S100 Family: 3.30.505.10.8.1.1.1

Representative domain: 3buxB03

Classification Lineage (3.30.505.10.8.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.30	2-Layer Sandwich
3.30.505	SHC Adaptor Protein
3.30.505.10	SHC Adaptor Protein	Gene3D
3.30.505.10.8
3.30.505.10.8.1
3.30.505.10.8.1.1
3.30.505.10.8.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	14

Non-Redundant Representatives (14)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.30.505.10.8.1.1.1 (14)

CATH code	Domain ID	Keywords
3.30.505.10.8.1.1.1.1	3buxB03	E3 ubiquitin-protein ligase CBL [EC:6.3.2.19], ubiquitin-protein ligase activity, Jak-STAT signaling pathway, Chronic myeloid leukemia, Ubiquitin mediated proteolysis, epidermal growth factor receptor signaling pathway, T cell receptor signaling pathway, sequence-specific DNA binding transcription factor activity, Homo sapiens, SH3 domain binding, protein ubiquitination, E3 ubiquitin-protein ligase CBL, Endocytosis, Insulin signaling pathway, positive regulation of receptor-mediated endocytosis, Acid--D-amino-acid ligases (peptide synthases)., Pathways in cancer, ErbB signaling pathway
3.30.505.10.8.1.1.1.2	3buxD03	E3 ubiquitin-protein ligase CBL [EC:6.3.2.19], ubiquitin-protein ligase activity, Chronic myeloid leukemia, epidermal growth factor receptor signaling pathway, Ubiquitin mediated proteolysis, Jak-STAT signaling pathway, Homo sapiens, SH3 domain binding, sequence-specific DNA binding transcription factor activity, T cell receptor signaling pathway, protein ubiquitination, E3 ubiquitin-protein ligase CBL, Endocytosis, Insulin signaling pathway, ErbB signaling pathway, Pathways in cancer, positive regulation of receptor-mediated endocytosis, Acid--D-amino-acid ligases (peptide synthases).
3.30.505.10.8.1.1.1.3	3buwB03	E3 ubiquitin-protein ligase CBL [EC:6.3.2.19], ubiquitin-protein ligase activity, Chronic myeloid leukemia, epidermal growth factor receptor signaling pathway, Ubiquitin mediated proteolysis, Jak-STAT signaling pathway, Homo sapiens, SH3 domain binding, sequence-specific DNA binding transcription factor activity, T cell receptor signaling pathway, protein ubiquitination, E3 ubiquitin-protein ligase CBL, Endocytosis, Insulin signaling pathway, ErbB signaling pathway, Pathways in cancer, positive regulation of receptor-mediated endocytosis, Acid--D-amino-acid ligases (peptide synthases).
3.30.505.10.8.1.1.1.4	3buwD03	Homo sapiens, SH3 domain binding, T cell receptor signaling pathway, sequence-specific DNA binding transcription factor activity, protein ubiquitination, E3 ubiquitin-protein ligase CBL, Endocytosis, Insulin signaling pathway, Pathways in cancer, ErbB signaling pathway, positive regulation of receptor-mediated endocytosis, Acid--D-amino-acid ligases (peptide synthases)., E3 ubiquitin-protein ligase CBL [EC:6.3.2.19], ubiquitin-protein ligase activity, Chronic myeloid leukemia, Ubiquitin mediated proteolysis, epidermal growth factor receptor signaling pathway, Jak-STAT signaling pathway
3.30.505.10.8.1.1.1.5	3bumB03	Jak-STAT signaling pathway, Chronic myeloid leukemia, epidermal growth factor receptor signaling pathway, Ubiquitin mediated proteolysis, ubiquitin-protein ligase activity, E3 ubiquitin-protein ligase CBL [EC:6.3.2.19], positive regulation of receptor-mediated endocytosis, Acid--D-amino-acid ligases (peptide synthases)., ErbB signaling pathway, Pathways in cancer, Endocytosis, Insulin signaling pathway, protein ubiquitination, E3 ubiquitin-protein ligase CBL, sequence-specific DNA binding transcription factor activity, T cell receptor signaling pathway, Homo sapiens, SH3 domain binding
3.30.505.10.8.1.1.1.6	3bunB03	Endocytosis, Insulin signaling pathway, positive regulation of receptor-mediated endocytosis, Acid--D-amino-acid ligases (peptide synthases)., Pathways in cancer, ErbB signaling pathway, T cell receptor signaling pathway, sequence-specific DNA binding transcription factor activity, Homo sapiens, SH3 domain binding, protein ubiquitination, E3 ubiquitin-protein ligase CBL, ubiquitin-protein ligase activity, Jak-STAT signaling pathway, Chronic myeloid leukemia, Ubiquitin mediated proteolysis, epidermal growth factor receptor signaling pathway, E3 ubiquitin-protein ligase CBL [EC:6.3.2.19]
3.30.505.10.8.1.1.1.7	1yvhA03	E3 ubiquitin-protein ligase CBL [EC:6.3.2.19], ubiquitin-protein ligase activity, epidermal growth factor receptor signaling pathway, Ubiquitin mediated proteolysis, Chronic myeloid leukemia, Jak-STAT signaling pathway, Homo sapiens, SH3 domain binding, sequence-specific DNA binding transcription factor activity, T cell receptor signaling pathway, E3 ubiquitin-protein ligase CBL, protein ubiquitination, Insulin signaling pathway, Endocytosis, ErbB signaling pathway, Pathways in cancer, Acid--D-amino-acid ligases (peptide synthases)., positive regulation of receptor-mediated endocytosis
3.30.505.10.8.1.1.1.8	2cblA03	Chronic myeloid leukemia, Ubiquitin mediated proteolysis, epidermal growth factor receptor signaling pathway, Jak-STAT signaling pathway, ubiquitin-protein ligase activity, E3 ubiquitin-protein ligase CBL [EC:6.3.2.19], Pathways in cancer, ErbB signaling pathway, positive regulation of receptor-mediated endocytosis, Acid--D-amino-acid ligases (peptide synthases)., Endocytosis, Insulin signaling pathway, protein ubiquitination, E3 ubiquitin-protein ligase CBL, Homo sapiens, SH3 domain binding, T cell receptor signaling pathway, sequence-specific DNA binding transcription factor activity
3.30.505.10.8.1.1.1.9	1b47A03	T cell receptor signaling pathway, sequence-specific DNA binding transcription factor activity, Homo sapiens, SH3 domain binding, E3 ubiquitin-protein ligase CBL, protein ubiquitination, Insulin signaling pathway, Endocytosis, Acid--D-amino-acid ligases (peptide synthases)., positive regulation of receptor-mediated endocytosis, Pathways in cancer, ErbB signaling pathway, E3 ubiquitin-protein ligase CBL [EC:6.3.2.19], ubiquitin-protein ligase activity, Jak-STAT signaling pathway, Ubiquitin mediated proteolysis, epidermal growth factor receptor signaling pathway, Chronic myeloid leukemia
3.30.505.10.8.1.1.1.10	1b47B03	Pathways in cancer, ErbB signaling pathway, Acid--D-amino-acid ligases (peptide synthases)., positive regulation of receptor-mediated endocytosis, Insulin signaling pathway, Endocytosis, E3 ubiquitin-protein ligase CBL, protein ubiquitination, Homo sapiens, SH3 domain binding, T cell receptor signaling pathway, sequence-specific DNA binding transcription factor activity, Ubiquitin mediated proteolysis, epidermal growth factor receptor signaling pathway, Chronic myeloid leukemia, Jak-STAT signaling pathway, ubiquitin-protein ligase activity, E3 ubiquitin-protein ligase CBL [EC:6.3.2.19]
3.30.505.10.8.1.1.1.11	1b47C03	E3 ubiquitin-protein ligase CBL, protein ubiquitination, sequence-specific DNA binding transcription factor activity, T cell receptor signaling pathway, Homo sapiens, SH3 domain binding, Acid--D-amino-acid ligases (peptide synthases)., positive regulation of receptor-mediated endocytosis, ErbB signaling pathway, Pathways in cancer, Insulin signaling pathway, Endocytosis, E3 ubiquitin-protein ligase CBL [EC:6.3.2.19], Jak-STAT signaling pathway, epidermal growth factor receptor signaling pathway, Ubiquitin mediated proteolysis, Chronic myeloid leukemia, ubiquitin-protein ligase activity
3.30.505.10.8.1.1.1.12	3buoB03	Endocytosis, Insulin signaling pathway, ErbB signaling pathway, Pathways in cancer, positive regulation of receptor-mediated endocytosis, Acid--D-amino-acid ligases (peptide synthases)., Homo sapiens, SH3 domain binding, sequence-specific DNA binding transcription factor activity, T cell receptor signaling pathway, protein ubiquitination, E3 ubiquitin-protein ligase CBL, ubiquitin-protein ligase activity, Chronic myeloid leukemia, epidermal growth factor receptor signaling pathway, Ubiquitin mediated proteolysis, Jak-STAT signaling pathway, E3 ubiquitin-protein ligase CBL [EC:6.3.2.19]
3.30.505.10.8.1.1.1.13	3buoD03	Homo sapiens, SH3 domain binding, T cell receptor signaling pathway, sequence-specific DNA binding transcription factor activity, protein ubiquitination, E3 ubiquitin-protein ligase CBL, Endocytosis, Insulin signaling pathway, Pathways in cancer, ErbB signaling pathway, positive regulation of receptor-mediated endocytosis, Acid--D-amino-acid ligases (peptide synthases)., E3 ubiquitin-protein ligase CBL [EC:6.3.2.19], ubiquitin-protein ligase activity, Chronic myeloid leukemia, Ubiquitin mediated proteolysis, epidermal growth factor receptor signaling pathway, Jak-STAT signaling pathway
3.30.505.10.8.1.1.1.14	1fbvA03	Chronic myeloid leukemia, Ubiquitin mediated proteolysis, epidermal growth factor receptor signaling pathway, Jak-STAT signaling pathway, ubiquitin-protein ligase activity, E3 ubiquitin-protein ligase CBL [EC:6.3.2.19], Pathways in cancer, ErbB signaling pathway, positive regulation of receptor-mediated endocytosis, Acid--D-amino-acid ligases (peptide synthases)., Endocytosis, Insulin signaling pathway, protein ubiquitination, E3 ubiquitin-protein ligase CBL, Homo sapiens, SH3 domain binding, T cell receptor signaling pathway, sequence-specific DNA binding transcription factor activity

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.30.505.10.8.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.30.505.10.8.1.1.1

Classification Lineage (3.30.505.10.8.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.30.505.10.8.1.1.1 (14)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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