S100 Family: 3.30.572.10.5.1.1.1

Representative domain: 1qzfA02

Classification Lineage (3.30.572.10.5.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.30	2-Layer Sandwich
3.30.572	Thymidylate Synthase; Chain A
3.30.572.10	Thymidylate Synthase, chain A	Gene3D
3.30.572.10.5
3.30.572.10.5.1
3.30.572.10.5.1.1
3.30.572.10.5.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	15

Non-Redundant Representatives (15)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.30.572.10.5.1.1.1 (15)

CATH code	Domain ID	Keywords
3.30.572.10.5.1.1.1.1	1qzfA02	Pyrimidine metabolism, One carbon pool by folate, Bifunctional dihydrofolate reductase-thymidylate synthase, Metabolic pathways, thymidylate synthase [EC:2.1.1.45], Folate biosynthesis, Cryptosporidium parvum, dihydrofolate reductase [EC:1.5.1.3]
3.30.572.10.5.1.1.1.2	1qzfB02	Folate biosynthesis, Metabolic pathways, thymidylate synthase [EC:2.1.1.45], dihydrofolate reductase [EC:1.5.1.3], Cryptosporidium parvum, Bifunctional dihydrofolate reductase-thymidylate synthase, Pyrimidine metabolism, One carbon pool by folate
3.30.572.10.5.1.1.1.3	1qzfC02	Folate biosynthesis, thymidylate synthase [EC:2.1.1.45], Metabolic pathways, dihydrofolate reductase [EC:1.5.1.3], Cryptosporidium parvum, Bifunctional dihydrofolate reductase-thymidylate synthase, One carbon pool by folate, Pyrimidine metabolism
3.30.572.10.5.1.1.1.4	1qzfD02	One carbon pool by folate, Pyrimidine metabolism, Bifunctional dihydrofolate reductase-thymidylate synthase, thymidylate synthase [EC:2.1.1.45], Metabolic pathways, Folate biosynthesis, Cryptosporidium parvum, dihydrofolate reductase [EC:1.5.1.3]
3.30.572.10.5.1.1.1.5	1qzfE02	One carbon pool by folate, Pyrimidine metabolism, Bifunctional dihydrofolate reductase-thymidylate synthase, Cryptosporidium parvum, dihydrofolate reductase [EC:1.5.1.3], thymidylate synthase [EC:2.1.1.45], Metabolic pathways, Folate biosynthesis
3.30.572.10.5.1.1.1.6	2oipA02	Metabolic pathways, thymidylate synthase [EC:2.1.1.45], Folate biosynthesis, dihydrofolate reductase [EC:1.5.1.3], Chain A, crystal structure of Dhfr, Cryptosporidium hominis, Pyrimidine metabolism, One carbon pool by folate
3.30.572.10.5.1.1.1.7	2oipB02	dihydrofolate reductase [EC:1.5.1.3], thymidylate synthase [EC:2.1.1.45], Metabolic pathways, Folate biosynthesis, One carbon pool by folate, Pyrimidine metabolism, Chain A, crystal structure of Dhfr, Cryptosporidium hominis
3.30.572.10.5.1.1.1.8	2oipD02	Cryptosporidium hominis, Chain A, crystal structure of Dhfr, Pyrimidine metabolism, One carbon pool by folate, Folate biosynthesis, Metabolic pathways, thymidylate synthase [EC:2.1.1.45], dihydrofolate reductase [EC:1.5.1.3]
3.30.572.10.5.1.1.1.9	2oipC02	dihydrofolate reductase [EC:1.5.1.3], Folate biosynthesis, Metabolic pathways, thymidylate synthase [EC:2.1.1.45], Pyrimidine metabolism, One carbon pool by folate, Cryptosporidium hominis, Chain A, crystal structure of Dhfr
3.30.572.10.5.1.1.1.10	1sejA02	Folate biosynthesis, thymidylate synthase [EC:2.1.1.45], Metabolic pathways, dihydrofolate reductase [EC:1.5.1.3], Cryptosporidium parvum, Bifunctional dihydrofolate reductase-thymidylate synthase, One carbon pool by folate, Pyrimidine metabolism
3.30.572.10.5.1.1.1.11	1sejB02	dihydrofolate reductase [EC:1.5.1.3], Cryptosporidium parvum, Folate biosynthesis, Metabolic pathways, thymidylate synthase [EC:2.1.1.45], Bifunctional dihydrofolate reductase-thymidylate synthase, Pyrimidine metabolism, One carbon pool by folate
3.30.572.10.5.1.1.1.12	1sejC02	Bifunctional dihydrofolate reductase-thymidylate synthase, Pyrimidine metabolism, One carbon pool by folate, dihydrofolate reductase [EC:1.5.1.3], Cryptosporidium parvum, Folate biosynthesis, Metabolic pathways, thymidylate synthase [EC:2.1.1.45]
3.30.572.10.5.1.1.1.13	1sejD02	Cryptosporidium parvum, dihydrofolate reductase [EC:1.5.1.3], Metabolic pathways, thymidylate synthase [EC:2.1.1.45], Folate biosynthesis, Pyrimidine metabolism, One carbon pool by folate, Bifunctional dihydrofolate reductase-thymidylate synthase
3.30.572.10.5.1.1.1.14	1sejE02	Bifunctional dihydrofolate reductase-thymidylate synthase, One carbon pool by folate, Pyrimidine metabolism, dihydrofolate reductase [EC:1.5.1.3], Cryptosporidium parvum, Folate biosynthesis, thymidylate synthase [EC:2.1.1.45], Metabolic pathways
3.30.572.10.5.1.1.1.15	2oipE02	Folate biosynthesis, thymidylate synthase [EC:2.1.1.45], Metabolic pathways, dihydrofolate reductase [EC:1.5.1.3], Cryptosporidium hominis, Chain A, crystal structure of Dhfr, One carbon pool by folate, Pyrimidine metabolism

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.30.572.10.5.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.30.572.10.5.1.1.1

Classification Lineage (3.30.572.10.5.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.30.572.10.5.1.1.1 (15)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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