S100 Family: 3.40.47.10.7.1.1.1

Representative domain: 2vu1A02

Classification Lineage (3.40.47.10.7.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.40	3-Layer(aba) Sandwich
3.40.47	Peroxisomal Thiolase; Chain A, domain 1
3.40.47.10		Gene3D
3.40.47.10.7
3.40.47.10.7.1
3.40.47.10.7.1.1
3.40.47.10.7.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	64

Non-Redundant Representatives (64)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.40.47.10.7.1.1.1 (64)

CATH code	Domain ID	Keywords
3.40.47.10.7.1.1.1.1	2vu1A02	Acetyl-CoA C-acetyltransferase., Acetyl-CoA acetyltransferase, Zoogloea ramigera
3.40.47.10.7.1.1.1.2	2vu1B02	Acetyl-CoA C-acetyltransferase., Acetyl-CoA acetyltransferase, Zoogloea ramigera
3.40.47.10.7.1.1.1.3	2vu1C02	Acetyl-CoA C-acetyltransferase., Zoogloea ramigera, Acetyl-CoA acetyltransferase
3.40.47.10.7.1.1.1.4	2vu1D02	Acetyl-CoA C-acetyltransferase., Acetyl-CoA acetyltransferase, Zoogloea ramigera
3.40.47.10.7.1.1.1.5	1m3kA02	Acetyl-CoA acetyltransferase, Zoogloea ramigera, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.6	1m3kB02	Acetyl-CoA C-acetyltransferase., Acetyl-CoA acetyltransferase, Zoogloea ramigera
3.40.47.10.7.1.1.1.7	1m3kC02	Acetyl-CoA C-acetyltransferase., Zoogloea ramigera, Acetyl-CoA acetyltransferase
3.40.47.10.7.1.1.1.8	1m3kD02	Acetyl-CoA acetyltransferase, Zoogloea ramigera, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.9	1m4tA02	Acetyl-CoA C-acetyltransferase., Acetyl-CoA acetyltransferase, Zoogloea ramigera
3.40.47.10.7.1.1.1.10	1m4tB02	Acetyl-CoA C-acetyltransferase., Acetyl-CoA acetyltransferase, Zoogloea ramigera
3.40.47.10.7.1.1.1.11	1m4tC02	Acetyl-CoA C-acetyltransferase., Acetyl-CoA acetyltransferase, Zoogloea ramigera
3.40.47.10.7.1.1.1.12	1m4tD02	Acetyl-CoA C-acetyltransferase., Zoogloea ramigera, Acetyl-CoA acetyltransferase
3.40.47.10.7.1.1.1.13	1m3zA02	Acetyl-CoA C-acetyltransferase., Zoogloea ramigera, Acetyl-CoA acetyltransferase
3.40.47.10.7.1.1.1.14	1m3zB02	Acetyl-CoA acetyltransferase, Zoogloea ramigera, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.15	1m3zC02	Acetyl-CoA C-acetyltransferase., Acetyl-CoA acetyltransferase, Zoogloea ramigera
3.40.47.10.7.1.1.1.16	1m3zD02	Acetyl-CoA C-acetyltransferase., Acetyl-CoA acetyltransferase, Zoogloea ramigera
3.40.47.10.7.1.1.1.17	1m4sA02	Acetyl-CoA C-acetyltransferase., Acetyl-CoA acetyltransferase, Zoogloea ramigera
3.40.47.10.7.1.1.1.18	1m4sB02	Zoogloea ramigera, Acetyl-CoA acetyltransferase, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.19	1m4sC02	Acetyl-CoA C-acetyltransferase., Acetyl-CoA acetyltransferase, Zoogloea ramigera
3.40.47.10.7.1.1.1.20	1m4sD02	Acetyl-CoA C-acetyltransferase., Zoogloea ramigera, Acetyl-CoA acetyltransferase
3.40.47.10.7.1.1.1.21	2vu0A02	Acetyl-CoA acetyltransferase, Zoogloea ramigera, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.22	2vu0B02	Zoogloea ramigera, Acetyl-CoA acetyltransferase, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.23	2vu0C02	Acetyl-CoA acetyltransferase, Zoogloea ramigera, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.24	2vu0D02	Zoogloea ramigera, Acetyl-CoA acetyltransferase, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.25	1nl7A02	Acetyl-CoA C-acetyltransferase., Zoogloea ramigera, Acetyl-CoA acetyltransferase
3.40.47.10.7.1.1.1.26	1nl7B02	Acetyl-CoA acetyltransferase, Zoogloea ramigera, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.27	1nl7C02	Acetyl-CoA acetyltransferase, Zoogloea ramigera, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.28	1nl7D02	Acetyl-CoA acetyltransferase, Zoogloea ramigera, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.29	1qflA02	Zoogloea ramigera, Acetyl-CoA acetyltransferase, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.30	1qflB02	Zoogloea ramigera, Acetyl-CoA acetyltransferase, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.31	1qflC02	Acetyl-CoA acetyltransferase, Zoogloea ramigera, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.32	1qflD02	Acetyl-CoA C-acetyltransferase., Acetyl-CoA acetyltransferase, Zoogloea ramigera
3.40.47.10.7.1.1.1.33	1m1tA02	Acetyl-CoA C-acetyltransferase., Acetyl-CoA acetyltransferase, Zoogloea ramigera
3.40.47.10.7.1.1.1.34	1m1tB02	Acetyl-CoA acetyltransferase, Zoogloea ramigera, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.35	1m1tC02	Zoogloea ramigera, Acetyl-CoA acetyltransferase, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.36	1m1tD02	Acetyl-CoA C-acetyltransferase., Zoogloea ramigera, Acetyl-CoA acetyltransferase
3.40.47.10.7.1.1.1.37	1m1oA02	Acetyl-CoA C-acetyltransferase., Acetyl-CoA acetyltransferase, Zoogloea ramigera
3.40.47.10.7.1.1.1.38	1m1oB02	Zoogloea ramigera, Acetyl-CoA acetyltransferase, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.39	1m1oC02	Acetyl-CoA C-acetyltransferase., Zoogloea ramigera, Acetyl-CoA acetyltransferase
3.40.47.10.7.1.1.1.40	1m1oD02	Acetyl-CoA C-acetyltransferase., Zoogloea ramigera, Acetyl-CoA acetyltransferase
3.40.47.10.7.1.1.1.41	1dm3A02	Acetyl-CoA acetyltransferase, Zoogloea ramigera, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.42	1dm3B02	Zoogloea ramigera, Acetyl-CoA acetyltransferase, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.43	1dm3C02	Acetyl-CoA acetyltransferase, Zoogloea ramigera, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.44	1dm3D02	Acetyl-CoA acetyltransferase, Zoogloea ramigera, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.45	1ou6A02	Acetyl-CoA acetyltransferase, Zoogloea ramigera, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.46	1ou6B02	Zoogloea ramigera, Acetyl-CoA acetyltransferase, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.47	1ou6C02	Acetyl-CoA C-acetyltransferase., Zoogloea ramigera, Acetyl-CoA acetyltransferase
3.40.47.10.7.1.1.1.48	1ou6D02	Acetyl-CoA C-acetyltransferase., Zoogloea ramigera, Acetyl-CoA acetyltransferase
3.40.47.10.7.1.1.1.49	1dluA02	Acetyl-CoA C-acetyltransferase., Zoogloea ramigera, Acetyl-CoA acetyltransferase
3.40.47.10.7.1.1.1.50	1dluB02	Acetyl-CoA C-acetyltransferase., Acetyl-CoA acetyltransferase, Zoogloea ramigera
3.40.47.10.7.1.1.1.51	1dluC02	Acetyl-CoA acetyltransferase, Zoogloea ramigera, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.52	1dluD02	Zoogloea ramigera, Acetyl-CoA acetyltransferase, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.53	1dlvB02	Acetyl-CoA C-acetyltransferase., Acetyl-CoA acetyltransferase, Zoogloea ramigera
3.40.47.10.7.1.1.1.54	1dlvA02	Acetyl-CoA acetyltransferase, Zoogloea ramigera, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.55	1dlvC02	Zoogloea ramigera, Acetyl-CoA acetyltransferase, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.56	1dlvD02	Acetyl-CoA C-acetyltransferase., Acetyl-CoA acetyltransferase, Zoogloea ramigera
3.40.47.10.7.1.1.1.57	2vtzA02	Acetyl-CoA acetyltransferase, Zoogloea ramigera, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.58	2vtzB02	Acetyl-CoA C-acetyltransferase., Zoogloea ramigera, Acetyl-CoA acetyltransferase
3.40.47.10.7.1.1.1.59	2vtzC02	Acetyl-CoA C-acetyltransferase., Zoogloea ramigera, Acetyl-CoA acetyltransferase
3.40.47.10.7.1.1.1.60	2vtzD02	Acetyl-CoA acetyltransferase, Zoogloea ramigera, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.61	2vu2A02	Acetyl-CoA C-acetyltransferase., Zoogloea ramigera, Acetyl-CoA acetyltransferase
3.40.47.10.7.1.1.1.62	2vu2B02	Acetyl-CoA acetyltransferase, Zoogloea ramigera, Acetyl-CoA C-acetyltransferase.
3.40.47.10.7.1.1.1.63	2vu2C02	Acetyl-CoA C-acetyltransferase., Zoogloea ramigera, Acetyl-CoA acetyltransferase
3.40.47.10.7.1.1.1.64	2vu2D02	Acetyl-CoA C-acetyltransferase., Zoogloea ramigera, Acetyl-CoA acetyltransferase

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.40.47.10.7.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.40.47.10.7.1.1.1

Classification Lineage (3.40.47.10.7.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.40.47.10.7.1.1.1 (64)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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