S100 Family: 3.30.428.10.5.1.1.1

Representative domain: 1gupB01

Classification Lineage (3.30.428.10.5.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.30	2-Layer Sandwich
3.30.428	HIT family, subunit A
3.30.428.10	HIT family, subunit A	Gene3D
3.30.428.10.5
3.30.428.10.5.1
3.30.428.10.5.1.1
3.30.428.10.5.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	11

Non-Redundant Representatives (11)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.30.428.10.5.1.1.1 (11)

CATH code	Domain ID	Keywords
3.30.428.10.5.1.1.1.1	1gupB01	Galactose metabolism, UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12], UDP-glucose--hexose-1-phosphate uridylyltransferase., protein binding, Escherichia coli K-12, Metabolic pathways, Galactose-1-phosphate uridylyltransferase, Amino sugar and nucleotide sugar metabolism, ferrous iron binding, galactose catabolic process via UDP-galactose, UDP-glucose:hexose-1-phosphate uridylyltransferase activity, zinc ion binding
3.30.428.10.5.1.1.1.2	1gupC01	zinc ion binding, UDP-glucose:hexose-1-phosphate uridylyltransferase activity, galactose catabolic process via UDP-galactose, ferrous iron binding, Galactose-1-phosphate uridylyltransferase, Amino sugar and nucleotide sugar metabolism, Metabolic pathways, protein binding, UDP-glucose--hexose-1-phosphate uridylyltransferase., Escherichia coli K-12, UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12], Galactose metabolism
3.30.428.10.5.1.1.1.3	1gupD01	UDP-glucose:hexose-1-phosphate uridylyltransferase activity, zinc ion binding, galactose catabolic process via UDP-galactose, ferrous iron binding, Amino sugar and nucleotide sugar metabolism, Galactose-1-phosphate uridylyltransferase, Metabolic pathways, Escherichia coli K-12, protein binding, UDP-glucose--hexose-1-phosphate uridylyltransferase., UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12], Galactose metabolism
3.30.428.10.5.1.1.1.4	1guqB01	UDP-glucose--hexose-1-phosphate uridylyltransferase., protein binding, Escherichia coli K-12, Metabolic pathways, Galactose metabolism, UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12], galactose catabolic process via UDP-galactose, zinc ion binding, UDP-glucose:hexose-1-phosphate uridylyltransferase activity, Galactose-1-phosphate uridylyltransferase, Amino sugar and nucleotide sugar metabolism, ferrous iron binding
3.30.428.10.5.1.1.1.5	1guqC01	galactose catabolic process via UDP-galactose, zinc ion binding, UDP-glucose:hexose-1-phosphate uridylyltransferase activity, Amino sugar and nucleotide sugar metabolism, Galactose-1-phosphate uridylyltransferase, ferrous iron binding, Escherichia coli K-12, protein binding, UDP-glucose--hexose-1-phosphate uridylyltransferase., Metabolic pathways, Galactose metabolism, UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12]
3.30.428.10.5.1.1.1.6	1guqD01	UDP-glucose:hexose-1-phosphate uridylyltransferase activity, zinc ion binding, galactose catabolic process via UDP-galactose, ferrous iron binding, Galactose-1-phosphate uridylyltransferase, Amino sugar and nucleotide sugar metabolism, Metabolic pathways, UDP-glucose--hexose-1-phosphate uridylyltransferase., protein binding, Escherichia coli K-12, UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12], Galactose metabolism
3.30.428.10.5.1.1.1.7	1gupA01	Metabolic pathways, protein binding, UDP-glucose--hexose-1-phosphate uridylyltransferase., Escherichia coli K-12, UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12], Galactose metabolism, zinc ion binding, UDP-glucose:hexose-1-phosphate uridylyltransferase activity, galactose catabolic process via UDP-galactose, ferrous iron binding, Galactose-1-phosphate uridylyltransferase, Amino sugar and nucleotide sugar metabolism
3.30.428.10.5.1.1.1.8	1guqA01	Galactose metabolism, UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12], protein binding, UDP-glucose--hexose-1-phosphate uridylyltransferase., Escherichia coli K-12, Metabolic pathways, Galactose-1-phosphate uridylyltransferase, Amino sugar and nucleotide sugar metabolism, ferrous iron binding, galactose catabolic process via UDP-galactose, zinc ion binding, UDP-glucose:hexose-1-phosphate uridylyltransferase activity
3.30.428.10.5.1.1.1.9	1hxqB01	UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12], Galactose metabolism, Metabolic pathways, protein binding, UDP-glucose--hexose-1-phosphate uridylyltransferase., Escherichia coli K-12, ferrous iron binding, Galactose-1-phosphate uridylyltransferase, Amino sugar and nucleotide sugar metabolism, zinc ion binding, UDP-glucose:hexose-1-phosphate uridylyltransferase activity, galactose catabolic process via UDP-galactose
3.30.428.10.5.1.1.1.10	1hxqA01	Amino sugar and nucleotide sugar metabolism, Galactose-1-phosphate uridylyltransferase, ferrous iron binding, galactose catabolic process via UDP-galactose, zinc ion binding, UDP-glucose:hexose-1-phosphate uridylyltransferase activity, Galactose metabolism, UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12], Escherichia coli K-12, protein binding, UDP-glucose--hexose-1-phosphate uridylyltransferase., Metabolic pathways
3.30.428.10.5.1.1.1.11	1hxpA01	Escherichia coli K-12, protein binding, UDP-glucose--hexose-1-phosphate uridylyltransferase., Metabolic pathways, Galactose metabolism, UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12], galactose catabolic process via UDP-galactose, zinc ion binding, UDP-glucose:hexose-1-phosphate uridylyltransferase activity, Amino sugar and nucleotide sugar metabolism, Galactose-1-phosphate uridylyltransferase, ferrous iron binding

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.30.428.10.5.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.30.428.10.5.1.1.1

Classification Lineage (3.30.428.10.5.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.30.428.10.5.1.1.1 (11)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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