S100 Family: 3.30.565.10.1.1.1.1

Representative domain: 1uylA00

Classification Lineage (3.30.565.10.1.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.30	2-Layer Sandwich
3.30.565	Heat Shock Protein 90
3.30.565.10		Gene3D
3.30.565.10.1
3.30.565.10.1.1
3.30.565.10.1.1.1
3.30.565.10.1.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	21

Non-Redundant Representatives (21)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.30.565.10.1.1.1.1 (21)

CATH code	Domain ID	Keywords
3.30.565.10.1.1.1.1.1	1uylA00	mitochondrial outer membrane translocase complex assembly, cellular chaperone-mediated protein complex assembly, Homo sapiens, mitochondrial transport, TPR domain binding, protein homodimerization activity, ATP binding, Heat shock protein HSP 90-alpha, protein refolding
3.30.565.10.1.1.1.1.2	3bm9A00	Heat shock protein HSP 90-alpha, protein refolding, ATP binding, protein homodimerization activity, mitochondrial transport, TPR domain binding, mitochondrial outer membrane translocase complex assembly, cellular chaperone-mediated protein complex assembly, Homo sapiens
3.30.565.10.1.1.1.1.3	2qfoA00	Heat shock protein HSP 90-alpha, protein refolding, ATP binding, TPR domain binding, mitochondrial transport, protein homodimerization activity, Homo sapiens, mitochondrial outer membrane translocase complex assembly, cellular chaperone-mediated protein complex assembly
3.30.565.10.1.1.1.1.4	2qfoB00	mitochondrial transport, TPR domain binding, protein homodimerization activity, Homo sapiens, mitochondrial outer membrane translocase complex assembly, cellular chaperone-mediated protein complex assembly, Heat shock protein HSP 90-alpha, protein refolding, ATP binding
3.30.565.10.1.1.1.1.5	3bmyA00	ATP binding, Heat shock protein HSP 90-alpha, protein refolding, mitochondrial outer membrane translocase complex assembly, cellular chaperone-mediated protein complex assembly, Homo sapiens, TPR domain binding, mitochondrial transport, protein homodimerization activity
3.30.565.10.1.1.1.1.6	2xduA00	Homo sapiens, mitochondrial outer membrane translocase complex assembly, cellular chaperone-mediated protein complex assembly, mitochondrial transport, TPR domain binding, protein homodimerization activity, ATP binding, Heat shock protein HSP 90-alpha, protein refolding
3.30.565.10.1.1.1.1.7	2qg0A00	protein refolding, Heat shock protein HSP 90-alpha, ATP binding, mitochondrial transport, TPR domain binding, protein homodimerization activity, Homo sapiens, cellular chaperone-mediated protein complex assembly, mitochondrial outer membrane translocase complex assembly
3.30.565.10.1.1.1.1.8	2qg0B00	protein refolding, Heat shock protein HSP 90-alpha, ATP binding, TPR domain binding, mitochondrial transport, protein homodimerization activity, cellular chaperone-mediated protein complex assembly, mitochondrial outer membrane translocase complex assembly, Homo sapiens
3.30.565.10.1.1.1.1.9	3ft5A00	Homo sapiens, cellular chaperone-mediated protein complex assembly, mitochondrial outer membrane translocase complex assembly, mitochondrial transport, TPR domain binding, protein homodimerization activity, ATP binding, protein refolding, Heat shock protein HSP 90-alpha
3.30.565.10.1.1.1.1.10	1uy6A00	ATP binding, protein refolding, Heat shock protein HSP 90-alpha, cellular chaperone-mediated protein complex assembly, mitochondrial outer membrane translocase complex assembly, Homo sapiens, protein homodimerization activity, TPR domain binding, mitochondrial transport
3.30.565.10.1.1.1.1.11	2xabA00	ATP binding, protein refolding, Heat shock protein HSP 90-alpha, Homo sapiens, cellular chaperone-mediated protein complex assembly, mitochondrial outer membrane translocase complex assembly, protein homodimerization activity, TPR domain binding, mitochondrial transport
3.30.565.10.1.1.1.1.12	2xabB00	Homo sapiens, cellular chaperone-mediated protein complex assembly, mitochondrial outer membrane translocase complex assembly, TPR domain binding, mitochondrial transport, protein homodimerization activity, ATP binding, protein refolding, Heat shock protein HSP 90-alpha
3.30.565.10.1.1.1.1.13	2xdsA00	TPR domain binding, mitochondrial transport, protein homodimerization activity, Homo sapiens, mitochondrial outer membrane translocase complex assembly, cellular chaperone-mediated protein complex assembly, Heat shock protein HSP 90-alpha, protein refolding, ATP binding
3.30.565.10.1.1.1.1.14	3ft8A00	mitochondrial outer membrane translocase complex assembly, cellular chaperone-mediated protein complex assembly, Homo sapiens, protein homodimerization activity, TPR domain binding, mitochondrial transport, ATP binding, Heat shock protein HSP 90-alpha, protein refolding
3.30.565.10.1.1.1.1.15	1uy8A00	protein refolding, Heat shock protein HSP 90-alpha, ATP binding, TPR domain binding, mitochondrial transport, protein homodimerization activity, cellular chaperone-mediated protein complex assembly, mitochondrial outer membrane translocase complex assembly, Homo sapiens
3.30.565.10.1.1.1.1.16	2xdlA00	mitochondrial transport, TPR domain binding, protein homodimerization activity, Homo sapiens, cellular chaperone-mediated protein complex assembly, mitochondrial outer membrane translocase complex assembly, protein refolding, Heat shock protein HSP 90-alpha, ATP binding
3.30.565.10.1.1.1.1.17	3k97A00	Heat shock protein HSP 90-alpha, protein refolding, ATP binding, mitochondrial transport, TPR domain binding, protein homodimerization activity, mitochondrial outer membrane translocase complex assembly, cellular chaperone-mediated protein complex assembly, Homo sapiens
3.30.565.10.1.1.1.1.18	2h55A00	Heat shock protein HSP 90-alpha, protein refolding, ATP binding, protein homodimerization activity, TPR domain binding, mitochondrial transport, Homo sapiens, mitochondrial outer membrane translocase complex assembly, cellular chaperone-mediated protein complex assembly
3.30.565.10.1.1.1.1.19	2fwyA00	protein homodimerization activity, mitochondrial transport, TPR domain binding, cellular chaperone-mediated protein complex assembly, mitochondrial outer membrane translocase complex assembly, Homo sapiens, protein refolding, Heat shock protein HSP 90-alpha, ATP binding
3.30.565.10.1.1.1.1.20	2fwzA00	protein refolding, Heat shock protein HSP 90-alpha, ATP binding, protein homodimerization activity, mitochondrial transport, TPR domain binding, Homo sapiens, cellular chaperone-mediated protein complex assembly, mitochondrial outer membrane translocase complex assembly
3.30.565.10.1.1.1.1.21	2xhrA00	Heat shock protein HSP 90-alpha, protein refolding, ATP binding, protein homodimerization activity, mitochondrial transport, TPR domain binding, Homo sapiens, mitochondrial outer membrane translocase complex assembly, cellular chaperone-mediated protein complex assembly

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.30.565.10.1.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.30.565.10.1.1.1.1

Classification Lineage (3.30.565.10.1.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.30.565.10.1.1.1.1 (21)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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