S100 Family: 3.40.120.10.8.1.1.1

Representative domain: 1p5dX02

Classification Lineage (3.40.120.10.8.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.40	3-Layer(aba) Sandwich
3.40.120	Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3
3.40.120.10	Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3	Gene3D
3.40.120.10.8
3.40.120.10.8.1
3.40.120.10.8.1.1
3.40.120.10.8.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	12

Non-Redundant Representatives (12)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.40.120.10.8.1.1.1 (12)

CATH code	Domain ID	Keywords
3.40.120.10.8.1.1.1.1	1p5dX02	Amino sugar and nucleotide sugar metabolism, Pentose phosphate pathway, Streptomycin biosynthesis, Phosphomannomutase/phosphoglucomutase, phosphoglucomutase [EC:5.4.2.2], Glycolysis / Gluconeogenesis, Phosphomannomutase., phosphomannomutase [EC:5.4.2.8], Galactose metabolism, Pseudomonas aeruginosa, Phosphoglucomutase., Fructose and mannose metabolism, Starch and sucrose metabolism, Metabolic pathways
3.40.120.10.8.1.1.1.2	1p5gX02	Phosphomannomutase., Glycolysis / Gluconeogenesis, phosphoglucomutase [EC:5.4.2.2], Phosphomannomutase/phosphoglucomutase, Streptomycin biosynthesis, Pentose phosphate pathway, Amino sugar and nucleotide sugar metabolism, Starch and sucrose metabolism, Metabolic pathways, Fructose and mannose metabolism, Galactose metabolism, Phosphoglucomutase., Pseudomonas aeruginosa, phosphomannomutase [EC:5.4.2.8]
3.40.120.10.8.1.1.1.3	2h5aX02	phosphoglucomutase [EC:5.4.2.2], Phosphomannomutase., Glycolysis / Gluconeogenesis, Streptomycin biosynthesis, Phosphomannomutase/phosphoglucomutase, Pentose phosphate pathway, Amino sugar and nucleotide sugar metabolism, Metabolic pathways, Starch and sucrose metabolism, Fructose and mannose metabolism, phosphomannomutase [EC:5.4.2.8], Galactose metabolism, Phosphoglucomutase., Pseudomonas aeruginosa
3.40.120.10.8.1.1.1.4	1k2yX02	phosphomannomutase [EC:5.4.2.8], Pseudomonas aeruginosa, Phosphoglucomutase., Galactose metabolism, Fructose and mannose metabolism, Metabolic pathways, Starch and sucrose metabolism, Amino sugar and nucleotide sugar metabolism, Pentose phosphate pathway, Streptomycin biosynthesis, Phosphomannomutase/phosphoglucomutase, phosphoglucomutase [EC:5.4.2.2], Glycolysis / Gluconeogenesis, Phosphomannomutase.
3.40.120.10.8.1.1.1.5	1pcmX02	Fructose and mannose metabolism, phosphomannomutase [EC:5.4.2.8], Galactose metabolism, Phosphoglucomutase., Pseudomonas aeruginosa, Starch and sucrose metabolism, Metabolic pathways, Pentose phosphate pathway, Amino sugar and nucleotide sugar metabolism, phosphoglucomutase [EC:5.4.2.2], Phosphomannomutase., Glycolysis / Gluconeogenesis, Streptomycin biosynthesis, Phosphomannomutase/phosphoglucomutase
3.40.120.10.8.1.1.1.6	2fkmX02	Fructose and mannose metabolism, Galactose metabolism, Pseudomonas aeruginosa, Phosphoglucomutase., phosphomannomutase [EC:5.4.2.8], Starch and sucrose metabolism, Metabolic pathways, Pentose phosphate pathway, Amino sugar and nucleotide sugar metabolism, Glycolysis / Gluconeogenesis, Phosphomannomutase., phosphoglucomutase [EC:5.4.2.2], Phosphomannomutase/phosphoglucomutase, Streptomycin biosynthesis
3.40.120.10.8.1.1.1.7	1pcjX02	Amino sugar and nucleotide sugar metabolism, Pentose phosphate pathway, Streptomycin biosynthesis, Phosphomannomutase/phosphoglucomutase, phosphoglucomutase [EC:5.4.2.2], Glycolysis / Gluconeogenesis, Phosphomannomutase., phosphomannomutase [EC:5.4.2.8], Galactose metabolism, Pseudomonas aeruginosa, Phosphoglucomutase., Fructose and mannose metabolism, Metabolic pathways, Starch and sucrose metabolism
3.40.120.10.8.1.1.1.8	2fkfA02	Galactose metabolism, Pseudomonas aeruginosa, Phosphoglucomutase., phosphomannomutase [EC:5.4.2.8], Fructose and mannose metabolism, Metabolic pathways, Starch and sucrose metabolism, Amino sugar and nucleotide sugar metabolism, Pentose phosphate pathway, Phosphomannomutase/phosphoglucomutase, Streptomycin biosynthesis, Glycolysis / Gluconeogenesis, Phosphomannomutase., phosphoglucomutase [EC:5.4.2.2]
3.40.120.10.8.1.1.1.9	3bkqX02	phosphoglucomutase [EC:5.4.2.2], Glycolysis / Gluconeogenesis, Phosphomannomutase., Streptomycin biosynthesis, Phosphomannomutase/phosphoglucomutase, Pentose phosphate pathway, Amino sugar and nucleotide sugar metabolism, Starch and sucrose metabolism, Metabolic pathways, Fructose and mannose metabolism, phosphomannomutase [EC:5.4.2.8], Galactose metabolism, Pseudomonas aeruginosa, Phosphoglucomutase.
3.40.120.10.8.1.1.1.10	1k35A02	Streptomycin biosynthesis, Phosphomannomutase/phosphoglucomutase, phosphoglucomutase [EC:5.4.2.2], Phosphomannomutase., Glycolysis / Gluconeogenesis, Amino sugar and nucleotide sugar metabolism, Pentose phosphate pathway, Starch and sucrose metabolism, Metabolic pathways, phosphomannomutase [EC:5.4.2.8], Galactose metabolism, Phosphoglucomutase., Pseudomonas aeruginosa, Fructose and mannose metabolism
3.40.120.10.8.1.1.1.11	3c04A02	Starch and sucrose metabolism, Metabolic pathways, phosphomannomutase [EC:5.4.2.8], Galactose metabolism, Phosphoglucomutase., Pseudomonas aeruginosa, Fructose and mannose metabolism, Streptomycin biosynthesis, Phosphomannomutase/phosphoglucomutase, phosphoglucomutase [EC:5.4.2.2], Phosphomannomutase., Glycolysis / Gluconeogenesis, Amino sugar and nucleotide sugar metabolism, Pentose phosphate pathway
3.40.120.10.8.1.1.1.12	2h4lX02	Fructose and mannose metabolism, phosphomannomutase [EC:5.4.2.8], Pseudomonas aeruginosa, Phosphoglucomutase., Galactose metabolism, Starch and sucrose metabolism, Metabolic pathways, Pentose phosphate pathway, Amino sugar and nucleotide sugar metabolism, phosphoglucomutase [EC:5.4.2.2], Glycolysis / Gluconeogenesis, Phosphomannomutase., Streptomycin biosynthesis, Phosphomannomutase/phosphoglucomutase

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.40.120.10.8.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.40.120.10.8.1.1.1

Classification Lineage (3.40.120.10.8.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.40.120.10.8.1.1.1 (12)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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