S100 Family: 3.30.200.20.3.1.1.1

Representative domain: 3bqcA02

Classification Lineage (3.30.200.20.3.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.30	2-Layer Sandwich
3.30.200	Phosphorylase Kinase; domain 1
3.30.200.20	Phosphorylase Kinase; domain 1	Gene3D
3.30.200.20.3
3.30.200.20.3.1
3.30.200.20.3.1.1
3.30.200.20.3.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	16

Non-Redundant Representatives (16)
Functional Families
Help

What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.30.200.20.3.1.1.1 (16)

CATH code	Domain ID	Keywords
3.30.200.20.3.1.1.1.1	3bqcA02	plasma membrane, protein phosphorylation, Casein kinase II subunit alpha, casein kinase 2, alpha polypeptide [EC:2.7.11.1], Adherens junction, Tight junction, Sin3 complex, Homo sapiens, protein N-terminus binding, Wnt signaling pathway, signal transduction, protein serine/threonine kinase activity, NuRD complex, Non-specific serine/threonine protein kinase.
3.30.200.20.3.1.1.1.2	3h30A02	Tight junction, casein kinase 2, alpha polypeptide [EC:2.7.11.1], Adherens junction, Casein kinase II subunit alpha, protein phosphorylation, plasma membrane, NuRD complex, Non-specific serine/threonine protein kinase., signal transduction, protein serine/threonine kinase activity, Wnt signaling pathway, Sin3 complex, protein N-terminus binding, Homo sapiens
3.30.200.20.3.1.1.1.3	3h30B02	Wnt signaling pathway, protein serine/threonine kinase activity, signal transduction, Sin3 complex, Homo sapiens, protein N-terminus binding, NuRD complex, Non-specific serine/threonine protein kinase., Casein kinase II subunit alpha, protein phosphorylation, plasma membrane, Tight junction, casein kinase 2, alpha polypeptide [EC:2.7.11.1], Adherens junction
3.30.200.20.3.1.1.1.4	2pvrA02	Casein kinase II subunit alpha, plasma membrane, protein phosphorylation, Tight junction, casein kinase 2, alpha polypeptide [EC:2.7.11.1], Adherens junction, Wnt signaling pathway, signal transduction, protein serine/threonine kinase activity, Sin3 complex, Homo sapiens, protein N-terminus binding, NuRD complex, Non-specific serine/threonine protein kinase.
3.30.200.20.3.1.1.1.5	3c13A02	Sin3 complex, Homo sapiens, protein N-terminus binding, Wnt signaling pathway, protein serine/threonine kinase activity, signal transduction, NuRD complex, Non-specific serine/threonine protein kinase., plasma membrane, protein phosphorylation, Casein kinase II subunit alpha, casein kinase 2, alpha polypeptide [EC:2.7.11.1], Adherens junction, Tight junction
3.30.200.20.3.1.1.1.6	3fwqA02	Tight junction, casein kinase 2, alpha polypeptide [EC:2.7.11.1], Adherens junction, Casein kinase II subunit alpha, protein phosphorylation, plasma membrane, NuRD complex, Non-specific serine/threonine protein kinase., Wnt signaling pathway, protein serine/threonine kinase activity, signal transduction, Sin3 complex, Homo sapiens, protein N-terminus binding
3.30.200.20.3.1.1.1.7	3fwqB02	protein phosphorylation, plasma membrane, Casein kinase II subunit alpha, casein kinase 2, alpha polypeptide [EC:2.7.11.1], Adherens junction, Tight junction, protein N-terminus binding, Homo sapiens, Sin3 complex, protein serine/threonine kinase activity, signal transduction, Wnt signaling pathway, Non-specific serine/threonine protein kinase., NuRD complex
3.30.200.20.3.1.1.1.8	2zjwA02	casein kinase 2, alpha polypeptide [EC:2.7.11.1], Adherens junction, Tight junction, protein phosphorylation, plasma membrane, Casein kinase II subunit alpha, Non-specific serine/threonine protein kinase., NuRD complex, protein N-terminus binding, Homo sapiens, Sin3 complex, protein serine/threonine kinase activity, signal transduction, Wnt signaling pathway
3.30.200.20.3.1.1.1.9	1pjkA01	Tight junction, casein kinase 2, alpha polypeptide [EC:2.7.11.1], Adherens junction, Casein kinase II subunit alpha, plasma membrane, protein phosphorylation, Non-specific serine/threonine protein kinase., NuRD complex, Wnt signaling pathway, signal transduction, protein serine/threonine kinase activity, Homo sapiens, protein N-terminus binding, Sin3 complex
3.30.200.20.3.1.1.1.10	1jwhA01	casein kinase 2, alpha polypeptide [EC:2.7.11.1], Adherens junction, Tight junction, protein phosphorylation, plasma membrane, Casein kinase II subunit alpha, NuRD complex, Non-specific serine/threonine protein kinase., Sin3 complex, Homo sapiens, protein N-terminus binding, Wnt signaling pathway, protein serine/threonine kinase activity, signal transduction
3.30.200.20.3.1.1.1.11	1jwhB01	casein kinase 2, alpha polypeptide [EC:2.7.11.1], Adherens junction, Tight junction, plasma membrane, protein phosphorylation, Casein kinase II subunit alpha, Non-specific serine/threonine protein kinase., NuRD complex, Homo sapiens, protein N-terminus binding, Sin3 complex, Wnt signaling pathway, protein serine/threonine kinase activity, signal transduction
3.30.200.20.3.1.1.1.12	2r7iA02	Casein kinase II subunit alpha, Tight junction, Rattus norvegicus, casein kinase 2, alpha polypeptide [EC:2.7.11.1], Adherens junction, Wnt signaling pathway, protein kinase CK2 complex, Non-specific serine/threonine protein kinase.
3.30.200.20.3.1.1.1.13	2r7iB02	Wnt signaling pathway, protein kinase CK2 complex, Non-specific serine/threonine protein kinase., Casein kinase II subunit alpha, casein kinase 2, alpha polypeptide [EC:2.7.11.1], Adherens junction, Tight junction, Rattus norvegicus
3.30.200.20.3.1.1.1.14	2r7iD02	Casein kinase II subunit alpha, casein kinase 2, alpha polypeptide [EC:2.7.11.1], Adherens junction, Rattus norvegicus, Tight junction, protein kinase CK2 complex, Wnt signaling pathway, Non-specific serine/threonine protein kinase.
3.30.200.20.3.1.1.1.15	2r7iC02	Non-specific serine/threonine protein kinase., Wnt signaling pathway, protein kinase CK2 complex, casein kinase 2, alpha polypeptide [EC:2.7.11.1], Adherens junction, Tight junction, Rattus norvegicus, Casein kinase II subunit alpha
3.30.200.20.3.1.1.1.16	2rkpA02

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.30.200.20.3.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.30.200.20.3.1.1.1

Classification Lineage (3.30.200.20.3.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.30.200.20.3.1.1.1 (16)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

CATH Shortcuts