S100 Family: 3.30.200.20.7.1.1.1

Representative domain: 3f66B01

Classification Lineage (3.30.200.20.7.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.30	2-Layer Sandwich
3.30.200	Phosphorylase Kinase; domain 1
3.30.200.20	Phosphorylase Kinase; domain 1	Gene3D
3.30.200.20.7
3.30.200.20.7.1
3.30.200.20.7.1.1
3.30.200.20.7.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	25

Non-Redundant Representatives (25)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.30.200.20.7.1.1.1 (25)

CATH code	Domain ID	Keywords
3.30.200.20.7.1.1.1.1	3f66B01	Endocytosis, protein binding, Pathways in cancer, Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1], Homo sapiens, Receptor protein-tyrosine kinase., signal transduction, Melanoma, Hepatocyte growth factor receptor, integral to plasma membrane, Focal adhesion, Adherens junction, Axon guidance, basal plasma membrane, Cytokine-cytokine receptor interaction, cell proliferation, Renal cell carcinoma
3.30.200.20.7.1.1.1.2	3dkcA01	Axon guidance, Adherens junction, Focal adhesion, Hepatocyte growth factor receptor, integral to plasma membrane, Renal cell carcinoma, cell proliferation, Cytokine-cytokine receptor interaction, basal plasma membrane, Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, Pathways in cancer, protein binding, Endocytosis, Melanoma, signal transduction, Receptor protein-tyrosine kinase., Homo sapiens, proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
3.30.200.20.7.1.1.1.3	3f66A01	Renal cell carcinoma, cell proliferation, Cytokine-cytokine receptor interaction, basal plasma membrane, Axon guidance, Adherens junction, Focal adhesion, Hepatocyte growth factor receptor, integral to plasma membrane, Melanoma, signal transduction, Receptor protein-tyrosine kinase., Homo sapiens, proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1], Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, Pathways in cancer, protein binding, Endocytosis
3.30.200.20.7.1.1.1.4	1r1wA01	protein binding, Pathways in cancer, Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, Endocytosis, Melanoma, Receptor protein-tyrosine kinase., signal transduction, Homo sapiens, proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1], Axon guidance, Adherens junction, Hepatocyte growth factor receptor, integral to plasma membrane, Focal adhesion, cell proliferation, Renal cell carcinoma, basal plasma membrane, Cytokine-cytokine receptor interaction
3.30.200.20.7.1.1.1.5	3dkfA01	signal transduction, Receptor protein-tyrosine kinase., Melanoma, proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1], Homo sapiens, Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, Pathways in cancer, protein binding, Endocytosis, Cytokine-cytokine receptor interaction, basal plasma membrane, Renal cell carcinoma, cell proliferation, Axon guidance, Focal adhesion, Hepatocyte growth factor receptor, integral to plasma membrane, Adherens junction
3.30.200.20.7.1.1.1.6	1r0pA01	Axon guidance, Adherens junction, Focal adhesion, Hepatocyte growth factor receptor, integral to plasma membrane, Renal cell carcinoma, cell proliferation, Cytokine-cytokine receptor interaction, basal plasma membrane, Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, Pathways in cancer, protein binding, Endocytosis, Melanoma, signal transduction, Receptor protein-tyrosine kinase., Homo sapiens, proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
3.30.200.20.7.1.1.1.7	3dkgA01	Cytokine-cytokine receptor interaction, basal plasma membrane, Renal cell carcinoma, cell proliferation, Axon guidance, Focal adhesion, Hepatocyte growth factor receptor, integral to plasma membrane, Adherens junction, signal transduction, Receptor protein-tyrosine kinase., Melanoma, proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1], Homo sapiens, Pathways in cancer, Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, protein binding, Endocytosis
3.30.200.20.7.1.1.1.8	3cd8A01	Met proto-oncogene variant, Homo sapiens
3.30.200.20.7.1.1.1.9	3ccnA01	Homo sapiens, Met proto-oncogene variant
3.30.200.20.7.1.1.1.10	3i5nA01	Focal adhesion, Hepatocyte growth factor receptor, integral to plasma membrane, Adherens junction, Axon guidance, Cytokine-cytokine receptor interaction, basal plasma membrane, Renal cell carcinoma, cell proliferation, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, Pathways in cancer, protein binding, proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1], Homo sapiens, signal transduction, Receptor protein-tyrosine kinase., Melanoma
3.30.200.20.7.1.1.1.11	3efkB01	Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, Pathways in cancer, protein binding, Homo sapiens, proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1], Melanoma, signal transduction, Receptor protein-tyrosine kinase., Adherens junction, Focal adhesion, Hepatocyte growth factor receptor, integral to plasma membrane, Axon guidance, Renal cell carcinoma, cell proliferation, Cytokine-cytokine receptor interaction, basal plasma membrane
3.30.200.20.7.1.1.1.12	2wd1A01	signal transduction, Receptor protein-tyrosine kinase., Melanoma, proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1], Homo sapiens, Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, Pathways in cancer, protein binding, Endocytosis, Cytokine-cytokine receptor interaction, basal plasma membrane, Renal cell carcinoma, cell proliferation, Axon guidance, Focal adhesion, Hepatocyte growth factor receptor, integral to plasma membrane, Adherens junction
3.30.200.20.7.1.1.1.13	3c1xA01	Homo sapiens, Met proto-oncogene variant
3.30.200.20.7.1.1.1.14	3efkA01	Endocytosis, Pathways in cancer, Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, protein binding, Homo sapiens, proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1], Melanoma, signal transduction, Receptor protein-tyrosine kinase., Adherens junction, Focal adhesion, Hepatocyte growth factor receptor, integral to plasma membrane, Axon guidance, Renal cell carcinoma, cell proliferation, Cytokine-cytokine receptor interaction, basal plasma membrane
3.30.200.20.7.1.1.1.15	3cthA01	Endocytosis, protein binding, Pathways in cancer, Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1], Homo sapiens, Receptor protein-tyrosine kinase., signal transduction, Melanoma, Hepatocyte growth factor receptor, integral to plasma membrane, Focal adhesion, Adherens junction, Axon guidance, basal plasma membrane, Cytokine-cytokine receptor interaction, cell proliferation, Renal cell carcinoma
3.30.200.20.7.1.1.1.16	2rfnA01	cell proliferation, Renal cell carcinoma, basal plasma membrane, Cytokine-cytokine receptor interaction, Adherens junction, Hepatocyte growth factor receptor, integral to plasma membrane, Focal adhesion, Axon guidance, Homo sapiens, proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1], Melanoma, Receptor protein-tyrosine kinase., signal transduction, Endocytosis, protein binding, Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, Pathways in cancer
3.30.200.20.7.1.1.1.17	2rfnB01	Melanoma, Receptor protein-tyrosine kinase., signal transduction, Homo sapiens, proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1], protein binding, Pathways in cancer, Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, Endocytosis, cell proliferation, Renal cell carcinoma, basal plasma membrane, Cytokine-cytokine receptor interaction, Axon guidance, Adherens junction, Hepatocyte growth factor receptor, integral to plasma membrane, Focal adhesion
3.30.200.20.7.1.1.1.18	3a4pA01	Adherens junction, Focal adhesion, Hepatocyte growth factor receptor, integral to plasma membrane, Axon guidance, Renal cell carcinoma, cell proliferation, Cytokine-cytokine receptor interaction, basal plasma membrane, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, Pathways in cancer, protein binding, Homo sapiens, proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1], Melanoma, signal transduction, Receptor protein-tyrosine kinase.
3.30.200.20.7.1.1.1.19	3ce3A01	Melanoma, Receptor protein-tyrosine kinase., signal transduction, Homo sapiens, proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1], protein binding, Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, Pathways in cancer, Endocytosis, cell proliferation, Renal cell carcinoma, basal plasma membrane, Cytokine-cytokine receptor interaction, Axon guidance, Adherens junction, Hepatocyte growth factor receptor, integral to plasma membrane, Focal adhesion
3.30.200.20.7.1.1.1.20	3l8vA01	Axon guidance, Focal adhesion, Hepatocyte growth factor receptor, integral to plasma membrane, Adherens junction, Cytokine-cytokine receptor interaction, basal plasma membrane, Renal cell carcinoma, cell proliferation, Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, Pathways in cancer, protein binding, Endocytosis, signal transduction, Receptor protein-tyrosine kinase., Melanoma, proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1], Homo sapiens
3.30.200.20.7.1.1.1.21	3f82A01	Axon guidance, Focal adhesion, Hepatocyte growth factor receptor, integral to plasma membrane, Adherens junction, Cytokine-cytokine receptor interaction, basal plasma membrane, Renal cell carcinoma, cell proliferation, Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, Pathways in cancer, protein binding, Endocytosis, signal transduction, Receptor protein-tyrosine kinase., Melanoma, proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1], Homo sapiens
3.30.200.20.7.1.1.1.22	3ctjA01	signal transduction, Receptor protein-tyrosine kinase., Melanoma, proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1], Homo sapiens, Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, Pathways in cancer, protein binding, Endocytosis, Cytokine-cytokine receptor interaction, basal plasma membrane, Renal cell carcinoma, cell proliferation, Axon guidance, Focal adhesion, Hepatocyte growth factor receptor, integral to plasma membrane, Adherens junction
3.30.200.20.7.1.1.1.23	2rfsA01	proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1], Homo sapiens, signal transduction, Receptor protein-tyrosine kinase., Melanoma, Endocytosis, Pathways in cancer, Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, protein binding, Cytokine-cytokine receptor interaction, basal plasma membrane, Renal cell carcinoma, cell proliferation, Focal adhesion, Hepatocyte growth factor receptor, integral to plasma membrane, Adherens junction, Axon guidance
3.30.200.20.7.1.1.1.24	3efjA01	Homo sapiens, proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1], Melanoma, Receptor protein-tyrosine kinase., signal transduction, Endocytosis, protein binding, Pathways in cancer, Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, cell proliferation, Renal cell carcinoma, basal plasma membrane, Cytokine-cytokine receptor interaction, Adherens junction, Hepatocyte growth factor receptor, integral to plasma membrane, Focal adhesion, Axon guidance
3.30.200.20.7.1.1.1.25	3efjB01	Renal cell carcinoma, cell proliferation, Cytokine-cytokine receptor interaction, basal plasma membrane, Axon guidance, Adherens junction, Focal adhesion, Hepatocyte growth factor receptor, integral to plasma membrane, Melanoma, signal transduction, Receptor protein-tyrosine kinase., Homo sapiens, proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1], Epithelial cell signaling in Helicobacter pylori infection, hepatocyte growth factor receptor activity, Pathways in cancer, protein binding, Endocytosis

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.30.200.20.7.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.30.200.20.7.1.1.1

Classification Lineage (3.30.200.20.7.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.30.200.20.7.1.1.1 (25)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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