.620.2.1.1.1.14	1jedB01	sulfate adenylyltransferase (ATP) activity, sulfate adenylyltransferase [EC:2.7.7.4], Saccharomyces cerevisiae, Sulfur metabolism, Purine metabolism, identical protein binding, Sulfate adenylyltransferase., mitochondrion, sulfate assimilation, Selenoamino acid metabolism, Sulfate adenylyltransferase, Metabolic pathways

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.40.50.620.2.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.40.50.620.2.1.1.1

Classification Lineage (3.40.50.620.2.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.40.50.620.2.1.1.1 (14)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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