S100 Family: 3.40.390.10.12.1.1.1
Representative domain: 2ddfA00
Classification Lineage (3.40.390.10.12.1.1.1)
Summary of Non-Redundant Representatives
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S100 Count Entries in S100 Family 3.40.390.10.12.1.1.1 (18)
| CATH Level | CATH code | Domain ID | Keywords | Thumbnail |
|---|---|---|---|---|
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3.40.390.10.12.1.1.1.1 | 2ddfA00 | metalloendopeptidase activity, epidermal growth factor receptor signaling pathway, cell surface, positive regulation of epidermal growth factor receptor activity, integral to plasma membrane, Disintegrin and metalloproteinase domain-containing protein 17, positive regulation of cell growth, response to lipopolysaccharide, actin cytoskeleton, Alzheimer's disease, wound healing, spreading of epidermal cells, response to hypoxia, ADAM 17 endopeptidase., integrin binding, interleukin-6 receptor binding, disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86], PMA-inducible membrane protein ectodomain proteolysis, positive regulation of chemokine production, positive regulation of protein phosphorylation, Notch signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, negative regulation of interleukin-8 production, cell adhesion mediated by integrin, apical plasma membrane, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, PDZ domain binding, membrane raft, positive regulation of cell proliferation, positive regulation of T cell chemotaxis, Homo sapiens, SH3 domain binding, response to high density lipoprotein stimulus | |
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3.40.390.10.12.1.1.1.2 | 2ddfB00 | apical plasma membrane, PDZ domain binding, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, positive regulation of T cell chemotaxis, positive regulation of cell proliferation, membrane raft, response to high density lipoprotein stimulus, Homo sapiens, SH3 domain binding, positive regulation of protein phosphorylation, Epithelial cell signaling in Helicobacter pylori infection, Notch signaling pathway, negative regulation of interleukin-8 production, cell adhesion mediated by integrin, actin cytoskeleton, response to hypoxia, Alzheimer's disease, wound healing, spreading of epidermal cells, ADAM 17 endopeptidase., integrin binding, interleukin-6 receptor binding, disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86], PMA-inducible membrane protein ectodomain proteolysis, positive regulation of chemokine production, metalloendopeptidase activity, cell surface, epidermal growth factor receptor signaling pathway, positive regulation of epidermal growth factor receptor activity, integral to plasma membrane, Disintegrin and metalloproteinase domain-containing protein 17, positive regulation of cell growth, response to lipopolysaccharide | |
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3.40.390.10.12.1.1.1.3 | 3l0vB00 | PDZ domain binding, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, apical plasma membrane, response to high density lipoprotein stimulus, Homo sapiens, SH3 domain binding, positive regulation of T cell chemotaxis, positive regulation of cell proliferation, membrane raft, positive regulation of protein phosphorylation, Epithelial cell signaling in Helicobacter pylori infection, Notch signaling pathway, cell adhesion mediated by integrin, negative regulation of interleukin-8 production, response to hypoxia, Alzheimer's disease, wound healing, spreading of epidermal cells, actin cytoskeleton, interleukin-6 receptor binding, ADAM 17 endopeptidase., integrin binding, disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86], PMA-inducible membrane protein ectodomain proteolysis, positive regulation of chemokine production, metalloendopeptidase activity, positive regulation of epidermal growth factor receptor activity, cell surface, epidermal growth factor receptor signaling pathway, integral to plasma membrane, Disintegrin and metalloproteinase domain-containing protein 17, positive regulation of cell growth, response to lipopolysaccharide | |
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3.40.390.10.12.1.1.1.4 | 3l0vA00 | positive regulation of protein phosphorylation, Notch signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, cell adhesion mediated by integrin, negative regulation of interleukin-8 production, PDZ domain binding, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, apical plasma membrane, response to high density lipoprotein stimulus, Homo sapiens, SH3 domain binding, positive regulation of T cell chemotaxis, membrane raft, positive regulation of cell proliferation, metalloendopeptidase activity, positive regulation of epidermal growth factor receptor activity, cell surface, epidermal growth factor receptor signaling pathway, integral to plasma membrane, Disintegrin and metalloproteinase domain-containing protein 17, response to lipopolysaccharide, positive regulation of cell growth, response to hypoxia, Alzheimer's disease, wound healing, spreading of epidermal cells, actin cytoskeleton, interleukin-6 receptor binding, ADAM 17 endopeptidase., integrin binding, disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86], PMA-inducible membrane protein ectodomain proteolysis, positive regulation of chemokine production | |
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3.40.390.10.12.1.1.1.5 | 3ewjA00 | positive regulation of cyclin-dependent protein kinase activity involved in G1/S, PDZ domain binding, apical plasma membrane, Homo sapiens, SH3 domain binding, response to high density lipoprotein stimulus, positive regulation of cell proliferation, membrane raft, positive regulation of T cell chemotaxis, positive regulation of protein phosphorylation, Notch signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, cell adhesion mediated by integrin, negative regulation of interleukin-8 production, Alzheimer's disease, wound healing, spreading of epidermal cells, response to hypoxia, actin cytoskeleton, interleukin-6 receptor binding, ADAM 17 endopeptidase., integrin binding, disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86], PMA-inducible membrane protein ectodomain proteolysis, positive regulation of chemokine production, metalloendopeptidase activity, positive regulation of epidermal growth factor receptor activity, epidermal growth factor receptor signaling pathway, cell surface, integral to plasma membrane, Disintegrin and metalloproteinase domain-containing protein 17, positive regulation of cell growth, response to lipopolysaccharide | |
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3.40.390.10.12.1.1.1.6 | 3kmcB00 | disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86], PMA-inducible membrane protein ectodomain proteolysis, positive regulation of chemokine production, actin cytoskeleton, response to hypoxia, Alzheimer's disease, wound healing, spreading of epidermal cells, ADAM 17 endopeptidase., integrin binding, interleukin-6 receptor binding, integral to plasma membrane, Disintegrin and metalloproteinase domain-containing protein 17, response to lipopolysaccharide, positive regulation of cell growth, metalloendopeptidase activity, cell surface, epidermal growth factor receptor signaling pathway, positive regulation of epidermal growth factor receptor activity, positive regulation of T cell chemotaxis, positive regulation of cell proliferation, membrane raft, response to high density lipoprotein stimulus, Homo sapiens, SH3 domain binding, apical plasma membrane, PDZ domain binding, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, negative regulation of interleukin-8 production, cell adhesion mediated by integrin, positive regulation of protein phosphorylation, Epithelial cell signaling in Helicobacter pylori infection, Notch signaling pathway | |
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3.40.390.10.12.1.1.1.7 | 3ewjB00 | positive regulation of protein phosphorylation, Epithelial cell signaling in Helicobacter pylori infection, Notch signaling pathway, cell adhesion mediated by integrin, negative regulation of interleukin-8 production, PDZ domain binding, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, apical plasma membrane, response to high density lipoprotein stimulus, Homo sapiens, SH3 domain binding, positive regulation of T cell chemotaxis, positive regulation of cell proliferation, membrane raft, metalloendopeptidase activity, positive regulation of epidermal growth factor receptor activity, cell surface, epidermal growth factor receptor signaling pathway, integral to plasma membrane, Disintegrin and metalloproteinase domain-containing protein 17, response to lipopolysaccharide, positive regulation of cell growth, response to hypoxia, Alzheimer's disease, wound healing, spreading of epidermal cells, actin cytoskeleton, interleukin-6 receptor binding, ADAM 17 endopeptidase., integrin binding, disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86], PMA-inducible membrane protein ectodomain proteolysis, positive regulation of chemokine production | |
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3.40.390.10.12.1.1.1.8 | 3kmcA00 | negative regulation of interleukin-8 production, cell adhesion mediated by integrin, Epithelial cell signaling in Helicobacter pylori infection, Notch signaling pathway, positive regulation of protein phosphorylation, positive regulation of T cell chemotaxis, membrane raft, positive regulation of cell proliferation, response to high density lipoprotein stimulus, Homo sapiens, SH3 domain binding, apical plasma membrane, PDZ domain binding, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, Disintegrin and metalloproteinase domain-containing protein 17, positive regulation of cell growth, response to lipopolysaccharide, integral to plasma membrane, cell surface, epidermal growth factor receptor signaling pathway, positive regulation of epidermal growth factor receptor activity, metalloendopeptidase activity, positive regulation of chemokine production, disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86], PMA-inducible membrane protein ectodomain proteolysis, ADAM 17 endopeptidase., integrin binding, interleukin-6 receptor binding, actin cytoskeleton, response to hypoxia, Alzheimer's disease, wound healing, spreading of epidermal cells | |
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3.40.390.10.12.1.1.1.9 | 3kmeA00 | disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86], PMA-inducible membrane protein ectodomain proteolysis, positive regulation of chemokine production, response to hypoxia, Alzheimer's disease, wound healing, spreading of epidermal cells, actin cytoskeleton, interleukin-6 receptor binding, ADAM 17 endopeptidase., integrin binding, integral to plasma membrane, Disintegrin and metalloproteinase domain-containing protein 17, positive regulation of cell growth, response to lipopolysaccharide, metalloendopeptidase activity, positive regulation of epidermal growth factor receptor activity, cell surface, epidermal growth factor receptor signaling pathway, response to high density lipoprotein stimulus, Homo sapiens, SH3 domain binding, positive regulation of T cell chemotaxis, positive regulation of cell proliferation, membrane raft, PDZ domain binding, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, apical plasma membrane, cell adhesion mediated by integrin, negative regulation of interleukin-8 production, positive regulation of protein phosphorylation, Notch signaling pathway, Epithelial cell signaling in Helicobacter pylori infection | |
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3.40.390.10.12.1.1.1.10 | 3e8rA00 | cell adhesion mediated by integrin, negative regulation of interleukin-8 production, Notch signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, positive regulation of protein phosphorylation, response to high density lipoprotein stimulus, Homo sapiens, SH3 domain binding, positive regulation of T cell chemotaxis, positive regulation of cell proliferation, membrane raft, PDZ domain binding, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, apical plasma membrane, Disintegrin and metalloproteinase domain-containing protein 17, positive regulation of cell growth, response to lipopolysaccharide, integral to plasma membrane, positive regulation of epidermal growth factor receptor activity, cell surface, epidermal growth factor receptor signaling pathway, metalloendopeptidase activity, positive regulation of chemokine production, disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86], PMA-inducible membrane protein ectodomain proteolysis, interleukin-6 receptor binding, ADAM 17 endopeptidase., integrin binding, response to hypoxia, Alzheimer's disease, wound healing, spreading of epidermal cells, actin cytoskeleton | |
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3.40.390.10.12.1.1.1.11 | 3kmeB00 | positive regulation of epidermal growth factor receptor activity, epidermal growth factor receptor signaling pathway, cell surface, metalloendopeptidase activity, Disintegrin and metalloproteinase domain-containing protein 17, response to lipopolysaccharide, positive regulation of cell growth, integral to plasma membrane, interleukin-6 receptor binding, ADAM 17 endopeptidase., integrin binding, Alzheimer's disease, wound healing, spreading of epidermal cells, response to hypoxia, actin cytoskeleton, positive regulation of chemokine production, disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86], PMA-inducible membrane protein ectodomain proteolysis, Notch signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, positive regulation of protein phosphorylation, cell adhesion mediated by integrin, negative regulation of interleukin-8 production, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, PDZ domain binding, apical plasma membrane, Homo sapiens, SH3 domain binding, response to high density lipoprotein stimulus, membrane raft, positive regulation of cell proliferation, positive regulation of T cell chemotaxis | |
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3.40.390.10.12.1.1.1.12 | 3e8rB00 | positive regulation of cell proliferation, membrane raft, positive regulation of T cell chemotaxis, Homo sapiens, SH3 domain binding, response to high density lipoprotein stimulus, apical plasma membrane, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, PDZ domain binding, negative regulation of interleukin-8 production, cell adhesion mediated by integrin, Notch signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, positive regulation of protein phosphorylation, positive regulation of chemokine production, disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86], PMA-inducible membrane protein ectodomain proteolysis, ADAM 17 endopeptidase., integrin binding, interleukin-6 receptor binding, actin cytoskeleton, Alzheimer's disease, wound healing, spreading of epidermal cells, response to hypoxia, Disintegrin and metalloproteinase domain-containing protein 17, response to lipopolysaccharide, positive regulation of cell growth, integral to plasma membrane, epidermal growth factor receptor signaling pathway, cell surface, positive regulation of epidermal growth factor receptor activity, metalloendopeptidase activity | |
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3.40.390.10.12.1.1.1.13 | 3edzB00 | apical plasma membrane, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, PDZ domain binding, positive regulation of cell proliferation, membrane raft, positive regulation of T cell chemotaxis, Homo sapiens, SH3 domain binding, response to high density lipoprotein stimulus, positive regulation of protein phosphorylation, Epithelial cell signaling in Helicobacter pylori infection, Notch signaling pathway, negative regulation of interleukin-8 production, cell adhesion mediated by integrin, actin cytoskeleton, Alzheimer's disease, wound healing, spreading of epidermal cells, response to hypoxia, ADAM 17 endopeptidase., integrin binding, interleukin-6 receptor binding, disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86], PMA-inducible membrane protein ectodomain proteolysis, positive regulation of chemokine production, metalloendopeptidase activity, epidermal growth factor receptor signaling pathway, cell surface, positive regulation of epidermal growth factor receptor activity, integral to plasma membrane, Disintegrin and metalloproteinase domain-containing protein 17, response to lipopolysaccharide, positive regulation of cell growth | |
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3.40.390.10.12.1.1.1.14 | 3l0tA00 | cell adhesion mediated by integrin, negative regulation of interleukin-8 production, positive regulation of protein phosphorylation, Notch signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, response to high density lipoprotein stimulus, Homo sapiens, SH3 domain binding, positive regulation of T cell chemotaxis, positive regulation of cell proliferation, membrane raft, PDZ domain binding, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, apical plasma membrane, integral to plasma membrane, Disintegrin and metalloproteinase domain-containing protein 17, positive regulation of cell growth, response to lipopolysaccharide, metalloendopeptidase activity, positive regulation of epidermal growth factor receptor activity, cell surface, epidermal growth factor receptor signaling pathway, disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86], PMA-inducible membrane protein ectodomain proteolysis, positive regulation of chemokine production, response to hypoxia, Alzheimer's disease, wound healing, spreading of epidermal cells, actin cytoskeleton, interleukin-6 receptor binding, ADAM 17 endopeptidase., integrin binding | |
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3.40.390.10.12.1.1.1.15 | 3l0tB00 | Homo sapiens, SH3 domain binding, response to high density lipoprotein stimulus, positive regulation of cell proliferation, membrane raft, positive regulation of T cell chemotaxis, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, PDZ domain binding, apical plasma membrane, cell adhesion mediated by integrin, negative regulation of interleukin-8 production, Notch signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, positive regulation of protein phosphorylation, positive regulation of chemokine production, disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86], PMA-inducible membrane protein ectodomain proteolysis, interleukin-6 receptor binding, ADAM 17 endopeptidase., integrin binding, Alzheimer's disease, wound healing, spreading of epidermal cells, response to hypoxia, actin cytoskeleton, Disintegrin and metalloproteinase domain-containing protein 17, positive regulation of cell growth, response to lipopolysaccharide, integral to plasma membrane, positive regulation of epidermal growth factor receptor activity, epidermal growth factor receptor signaling pathway, cell surface, metalloendopeptidase activity | |
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3.40.390.10.12.1.1.1.16 | 3edzA00 | Disintegrin and metalloproteinase domain-containing protein 17, positive regulation of cell growth, response to lipopolysaccharide, integral to plasma membrane, positive regulation of epidermal growth factor receptor activity, cell surface, epidermal growth factor receptor signaling pathway, metalloendopeptidase activity, positive regulation of chemokine production, disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86], PMA-inducible membrane protein ectodomain proteolysis, interleukin-6 receptor binding, ADAM 17 endopeptidase., integrin binding, response to hypoxia, Alzheimer's disease, wound healing, spreading of epidermal cells, actin cytoskeleton, cell adhesion mediated by integrin, negative regulation of interleukin-8 production, Epithelial cell signaling in Helicobacter pylori infection, Notch signaling pathway, positive regulation of protein phosphorylation, response to high density lipoprotein stimulus, Homo sapiens, SH3 domain binding, positive regulation of T cell chemotaxis, positive regulation of cell proliferation, membrane raft, PDZ domain binding, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, apical plasma membrane | |
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3.40.390.10.12.1.1.1.17 | 2fv9A00 | epidermal growth factor receptor signaling pathway, cell surface, positive regulation of epidermal growth factor receptor activity, metalloendopeptidase activity, Disintegrin and metalloproteinase domain-containing protein 17, response to lipopolysaccharide, positive regulation of cell growth, integral to plasma membrane, ADAM 17 endopeptidase., integrin binding, interleukin-6 receptor binding, actin cytoskeleton, Alzheimer's disease, wound healing, spreading of epidermal cells, response to hypoxia, positive regulation of chemokine production, disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86], PMA-inducible membrane protein ectodomain proteolysis, Epithelial cell signaling in Helicobacter pylori infection, Notch signaling pathway, positive regulation of protein phosphorylation, negative regulation of interleukin-8 production, cell adhesion mediated by integrin, apical plasma membrane, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, PDZ domain binding, positive regulation of cell proliferation, membrane raft, positive regulation of T cell chemotaxis, Homo sapiens, SH3 domain binding, response to high density lipoprotein stimulus | |
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3.40.390.10.12.1.1.1.18 | 2fv9B00 | cell adhesion mediated by integrin, negative regulation of interleukin-8 production, positive regulation of protein phosphorylation, Notch signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, Homo sapiens, SH3 domain binding, response to high density lipoprotein stimulus, membrane raft, positive regulation of cell proliferation, positive regulation of T cell chemotaxis, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, PDZ domain binding, apical plasma membrane, integral to plasma membrane, Disintegrin and metalloproteinase domain-containing protein 17, response to lipopolysaccharide, positive regulation of cell growth, metalloendopeptidase activity, positive regulation of epidermal growth factor receptor activity, epidermal growth factor receptor signaling pathway, cell surface, disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86], PMA-inducible membrane protein ectodomain proteolysis, positive regulation of chemokine production, Alzheimer's disease, wound healing, spreading of epidermal cells, response to hypoxia, actin cytoskeleton, interleukin-6 receptor binding, ADAM 17 endopeptidase., integrin binding |
The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:
- Multiple alignments for each functional family
- Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
- Detailed functional information on diversity and conservation within Functional families
- Multi-domain architectures