S100 Family: 3.40.50.300.19.1.1.1

Representative domain: 1cipA01

Classification Lineage (3.40.50.300.19.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.40	3-Layer(aba) Sandwich
3.40.50	Rossmann fold
3.40.50.300	P-loop containing nucleotide triphosphate hydrolases	Gene3D
3.40.50.300.19
3.40.50.300.19.1
3.40.50.300.19.1.1
3.40.50.300.19.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	16

Non-Redundant Representatives (16)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.40.50.300.19.1.1.1 (16)

CATH code	Domain ID	Keywords
3.40.50.300.19.1.1.1.1	1cipA01	membrane fraction, Melanogenesis, Chemokine signaling pathway, Guanine nucleotide-binding protein G(i) subunit alpha-1, heterotrimeric G-protein complex, membrane raft, G-protein coupled receptor protein signaling pathway, Leukocyte transendothelial migration, metabotropic serotonin receptor binding, negative regulation of synaptic transmission, Gap junction, Long-term depression, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide, Chagas disease, Tight junction, Axon guidance, Progesterone-mediated oocyte maturation, Rattus norvegicus
3.40.50.300.19.1.1.1.2	1svsA01	Melanogenesis, membrane fraction, heterotrimeric G-protein complex, membrane raft, Chemokine signaling pathway, Guanine nucleotide-binding protein G(i) subunit alpha-1, G-protein coupled receptor protein signaling pathway, Leukocyte transendothelial migration, metabotropic serotonin receptor binding, negative regulation of synaptic transmission, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide, Gap junction, Long-term depression, Chagas disease, Progesterone-mediated oocyte maturation, Axon guidance, Tight junction, Rattus norvegicus
3.40.50.300.19.1.1.1.3	1svkA01	negative regulation of synaptic transmission, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide, Long-term depression, Gap junction, Progesterone-mediated oocyte maturation, Tight junction, Axon guidance, Rattus norvegicus, Chagas disease, G-protein coupled receptor protein signaling pathway, Leukocyte transendothelial migration, metabotropic serotonin receptor binding, Melanogenesis, membrane fraction, membrane raft, heterotrimeric G-protein complex, Guanine nucleotide-binding protein G(i) subunit alpha-1, Chemokine signaling pathway
3.40.50.300.19.1.1.1.4	1gddA01	negative regulation of synaptic transmission, Long-term depression, Gap junction, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide, Chagas disease, Tight junction, Axon guidance, Progesterone-mediated oocyte maturation, Rattus norvegicus, membrane fraction, Melanogenesis, Guanine nucleotide-binding protein G(i) subunit alpha-1, Chemokine signaling pathway, membrane raft, heterotrimeric G-protein complex, G-protein coupled receptor protein signaling pathway, Leukocyte transendothelial migration, metabotropic serotonin receptor binding
3.40.50.300.19.1.1.1.5	1giaA01	negative regulation of synaptic transmission, Long-term depression, Gap junction, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide, Axon guidance, Tight junction, Progesterone-mediated oocyte maturation, Rattus norvegicus, Chagas disease, G-protein coupled receptor protein signaling pathway, Leukocyte transendothelial migration, metabotropic serotonin receptor binding, membrane fraction, Melanogenesis, Guanine nucleotide-binding protein G(i) subunit alpha-1, Chemokine signaling pathway, membrane raft, heterotrimeric G-protein complex
3.40.50.300.19.1.1.1.6	1gfiA01	Chemokine signaling pathway, Guanine nucleotide-binding protein G(i) subunit alpha-1, heterotrimeric G-protein complex, membrane raft, membrane fraction, Melanogenesis, Leukocyte transendothelial migration, metabotropic serotonin receptor binding, G-protein coupled receptor protein signaling pathway, Chagas disease, Rattus norvegicus, Axon guidance, Tight junction, Progesterone-mediated oocyte maturation, Gap junction, Long-term depression, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide, negative regulation of synaptic transmission
3.40.50.300.19.1.1.1.7	1gp2A01	Chagas disease, Rattus norvegicus, Progesterone-mediated oocyte maturation, Axon guidance, Tight junction, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide, Gap junction, Long-term depression, negative regulation of synaptic transmission, heterotrimeric G-protein complex, membrane raft, Chemokine signaling pathway, Guanine nucleotide-binding protein G(i) subunit alpha-1, Melanogenesis, membrane fraction, Leukocyte transendothelial migration, metabotropic serotonin receptor binding, G-protein coupled receptor protein signaling pathway
3.40.50.300.19.1.1.1.8	2om2A01	protein binding, Melanogenesis, Homo sapiens, Guanine nucleotide-binding protein G(i) subunit alpha-1, Chemokine signaling pathway, heterotrimeric G-protein complex, Leukocyte transendothelial migration, Chagas disease, Axon guidance, Tight junction, Progesterone-mediated oocyte maturation, Long-term depression, Gap junction, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide
3.40.50.300.19.1.1.1.9	2om2C01	Long-term depression, Gap junction, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide, Axon guidance, Tight junction, Progesterone-mediated oocyte maturation, Chagas disease, Leukocyte transendothelial migration, Melanogenesis, Homo sapiens, Guanine nucleotide-binding protein G(i) subunit alpha-1, Chemokine signaling pathway, heterotrimeric G-protein complex, protein binding
3.40.50.300.19.1.1.1.10	2gtpA01	protein binding, Melanogenesis, Chemokine signaling pathway, Homo sapiens, Guanine nucleotide-binding protein G(i) subunit alpha-1, heterotrimeric G-protein complex, Leukocyte transendothelial migration, Chagas disease, Tight junction, Axon guidance, Progesterone-mediated oocyte maturation, Gap junction, Long-term depression, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide
3.40.50.300.19.1.1.1.11	2gtpB01	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide, Long-term depression, Gap junction, Chagas disease, Progesterone-mediated oocyte maturation, Tight junction, Axon guidance, Melanogenesis, heterotrimeric G-protein complex, Homo sapiens, Guanine nucleotide-binding protein G(i) subunit alpha-1, Chemokine signaling pathway, Leukocyte transendothelial migration, protein binding
3.40.50.300.19.1.1.1.12	2zjzA01	Melanogenesis, membrane fraction, membrane raft, heterotrimeric G-protein complex, Guanine nucleotide-binding protein G(i) subunit alpha-1, Chemokine signaling pathway, G-protein coupled receptor protein signaling pathway, Leukocyte transendothelial migration, metabotropic serotonin receptor binding, negative regulation of synaptic transmission, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide, Long-term depression, Gap junction, Chagas disease, Progesterone-mediated oocyte maturation, Tight junction, Axon guidance, Rattus norvegicus
3.40.50.300.19.1.1.1.13	1kjyA01	protein binding, Leukocyte transendothelial migration, Chemokine signaling pathway, Homo sapiens, Guanine nucleotide-binding protein G(i) subunit alpha-1, heterotrimeric G-protein complex, Melanogenesis, Tight junction, Axon guidance, Progesterone-mediated oocyte maturation, Chagas disease, Gap junction, Long-term depression, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide
3.40.50.300.19.1.1.1.14	1kjyC01	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide, Long-term depression, Gap junction, Chagas disease, Progesterone-mediated oocyte maturation, Axon guidance, Tight junction, Melanogenesis, heterotrimeric G-protein complex, Homo sapiens, Guanine nucleotide-binding protein G(i) subunit alpha-1, Chemokine signaling pathway, Leukocyte transendothelial migration, protein binding
3.40.50.300.19.1.1.1.15	2ik8A01	Gap junction, Long-term depression, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide, Chagas disease, Axon guidance, Tight junction, Progesterone-mediated oocyte maturation, Melanogenesis, Chemokine signaling pathway, Homo sapiens, Guanine nucleotide-binding protein G(i) subunit alpha-1, heterotrimeric G-protein complex, Leukocyte transendothelial migration, protein binding
3.40.50.300.19.1.1.1.16	2ik8C01	Chemokine signaling pathway, Homo sapiens, Guanine nucleotide-binding protein G(i) subunit alpha-1, heterotrimeric G-protein complex, Melanogenesis, Leukocyte transendothelial migration, protein binding, Gap junction, Long-term depression, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide, Chagas disease, Tight junction, Axon guidance, Progesterone-mediated oocyte maturation

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.40.50.300.19.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.40.50.300.19.1.1.1

Classification Lineage (3.40.50.300.19.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.40.50.300.19.1.1.1 (16)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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