S100 Family: 3.30.505.10.13.1.1.1

Representative domain: 1ayaA00

Classification Lineage (3.30.505.10.13.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.30	2-Layer Sandwich
3.30.505	SHC Adaptor Protein
3.30.505.10	SHC Adaptor Protein	Gene3D
3.30.505.10.13
3.30.505.10.13.1
3.30.505.10.13.1.1
3.30.505.10.13.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	5

Non-Redundant Representatives (5)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.30.505.10.13.1.1.1 (5)

CATH code	Domain ID	Keywords
3.30.505.10.13.1.1.1.1	1ayaA00	negative regulation of insulin secretion, peptide hormone receptor binding, Mus musculus, Protein-tyrosine-phosphatase., activation of MAPK activity, positive regulation of hormone secretion, DNA damage checkpoint, regulation of multicellular organism growth, nerve growth factor receptor signaling pathway, negative regulation of growth hormone secretion, triglyceride metabolic process, multicellular organismal reproductive process, hormone-mediated signaling pathway, positive regulation of signal transduction, Tyrosine-protein phosphatase non-receptor type 11, glucose homeostasis, hormone metabolic process, negative regulation of cortisol secretion, axonogenesis, regulation of protein export from nucleus, organ growth
3.30.505.10.13.1.1.1.2	1ayaB00	negative regulation of cortisol secretion, Tyrosine-protein phosphatase non-receptor type 11, hormone metabolic process, glucose homeostasis, axonogenesis, regulation of protein export from nucleus, organ growth, regulation of multicellular organism growth, nerve growth factor receptor signaling pathway, negative regulation of growth hormone secretion, triglyceride metabolic process, multicellular organismal reproductive process, positive regulation of signal transduction, hormone-mediated signaling pathway, negative regulation of insulin secretion, peptide hormone receptor binding, Mus musculus, DNA damage checkpoint, Protein-tyrosine-phosphatase., activation of MAPK activity, positive regulation of hormone secretion
3.30.505.10.13.1.1.1.3	1aydA00	negative regulation of growth hormone secretion, nerve growth factor receptor signaling pathway, regulation of multicellular organism growth, hormone-mediated signaling pathway, positive regulation of signal transduction, multicellular organismal reproductive process, triglyceride metabolic process, peptide hormone receptor binding, negative regulation of insulin secretion, Protein-tyrosine-phosphatase., activation of MAPK activity, positive regulation of hormone secretion, DNA damage checkpoint, Mus musculus, Tyrosine-protein phosphatase non-receptor type 11, hormone metabolic process, glucose homeostasis, negative regulation of cortisol secretion, regulation of protein export from nucleus, organ growth, axonogenesis
3.30.505.10.13.1.1.1.4	1aycA00	Tyrosine-protein phosphatase non-receptor type 11, glucose homeostasis, hormone metabolic process, negative regulation of cortisol secretion, regulation of protein export from nucleus, organ growth, axonogenesis, peptide hormone receptor binding, negative regulation of insulin secretion, Protein-tyrosine-phosphatase., positive regulation of hormone secretion, activation of MAPK activity, DNA damage checkpoint, Mus musculus, negative regulation of growth hormone secretion, nerve growth factor receptor signaling pathway, regulation of multicellular organism growth, hormone-mediated signaling pathway, positive regulation of signal transduction, multicellular organismal reproductive process, triglyceride metabolic process
3.30.505.10.13.1.1.1.5	1aybA00	negative regulation of cortisol secretion, Tyrosine-protein phosphatase non-receptor type 11, hormone metabolic process, glucose homeostasis, axonogenesis, organ growth, regulation of protein export from nucleus, negative regulation of insulin secretion, peptide hormone receptor binding, Mus musculus, DNA damage checkpoint, Protein-tyrosine-phosphatase., positive regulation of hormone secretion, activation of MAPK activity, regulation of multicellular organism growth, nerve growth factor receptor signaling pathway, negative regulation of growth hormone secretion, triglyceride metabolic process, multicellular organismal reproductive process, positive regulation of signal transduction, hormone-mediated signaling pathway

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.30.505.10.13.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.30.505.10.13.1.1.1

Classification Lineage (3.30.505.10.13.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.30.505.10.13.1.1.1 (5)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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