S100 Family: 3.30.505.10.1.1.1.1

Molscript image for 1lkkA00
Representative domain: 1lkkA00
PDB coordinates for domain 1lkkA00

Classification Lineage (3.30.505.10.1.1.1.1)

CATH CodeLevel DescriptionLinks
3 Alpha Beta
3.30 2-Layer Sandwich
3.30.505 SHC Adaptor Protein
3.30.505.10 SHC Adaptor Protein Gene3D
3.30.505.10.1
3.30.505.10.1.1
3.30.505.10.1.1.1
3.30.505.10.1.1.1.1

Summary of Non-Redundant Representatives
- - - - - - - - 13

S100 Count Entries in S100 Family 3.30.505.10.1.1.1.1 (13)

CATH Level CATH code Domain ID Keywords Thumbnail
3.30.505.10.1.1.1.1.1 1lkkA00 CD8 receptor binding, protein C-terminus binding, positive regulation of T cell activation, CD4 receptor binding, protein kinase binding, response to drug, Golgi apparatus, Non-specific protein-tyrosine kinase., membrane raft, T cell differentiation, Homo sapiens, SH2 domain binding, T cell receptor signaling pathway, ATPase binding, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], pericentriolar material, cellular zinc ion homeostasis, glycoprotein binding, Tyrosine-protein kinase Lck, induction of apoptosis, activation of caspase activity, Natural killer cell mediated cytotoxicity, protein serine/threonine phosphatase activity, phosphoinositide 3-kinase binding, Primary immunodeficiency, protein phosphorylation Molscript image for 1lkkA00
3.30.505.10.1.1.1.1.2 1lcjA00 protein serine/threonine phosphatase activity, phosphoinositide 3-kinase binding, Primary immunodeficiency, protein phosphorylation, glycoprotein binding, Tyrosine-protein kinase Lck, induction of apoptosis, activation of caspase activity, Natural killer cell mediated cytotoxicity, membrane raft, T cell differentiation, Homo sapiens, SH2 domain binding, T cell receptor signaling pathway, ATPase binding, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], pericentriolar material, cellular zinc ion homeostasis, CD8 receptor binding, protein C-terminus binding, positive regulation of T cell activation, CD4 receptor binding, protein kinase binding, response to drug, Golgi apparatus, Non-specific protein-tyrosine kinase. Molscript image for 1lcjA00
3.30.505.10.1.1.1.1.3 1lklA00 protein C-terminus binding, CD8 receptor binding, protein kinase binding, CD4 receptor binding, positive regulation of T cell activation, response to drug, Non-specific protein-tyrosine kinase., Golgi apparatus, Homo sapiens, SH2 domain binding, T cell differentiation, membrane raft, ATPase binding, T cell receptor signaling pathway, cellular zinc ion homeostasis, pericentriolar material, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], glycoprotein binding, induction of apoptosis, Tyrosine-protein kinase Lck, activation of caspase activity, Natural killer cell mediated cytotoxicity, protein serine/threonine phosphatase activity, protein phosphorylation, Primary immunodeficiency, phosphoinositide 3-kinase binding Molscript image for 1lklA00
3.30.505.10.1.1.1.1.4 1bhfA00 activation of caspase activity, Natural killer cell mediated cytotoxicity, glycoprotein binding, induction of apoptosis, Tyrosine-protein kinase Lck, protein serine/threonine phosphatase activity, Primary immunodeficiency, protein phosphorylation, phosphoinositide 3-kinase binding, response to drug, Non-specific protein-tyrosine kinase., Golgi apparatus, protein C-terminus binding, CD8 receptor binding, CD4 receptor binding, protein kinase binding, positive regulation of T cell activation, cellular zinc ion homeostasis, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], pericentriolar material, Homo sapiens, SH2 domain binding, membrane raft, T cell differentiation, ATPase binding, T cell receptor signaling pathway Molscript image for 1bhfA00
3.30.505.10.1.1.1.1.5 1bhhB00 Primary immunodeficiency, protein phosphorylation, phosphoinositide 3-kinase binding, protein serine/threonine phosphatase activity, induction of apoptosis, Tyrosine-protein kinase Lck, glycoprotein binding, Natural killer cell mediated cytotoxicity, activation of caspase activity, ATPase binding, T cell receptor signaling pathway, Homo sapiens, SH2 domain binding, membrane raft, T cell differentiation, cellular zinc ion homeostasis, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], pericentriolar material, CD4 receptor binding, protein kinase binding, positive regulation of T cell activation, protein C-terminus binding, CD8 receptor binding, Non-specific protein-tyrosine kinase., Golgi apparatus, response to drug Molscript image for 1bhhB00
3.30.505.10.1.1.1.1.6 1bhhA00 phosphoinositide 3-kinase binding, protein phosphorylation, Primary immunodeficiency, protein serine/threonine phosphatase activity, Tyrosine-protein kinase Lck, induction of apoptosis, glycoprotein binding, Natural killer cell mediated cytotoxicity, activation of caspase activity, T cell receptor signaling pathway, ATPase binding, T cell differentiation, membrane raft, Homo sapiens, SH2 domain binding, pericentriolar material, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], cellular zinc ion homeostasis, positive regulation of T cell activation, protein kinase binding, CD4 receptor binding, CD8 receptor binding, protein C-terminus binding, Golgi apparatus, Non-specific protein-tyrosine kinase., response to drug Molscript image for 1bhhA00
3.30.505.10.1.1.1.1.7 1lckA02 CD4 receptor binding, protein kinase binding, positive regulation of T cell activation, protein C-terminus binding, CD8 receptor binding, Non-specific protein-tyrosine kinase., Golgi apparatus, response to drug, ATPase binding, T cell receptor signaling pathway, Homo sapiens, SH2 domain binding, membrane raft, T cell differentiation, cellular zinc ion homeostasis, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], pericentriolar material, induction of apoptosis, Tyrosine-protein kinase Lck, glycoprotein binding, Natural killer cell mediated cytotoxicity, activation of caspase activity, Primary immunodeficiency, protein phosphorylation, phosphoinositide 3-kinase binding, protein serine/threonine phosphatase activity Molscript image for 1lckA02
3.30.505.10.1.1.1.1.8 1x27A02 activation of caspase activity, Natural killer cell mediated cytotoxicity, glycoprotein binding, Tyrosine-protein kinase Lck, induction of apoptosis, protein serine/threonine phosphatase activity, phosphoinositide 3-kinase binding, Primary immunodeficiency, protein phosphorylation, response to drug, Golgi apparatus, Non-specific protein-tyrosine kinase., CD8 receptor binding, protein C-terminus binding, positive regulation of T cell activation, CD4 receptor binding, protein kinase binding, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], pericentriolar material, cellular zinc ion homeostasis, membrane raft, T cell differentiation, Homo sapiens, SH2 domain binding, T cell receptor signaling pathway, ATPase binding Molscript image for 1x27A02
3.30.505.10.1.1.1.1.9 1x27B02 Primary immunodeficiency, protein phosphorylation, phosphoinositide 3-kinase binding, protein serine/threonine phosphatase activity, induction of apoptosis, Tyrosine-protein kinase Lck, glycoprotein binding, Natural killer cell mediated cytotoxicity, activation of caspase activity, ATPase binding, T cell receptor signaling pathway, Homo sapiens, SH2 domain binding, membrane raft, T cell differentiation, cellular zinc ion homeostasis, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], pericentriolar material, CD4 receptor binding, protein kinase binding, positive regulation of T cell activation, protein C-terminus binding, CD8 receptor binding, Non-specific protein-tyrosine kinase., Golgi apparatus, response to drug Molscript image for 1x27B02
3.30.505.10.1.1.1.1.10 1x27C02 ATPase binding, T cell receptor signaling pathway, Homo sapiens, SH2 domain binding, membrane raft, T cell differentiation, cellular zinc ion homeostasis, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], pericentriolar material, CD4 receptor binding, protein kinase binding, positive regulation of T cell activation, protein C-terminus binding, CD8 receptor binding, Non-specific protein-tyrosine kinase., Golgi apparatus, response to drug, Primary immunodeficiency, protein phosphorylation, phosphoinositide 3-kinase binding, protein serine/threonine phosphatase activity, induction of apoptosis, Tyrosine-protein kinase Lck, glycoprotein binding, Natural killer cell mediated cytotoxicity, activation of caspase activity Molscript image for 1x27C02
3.30.505.10.1.1.1.1.11 1x27D02 Natural killer cell mediated cytotoxicity, activation of caspase activity, Tyrosine-protein kinase Lck, induction of apoptosis, glycoprotein binding, phosphoinositide 3-kinase binding, Primary immunodeficiency, protein phosphorylation, protein serine/threonine phosphatase activity, Golgi apparatus, Non-specific protein-tyrosine kinase., response to drug, positive regulation of T cell activation, CD4 receptor binding, protein kinase binding, CD8 receptor binding, protein C-terminus binding, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], pericentriolar material, cellular zinc ion homeostasis, T cell receptor signaling pathway, ATPase binding, membrane raft, T cell differentiation, Homo sapiens, SH2 domain binding Molscript image for 1x27D02
3.30.505.10.1.1.1.1.12 1x27E02 Natural killer cell mediated cytotoxicity, activation of caspase activity, Tyrosine-protein kinase Lck, induction of apoptosis, glycoprotein binding, phosphoinositide 3-kinase binding, Primary immunodeficiency, protein phosphorylation, protein serine/threonine phosphatase activity, Golgi apparatus, Non-specific protein-tyrosine kinase., response to drug, positive regulation of T cell activation, CD4 receptor binding, protein kinase binding, CD8 receptor binding, protein C-terminus binding, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], pericentriolar material, cellular zinc ion homeostasis, T cell receptor signaling pathway, ATPase binding, membrane raft, T cell differentiation, Homo sapiens, SH2 domain binding Molscript image for 1x27E02
3.30.505.10.1.1.1.1.13 1x27F02 Primary immunodeficiency, protein phosphorylation, phosphoinositide 3-kinase binding, protein serine/threonine phosphatase activity, induction of apoptosis, Tyrosine-protein kinase Lck, glycoprotein binding, Natural killer cell mediated cytotoxicity, activation of caspase activity, ATPase binding, T cell receptor signaling pathway, Homo sapiens, SH2 domain binding, membrane raft, T cell differentiation, cellular zinc ion homeostasis, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], pericentriolar material, CD4 receptor binding, protein kinase binding, positive regulation of T cell activation, protein C-terminus binding, CD8 receptor binding, Non-specific protein-tyrosine kinase., Golgi apparatus, response to drug Molscript image for 1x27F02

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:
  • Multiple alignments for each functional family
  • Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
  • Detailed functional information on diversity and conservation within Functional families
  • Multi-domain architectures
In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:
http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.30.505.10.1.1.1.1