S100 Family: 3.30.70.141.1.1.1.1

Representative domain: 1s57B00

Classification Lineage (3.30.70.141.1.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.30	2-Layer Sandwich
3.30.70	Alpha-Beta Plaits
3.30.70.141		Gene3D
3.30.70.141.1
3.30.70.141.1.1
3.30.70.141.1.1.1
3.30.70.141.1.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	12

Non-Redundant Representatives (12)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.30.70.141.1.1.1.1 (12)

CATH code	Domain ID	Keywords
3.30.70.141.1.1.1.1.1	1s57B00	nucleoside diphosphate kinase activity, red, far-red light phototransduction, Metabolic pathways, Nucleoside-diphosphate kinase., auxin mediated signaling pathway, thylakoid, response to hydrogen peroxide, Arabidopsis thaliana, Purine metabolism, Pyrimidine metabolism, identical protein binding, response to UV, Nucleoside diphosphate kinase II, chloroplastic, chloroplast stroma, nucleoside-diphosphate kinase [EC:2.7.4.6], chloroplast envelope, nucleus
3.30.70.141.1.1.1.1.2	1s57C00	nucleoside diphosphate kinase activity, Arabidopsis thaliana, response to hydrogen peroxide, thylakoid, Nucleoside-diphosphate kinase., auxin mediated signaling pathway, Metabolic pathways, red, far-red light phototransduction, chloroplast stroma, Nucleoside diphosphate kinase II, chloroplastic, response to UV, Pyrimidine metabolism, identical protein binding, Purine metabolism, nucleus, chloroplast envelope, nucleoside-diphosphate kinase [EC:2.7.4.6]
3.30.70.141.1.1.1.1.3	1s57E00	nucleoside diphosphate kinase activity, red, far-red light phototransduction, Metabolic pathways, Nucleoside-diphosphate kinase., auxin mediated signaling pathway, thylakoid, response to hydrogen peroxide, Arabidopsis thaliana, Purine metabolism, Pyrimidine metabolism, identical protein binding, response to UV, Nucleoside diphosphate kinase II, chloroplastic, chloroplast stroma, nucleoside-diphosphate kinase [EC:2.7.4.6], chloroplast envelope, nucleus
3.30.70.141.1.1.1.1.4	1s57A00	Nucleoside-diphosphate kinase., auxin mediated signaling pathway, thylakoid, Metabolic pathways, red, far-red light phototransduction, Arabidopsis thaliana, response to hydrogen peroxide, nucleoside diphosphate kinase activity, nucleoside-diphosphate kinase [EC:2.7.4.6], chloroplast envelope, nucleus, response to UV, Pyrimidine metabolism, identical protein binding, Purine metabolism, chloroplast stroma, Nucleoside diphosphate kinase II, chloroplastic
3.30.70.141.1.1.1.1.5	1s57D00	response to hydrogen peroxide, Arabidopsis thaliana, Metabolic pathways, red, far-red light phototransduction, Nucleoside-diphosphate kinase., auxin mediated signaling pathway, thylakoid, nucleoside diphosphate kinase activity, chloroplast envelope, nucleus, nucleoside-diphosphate kinase [EC:2.7.4.6], Nucleoside diphosphate kinase II, chloroplastic, chloroplast stroma, Pyrimidine metabolism, identical protein binding, Purine metabolism, response to UV
3.30.70.141.1.1.1.1.6	1s57F00	chloroplast stroma, Nucleoside diphosphate kinase II, chloroplastic, response to UV, Purine metabolism, Pyrimidine metabolism, identical protein binding, chloroplast envelope, nucleus, nucleoside-diphosphate kinase [EC:2.7.4.6], nucleoside diphosphate kinase activity, Arabidopsis thaliana, response to hydrogen peroxide, Nucleoside-diphosphate kinase., auxin mediated signaling pathway, thylakoid, red, far-red light phototransduction, Metabolic pathways
3.30.70.141.1.1.1.1.7	1s59B00	chloroplast envelope, nucleus, nucleoside-diphosphate kinase [EC:2.7.4.6], Nucleoside diphosphate kinase II, chloroplastic, chloroplast stroma, Purine metabolism, Pyrimidine metabolism, identical protein binding, response to UV, response to hydrogen peroxide, Arabidopsis thaliana, red, far-red light phototransduction, Metabolic pathways, Nucleoside-diphosphate kinase., auxin mediated signaling pathway, thylakoid, nucleoside diphosphate kinase activity
3.30.70.141.1.1.1.1.8	1s59C00	Metabolic pathways, red, far-red light phototransduction, Nucleoside-diphosphate kinase., auxin mediated signaling pathway, thylakoid, response to hydrogen peroxide, Arabidopsis thaliana, nucleoside diphosphate kinase activity, nucleoside-diphosphate kinase [EC:2.7.4.6], chloroplast envelope, nucleus, Pyrimidine metabolism, identical protein binding, Purine metabolism, response to UV, Nucleoside diphosphate kinase II, chloroplastic, chloroplast stroma
3.30.70.141.1.1.1.1.9	1s59E00	response to hydrogen peroxide, Arabidopsis thaliana, Metabolic pathways, red, far-red light phototransduction, Nucleoside-diphosphate kinase., auxin mediated signaling pathway, thylakoid, nucleoside diphosphate kinase activity, chloroplast envelope, nucleus, nucleoside-diphosphate kinase [EC:2.7.4.6], Nucleoside diphosphate kinase II, chloroplastic, chloroplast stroma, Pyrimidine metabolism, identical protein binding, Purine metabolism, response to UV
3.30.70.141.1.1.1.1.10	1s59A00	nucleoside diphosphate kinase activity, Arabidopsis thaliana, response to hydrogen peroxide, thylakoid, Nucleoside-diphosphate kinase., auxin mediated signaling pathway, Metabolic pathways, red, far-red light phototransduction, chloroplast stroma, Nucleoside diphosphate kinase II, chloroplastic, response to UV, Pyrimidine metabolism, identical protein binding, Purine metabolism, nucleus, chloroplast envelope, nucleoside-diphosphate kinase [EC:2.7.4.6]
3.30.70.141.1.1.1.1.11	1s59D00	nucleoside diphosphate kinase activity, red, far-red light phototransduction, Metabolic pathways, thylakoid, Nucleoside-diphosphate kinase., auxin mediated signaling pathway, response to hydrogen peroxide, Arabidopsis thaliana, Purine metabolism, Pyrimidine metabolism, identical protein binding, response to UV, Nucleoside diphosphate kinase II, chloroplastic, chloroplast stroma, nucleoside-diphosphate kinase [EC:2.7.4.6], nucleus, chloroplast envelope
3.30.70.141.1.1.1.1.12	1s59F00	chloroplast envelope, nucleus, nucleoside-diphosphate kinase [EC:2.7.4.6], chloroplast stroma, Nucleoside diphosphate kinase II, chloroplastic, response to UV, Purine metabolism, Pyrimidine metabolism, identical protein binding, Arabidopsis thaliana, response to hydrogen peroxide, Nucleoside-diphosphate kinase., auxin mediated signaling pathway, thylakoid, red, far-red light phototransduction, Metabolic pathways, nucleoside diphosphate kinase activity

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.30.70.141.1.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.30.70.141.1.1.1.1

Classification Lineage (3.30.70.141.1.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.30.70.141.1.1.1.1 (12)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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