S100 Family: 3.30.505.10.5.1.1.1

Representative domain: 3c7iA00

Classification Lineage (3.30.505.10.5.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.30	2-Layer Sandwich
3.30.505	SHC Adaptor Protein
3.30.505.10	SHC Adaptor Protein	Gene3D
3.30.505.10.5
3.30.505.10.5.1
3.30.505.10.5.1.1
3.30.505.10.5.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	24

Non-Redundant Representatives (24)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.30.505.10.5.1.1.1 (24)

CATH code	Domain ID	Keywords
3.30.505.10.5.1.1.1.1	3c7iA00	ErbB signaling pathway, Ras protein signal transduction, growth factor receptor-binding protein 2, Pathways in cancer, Glioma, Acute myeloid leukemia, Prostate cancer, insulin receptor signaling pathway, epidermal growth factor receptor binding, Dorso-ventral axis formation, Insulin signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, receptor internalization, Homo sapiens, Chemokine signaling pathway, T cell receptor signaling pathway, epidermal growth factor receptor signaling pathway, Non-small cell lung cancer, Chronic myeloid leukemia, Jak-STAT signaling pathway, SH3/SH2 adaptor activity, Natural killer cell mediated cytotoxicity, Fc epsilon RI signaling pathway, Focal adhesion, B cell receptor signaling pathway, cell-cell signaling, Growth factor receptor-bound protein 2, Renal cell carcinoma, insulin receptor substrate binding, Endometrial cancer, cytosol, Gap junction, GnRH signaling pathway
3.30.505.10.5.1.1.1.2	1zfpE00	ErbB signaling pathway, Ras protein signal transduction, growth factor receptor-binding protein 2, Pathways in cancer, Glioma, Acute myeloid leukemia, Prostate cancer, insulin receptor signaling pathway, epidermal growth factor receptor binding, Insulin signaling pathway, Dorso-ventral axis formation, MAPK signaling pathway, Neurotrophin signaling pathway, receptor internalization, Homo sapiens, Chemokine signaling pathway, T cell receptor signaling pathway, epidermal growth factor receptor signaling pathway, Non-small cell lung cancer, Chronic myeloid leukemia, Jak-STAT signaling pathway, SH3/SH2 adaptor activity, Natural killer cell mediated cytotoxicity, Fc epsilon RI signaling pathway, Focal adhesion, B cell receptor signaling pathway, cell-cell signaling, Growth factor receptor-bound protein 2, Renal cell carcinoma, insulin receptor substrate binding, Endometrial cancer, cytosol, Gap junction, GnRH signaling pathway
3.30.505.10.5.1.1.1.3	2huwA00	Gap junction, Endometrial cancer, cytosol, GnRH signaling pathway, Growth factor receptor-bound protein 2, Renal cell carcinoma, insulin receptor substrate binding, Fc epsilon RI signaling pathway, B cell receptor signaling pathway, Focal adhesion, cell-cell signaling, Chronic myeloid leukemia, epidermal growth factor receptor signaling pathway, Non-small cell lung cancer, SH3/SH2 adaptor activity, Natural killer cell mediated cytotoxicity, Jak-STAT signaling pathway, Homo sapiens, Chemokine signaling pathway, T cell receptor signaling pathway, Neurotrophin signaling pathway, receptor internalization, Prostate cancer, insulin receptor signaling pathway, epidermal growth factor receptor binding, MAPK signaling pathway, Insulin signaling pathway, Dorso-ventral axis formation, ErbB signaling pathway, Ras protein signal transduction, growth factor receptor-binding protein 2, Pathways in cancer, Glioma, Acute myeloid leukemia
3.30.505.10.5.1.1.1.4	2aobA00	Gap junction, Endometrial cancer, cytosol, GnRH signaling pathway, Growth factor receptor-bound protein 2, Renal cell carcinoma, insulin receptor substrate binding, Fc epsilon RI signaling pathway, B cell receptor signaling pathway, Focal adhesion, cell-cell signaling, Chronic myeloid leukemia, epidermal growth factor receptor signaling pathway, Non-small cell lung cancer, SH3/SH2 adaptor activity, Natural killer cell mediated cytotoxicity, Jak-STAT signaling pathway, Homo sapiens, Chemokine signaling pathway, T cell receptor signaling pathway, Neurotrophin signaling pathway, receptor internalization, Prostate cancer, insulin receptor signaling pathway, epidermal growth factor receptor binding, MAPK signaling pathway, Insulin signaling pathway, Dorso-ventral axis formation, ErbB signaling pathway, Ras protein signal transduction, growth factor receptor-binding protein 2, Pathways in cancer, Glioma, Acute myeloid leukemia
3.30.505.10.5.1.1.1.5	2aobC00	Acute myeloid leukemia, growth factor receptor-binding protein 2, Glioma, Pathways in cancer, ErbB signaling pathway, Ras protein signal transduction, MAPK signaling pathway, Insulin signaling pathway, Dorso-ventral axis formation, epidermal growth factor receptor binding, Prostate cancer, insulin receptor signaling pathway, receptor internalization, Neurotrophin signaling pathway, T cell receptor signaling pathway, Chemokine signaling pathway, Homo sapiens, Natural killer cell mediated cytotoxicity, SH3/SH2 adaptor activity, Jak-STAT signaling pathway, Chronic myeloid leukemia, Non-small cell lung cancer, epidermal growth factor receptor signaling pathway, B cell receptor signaling pathway, Focal adhesion, cell-cell signaling, Fc epsilon RI signaling pathway, insulin receptor substrate binding, Renal cell carcinoma, Growth factor receptor-bound protein 2, GnRH signaling pathway, Gap junction, Endometrial cancer, cytosol
3.30.505.10.5.1.1.1.6	2huwB00	GnRH signaling pathway, Gap junction, Endometrial cancer, cytosol, insulin receptor substrate binding, Growth factor receptor-bound protein 2, Renal cell carcinoma, B cell receptor signaling pathway, Focal adhesion, cell-cell signaling, Fc epsilon RI signaling pathway, SH3/SH2 adaptor activity, Natural killer cell mediated cytotoxicity, Jak-STAT signaling pathway, Chronic myeloid leukemia, epidermal growth factor receptor signaling pathway, Non-small cell lung cancer, T cell receptor signaling pathway, Homo sapiens, Chemokine signaling pathway, receptor internalization, Neurotrophin signaling pathway, MAPK signaling pathway, Insulin signaling pathway, Dorso-ventral axis formation, Prostate cancer, insulin receptor signaling pathway, epidermal growth factor receptor binding, Acute myeloid leukemia, ErbB signaling pathway, Ras protein signal transduction, growth factor receptor-binding protein 2, Glioma, Pathways in cancer
3.30.505.10.5.1.1.1.7	2aobB00	insulin receptor substrate binding, Growth factor receptor-bound protein 2, Renal cell carcinoma, GnRH signaling pathway, Gap junction, Endometrial cancer, cytosol, SH3/SH2 adaptor activity, Natural killer cell mediated cytotoxicity, Jak-STAT signaling pathway, Chronic myeloid leukemia, epidermal growth factor receptor signaling pathway, Non-small cell lung cancer, B cell receptor signaling pathway, Focal adhesion, cell-cell signaling, Fc epsilon RI signaling pathway, receptor internalization, Neurotrophin signaling pathway, T cell receptor signaling pathway, Homo sapiens, Chemokine signaling pathway, Acute myeloid leukemia, ErbB signaling pathway, Ras protein signal transduction, growth factor receptor-binding protein 2, Glioma, Pathways in cancer, MAPK signaling pathway, Insulin signaling pathway, Dorso-ventral axis formation, Prostate cancer, insulin receptor signaling pathway, epidermal growth factor receptor binding
3.30.505.10.5.1.1.1.8	2aobD00	epidermal growth factor receptor binding, Prostate cancer, insulin receptor signaling pathway, Insulin signaling pathway, Dorso-ventral axis formation, MAPK signaling pathway, growth factor receptor-binding protein 2, Pathways in cancer, Glioma, ErbB signaling pathway, Ras protein signal transduction, Acute myeloid leukemia, Chemokine signaling pathway, Homo sapiens, T cell receptor signaling pathway, Neurotrophin signaling pathway, receptor internalization, Fc epsilon RI signaling pathway, Focal adhesion, B cell receptor signaling pathway, cell-cell signaling, Non-small cell lung cancer, epidermal growth factor receptor signaling pathway, Chronic myeloid leukemia, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, SH3/SH2 adaptor activity, Endometrial cancer, cytosol, Gap junction, GnRH signaling pathway, Renal cell carcinoma, Growth factor receptor-bound protein 2, insulin receptor substrate binding
3.30.505.10.5.1.1.1.9	3in7A00	SH3/SH2 adaptor activity, Natural killer cell mediated cytotoxicity, Jak-STAT signaling pathway, Chronic myeloid leukemia, epidermal growth factor receptor signaling pathway, Non-small cell lung cancer, Focal adhesion, B cell receptor signaling pathway, cell-cell signaling, Fc epsilon RI signaling pathway, insulin receptor substrate binding, Growth factor receptor-bound protein 2, Renal cell carcinoma, GnRH signaling pathway, Gap junction, Endometrial cancer, cytosol, Acute myeloid leukemia, ErbB signaling pathway, Ras protein signal transduction, growth factor receptor-binding protein 2, Pathways in cancer, Glioma, MAPK signaling pathway, Insulin signaling pathway, Dorso-ventral axis formation, Prostate cancer, insulin receptor signaling pathway, epidermal growth factor receptor binding, receptor internalization, Neurotrophin signaling pathway, T cell receptor signaling pathway, Homo sapiens, Chemokine signaling pathway
3.30.505.10.5.1.1.1.10	2aoaA00	epidermal growth factor receptor binding, Prostate cancer, insulin receptor signaling pathway, Insulin signaling pathway, Dorso-ventral axis formation, MAPK signaling pathway, growth factor receptor-binding protein 2, Pathways in cancer, Glioma, ErbB signaling pathway, Ras protein signal transduction, Acute myeloid leukemia, Chemokine signaling pathway, Homo sapiens, T cell receptor signaling pathway, Neurotrophin signaling pathway, receptor internalization, Fc epsilon RI signaling pathway, Focal adhesion, B cell receptor signaling pathway, cell-cell signaling, Non-small cell lung cancer, epidermal growth factor receptor signaling pathway, Chronic myeloid leukemia, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, SH3/SH2 adaptor activity, Endometrial cancer, cytosol, Gap junction, GnRH signaling pathway, Renal cell carcinoma, Growth factor receptor-bound protein 2, insulin receptor substrate binding
3.30.505.10.5.1.1.1.11	2aoaB00	Endometrial cancer, cytosol, Gap junction, GnRH signaling pathway, Renal cell carcinoma, Growth factor receptor-bound protein 2, insulin receptor substrate binding, Fc epsilon RI signaling pathway, Focal adhesion, B cell receptor signaling pathway, cell-cell signaling, Non-small cell lung cancer, epidermal growth factor receptor signaling pathway, Chronic myeloid leukemia, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, SH3/SH2 adaptor activity, Chemokine signaling pathway, Homo sapiens, T cell receptor signaling pathway, Neurotrophin signaling pathway, receptor internalization, epidermal growth factor receptor binding, Prostate cancer, insulin receptor signaling pathway, Dorso-ventral axis formation, Insulin signaling pathway, MAPK signaling pathway, growth factor receptor-binding protein 2, Glioma, Pathways in cancer, ErbB signaling pathway, Ras protein signal transduction, Acute myeloid leukemia
3.30.505.10.5.1.1.1.12	1cj1A00	Chemokine signaling pathway, Homo sapiens, T cell receptor signaling pathway, Neurotrophin signaling pathway, receptor internalization, epidermal growth factor receptor binding, Prostate cancer, insulin receptor signaling pathway, MAPK signaling pathway, Insulin signaling pathway, Dorso-ventral axis formation, growth factor receptor-binding protein 2, Glioma, Pathways in cancer, ErbB signaling pathway, Ras protein signal transduction, Acute myeloid leukemia, Gap junction, Endometrial cancer, cytosol, GnRH signaling pathway, Renal cell carcinoma, Growth factor receptor-bound protein 2, insulin receptor substrate binding, Fc epsilon RI signaling pathway, Focal adhesion, B cell receptor signaling pathway, cell-cell signaling, Chronic myeloid leukemia, Non-small cell lung cancer, epidermal growth factor receptor signaling pathway, Natural killer cell mediated cytotoxicity, SH3/SH2 adaptor activity, Jak-STAT signaling pathway
3.30.505.10.5.1.1.1.13	1cj1B00	insulin receptor substrate binding, Growth factor receptor-bound protein 2, Renal cell carcinoma, GnRH signaling pathway, Endometrial cancer, cytosol, Gap junction, Jak-STAT signaling pathway, SH3/SH2 adaptor activity, Natural killer cell mediated cytotoxicity, epidermal growth factor receptor signaling pathway, Non-small cell lung cancer, Chronic myeloid leukemia, B cell receptor signaling pathway, Focal adhesion, cell-cell signaling, Fc epsilon RI signaling pathway, receptor internalization, Neurotrophin signaling pathway, T cell receptor signaling pathway, Homo sapiens, Chemokine signaling pathway, Acute myeloid leukemia, ErbB signaling pathway, Ras protein signal transduction, growth factor receptor-binding protein 2, Pathways in cancer, Glioma, Dorso-ventral axis formation, Insulin signaling pathway, MAPK signaling pathway, Prostate cancer, insulin receptor signaling pathway, epidermal growth factor receptor binding
3.30.505.10.5.1.1.1.14	1cj1C00	Chemokine signaling pathway, Homo sapiens, T cell receptor signaling pathway, Neurotrophin signaling pathway, receptor internalization, epidermal growth factor receptor binding, Prostate cancer, insulin receptor signaling pathway, Insulin signaling pathway, Dorso-ventral axis formation, MAPK signaling pathway, growth factor receptor-binding protein 2, Glioma, Pathways in cancer, ErbB signaling pathway, Ras protein signal transduction, Acute myeloid leukemia, Endometrial cancer, cytosol, Gap junction, GnRH signaling pathway, Renal cell carcinoma, Growth factor receptor-bound protein 2, insulin receptor substrate binding, Fc epsilon RI signaling pathway, Focal adhesion, B cell receptor signaling pathway, cell-cell signaling, Non-small cell lung cancer, epidermal growth factor receptor signaling pathway, Chronic myeloid leukemia, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, SH3/SH2 adaptor activity
3.30.505.10.5.1.1.1.15	1cj1D00	insulin receptor substrate binding, Growth factor receptor-bound protein 2, Renal cell carcinoma, GnRH signaling pathway, Gap junction, Endometrial cancer, cytosol, SH3/SH2 adaptor activity, Natural killer cell mediated cytotoxicity, Jak-STAT signaling pathway, Chronic myeloid leukemia, epidermal growth factor receptor signaling pathway, Non-small cell lung cancer, B cell receptor signaling pathway, Focal adhesion, cell-cell signaling, Fc epsilon RI signaling pathway, receptor internalization, Neurotrophin signaling pathway, T cell receptor signaling pathway, Homo sapiens, Chemokine signaling pathway, Acute myeloid leukemia, ErbB signaling pathway, Ras protein signal transduction, growth factor receptor-binding protein 2, Pathways in cancer, Glioma, MAPK signaling pathway, Insulin signaling pathway, Dorso-ventral axis formation, Prostate cancer, insulin receptor signaling pathway, epidermal growth factor receptor binding
3.30.505.10.5.1.1.1.16	1cj1E00	Homo sapiens, Chemokine signaling pathway, T cell receptor signaling pathway, Neurotrophin signaling pathway, receptor internalization, Prostate cancer, insulin receptor signaling pathway, epidermal growth factor receptor binding, MAPK signaling pathway, Insulin signaling pathway, Dorso-ventral axis formation, ErbB signaling pathway, Ras protein signal transduction, growth factor receptor-binding protein 2, Pathways in cancer, Glioma, Acute myeloid leukemia, Gap junction, Endometrial cancer, cytosol, GnRH signaling pathway, Growth factor receptor-bound protein 2, Renal cell carcinoma, insulin receptor substrate binding, Fc epsilon RI signaling pathway, Focal adhesion, B cell receptor signaling pathway, cell-cell signaling, Chronic myeloid leukemia, epidermal growth factor receptor signaling pathway, Non-small cell lung cancer, SH3/SH2 adaptor activity, Natural killer cell mediated cytotoxicity, Jak-STAT signaling pathway
3.30.505.10.5.1.1.1.17	1cj1F00	MAPK signaling pathway, Insulin signaling pathway, Dorso-ventral axis formation, Prostate cancer, insulin receptor signaling pathway, epidermal growth factor receptor binding, Acute myeloid leukemia, ErbB signaling pathway, Ras protein signal transduction, growth factor receptor-binding protein 2, Pathways in cancer, Glioma, T cell receptor signaling pathway, Homo sapiens, Chemokine signaling pathway, receptor internalization, Neurotrophin signaling pathway, B cell receptor signaling pathway, Focal adhesion, cell-cell signaling, Fc epsilon RI signaling pathway, SH3/SH2 adaptor activity, Natural killer cell mediated cytotoxicity, Jak-STAT signaling pathway, Chronic myeloid leukemia, epidermal growth factor receptor signaling pathway, Non-small cell lung cancer, GnRH signaling pathway, Gap junction, Endometrial cancer, cytosol, insulin receptor substrate binding, Growth factor receptor-bound protein 2, Renal cell carcinoma
3.30.505.10.5.1.1.1.18	1cj1G00	Endometrial cancer, cytosol, Gap junction, GnRH signaling pathway, Growth factor receptor-bound protein 2, Renal cell carcinoma, insulin receptor substrate binding, Fc epsilon RI signaling pathway, B cell receptor signaling pathway, Focal adhesion, cell-cell signaling, epidermal growth factor receptor signaling pathway, Non-small cell lung cancer, Chronic myeloid leukemia, Jak-STAT signaling pathway, SH3/SH2 adaptor activity, Natural killer cell mediated cytotoxicity, Homo sapiens, Chemokine signaling pathway, T cell receptor signaling pathway, Neurotrophin signaling pathway, receptor internalization, Prostate cancer, insulin receptor signaling pathway, epidermal growth factor receptor binding, Dorso-ventral axis formation, Insulin signaling pathway, MAPK signaling pathway, ErbB signaling pathway, Ras protein signal transduction, growth factor receptor-binding protein 2, Pathways in cancer, Glioma, Acute myeloid leukemia
3.30.505.10.5.1.1.1.19	1cj1H00	Chronic myeloid leukemia, epidermal growth factor receptor signaling pathway, Non-small cell lung cancer, SH3/SH2 adaptor activity, Natural killer cell mediated cytotoxicity, Jak-STAT signaling pathway, Fc epsilon RI signaling pathway, B cell receptor signaling pathway, Focal adhesion, cell-cell signaling, Growth factor receptor-bound protein 2, Renal cell carcinoma, insulin receptor substrate binding, Gap junction, Endometrial cancer, cytosol, GnRH signaling pathway, ErbB signaling pathway, Ras protein signal transduction, growth factor receptor-binding protein 2, Pathways in cancer, Glioma, Acute myeloid leukemia, Prostate cancer, insulin receptor signaling pathway, epidermal growth factor receptor binding, MAPK signaling pathway, Dorso-ventral axis formation, Insulin signaling pathway, Neurotrophin signaling pathway, receptor internalization, Homo sapiens, Chemokine signaling pathway, T cell receptor signaling pathway
3.30.505.10.5.1.1.1.20	1cj1I00	receptor internalization, Neurotrophin signaling pathway, T cell receptor signaling pathway, Homo sapiens, Chemokine signaling pathway, Acute myeloid leukemia, ErbB signaling pathway, Ras protein signal transduction, growth factor receptor-binding protein 2, Glioma, Pathways in cancer, Insulin signaling pathway, Dorso-ventral axis formation, MAPK signaling pathway, Prostate cancer, insulin receptor signaling pathway, epidermal growth factor receptor binding, insulin receptor substrate binding, Growth factor receptor-bound protein 2, Renal cell carcinoma, GnRH signaling pathway, Endometrial cancer, cytosol, Gap junction, Jak-STAT signaling pathway, SH3/SH2 adaptor activity, Natural killer cell mediated cytotoxicity, epidermal growth factor receptor signaling pathway, Non-small cell lung cancer, Chronic myeloid leukemia, Focal adhesion, B cell receptor signaling pathway, cell-cell signaling, Fc epsilon RI signaling pathway
3.30.505.10.5.1.1.1.21	1cj1J00	Renal cell carcinoma, Growth factor receptor-bound protein 2, insulin receptor substrate binding, Gap junction, Endometrial cancer, cytosol, GnRH signaling pathway, Chronic myeloid leukemia, Non-small cell lung cancer, epidermal growth factor receptor signaling pathway, Natural killer cell mediated cytotoxicity, SH3/SH2 adaptor activity, Jak-STAT signaling pathway, Fc epsilon RI signaling pathway, B cell receptor signaling pathway, Focal adhesion, cell-cell signaling, Neurotrophin signaling pathway, receptor internalization, Chemokine signaling pathway, Homo sapiens, T cell receptor signaling pathway, growth factor receptor-binding protein 2, Pathways in cancer, Glioma, ErbB signaling pathway, Ras protein signal transduction, Acute myeloid leukemia, epidermal growth factor receptor binding, Prostate cancer, insulin receptor signaling pathway, MAPK signaling pathway, Insulin signaling pathway, Dorso-ventral axis formation
3.30.505.10.5.1.1.1.22	1cj1K00	Focal adhesion, B cell receptor signaling pathway, cell-cell signaling, Fc epsilon RI signaling pathway, Natural killer cell mediated cytotoxicity, SH3/SH2 adaptor activity, Jak-STAT signaling pathway, Chronic myeloid leukemia, Non-small cell lung cancer, epidermal growth factor receptor signaling pathway, GnRH signaling pathway, Gap junction, Endometrial cancer, cytosol, insulin receptor substrate binding, Renal cell carcinoma, Growth factor receptor-bound protein 2, MAPK signaling pathway, Insulin signaling pathway, Dorso-ventral axis formation, epidermal growth factor receptor binding, Prostate cancer, insulin receptor signaling pathway, Acute myeloid leukemia, growth factor receptor-binding protein 2, Pathways in cancer, Glioma, ErbB signaling pathway, Ras protein signal transduction, T cell receptor signaling pathway, Chemokine signaling pathway, Homo sapiens, receptor internalization, Neurotrophin signaling pathway
3.30.505.10.5.1.1.1.23	1cj1L00	Gap junction, Endometrial cancer, cytosol, GnRH signaling pathway, Renal cell carcinoma, Growth factor receptor-bound protein 2, insulin receptor substrate binding, Fc epsilon RI signaling pathway, Focal adhesion, B cell receptor signaling pathway, cell-cell signaling, Chronic myeloid leukemia, Non-small cell lung cancer, epidermal growth factor receptor signaling pathway, Natural killer cell mediated cytotoxicity, SH3/SH2 adaptor activity, Jak-STAT signaling pathway, Chemokine signaling pathway, Homo sapiens, T cell receptor signaling pathway, Neurotrophin signaling pathway, receptor internalization, epidermal growth factor receptor binding, Prostate cancer, insulin receptor signaling pathway, MAPK signaling pathway, Dorso-ventral axis formation, Insulin signaling pathway, growth factor receptor-binding protein 2, Glioma, Pathways in cancer, ErbB signaling pathway, Ras protein signal transduction, Acute myeloid leukemia
3.30.505.10.5.1.1.1.24	2huyA00

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.30.505.10.5.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.30.505.10.5.1.1.1

Classification Lineage (3.30.505.10.5.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.30.505.10.5.1.1.1 (24)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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