S100 Family: 3.40.50.1400.3.1.1.1

Representative domain: 3hcnA02

Classification Lineage (3.40.50.1400.3.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.40	3-Layer(aba) Sandwich
3.40.50	Rossmann fold
3.40.50.1400		Gene3D
3.40.50.1400.3
3.40.50.1400.3.1
3.40.50.1400.3.1.1
3.40.50.1400.3.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	20

Non-Redundant Representatives (20)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.40.50.1400.3.1.1.1 (20)

CATH code	Domain ID	Keywords
3.40.50.1400.3.1.1.1.1	3hcnA02	ferrochelatase [EC:4.99.1.1], response to light stimulus, protoporphyrinogen IX metabolic process, Porphyrin and chlorophyll metabolism, ferrochelatase activity, ferrous iron binding, Ferrochelatase., heme biosynthetic process, generation of precursor metabolites and energy, Metabolic pathways, protein binding, Ferrochelatase, mitochondrial, Homo sapiens
3.40.50.1400.3.1.1.1.2	3hcnB02	Ferrochelatase., heme biosynthetic process, generation of precursor metabolites and energy, ferrochelatase activity, ferrous iron binding, protoporphyrinogen IX metabolic process, Porphyrin and chlorophyll metabolism, ferrochelatase [EC:4.99.1.1], response to light stimulus, Ferrochelatase, mitochondrial, Homo sapiens, protein binding, Metabolic pathways
3.40.50.1400.3.1.1.1.3	2hrcA02	Ferrochelatase, mitochondrial, Homo sapiens, protein binding, Metabolic pathways, Ferrochelatase., heme biosynthetic process, generation of precursor metabolites and energy, ferrochelatase activity, ferrous iron binding, protoporphyrinogen IX metabolic process, Porphyrin and chlorophyll metabolism, ferrochelatase [EC:4.99.1.1], response to light stimulus
3.40.50.1400.3.1.1.1.4	2hrcB02	protoporphyrinogen IX metabolic process, Porphyrin and chlorophyll metabolism, response to light stimulus, ferrochelatase [EC:4.99.1.1], Ferrochelatase., heme biosynthetic process, generation of precursor metabolites and energy, ferrous iron binding, ferrochelatase activity, protein binding, Metabolic pathways, Ferrochelatase, mitochondrial, Homo sapiens
3.40.50.1400.3.1.1.1.5	3hcoA02	Metabolic pathways, protein binding, Ferrochelatase, mitochondrial, Homo sapiens, ferrochelatase [EC:4.99.1.1], response to light stimulus, protoporphyrinogen IX metabolic process, Porphyrin and chlorophyll metabolism, ferrochelatase activity, ferrous iron binding, Ferrochelatase., heme biosynthetic process, generation of precursor metabolites and energy
3.40.50.1400.3.1.1.1.6	3hcoB02	Homo sapiens, Ferrochelatase, mitochondrial, Metabolic pathways, protein binding, ferrous iron binding, ferrochelatase activity, generation of precursor metabolites and energy, Ferrochelatase., heme biosynthetic process, response to light stimulus, ferrochelatase [EC:4.99.1.1], Porphyrin and chlorophyll metabolism, protoporphyrinogen IX metabolic process
3.40.50.1400.3.1.1.1.7	1hrkA02	response to light stimulus, ferrochelatase [EC:4.99.1.1], Porphyrin and chlorophyll metabolism, protoporphyrinogen IX metabolic process, ferrous iron binding, ferrochelatase activity, generation of precursor metabolites and energy, Ferrochelatase., heme biosynthetic process, Metabolic pathways, protein binding, Homo sapiens, Ferrochelatase, mitochondrial
3.40.50.1400.3.1.1.1.8	1hrkB02	protein binding, Metabolic pathways, Homo sapiens, Ferrochelatase, mitochondrial, Porphyrin and chlorophyll metabolism, protoporphyrinogen IX metabolic process, response to light stimulus, ferrochelatase [EC:4.99.1.1], generation of precursor metabolites and energy, Ferrochelatase., heme biosynthetic process, ferrous iron binding, ferrochelatase activity
3.40.50.1400.3.1.1.1.9	2qd4A02	Ferrochelatase, mitochondrial, Homo sapiens, Metabolic pathways, protein binding, ferrous iron binding, ferrochelatase activity, Ferrochelatase., heme biosynthetic process, generation of precursor metabolites and energy, response to light stimulus, ferrochelatase [EC:4.99.1.1], protoporphyrinogen IX metabolic process, Porphyrin and chlorophyll metabolism
3.40.50.1400.3.1.1.1.10	2qd4B02	protein binding, Metabolic pathways, Ferrochelatase, mitochondrial, Homo sapiens, protoporphyrinogen IX metabolic process, Porphyrin and chlorophyll metabolism, response to light stimulus, ferrochelatase [EC:4.99.1.1], Ferrochelatase., heme biosynthetic process, generation of precursor metabolites and energy, ferrous iron binding, ferrochelatase activity
3.40.50.1400.3.1.1.1.11	3hcpA02	protoporphyrinogen IX metabolic process, Porphyrin and chlorophyll metabolism, response to light stimulus, ferrochelatase [EC:4.99.1.1], Ferrochelatase., heme biosynthetic process, generation of precursor metabolites and energy, ferrous iron binding, ferrochelatase activity, protein binding, Metabolic pathways, Ferrochelatase, mitochondrial, Homo sapiens
3.40.50.1400.3.1.1.1.12	3hcpB02	ferrochelatase activity, ferrous iron binding, generation of precursor metabolites and energy, Ferrochelatase., heme biosynthetic process, ferrochelatase [EC:4.99.1.1], response to light stimulus, Porphyrin and chlorophyll metabolism, protoporphyrinogen IX metabolic process, Homo sapiens, Ferrochelatase, mitochondrial, Metabolic pathways, protein binding
3.40.50.1400.3.1.1.1.13	2qd2A02	Ferrochelatase, Homo sapiens, Ferrochelatase.
3.40.50.1400.3.1.1.1.14	2qd2B02	Ferrochelatase., Ferrochelatase, Homo sapiens
3.40.50.1400.3.1.1.1.15	2qd3A02	ferrochelatase [EC:4.99.1.1], response to light stimulus, protoporphyrinogen IX metabolic process, Porphyrin and chlorophyll metabolism, ferrochelatase activity, ferrous iron binding, Ferrochelatase., heme biosynthetic process, generation of precursor metabolites and energy, Metabolic pathways, protein binding, Ferrochelatase, mitochondrial, Homo sapiens
3.40.50.1400.3.1.1.1.16	2qd3B02	response to light stimulus, ferrochelatase [EC:4.99.1.1], protoporphyrinogen IX metabolic process, Porphyrin and chlorophyll metabolism, ferrous iron binding, ferrochelatase activity, Ferrochelatase., heme biosynthetic process, generation of precursor metabolites and energy, Metabolic pathways, protein binding, Ferrochelatase, mitochondrial, Homo sapiens
3.40.50.1400.3.1.1.1.17	3hcrA02	Metabolic pathways, protein binding, Ferrochelatase, mitochondrial, Homo sapiens, ferrochelatase [EC:4.99.1.1], response to light stimulus, protoporphyrinogen IX metabolic process, Porphyrin and chlorophyll metabolism, ferrochelatase activity, ferrous iron binding, Ferrochelatase., heme biosynthetic process, generation of precursor metabolites and energy
3.40.50.1400.3.1.1.1.18	3hcrB02	Homo sapiens, Ferrochelatase, mitochondrial, protein binding, Metabolic pathways, generation of precursor metabolites and energy, Ferrochelatase., heme biosynthetic process, ferrous iron binding, ferrochelatase activity, Porphyrin and chlorophyll metabolism, protoporphyrinogen IX metabolic process, response to light stimulus, ferrochelatase [EC:4.99.1.1]
3.40.50.1400.3.1.1.1.19	2qd5A02	Homo sapiens, Ferrochelatase, mitochondrial, protein binding, Metabolic pathways, generation of precursor metabolites and energy, Ferrochelatase., heme biosynthetic process, ferrochelatase activity, ferrous iron binding, Porphyrin and chlorophyll metabolism, protoporphyrinogen IX metabolic process, ferrochelatase [EC:4.99.1.1], response to light stimulus
3.40.50.1400.3.1.1.1.20	2qd5B02	Ferrochelatase, mitochondrial, Homo sapiens, Metabolic pathways, protein binding, ferrochelatase activity, ferrous iron binding, Ferrochelatase., heme biosynthetic process, generation of precursor metabolites and energy, ferrochelatase [EC:4.99.1.1], response to light stimulus, protoporphyrinogen IX metabolic process, Porphyrin and chlorophyll metabolism

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.40.50.1400.3.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.40.50.1400.3.1.1.1

Classification Lineage (3.40.50.1400.3.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.40.50.1400.3.1.1.1 (20)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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