S95 Family: 3.30.572.10.1.1.1

Representative domain: 2g8mA00

Classification Lineage (3.30.572.10.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.30	2-Layer Sandwich
3.30.572	Thymidylate Synthase; Chain A
3.30.572.10	Thymidylate Synthase, chain A	Gene3D
3.30.572.10.1
3.30.572.10.1.1
3.30.572.10.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	94	103

Non-Redundant Representatives (94)
Functional Families
Help

What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Family Entries in S95 Family 3.30.572.10.1.1.1 (94)

CATH code	Representative Domain	Representative Keywords	Number of Domains
3.30.572.10.1.1.1.1	2g8mA00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.2	2g8mB00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.3	2g8oA00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]Thymidylate synthase	1
3.30.572.10.1.1.1.4	2g8oB00	Pyrimidine metabolismThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.5	3bhlA00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.6	3bhlB00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]Thymidylate synthase	1
3.30.572.10.1.1.1.7	1qqqA00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.8	2ftnA00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.9	2a9wA00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.10	2a9wB00	Pyrimidine metabolismThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.11	2a9wC00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.Thymidylate synthase	1
3.30.572.10.1.1.1.12	2a9wD00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.13	1axwA00	Pyrimidine metabolismThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.One carbon pool by folateThymidylate synthase	7
3.30.572.10.1.1.1.14	1axwB00	Pyrimidine metabolismThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.15	1ev5A00	Pyrimidine metabolismThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.16	1evfA00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.Thymidylate synthase	1
3.30.572.10.1.1.1.17	1f4bA00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.18	1kziA00	Pyrimidine metabolismThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.19	1kziB00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.20	1f4gA00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.21	1f4gB00	Pyrimidine metabolismThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.22	1tysA00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.23	2ftqA00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]Thymidylate synthase	1
3.30.572.10.1.1.1.24	2g8xA00	Pyrimidine metabolismThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.25	2g8xB00	Pyrimidine metabolismThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.26	1trgA00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.Thymidylate synthase	1
3.30.572.10.1.1.1.27	1f4eA00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.28	3bhrA00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.29	3bgxA00	Pyrimidine metabolismThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.30	1tsdA00	Pyrimidine metabolismEscherichia coli O157:H7One carbon pool by folateThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]	1
3.30.572.10.1.1.1.31	1tsdB00	Escherichia coli O157:H7Pyrimidine metabolismThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.One carbon pool by folate	1
3.30.572.10.1.1.1.32	2tscA00	Pyrimidine metabolismThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.One carbon pool by folateThymidylate synthase	2
3.30.572.10.1.1.1.33	1synA00	Pyrimidine metabolismThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.34	1synB00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]Thymidylate synthase	1
3.30.572.10.1.1.1.35	1kceA00	Pyrimidine metabolismThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.36	1kceB00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]Thymidylate synthase	1
3.30.572.10.1.1.1.37	2ftoX00	Pyrimidine metabolismThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.38	1jg0A00	Pyrimidine metabolismThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.39	1jg0B00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.40	1evgA00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]Thymidylate synthase	1
3.30.572.10.1.1.1.41	1f4cA00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.42	1f4fA00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.43	1f4cB00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.44	1f4fB00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.45	1bduA00	Pyrimidine metabolismEscherichia coli O157:H7One carbon pool by folateThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]	1
3.30.572.10.1.1.1.46	1dduA00	Pyrimidine metabolismThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.47	1dduB00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.48	1tduA00	Pyrimidine metabolismThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.49	1tduB00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.50	1tlcA00	Pyrimidine metabolismEscherichia coli O157:H7One carbon pool by folateThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.	1
3.30.572.10.1.1.1.51	1tlcB00	Pyrimidine metabolismEscherichia coli O157:H7One carbon pool by folateThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.	1
3.30.572.10.1.1.1.52	1f4dA00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.53	1f4dB00	Pyrimidine metabolismThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.54	1bidA00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.55	1bq2A00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.56	1tjsA00	Pyrimidine metabolismEscherichia coli O157:H7One carbon pool by folateThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.	1
3.30.572.10.1.1.1.57	2vetA00	Pyrimidine metabolismThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.One carbon pool by folateThymidylate synthase	3
3.30.572.10.1.1.1.58	1aiqA00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.59	1aiqB00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]Thymidylate synthase	1
3.30.572.10.1.1.1.60	1dnaA00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.61	1dnaB00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.Thymidylate synthase	1
3.30.572.10.1.1.1.62	1fwmA00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]Thymidylate synthase	1
3.30.572.10.1.1.1.63	1fwmB00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.64	1jtuA00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.65	1jtuB00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]Thymidylate synthase	1
3.30.572.10.1.1.1.66	1tsnA00	Escherichia coli O157:H7Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folate	1
3.30.572.10.1.1.1.67	3bfiA00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]Thymidylate synthase	1
3.30.572.10.1.1.1.68	1bjgA00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]Thymidylate synthase	1
3.30.572.10.1.1.1.69	1ajmA00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]Thymidylate synthase	1
3.30.572.10.1.1.1.70	1nceA00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.71	1nceB00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.72	3b9hA00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.73	1bq1A00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.74	1bq1B00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.75	1jtqA00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.Thymidylate synthase	1
3.30.572.10.1.1.1.76	1jtqB00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.77	1zprA00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]Thymidylate synthase	1
3.30.572.10.1.1.1.78	1zprB00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.79	1an5A00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]Thymidylate synthase	1
3.30.572.10.1.1.1.80	1an5B00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.81	1kzjA00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.Thymidylate synthase	1
3.30.572.10.1.1.1.82	1kzjB00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.83	1kzjC00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]Thymidylate synthase	1
3.30.572.10.1.1.1.84	1kzjD00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]Thymidylate synthase	1
3.30.572.10.1.1.1.85	1kzjF00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.Thymidylate synthase	1
3.30.572.10.1.1.1.86	1tlsA00	Pyrimidine metabolismEscherichia coli O157:H7One carbon pool by folateThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]	1
3.30.572.10.1.1.1.87	1tlsB00	Escherichia coli O157:H7Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folate	1
3.30.572.10.1.1.1.88	1kzjE00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]Thymidylate synthase	1
3.30.572.10.1.1.1.89	1ev8A00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.90	1jutA00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]Thymidylate synthase	1
3.30.572.10.1.1.1.91	1jutB00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.92	1fflA00	Pyrimidine metabolismThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.93	2vf0A00	Pyrimidine metabolismThymidylate synthase.Thymidylate synthase [EC:2.1.1.45]One carbon pool by folateThymidylate synthase	1
3.30.572.10.1.1.1.94	2vf0B00	Pyrimidine metabolismOne carbon pool by folateThymidylate synthase [EC:2.1.1.45]Thymidylate synthase.Thymidylate synthase	1

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.30.572.10.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S95 Family: 3.30.572.10.1.1.1

Classification Lineage (3.30.572.10.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Family Entries in S95 Family 3.30.572.10.1.1.1 (94)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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