S100 Family: 3.40.50.10190.1.1.1.1

Molscript image for 1t15A02
Representative domain: 1t15A02
PDB coordinates for domain 1t15A02

Classification Lineage (3.40.50.10190.1.1.1.1)

CATH CodeLevel DescriptionLinks
3 Alpha Beta
3.40 3-Layer(aba) Sandwich
3.40.50 Rossmann fold
3.40.50.10190 Gene3D
3.40.50.10190.1
3.40.50.10190.1.1
3.40.50.10190.1.1.1
3.40.50.10190.1.1.1.1

Summary of Non-Redundant Representatives
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S100 Count Entries in S100 Family 3.40.50.10190.1.1.1.1 (20)

CATH Level CATH code Domain ID Keywords Thumbnail
3.40.50.10190.1.1.1.1.1 1t15A02 Breast cancer type 1 susceptibility protein, identical protein binding, regulation of transcription from RNA polymerase II promoter, negative regulation of transcription, RNA binding, regulation of cell proliferation, positive regulation of protein ubiquitination, regulation of transcription from RNA polymerase III promoter, response to estrogen stimulus, DNA binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, zinc ion binding, G2/M transition DNA damage checkpoint, BRCA1-A complex, Ubiquitin mediated proteolysis, BRCA1-BARD1 complex, breast cancer type 1 susceptibility protein, Homo sapiens, response to ionizing radiation, chromosome segregation, protein ubiquitination, enzyme binding, DNA damage response, signal transduction resulting in induction of apoptosis, postreplication repair, double-strand break repair via homologous recombination, positive regulation of DNA repair, ribonucleoprotein complex, negative regulation of fatty acid biosynthetic process, apoptosis, Acid--D-amino-acid ligases (peptide synthases). Molscript image for 1t15A02
3.40.50.10190.1.1.1.1.2 1t29A02 BRCA1-A complex, Ubiquitin mediated proteolysis, G2/M transition DNA damage checkpoint, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, zinc ion binding, positive regulation of protein ubiquitination, regulation of transcription from RNA polymerase III promoter, response to estrogen stimulus, DNA binding, regulation of cell proliferation, negative regulation of transcription, RNA binding, identical protein binding, regulation of transcription from RNA polymerase II promoter, Breast cancer type 1 susceptibility protein, Acid--D-amino-acid ligases (peptide synthases)., negative regulation of fatty acid biosynthetic process, apoptosis, positive regulation of DNA repair, ribonucleoprotein complex, enzyme binding, double-strand break repair via homologous recombination, DNA damage response, signal transduction resulting in induction of apoptosis, postreplication repair, protein ubiquitination, Homo sapiens, response to ionizing radiation, chromosome segregation, breast cancer type 1 susceptibility protein, BRCA1-BARD1 complex Molscript image for 1t29A02
3.40.50.10190.1.1.1.1.3 1y98A02 positive regulation of protein ubiquitination, DNA binding, response to estrogen stimulus, regulation of transcription from RNA polymerase III promoter, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, zinc ion binding, G2/M transition DNA damage checkpoint, BRCA1-A complex, Ubiquitin mediated proteolysis, Breast cancer type 1 susceptibility protein, identical protein binding, regulation of transcription from RNA polymerase II promoter, RNA binding, negative regulation of transcription, regulation of cell proliferation, enzyme binding, double-strand break repair via homologous recombination, postreplication repair, DNA damage response, signal transduction resulting in induction of apoptosis, positive regulation of DNA repair, ribonucleoprotein complex, Acid--D-amino-acid ligases (peptide synthases)., apoptosis, negative regulation of fatty acid biosynthetic process, breast cancer type 1 susceptibility protein, BRCA1-BARD1 complex, Homo sapiens, response to ionizing radiation, chromosome segregation, protein ubiquitination Molscript image for 1y98A02
3.40.50.10190.1.1.1.1.4 1jnxX02 protein ubiquitination, chromosome segregation, Homo sapiens, response to ionizing radiation, BRCA1-BARD1 complex, breast cancer type 1 susceptibility protein, apoptosis, negative regulation of fatty acid biosynthetic process, Acid--D-amino-acid ligases (peptide synthases)., ribonucleoprotein complex, positive regulation of DNA repair, postreplication repair, DNA damage response, signal transduction resulting in induction of apoptosis, double-strand break repair via homologous recombination, enzyme binding, regulation of cell proliferation, negative regulation of transcription, RNA binding, regulation of transcription from RNA polymerase II promoter, identical protein binding, Breast cancer type 1 susceptibility protein, Ubiquitin mediated proteolysis, BRCA1-A complex, G2/M transition DNA damage checkpoint, zinc ion binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, DNA binding, regulation of transcription from RNA polymerase III promoter, response to estrogen stimulus, positive regulation of protein ubiquitination Molscript image for 1jnxX02
3.40.50.10190.1.1.1.1.5 3k0hA02 Breast cancer type 1 susceptibility protein, identical protein binding, regulation of transcription from RNA polymerase II promoter, negative regulation of transcription, RNA binding, regulation of cell proliferation, positive regulation of protein ubiquitination, regulation of transcription from RNA polymerase III promoter, response to estrogen stimulus, DNA binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, zinc ion binding, G2/M transition DNA damage checkpoint, BRCA1-A complex, Ubiquitin mediated proteolysis, breast cancer type 1 susceptibility protein, BRCA1-BARD1 complex, Homo sapiens, response to ionizing radiation, chromosome segregation, protein ubiquitination, enzyme binding, double-strand break repair via homologous recombination, DNA damage response, signal transduction resulting in induction of apoptosis, postreplication repair, positive regulation of DNA repair, ribonucleoprotein complex, Acid--D-amino-acid ligases (peptide synthases)., apoptosis, negative regulation of fatty acid biosynthetic process Molscript image for 3k0hA02
3.40.50.10190.1.1.1.1.6 3k0kA02 G2/M transition DNA damage checkpoint, Ubiquitin mediated proteolysis, BRCA1-A complex, response to estrogen stimulus, DNA binding, regulation of transcription from RNA polymerase III promoter, positive regulation of protein ubiquitination, zinc ion binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, RNA binding, negative regulation of transcription, regulation of cell proliferation, Breast cancer type 1 susceptibility protein, regulation of transcription from RNA polymerase II promoter, identical protein binding, Acid--D-amino-acid ligases (peptide synthases)., negative regulation of fatty acid biosynthetic process, apoptosis, double-strand break repair via homologous recombination, DNA damage response, signal transduction resulting in induction of apoptosis, postreplication repair, enzyme binding, ribonucleoprotein complex, positive regulation of DNA repair, protein ubiquitination, breast cancer type 1 susceptibility protein, BRCA1-BARD1 complex, chromosome segregation, Homo sapiens, response to ionizing radiation Molscript image for 3k0kA02
3.40.50.10190.1.1.1.1.7 3cojA02 Acid--D-amino-acid ligases (peptide synthases)., apoptosis, negative regulation of fatty acid biosynthetic process, double-strand break repair via homologous recombination, postreplication repair, DNA damage response, signal transduction resulting in induction of apoptosis, enzyme binding, ribonucleoprotein complex, positive regulation of DNA repair, protein ubiquitination, breast cancer type 1 susceptibility protein, BRCA1-BARD1 complex, chromosome segregation, Homo sapiens, response to ionizing radiation, G2/M transition DNA damage checkpoint, Ubiquitin mediated proteolysis, BRCA1-A complex, response to estrogen stimulus, regulation of transcription from RNA polymerase III promoter, DNA binding, positive regulation of protein ubiquitination, zinc ion binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, negative regulation of transcription, RNA binding, regulation of cell proliferation, Breast cancer type 1 susceptibility protein, regulation of transcription from RNA polymerase II promoter, identical protein binding Molscript image for 3cojA02
3.40.50.10190.1.1.1.1.8 3cojB02 RNA binding, negative regulation of transcription, regulation of cell proliferation, Breast cancer type 1 susceptibility protein, regulation of transcription from RNA polymerase II promoter, identical protein binding, G2/M transition DNA damage checkpoint, Ubiquitin mediated proteolysis, BRCA1-A complex, response to estrogen stimulus, regulation of transcription from RNA polymerase III promoter, DNA binding, positive regulation of protein ubiquitination, zinc ion binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, protein ubiquitination, breast cancer type 1 susceptibility protein, BRCA1-BARD1 complex, chromosome segregation, Homo sapiens, response to ionizing radiation, Acid--D-amino-acid ligases (peptide synthases)., apoptosis, negative regulation of fatty acid biosynthetic process, double-strand break repair via homologous recombination, DNA damage response, signal transduction resulting in induction of apoptosis, postreplication repair, enzyme binding, ribonucleoprotein complex, positive regulation of DNA repair Molscript image for 3cojB02
3.40.50.10190.1.1.1.1.9 3cojC02 BRCA1-A complex, Ubiquitin mediated proteolysis, G2/M transition DNA damage checkpoint, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, zinc ion binding, positive regulation of protein ubiquitination, response to estrogen stimulus, DNA binding, regulation of transcription from RNA polymerase III promoter, regulation of cell proliferation, RNA binding, negative regulation of transcription, identical protein binding, regulation of transcription from RNA polymerase II promoter, Breast cancer type 1 susceptibility protein, Acid--D-amino-acid ligases (peptide synthases)., negative regulation of fatty acid biosynthetic process, apoptosis, positive regulation of DNA repair, ribonucleoprotein complex, enzyme binding, double-strand break repair via homologous recombination, DNA damage response, signal transduction resulting in induction of apoptosis, postreplication repair, protein ubiquitination, Homo sapiens, response to ionizing radiation, chromosome segregation, breast cancer type 1 susceptibility protein, BRCA1-BARD1 complex Molscript image for 3cojC02
3.40.50.10190.1.1.1.1.10 3cojD02 BRCA1-A complex, Ubiquitin mediated proteolysis, G2/M transition DNA damage checkpoint, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, zinc ion binding, positive regulation of protein ubiquitination, response to estrogen stimulus, regulation of transcription from RNA polymerase III promoter, DNA binding, regulation of cell proliferation, negative regulation of transcription, RNA binding, identical protein binding, regulation of transcription from RNA polymerase II promoter, Breast cancer type 1 susceptibility protein, Acid--D-amino-acid ligases (peptide synthases)., apoptosis, negative regulation of fatty acid biosynthetic process, positive regulation of DNA repair, ribonucleoprotein complex, enzyme binding, double-strand break repair via homologous recombination, DNA damage response, signal transduction resulting in induction of apoptosis, postreplication repair, protein ubiquitination, Homo sapiens, response to ionizing radiation, chromosome segregation, breast cancer type 1 susceptibility protein, BRCA1-BARD1 complex Molscript image for 3cojD02
3.40.50.10190.1.1.1.1.11 3cojE02 regulation of transcription from RNA polymerase III promoter, DNA binding, response to estrogen stimulus, positive regulation of protein ubiquitination, zinc ion binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, G2/M transition DNA damage checkpoint, Ubiquitin mediated proteolysis, BRCA1-A complex, Breast cancer type 1 susceptibility protein, regulation of transcription from RNA polymerase II promoter, identical protein binding, negative regulation of transcription, RNA binding, regulation of cell proliferation, double-strand break repair via homologous recombination, DNA damage response, signal transduction resulting in induction of apoptosis, postreplication repair, enzyme binding, ribonucleoprotein complex, positive regulation of DNA repair, Acid--D-amino-acid ligases (peptide synthases)., apoptosis, negative regulation of fatty acid biosynthetic process, breast cancer type 1 susceptibility protein, BRCA1-BARD1 complex, chromosome segregation, Homo sapiens, response to ionizing radiation, protein ubiquitination Molscript image for 3cojE02
3.40.50.10190.1.1.1.1.12 3cojF02 regulation of transcription from RNA polymerase II promoter, identical protein binding, Breast cancer type 1 susceptibility protein, regulation of cell proliferation, negative regulation of transcription, RNA binding, zinc ion binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, response to estrogen stimulus, regulation of transcription from RNA polymerase III promoter, DNA binding, positive regulation of protein ubiquitination, Ubiquitin mediated proteolysis, BRCA1-A complex, G2/M transition DNA damage checkpoint, chromosome segregation, Homo sapiens, response to ionizing radiation, breast cancer type 1 susceptibility protein, BRCA1-BARD1 complex, protein ubiquitination, ribonucleoprotein complex, positive regulation of DNA repair, double-strand break repair via homologous recombination, DNA damage response, signal transduction resulting in induction of apoptosis, postreplication repair, enzyme binding, Acid--D-amino-acid ligases (peptide synthases)., apoptosis, negative regulation of fatty acid biosynthetic process Molscript image for 3cojF02
3.40.50.10190.1.1.1.1.13 3cojX02 enzyme binding, double-strand break repair via homologous recombination, DNA damage response, signal transduction resulting in induction of apoptosis, postreplication repair, positive regulation of DNA repair, ribonucleoprotein complex, Acid--D-amino-acid ligases (peptide synthases)., apoptosis, negative regulation of fatty acid biosynthetic process, breast cancer type 1 susceptibility protein, BRCA1-BARD1 complex, Homo sapiens, response to ionizing radiation, chromosome segregation, protein ubiquitination, positive regulation of protein ubiquitination, DNA binding, regulation of transcription from RNA polymerase III promoter, response to estrogen stimulus, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, zinc ion binding, G2/M transition DNA damage checkpoint, BRCA1-A complex, Ubiquitin mediated proteolysis, Breast cancer type 1 susceptibility protein, identical protein binding, regulation of transcription from RNA polymerase II promoter, negative regulation of transcription, RNA binding, regulation of cell proliferation Molscript image for 3cojX02
3.40.50.10190.1.1.1.1.14 1t2vE02 Acid--D-amino-acid ligases (peptide synthases)., apoptosis, negative regulation of fatty acid biosynthetic process, ribonucleoprotein complex, positive regulation of DNA repair, double-strand break repair via homologous recombination, postreplication repair, DNA damage response, signal transduction resulting in induction of apoptosis, enzyme binding, protein ubiquitination, chromosome segregation, Homo sapiens, response to ionizing radiation, breast cancer type 1 susceptibility protein, BRCA1-BARD1 complex, Ubiquitin mediated proteolysis, BRCA1-A complex, G2/M transition DNA damage checkpoint, zinc ion binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, regulation of transcription from RNA polymerase III promoter, response to estrogen stimulus, DNA binding, positive regulation of protein ubiquitination, regulation of cell proliferation, RNA binding, negative regulation of transcription, regulation of transcription from RNA polymerase II promoter, identical protein binding, Breast cancer type 1 susceptibility protein Molscript image for 1t2vE02
3.40.50.10190.1.1.1.1.15 3cojG02 BRCA1-BARD1 complex, breast cancer type 1 susceptibility protein, Homo sapiens, response to ionizing radiation, chromosome segregation, protein ubiquitination, enzyme binding, postreplication repair, DNA damage response, signal transduction resulting in induction of apoptosis, double-strand break repair via homologous recombination, positive regulation of DNA repair, ribonucleoprotein complex, apoptosis, negative regulation of fatty acid biosynthetic process, Acid--D-amino-acid ligases (peptide synthases)., Breast cancer type 1 susceptibility protein, identical protein binding, regulation of transcription from RNA polymerase II promoter, RNA binding, negative regulation of transcription, regulation of cell proliferation, positive regulation of protein ubiquitination, DNA binding, regulation of transcription from RNA polymerase III promoter, response to estrogen stimulus, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, zinc ion binding, G2/M transition DNA damage checkpoint, BRCA1-A complex, Ubiquitin mediated proteolysis Molscript image for 3cojG02
3.40.50.10190.1.1.1.1.16 1t2vA02 BRCA1-BARD1 complex, breast cancer type 1 susceptibility protein, Homo sapiens, response to ionizing radiation, chromosome segregation, protein ubiquitination, enzyme binding, DNA damage response, signal transduction resulting in induction of apoptosis, postreplication repair, double-strand break repair via homologous recombination, positive regulation of DNA repair, ribonucleoprotein complex, apoptosis, negative regulation of fatty acid biosynthetic process, Acid--D-amino-acid ligases (peptide synthases)., Breast cancer type 1 susceptibility protein, identical protein binding, regulation of transcription from RNA polymerase II promoter, RNA binding, negative regulation of transcription, regulation of cell proliferation, positive regulation of protein ubiquitination, response to estrogen stimulus, DNA binding, regulation of transcription from RNA polymerase III promoter, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, zinc ion binding, G2/M transition DNA damage checkpoint, BRCA1-A complex, Ubiquitin mediated proteolysis Molscript image for 1t2vA02
3.40.50.10190.1.1.1.1.17 1t2vB02 protein ubiquitination, Homo sapiens, response to ionizing radiation, chromosome segregation, BRCA1-BARD1 complex, breast cancer type 1 susceptibility protein, apoptosis, negative regulation of fatty acid biosynthetic process, Acid--D-amino-acid ligases (peptide synthases)., positive regulation of DNA repair, ribonucleoprotein complex, enzyme binding, DNA damage response, signal transduction resulting in induction of apoptosis, postreplication repair, double-strand break repair via homologous recombination, regulation of cell proliferation, RNA binding, negative regulation of transcription, identical protein binding, regulation of transcription from RNA polymerase II promoter, Breast cancer type 1 susceptibility protein, BRCA1-A complex, Ubiquitin mediated proteolysis, G2/M transition DNA damage checkpoint, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, zinc ion binding, positive regulation of protein ubiquitination, DNA binding, response to estrogen stimulus, regulation of transcription from RNA polymerase III promoter Molscript image for 1t2vB02
3.40.50.10190.1.1.1.1.18 1t2vD02 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, zinc ion binding, positive regulation of protein ubiquitination, response to estrogen stimulus, DNA binding, regulation of transcription from RNA polymerase III promoter, BRCA1-A complex, Ubiquitin mediated proteolysis, G2/M transition DNA damage checkpoint, identical protein binding, regulation of transcription from RNA polymerase II promoter, Breast cancer type 1 susceptibility protein, regulation of cell proliferation, RNA binding, negative regulation of transcription, positive regulation of DNA repair, ribonucleoprotein complex, enzyme binding, postreplication repair, DNA damage response, signal transduction resulting in induction of apoptosis, double-strand break repair via homologous recombination, apoptosis, negative regulation of fatty acid biosynthetic process, Acid--D-amino-acid ligases (peptide synthases)., Homo sapiens, response to ionizing radiation, chromosome segregation, BRCA1-BARD1 complex, breast cancer type 1 susceptibility protein, protein ubiquitination Molscript image for 1t2vD02
3.40.50.10190.1.1.1.1.19 1t2vC02 DNA damage response, signal transduction resulting in induction of apoptosis, postreplication repair, double-strand break repair via homologous recombination, enzyme binding, ribonucleoprotein complex, positive regulation of DNA repair, negative regulation of fatty acid biosynthetic process, apoptosis, Acid--D-amino-acid ligases (peptide synthases)., BRCA1-BARD1 complex, breast cancer type 1 susceptibility protein, chromosome segregation, Homo sapiens, response to ionizing radiation, protein ubiquitination, response to estrogen stimulus, DNA binding, regulation of transcription from RNA polymerase III promoter, positive regulation of protein ubiquitination, zinc ion binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, G2/M transition DNA damage checkpoint, Ubiquitin mediated proteolysis, BRCA1-A complex, Breast cancer type 1 susceptibility protein, regulation of transcription from RNA polymerase II promoter, identical protein binding, negative regulation of transcription, RNA binding, regulation of cell proliferation Molscript image for 1t2vC02
3.40.50.10190.1.1.1.1.20 1oqaA00 regulation of transcription from RNA polymerase II promoter, identical protein binding, Breast cancer type 1 susceptibility protein, regulation of cell proliferation, negative regulation of transcription, RNA binding, zinc ion binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, regulation of transcription from RNA polymerase III promoter, DNA binding, response to estrogen stimulus, positive regulation of protein ubiquitination, Ubiquitin mediated proteolysis, BRCA1-A complex, G2/M transition DNA damage checkpoint, chromosome segregation, Homo sapiens, response to ionizing radiation, breast cancer type 1 susceptibility protein, BRCA1-BARD1 complex, protein ubiquitination, ribonucleoprotein complex, positive regulation of DNA repair, double-strand break repair via homologous recombination, DNA damage response, signal transduction resulting in induction of apoptosis, postreplication repair, enzyme binding, Acid--D-amino-acid ligases (peptide synthases)., apoptosis, negative regulation of fatty acid biosynthetic process Molscript image for 1oqaA00

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:
  • Multiple alignments for each functional family
  • Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
  • Detailed functional information on diversity and conservation within Functional families
  • Multi-domain architectures
In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:
http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.40.50.10190.1.1.1.1