S100 Family: 3.40.430.10.1.1.1.1

Representative domain: 1kmvA00

Classification Lineage (3.40.430.10.1.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.40	3-Layer(aba) Sandwich
3.40.430	Dihydrofolate Reductase, subunit A
3.40.430.10	Dihydrofolate Reductase, subunit A	Gene3D
3.40.430.10.1
3.40.430.10.1.1
3.40.430.10.1.1.1
3.40.430.10.1.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	33

Non-Redundant Representatives (33)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.40.430.10.1.1.1.1 (33)

CATH code	Domain ID	Keywords
3.40.430.10.1.1.1.1.1	1kmvA00	dihydrofolate reductase activity, Dihydrofolate reductase, One carbon pool by folate, tetrahydrofolate metabolic process, dihydrofolate reductase [EC:1.5.1.3], Homo sapiens, Dihydrofolate reductase., Folate biosynthesis, drug binding, Metabolic pathways
3.40.430.10.1.1.1.1.2	1kmsA00	One carbon pool by folate, Dihydrofolate reductase, dihydrofolate reductase activity, tetrahydrofolate metabolic process, Homo sapiens, dihydrofolate reductase [EC:1.5.1.3], Metabolic pathways, drug binding, Folate biosynthesis, Dihydrofolate reductase.
3.40.430.10.1.1.1.1.3	3fs6A00	dihydrofolate reductase [EC:1.5.1.3], Homo sapiens, Dihydrofolate reductase., Folate biosynthesis, drug binding, Metabolic pathways, dihydrofolate reductase activity, Dihydrofolate reductase, One carbon pool by folate, tetrahydrofolate metabolic process
3.40.430.10.1.1.1.1.4	3ghwA00	dihydrofolate reductase [EC:1.5.1.3], Homo sapiens, Dihydrofolate reductase., Folate biosynthesis, Metabolic pathways, drug binding, dihydrofolate reductase activity, Dihydrofolate reductase, One carbon pool by folate, tetrahydrofolate metabolic process
3.40.430.10.1.1.1.1.5	2w3bA00	drug binding, Metabolic pathways, Folate biosynthesis, Dihydrofolate reductase., Homo sapiens, dihydrofolate reductase [EC:1.5.1.3], tetrahydrofolate metabolic process, One carbon pool by folate, Dihydrofolate reductase, dihydrofolate reductase activity
3.40.430.10.1.1.1.1.6	2w3bB00	dihydrofolate reductase [EC:1.5.1.3], Homo sapiens, Folate biosynthesis, Dihydrofolate reductase., drug binding, Metabolic pathways, dihydrofolate reductase activity, One carbon pool by folate, Dihydrofolate reductase, tetrahydrofolate metabolic process
3.40.430.10.1.1.1.1.7	2c2sA00	Homo sapiens, dihydrofolate reductase [EC:1.5.1.3], drug binding, Metabolic pathways, Dihydrofolate reductase., Folate biosynthesis, Dihydrofolate reductase, One carbon pool by folate, dihydrofolate reductase activity, tetrahydrofolate metabolic process
3.40.430.10.1.1.1.1.8	2c2sB00	Metabolic pathways, drug binding, Folate biosynthesis, Dihydrofolate reductase., Homo sapiens, dihydrofolate reductase [EC:1.5.1.3], tetrahydrofolate metabolic process, One carbon pool by folate, Dihydrofolate reductase, dihydrofolate reductase activity
3.40.430.10.1.1.1.1.9	2c2tA00	Dihydrofolate reductase, One carbon pool by folate, dihydrofolate reductase activity, tetrahydrofolate metabolic process, Homo sapiens, dihydrofolate reductase [EC:1.5.1.3], drug binding, Metabolic pathways, Dihydrofolate reductase., Folate biosynthesis
3.40.430.10.1.1.1.1.10	2c2tB00	tetrahydrofolate metabolic process, dihydrofolate reductase activity, One carbon pool by folate, Dihydrofolate reductase, Folate biosynthesis, Dihydrofolate reductase., drug binding, Metabolic pathways, dihydrofolate reductase [EC:1.5.1.3], Homo sapiens
3.40.430.10.1.1.1.1.11	2w3aA00	One carbon pool by folate, Dihydrofolate reductase, dihydrofolate reductase activity, tetrahydrofolate metabolic process, Homo sapiens, dihydrofolate reductase [EC:1.5.1.3], Metabolic pathways, drug binding, Folate biosynthesis, Dihydrofolate reductase.
3.40.430.10.1.1.1.1.12	2w3aB00	tetrahydrofolate metabolic process, dihydrofolate reductase activity, Dihydrofolate reductase, One carbon pool by folate, Dihydrofolate reductase., Folate biosynthesis, Metabolic pathways, drug binding, dihydrofolate reductase [EC:1.5.1.3], Homo sapiens
3.40.430.10.1.1.1.1.13	2w3mA00	dihydrofolate reductase [EC:1.5.1.3], Homo sapiens, Dihydrofolate reductase., Folate biosynthesis, drug binding, Metabolic pathways, dihydrofolate reductase activity, Dihydrofolate reductase, One carbon pool by folate, tetrahydrofolate metabolic process
3.40.430.10.1.1.1.1.14	2w3mB00	One carbon pool by folate, Dihydrofolate reductase, dihydrofolate reductase activity, tetrahydrofolate metabolic process, Homo sapiens, dihydrofolate reductase [EC:1.5.1.3], drug binding, Metabolic pathways, Folate biosynthesis, Dihydrofolate reductase.
3.40.430.10.1.1.1.1.15	3gyfA00	Dihydrofolate reductase, One carbon pool by folate, dihydrofolate reductase activity, tetrahydrofolate metabolic process, Homo sapiens, dihydrofolate reductase [EC:1.5.1.3], Metabolic pathways, drug binding, Dihydrofolate reductase., Folate biosynthesis
3.40.430.10.1.1.1.1.16	1mvtA00	dihydrofolate reductase activity, One carbon pool by folate, Dihydrofolate reductase, tetrahydrofolate metabolic process, dihydrofolate reductase [EC:1.5.1.3], Homo sapiens, Folate biosynthesis, Dihydrofolate reductase., Metabolic pathways, drug binding
3.40.430.10.1.1.1.1.17	1s3vA00	dihydrofolate reductase [EC:1.5.1.3], Homo sapiens, Dihydrofolate reductase., Folate biosynthesis, Metabolic pathways, drug binding, dihydrofolate reductase activity, Dihydrofolate reductase, One carbon pool by folate, tetrahydrofolate metabolic process
3.40.430.10.1.1.1.1.18	1mvsA00	One carbon pool by folate, Dihydrofolate reductase, dihydrofolate reductase activity, tetrahydrofolate metabolic process, Homo sapiens, dihydrofolate reductase [EC:1.5.1.3], Metabolic pathways, drug binding, Folate biosynthesis, Dihydrofolate reductase.
3.40.430.10.1.1.1.1.19	1s3wA00	Metabolic pathways, drug binding, Dihydrofolate reductase., Folate biosynthesis, Homo sapiens, dihydrofolate reductase [EC:1.5.1.3], tetrahydrofolate metabolic process, Dihydrofolate reductase, One carbon pool by folate, dihydrofolate reductase activity
3.40.430.10.1.1.1.1.20	1u72A00	tetrahydrofolate metabolic process, One carbon pool by folate, Dihydrofolate reductase, dihydrofolate reductase activity, Metabolic pathways, drug binding, Folate biosynthesis, Dihydrofolate reductase., Homo sapiens, dihydrofolate reductase [EC:1.5.1.3]
3.40.430.10.1.1.1.1.21	1drfA00	Metabolic pathways, drug binding, Dihydrofolate reductase., Folate biosynthesis, Homo sapiens, dihydrofolate reductase [EC:1.5.1.3], tetrahydrofolate metabolic process, Dihydrofolate reductase, One carbon pool by folate, dihydrofolate reductase activity
3.40.430.10.1.1.1.1.22	1hfrA00	dihydrofolate reductase [EC:1.5.1.3], Homo sapiens, Folate biosynthesis, Dihydrofolate reductase., Metabolic pathways, drug binding, dihydrofolate reductase activity, One carbon pool by folate, Dihydrofolate reductase, tetrahydrofolate metabolic process
3.40.430.10.1.1.1.1.23	1pd8A00	drug binding, Metabolic pathways, Folate biosynthesis, Dihydrofolate reductase., Homo sapiens, dihydrofolate reductase [EC:1.5.1.3], tetrahydrofolate metabolic process, One carbon pool by folate, Dihydrofolate reductase, dihydrofolate reductase activity
3.40.430.10.1.1.1.1.24	1pd9A00	dihydrofolate reductase activity, One carbon pool by folate, Dihydrofolate reductase, tetrahydrofolate metabolic process, dihydrofolate reductase [EC:1.5.1.3], Homo sapiens, Folate biosynthesis, Dihydrofolate reductase., Metabolic pathways, drug binding
3.40.430.10.1.1.1.1.25	1pdbA00	Homo sapiens, dihydrofolate reductase [EC:1.5.1.3], drug binding, Metabolic pathways, Dihydrofolate reductase., Folate biosynthesis, Dihydrofolate reductase, One carbon pool by folate, dihydrofolate reductase activity, tetrahydrofolate metabolic process
3.40.430.10.1.1.1.1.26	1dhfA00	tetrahydrofolate metabolic process, One carbon pool by folate, Dihydrofolate reductase, dihydrofolate reductase activity, drug binding, Metabolic pathways, Folate biosynthesis, Dihydrofolate reductase., Homo sapiens, dihydrofolate reductase [EC:1.5.1.3]
3.40.430.10.1.1.1.1.27	1dhfB00	dihydrofolate reductase activity, One carbon pool by folate, Dihydrofolate reductase, tetrahydrofolate metabolic process, dihydrofolate reductase [EC:1.5.1.3], Homo sapiens, Folate biosynthesis, Dihydrofolate reductase., drug binding, Metabolic pathways
3.40.430.10.1.1.1.1.28	2dhfA00	tetrahydrofolate metabolic process, dihydrofolate reductase activity, One carbon pool by folate, Dihydrofolate reductase, Folate biosynthesis, Dihydrofolate reductase., drug binding, Metabolic pathways, dihydrofolate reductase [EC:1.5.1.3], Homo sapiens
3.40.430.10.1.1.1.1.29	2dhfB00	tetrahydrofolate metabolic process, Dihydrofolate reductase, One carbon pool by folate, dihydrofolate reductase activity, drug binding, Metabolic pathways, Dihydrofolate reductase., Folate biosynthesis, Homo sapiens, dihydrofolate reductase [EC:1.5.1.3]
3.40.430.10.1.1.1.1.30	1ohjA00	drug binding, Metabolic pathways, Dihydrofolate reductase., Folate biosynthesis, Homo sapiens, dihydrofolate reductase [EC:1.5.1.3], tetrahydrofolate metabolic process, Dihydrofolate reductase, One carbon pool by folate, dihydrofolate reductase activity
3.40.430.10.1.1.1.1.31	1ohkA00	dihydrofolate reductase [EC:1.5.1.3], Homo sapiens, Dihydrofolate reductase., Folate biosynthesis, Metabolic pathways, drug binding, dihydrofolate reductase activity, Dihydrofolate reductase, One carbon pool by folate, tetrahydrofolate metabolic process
3.40.430.10.1.1.1.1.32	1s3uA00	drug binding, Metabolic pathways, Folate biosynthesis, Dihydrofolate reductase., Homo sapiens, dihydrofolate reductase [EC:1.5.1.3], tetrahydrofolate metabolic process, One carbon pool by folate, Dihydrofolate reductase, dihydrofolate reductase activity
3.40.430.10.1.1.1.1.33	1yhoA00	Metabolic pathways, drug binding, Dihydrofolate reductase., Folate biosynthesis, Homo sapiens, dihydrofolate reductase [EC:1.5.1.3], tetrahydrofolate metabolic process, Dihydrofolate reductase, One carbon pool by folate, dihydrofolate reductase activity

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.40.430.10.1.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.40.430.10.1.1.1.1

Classification Lineage (3.40.430.10.1.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.40.430.10.1.1.1.1 (33)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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