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CATH Superfamily 3.40.30.50

Sep15/SelM thioredoxin-like domain, active-site redox motif

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Sep15/SelM thioredoxin-like domain, active-site redox motif
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Sep15/SelM thioredoxin-like domain, active-site redox motif

Sep15 and its ortholog SelM are eukaryotic selenoproteins that have a thioredoxin-like domain and a surface accessible active-site redox motif. This suggests that they function as thiol-disulphide isomerases involved in disulphide bond formation in the endoplasmic reticulum. This superfamily is represented by the active-site redox motif found in both Sem15 and SelM (selenocysteine-containing CXXC-like motifs or CXXC-like derived motifs) whose function is to regulate the redox potential and catalytic efficiency of these enzymes.

PFAM:PF08806,DOI:10.1074/jbc.M511386200

GO Diversity

Unique GO annotations
18 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
547 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 2
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 2
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 2
Function
Unique EC:
Unique GO: 18
Taxonomy
Unique Species: 547
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