S100 Family: 3.30.379.10.5.1.1.1

Representative domain: 1nowA01

Classification Lineage (3.30.379.10.5.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.30	2-Layer Sandwich
3.30.379	Chitobiase; domain 2
3.30.379.10	Chitobiase, domain 2	Gene3D
3.30.379.10.5
3.30.379.10.5.1
3.30.379.10.5.1.1
3.30.379.10.5.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	20

Non-Redundant Representatives (20)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.30.379.10.5.1.1.1 (20)

CATH code	Domain ID	Keywords
3.30.379.10.5.1.1.1.1	1nowA01	Glycosphingolipid biosynthesis - ganglio series, Other glycan degradation, Amino sugar and nucleotide sugar metabolism, Beta-hexosaminidase subunit beta, Homo sapiens, Glycosaminoglycan degradation, Beta-N-acetylhexosaminidase., Metabolic pathways, Glycosphingolipid biosynthesis - globo series, beta-hexosaminidase [EC:3.2.1.52], Lysosome
3.30.379.10.5.1.1.1.2	1nowB01	Beta-N-acetylhexosaminidase., Metabolic pathways, beta-hexosaminidase [EC:3.2.1.52], Lysosome, Glycosphingolipid biosynthesis - globo series, Homo sapiens, Glycosaminoglycan degradation, Beta-hexosaminidase subunit beta, Glycosphingolipid biosynthesis - ganglio series, Other glycan degradation, Amino sugar and nucleotide sugar metabolism
3.30.379.10.5.1.1.1.3	1o7aA01	Glycosaminoglycan degradation, Homo sapiens, Glycosphingolipid biosynthesis - globo series, beta-hexosaminidase [EC:3.2.1.52], Lysosome, Metabolic pathways, Beta-N-acetylhexosaminidase., Amino sugar and nucleotide sugar metabolism, Other glycan degradation, Glycosphingolipid biosynthesis - ganglio series, Beta-hexosaminidase subunit beta
3.30.379.10.5.1.1.1.4	1o7aB01	Glycosphingolipid biosynthesis - ganglio series, Other glycan degradation, Amino sugar and nucleotide sugar metabolism, Beta-hexosaminidase subunit beta, Homo sapiens, Glycosaminoglycan degradation, Metabolic pathways, Beta-N-acetylhexosaminidase., beta-hexosaminidase [EC:3.2.1.52], Lysosome, Glycosphingolipid biosynthesis - globo series
3.30.379.10.5.1.1.1.5	1o7aC01	Beta-hexosaminidase subunit beta, Other glycan degradation, Amino sugar and nucleotide sugar metabolism, Glycosphingolipid biosynthesis - ganglio series, Glycosphingolipid biosynthesis - globo series, beta-hexosaminidase [EC:3.2.1.52], Lysosome, Metabolic pathways, Beta-N-acetylhexosaminidase., Glycosaminoglycan degradation, Homo sapiens
3.30.379.10.5.1.1.1.6	1o7aD01	Homo sapiens, Glycosaminoglycan degradation, Metabolic pathways, Beta-N-acetylhexosaminidase., Glycosphingolipid biosynthesis - globo series, beta-hexosaminidase [EC:3.2.1.52], Lysosome, Glycosphingolipid biosynthesis - ganglio series, Other glycan degradation, Amino sugar and nucleotide sugar metabolism, Beta-hexosaminidase subunit beta
3.30.379.10.5.1.1.1.7	1o7aE01	Amino sugar and nucleotide sugar metabolism, Other glycan degradation, Glycosphingolipid biosynthesis - ganglio series, Beta-hexosaminidase subunit beta, Glycosaminoglycan degradation, Homo sapiens, beta-hexosaminidase [EC:3.2.1.52], Lysosome, Glycosphingolipid biosynthesis - globo series, Beta-N-acetylhexosaminidase., Metabolic pathways
3.30.379.10.5.1.1.1.8	1o7aF01	Beta-hexosaminidase subunit beta, Glycosphingolipid biosynthesis - ganglio series, Other glycan degradation, Amino sugar and nucleotide sugar metabolism, Metabolic pathways, Beta-N-acetylhexosaminidase., beta-hexosaminidase [EC:3.2.1.52], Lysosome, Glycosphingolipid biosynthesis - globo series, Homo sapiens, Glycosaminoglycan degradation
3.30.379.10.5.1.1.1.9	1nouA01	Glycosphingolipid biosynthesis - ganglio series, Other glycan degradation, Amino sugar and nucleotide sugar metabolism, Beta-hexosaminidase subunit beta, Homo sapiens, Glycosaminoglycan degradation, Beta-N-acetylhexosaminidase., Metabolic pathways, Glycosphingolipid biosynthesis - globo series, beta-hexosaminidase [EC:3.2.1.52], Lysosome
3.30.379.10.5.1.1.1.10	1nouB01	beta-hexosaminidase [EC:3.2.1.52], Lysosome, Glycosphingolipid biosynthesis - globo series, Beta-N-acetylhexosaminidase., Metabolic pathways, Glycosaminoglycan degradation, Homo sapiens, Beta-hexosaminidase subunit beta, Amino sugar and nucleotide sugar metabolism, Other glycan degradation, Glycosphingolipid biosynthesis - ganglio series
3.30.379.10.5.1.1.1.11	1np0A01	Metabolic pathways, Beta-N-acetylhexosaminidase., Glycosphingolipid biosynthesis - globo series, beta-hexosaminidase [EC:3.2.1.52], Lysosome, Homo sapiens, Glycosaminoglycan degradation, Beta-hexosaminidase subunit beta, Glycosphingolipid biosynthesis - ganglio series, Other glycan degradation, Amino sugar and nucleotide sugar metabolism
3.30.379.10.5.1.1.1.12	1np0B01	Amino sugar and nucleotide sugar metabolism, Other glycan degradation, Glycosphingolipid biosynthesis - ganglio series, Beta-hexosaminidase subunit beta, Glycosaminoglycan degradation, Homo sapiens, Glycosphingolipid biosynthesis - globo series, beta-hexosaminidase [EC:3.2.1.52], Lysosome, Beta-N-acetylhexosaminidase., Metabolic pathways
3.30.379.10.5.1.1.1.13	2gjxB01	Beta-N-acetylhexosaminidase., Metabolic pathways, Glycosphingolipid biosynthesis - globo series, beta-hexosaminidase [EC:3.2.1.52], Lysosome, Homo sapiens, Glycosaminoglycan degradation, Beta-hexosaminidase subunit beta, Glycosphingolipid biosynthesis - ganglio series, Other glycan degradation, Amino sugar and nucleotide sugar metabolism
3.30.379.10.5.1.1.1.14	2gjxC01	beta-hexosaminidase [EC:3.2.1.52], Lysosome, Glycosphingolipid biosynthesis - globo series, Metabolic pathways, Beta-N-acetylhexosaminidase., Glycosaminoglycan degradation, Homo sapiens, Beta-hexosaminidase subunit beta, Other glycan degradation, Amino sugar and nucleotide sugar metabolism, Glycosphingolipid biosynthesis - ganglio series
3.30.379.10.5.1.1.1.15	2gjxF01	Amino sugar and nucleotide sugar metabolism, Other glycan degradation, Glycosphingolipid biosynthesis - ganglio series, Beta-hexosaminidase subunit beta, Glycosaminoglycan degradation, Homo sapiens, beta-hexosaminidase [EC:3.2.1.52], Lysosome, Glycosphingolipid biosynthesis - globo series, Metabolic pathways, Beta-N-acetylhexosaminidase.
3.30.379.10.5.1.1.1.16	2gjxG01	Beta-hexosaminidase subunit beta, Other glycan degradation, Amino sugar and nucleotide sugar metabolism, Glycosphingolipid biosynthesis - ganglio series, beta-hexosaminidase [EC:3.2.1.52], Lysosome, Glycosphingolipid biosynthesis - globo series, Metabolic pathways, Beta-N-acetylhexosaminidase., Glycosaminoglycan degradation, Homo sapiens
3.30.379.10.5.1.1.1.17	2gk1B01	Beta-hexosaminidase subunit beta, Glycosphingolipid biosynthesis - ganglio series, Amino sugar and nucleotide sugar metabolism, Other glycan degradation, Beta-N-acetylhexosaminidase., Metabolic pathways, beta-hexosaminidase [EC:3.2.1.52], Lysosome, Glycosphingolipid biosynthesis - globo series, Homo sapiens, Glycosaminoglycan degradation
3.30.379.10.5.1.1.1.18	2gk1D01	Homo sapiens, Glycosaminoglycan degradation, Metabolic pathways, Beta-N-acetylhexosaminidase., beta-hexosaminidase [EC:3.2.1.52], Lysosome, Glycosphingolipid biosynthesis - globo series, Glycosphingolipid biosynthesis - ganglio series, Other glycan degradation, Amino sugar and nucleotide sugar metabolism, Beta-hexosaminidase subunit beta
3.30.379.10.5.1.1.1.19	2gk1F01	Beta-hexosaminidase subunit beta, Amino sugar and nucleotide sugar metabolism, Other glycan degradation, Glycosphingolipid biosynthesis - ganglio series, beta-hexosaminidase [EC:3.2.1.52], Lysosome, Glycosphingolipid biosynthesis - globo series, Beta-N-acetylhexosaminidase., Metabolic pathways, Glycosaminoglycan degradation, Homo sapiens
3.30.379.10.5.1.1.1.20	2gk1H01	Beta-N-acetylhexosaminidase., Metabolic pathways, Glycosphingolipid biosynthesis - globo series, beta-hexosaminidase [EC:3.2.1.52], Lysosome, Homo sapiens, Glycosaminoglycan degradation, Beta-hexosaminidase subunit beta, Glycosphingolipid biosynthesis - ganglio series, Other glycan degradation, Amino sugar and nucleotide sugar metabolism

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.30.379.10.5.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.30.379.10.5.1.1.1

Classification Lineage (3.30.379.10.5.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.30.379.10.5.1.1.1 (20)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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