S100 Family: 3.30.420.10.19.1.1.1

Representative domain: 2kfnA01

Classification Lineage (3.30.420.10.19.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.30	2-Layer Sandwich
3.30.420	Nucleotidyltransferase; domain 5
3.30.420.10		Gene3D
3.30.420.10.19
3.30.420.10.19.1
3.30.420.10.19.1.1
3.30.420.10.19.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	10

Non-Redundant Representatives (10)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.30.420.10.19.1.1.1 (10)

CATH code	Domain ID	Keywords
3.30.420.10.19.1.1.1.1	2kfnA01	Metabolic pathways, Base excision repair, protein binding, DNA polymerase I, Escherichia coli K-12, Homologous recombination, Nucleotide excision repair, DNA replication, DNA polymerase I [EC:2.7.7.7], Purine metabolism, Pyrimidine metabolism, DNA-directed DNA polymerase.
3.30.420.10.19.1.1.1.2	2kfzA01	Pyrimidine metabolism, Purine metabolism, DNA-directed DNA polymerase., DNA replication, DNA polymerase I [EC:2.7.7.7], Homologous recombination, Nucleotide excision repair, Metabolic pathways, Base excision repair, protein binding, DNA polymerase I, Escherichia coli K-12
3.30.420.10.19.1.1.1.3	1kfsA01	Escherichia coli K-12, Base excision repair, protein binding, DNA polymerase I, Metabolic pathways, Nucleotide excision repair, Homologous recombination, DNA polymerase I [EC:2.7.7.7], DNA replication, DNA-directed DNA polymerase., Purine metabolism, Pyrimidine metabolism
3.30.420.10.19.1.1.1.4	1d9dA01	Nucleotide excision repair, Homologous recombination, Escherichia coli K-12, Base excision repair, protein binding, DNA polymerase I, Metabolic pathways, DNA-directed DNA polymerase., Purine metabolism, Pyrimidine metabolism, DNA polymerase I [EC:2.7.7.7], DNA replication
3.30.420.10.19.1.1.1.5	1qslA01	Escherichia coli K-12, Base excision repair, protein binding, DNA polymerase I, Metabolic pathways, Nucleotide excision repair, Homologous recombination, DNA polymerase I [EC:2.7.7.7], DNA replication, DNA-directed DNA polymerase., Purine metabolism, Pyrimidine metabolism
3.30.420.10.19.1.1.1.6	1krpA01	Metabolic pathways, Base excision repair, protein binding, DNA polymerase I, Escherichia coli K-12, Homologous recombination, Nucleotide excision repair, DNA replication, DNA polymerase I [EC:2.7.7.7], Pyrimidine metabolism, Purine metabolism, DNA-directed DNA polymerase.
3.30.420.10.19.1.1.1.7	2kzzA01	DNA-directed DNA polymerase., Purine metabolism, Pyrimidine metabolism, DNA polymerase I [EC:2.7.7.7], DNA replication, Nucleotide excision repair, Homologous recombination, Escherichia coli K-12, DNA polymerase I, Base excision repair, protein binding, Metabolic pathways
3.30.420.10.19.1.1.1.8	1kspA01	DNA replication, DNA polymerase I [EC:2.7.7.7], Pyrimidine metabolism, Purine metabolism, DNA-directed DNA polymerase., Metabolic pathways, DNA polymerase I, Base excision repair, protein binding, Escherichia coli K-12, Homologous recombination, Nucleotide excision repair
3.30.420.10.19.1.1.1.9	2kzmA01	Nucleotide excision repair, Homologous recombination, Base excision repair, protein binding, DNA polymerase I, Escherichia coli K-12, Metabolic pathways, Pyrimidine metabolism, Purine metabolism, DNA-directed DNA polymerase., DNA replication, DNA polymerase I [EC:2.7.7.7]
3.30.420.10.19.1.1.1.10	1d9fA01	DNA polymerase I [EC:2.7.7.7], DNA replication, DNA-directed DNA polymerase., Pyrimidine metabolism, Purine metabolism, Escherichia coli K-12, Base excision repair, protein binding, DNA polymerase I, Metabolic pathways, Nucleotide excision repair, Homologous recombination

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.30.420.10.19.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.30.420.10.19.1.1.1

Classification Lineage (3.30.420.10.19.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.30.420.10.19.1.1.1 (10)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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