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CATH Superfamily 3.30.2310.30

Colicin E5 C-terminal ribonuclease domain (CRD)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Colicin E5 C-terminal ribonuclease domain (CRD)

Colicins are defensive weapons produced by some Escherichia coli in order to survive under nutrition-deficient conditions. Colicin classification is based on the type of the receptor that it binds for cell entry. The E group of colicins bind to the vitamin B12 receptor (BtuB) and are nucleases (with one exception, E1, which is a pore-forming toxin) PMID:16524591. Colicin E5 is a ribonuclease, but it lacks sequence homology with other E group members. Its activity resides within its C-terminal ribonuclease domain (E5-CRD), and this domain is responsible for its substrate specificity PMID:17099236. This entry represents E5-CRD which is composed of two alpha-helices and a five-stranded beta-sheet PMID:16060658.

PMID:16524591 PMID:17099236 PMID:16060658

GO Diversity

Unique GO annotations
1 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
59 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 10
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 6
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC:
Unique GO: 1
Taxonomy
Unique Species: 59
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