S100 Family: 3.40.50.2000.1.1.1.1

Representative domain: 2gj4A02

Classification Lineage (3.40.50.2000.1.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.40	3-Layer(aba) Sandwich
3.40.50	Rossmann fold
3.40.50.2000	Glycogen Phosphorylase B;	Gene3D
3.40.50.2000.1
3.40.50.2000.1.1
3.40.50.2000.1.1.1
3.40.50.2000.1.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	105

Non-Redundant Representatives (105)
Functional Families
Help

What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.40.50.2000.1.1.1.1 (105)

CATH code	Domain ID	Keywords
3.40.50.2000.1.1.1.1.1	2gj4A02	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.1.1.1.1.2	1c8kA02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.3	1h5uA02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.4	1k06A02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.5	1ww3A02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.6	1xc7A02	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.1.1.1.1.7	2qn7A02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.8	1gpbA02	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.1.1.1.1.9	1ww2A02	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.1.1.1.1.10	1z62A02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.11	2iegA02	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.1.1.1.1.12	2iegB02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.13	2qn8A02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.14	3bd7A02	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.1.1.1.1.15	2ieiA02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.16	1xl0A02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.17	1xkxA02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.18	2f3uA02	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.1.1.1.1.19	1p2dA02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.20	2f3pA02	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.1.1.1.1.21	2ieiB02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.22	2f3qA02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.23	2f3sA02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.24	1ktiA02	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.1.1.1.1.25	1b4dA02	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.1.1.1.1.26	1lwnA02	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.1.1.1.1.27	1lwoA02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.28	1p4jA02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.29	2gpaA02	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.1.1.1.1.30	2qn9A02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.31	3bdaA02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.32	2fetA02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.33	2ff5A02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.34	2ffrA02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.35	1p4hA02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.36	1p4gA02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.37	1xl1A02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.38	3amvA02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.39	3bd8A02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.40	1p29A02	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.1.1.1.1.41	1p2bA02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.42	8gpbA02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.43	1e1yA02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.44	1hlfA02	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.1.1.1.1.45	1k08A02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.46	1wutA02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.47	1wuyA02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.48	1wv0A02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.49	1wv1A02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.50	1axrA02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.51	1bx3A02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.52	1c50A02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.53	1c8lA02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.54	1gfzA02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.55	1p2gA02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.56	1uzuA02	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.1.1.1.1.57	2amvA02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.58	2gm9A02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.59	2gpbA02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.60	2priA02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.61	2prjA02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.62	3gpbA02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.63	4gpbA02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.64	5gpbA02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.65	1gg8A02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.66	1ftqA02	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.1.1.1.1.67	1fu8A02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.68	1ftwA02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.69	1fu4A02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.70	1fu7A02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.71	1ggnA02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.72	1fs4A02	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.1.1.1.1.73	1ftyA02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.74	1gpyA02	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.1.1.1.1.75	2skcA02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.76	2skdA02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.77	2skeA02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.78	1abbA02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.79	1abbB02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.80	1abbC02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.81	1abbD02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.82	6gpbA02	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.1.1.1.1.83	1pygA02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.84	1pygB02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.85	1pygC02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.86	1pygD02	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.1.1.1.1.87	1gpaA02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.88	1gpaB02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.89	1gpaC02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.90	1gpaD02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.91	7gpbA02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.92	7gpbB02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.93	7gpbC02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.94	7gpbD02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.95	9gpbA02	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.1.1.1.1.96	9gpbB02	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.1.1.1.1.97	9gpbC02	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.1.1.1.1.98	9gpbD02	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.1.1.1.1.99	1amv002
3.40.50.2000.1.1.1.1.100	1k0qA02
3.40.50.2000.1.1.1.1.101	1pri002
3.40.50.2000.1.1.1.1.102	1prj002
3.40.50.2000.1.1.1.1.103	1skc002
3.40.50.2000.1.1.1.1.104	1skd002
3.40.50.2000.1.1.1.1.105	1ske002

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.40.50.2000.1.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.40.50.2000.1.1.1.1

Classification Lineage (3.40.50.2000.1.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.40.50.2000.1.1.1.1 (105)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

CATH Shortcuts