S100 Family: 3.30.200.20.19.1.1.1
Representative domain: 1qpcA01
Classification Lineage (3.30.200.20.19.1.1.1)
Summary of Non-Redundant Representatives
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S100 Count Entries in S100 Family 3.30.200.20.19.1.1.1 (22)
| CATH Level | CATH code | Domain ID | Keywords | Thumbnail |
|---|---|---|---|---|
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3.30.200.20.19.1.1.1.1 | 1qpcA01 | cellular zinc ion homeostasis, pericentriolar material, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], ATPase binding, T cell receptor signaling pathway, Homo sapiens, SH2 domain binding, T cell differentiation, membrane raft, Non-specific protein-tyrosine kinase., Golgi apparatus, response to drug, protein kinase binding, CD4 receptor binding, positive regulation of T cell activation, protein C-terminus binding, CD8 receptor binding, protein phosphorylation, Primary immunodeficiency, phosphoinositide 3-kinase binding, protein serine/threonine phosphatase activity, Natural killer cell mediated cytotoxicity, activation of caspase activity, induction of apoptosis, Tyrosine-protein kinase Lck, glycoprotein binding | |
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3.30.200.20.19.1.1.1.2 | 3lckA01 | glycoprotein binding, Tyrosine-protein kinase Lck, induction of apoptosis, activation of caspase activity, Natural killer cell mediated cytotoxicity, protein serine/threonine phosphatase activity, phosphoinositide 3-kinase binding, protein phosphorylation, Primary immunodeficiency, CD8 receptor binding, protein C-terminus binding, positive regulation of T cell activation, protein kinase binding, CD4 receptor binding, response to drug, Golgi apparatus, Non-specific protein-tyrosine kinase., T cell differentiation, membrane raft, Homo sapiens, SH2 domain binding, T cell receptor signaling pathway, ATPase binding, pericentriolar material, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], cellular zinc ion homeostasis | |
|
3.30.200.20.19.1.1.1.3 | 2ofuA01 | Homo sapiens, SH2 domain binding, T cell differentiation, membrane raft, ATPase binding, T cell receptor signaling pathway, cellular zinc ion homeostasis, pericentriolar material, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], protein C-terminus binding, CD8 receptor binding, protein kinase binding, CD4 receptor binding, positive regulation of T cell activation, response to drug, Non-specific protein-tyrosine kinase., Golgi apparatus, protein serine/threonine phosphatase activity, protein phosphorylation, Primary immunodeficiency, phosphoinositide 3-kinase binding, glycoprotein binding, induction of apoptosis, Tyrosine-protein kinase Lck, activation of caspase activity, Natural killer cell mediated cytotoxicity | |
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3.30.200.20.19.1.1.1.4 | 3bymA01 | cellular zinc ion homeostasis, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], pericentriolar material, Homo sapiens, SH2 domain binding, membrane raft, T cell differentiation, ATPase binding, T cell receptor signaling pathway, response to drug, Non-specific protein-tyrosine kinase., Golgi apparatus, protein C-terminus binding, CD8 receptor binding, CD4 receptor binding, protein kinase binding, positive regulation of T cell activation, protein serine/threonine phosphatase activity, Primary immunodeficiency, protein phosphorylation, phosphoinositide 3-kinase binding, activation of caspase activity, Natural killer cell mediated cytotoxicity, glycoprotein binding, induction of apoptosis, Tyrosine-protein kinase Lck | |
|
3.30.200.20.19.1.1.1.5 | 3ac1A01 | positive regulation of T cell activation, protein kinase binding, CD4 receptor binding, CD8 receptor binding, protein C-terminus binding, Golgi apparatus, Non-specific protein-tyrosine kinase., response to drug, T cell receptor signaling pathway, ATPase binding, T cell differentiation, membrane raft, Homo sapiens, SH2 domain binding, pericentriolar material, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], cellular zinc ion homeostasis, Tyrosine-protein kinase Lck, induction of apoptosis, glycoprotein binding, Natural killer cell mediated cytotoxicity, activation of caspase activity, phosphoinositide 3-kinase binding, protein phosphorylation, Primary immunodeficiency, protein serine/threonine phosphatase activity | |
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3.30.200.20.19.1.1.1.6 | 1qpeA01 | response to drug, Golgi apparatus, Non-specific protein-tyrosine kinase., CD8 receptor binding, protein C-terminus binding, positive regulation of T cell activation, CD4 receptor binding, protein kinase binding, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], pericentriolar material, cellular zinc ion homeostasis, membrane raft, T cell differentiation, Homo sapiens, SH2 domain binding, T cell receptor signaling pathway, ATPase binding, activation of caspase activity, Natural killer cell mediated cytotoxicity, glycoprotein binding, Tyrosine-protein kinase Lck, induction of apoptosis, protein serine/threonine phosphatase activity, phosphoinositide 3-kinase binding, Primary immunodeficiency, protein phosphorylation | |
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3.30.200.20.19.1.1.1.7 | 2of2A01 | protein C-terminus binding, CD8 receptor binding, CD4 receptor binding, protein kinase binding, positive regulation of T cell activation, response to drug, Non-specific protein-tyrosine kinase., Golgi apparatus, Homo sapiens, SH2 domain binding, membrane raft, T cell differentiation, ATPase binding, T cell receptor signaling pathway, cellular zinc ion homeostasis, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], pericentriolar material, glycoprotein binding, induction of apoptosis, Tyrosine-protein kinase Lck, activation of caspase activity, Natural killer cell mediated cytotoxicity, protein serine/threonine phosphatase activity, Primary immunodeficiency, protein phosphorylation, phosphoinositide 3-kinase binding | |
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3.30.200.20.19.1.1.1.8 | 3byoA01 | Non-specific protein-tyrosine kinase., Golgi apparatus, response to drug, protein kinase binding, CD4 receptor binding, positive regulation of T cell activation, protein C-terminus binding, CD8 receptor binding, cellular zinc ion homeostasis, pericentriolar material, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], ATPase binding, T cell receptor signaling pathway, Homo sapiens, SH2 domain binding, T cell differentiation, membrane raft, Natural killer cell mediated cytotoxicity, activation of caspase activity, induction of apoptosis, Tyrosine-protein kinase Lck, glycoprotein binding, protein phosphorylation, Primary immunodeficiency, phosphoinositide 3-kinase binding, protein serine/threonine phosphatase activity | |
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3.30.200.20.19.1.1.1.9 | 3bysA01 | protein C-terminus binding, CD8 receptor binding, CD4 receptor binding, protein kinase binding, positive regulation of T cell activation, response to drug, Non-specific protein-tyrosine kinase., Golgi apparatus, Homo sapiens, SH2 domain binding, membrane raft, T cell differentiation, ATPase binding, T cell receptor signaling pathway, cellular zinc ion homeostasis, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], pericentriolar material, glycoprotein binding, induction of apoptosis, Tyrosine-protein kinase Lck, activation of caspase activity, Natural killer cell mediated cytotoxicity, protein serine/threonine phosphatase activity, Primary immunodeficiency, protein phosphorylation, phosphoinositide 3-kinase binding | |
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3.30.200.20.19.1.1.1.10 | 2zm1A01 | Non-specific protein-tyrosine kinase., Golgi apparatus, response to drug, protein kinase binding, CD4 receptor binding, positive regulation of T cell activation, protein C-terminus binding, CD8 receptor binding, cellular zinc ion homeostasis, pericentriolar material, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], ATPase binding, T cell receptor signaling pathway, Homo sapiens, SH2 domain binding, T cell differentiation, membrane raft, Natural killer cell mediated cytotoxicity, activation of caspase activity, induction of apoptosis, Tyrosine-protein kinase Lck, glycoprotein binding, protein phosphorylation, Primary immunodeficiency, phosphoinositide 3-kinase binding, protein serine/threonine phosphatase activity | |
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3.30.200.20.19.1.1.1.11 | 3ac2A01 | CD8 receptor binding, protein C-terminus binding, positive regulation of T cell activation, protein kinase binding, CD4 receptor binding, response to drug, Golgi apparatus, Non-specific protein-tyrosine kinase., T cell differentiation, membrane raft, Homo sapiens, SH2 domain binding, T cell receptor signaling pathway, ATPase binding, pericentriolar material, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], cellular zinc ion homeostasis, glycoprotein binding, Tyrosine-protein kinase Lck, induction of apoptosis, activation of caspase activity, Natural killer cell mediated cytotoxicity, protein serine/threonine phosphatase activity, phosphoinositide 3-kinase binding, protein phosphorylation, Primary immunodeficiency | |
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3.30.200.20.19.1.1.1.12 | 3acjA01 | Tyrosine-protein kinase Lck, induction of apoptosis, glycoprotein binding, Natural killer cell mediated cytotoxicity, activation of caspase activity, phosphoinositide 3-kinase binding, protein phosphorylation, Primary immunodeficiency, protein serine/threonine phosphatase activity, positive regulation of T cell activation, protein kinase binding, CD4 receptor binding, CD8 receptor binding, protein C-terminus binding, Golgi apparatus, Non-specific protein-tyrosine kinase., response to drug, T cell receptor signaling pathway, ATPase binding, T cell differentiation, membrane raft, Homo sapiens, SH2 domain binding, pericentriolar material, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], cellular zinc ion homeostasis | |
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3.30.200.20.19.1.1.1.13 | 3byuA01 | Homo sapiens, SH2 domain binding, T cell differentiation, membrane raft, ATPase binding, T cell receptor signaling pathway, cellular zinc ion homeostasis, pericentriolar material, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], protein C-terminus binding, CD8 receptor binding, protein kinase binding, CD4 receptor binding, positive regulation of T cell activation, response to drug, Non-specific protein-tyrosine kinase., Golgi apparatus, protein serine/threonine phosphatase activity, protein phosphorylation, Primary immunodeficiency, phosphoinositide 3-kinase binding, glycoprotein binding, induction of apoptosis, Tyrosine-protein kinase Lck, activation of caspase activity, Natural killer cell mediated cytotoxicity | |
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3.30.200.20.19.1.1.1.14 | 3ac8A01 | CD8 receptor binding, protein C-terminus binding, positive regulation of T cell activation, protein kinase binding, CD4 receptor binding, response to drug, Golgi apparatus, Non-specific protein-tyrosine kinase., T cell differentiation, membrane raft, Homo sapiens, SH2 domain binding, T cell receptor signaling pathway, ATPase binding, pericentriolar material, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], cellular zinc ion homeostasis, glycoprotein binding, Tyrosine-protein kinase Lck, induction of apoptosis, activation of caspase activity, Natural killer cell mediated cytotoxicity, protein serine/threonine phosphatase activity, phosphoinositide 3-kinase binding, protein phosphorylation, Primary immunodeficiency | |
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3.30.200.20.19.1.1.1.15 | 1qpjA01 | Golgi apparatus, Non-specific protein-tyrosine kinase., response to drug, positive regulation of T cell activation, protein kinase binding, CD4 receptor binding, CD8 receptor binding, protein C-terminus binding, pericentriolar material, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], cellular zinc ion homeostasis, T cell receptor signaling pathway, ATPase binding, T cell differentiation, membrane raft, Homo sapiens, SH2 domain binding, Natural killer cell mediated cytotoxicity, activation of caspase activity, Tyrosine-protein kinase Lck, induction of apoptosis, glycoprotein binding, phosphoinositide 3-kinase binding, protein phosphorylation, Primary immunodeficiency, protein serine/threonine phosphatase activity | |
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3.30.200.20.19.1.1.1.16 | 3ac5A01 | response to drug, Non-specific protein-tyrosine kinase., Golgi apparatus, protein C-terminus binding, CD8 receptor binding, CD4 receptor binding, protein kinase binding, positive regulation of T cell activation, cellular zinc ion homeostasis, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], pericentriolar material, Homo sapiens, SH2 domain binding, membrane raft, T cell differentiation, ATPase binding, T cell receptor signaling pathway, activation of caspase activity, Natural killer cell mediated cytotoxicity, glycoprotein binding, induction of apoptosis, Tyrosine-protein kinase Lck, protein serine/threonine phosphatase activity, Primary immunodeficiency, protein phosphorylation, phosphoinositide 3-kinase binding | |
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3.30.200.20.19.1.1.1.17 | 2zybA01 | Primary immunodeficiency, protein phosphorylation, phosphoinositide 3-kinase binding, protein serine/threonine phosphatase activity, induction of apoptosis, Tyrosine-protein kinase Lck, glycoprotein binding, Natural killer cell mediated cytotoxicity, activation of caspase activity, ATPase binding, T cell receptor signaling pathway, Homo sapiens, SH2 domain binding, membrane raft, T cell differentiation, cellular zinc ion homeostasis, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], pericentriolar material, CD4 receptor binding, protein kinase binding, positive regulation of T cell activation, protein C-terminus binding, CD8 receptor binding, Non-specific protein-tyrosine kinase., Golgi apparatus, response to drug | |
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3.30.200.20.19.1.1.1.18 | 3ac3A01 | CD8 receptor binding, protein C-terminus binding, positive regulation of T cell activation, CD4 receptor binding, protein kinase binding, response to drug, Golgi apparatus, Non-specific protein-tyrosine kinase., membrane raft, T cell differentiation, Homo sapiens, SH2 domain binding, T cell receptor signaling pathway, ATPase binding, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], pericentriolar material, cellular zinc ion homeostasis, glycoprotein binding, Tyrosine-protein kinase Lck, induction of apoptosis, activation of caspase activity, Natural killer cell mediated cytotoxicity, protein serine/threonine phosphatase activity, phosphoinositide 3-kinase binding, Primary immunodeficiency, protein phosphorylation | |
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3.30.200.20.19.1.1.1.19 | 3ackA01 | membrane raft, T cell differentiation, Homo sapiens, SH2 domain binding, T cell receptor signaling pathway, ATPase binding, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], pericentriolar material, cellular zinc ion homeostasis, CD8 receptor binding, protein C-terminus binding, positive regulation of T cell activation, CD4 receptor binding, protein kinase binding, response to drug, Golgi apparatus, Non-specific protein-tyrosine kinase., protein serine/threonine phosphatase activity, phosphoinositide 3-kinase binding, Primary immunodeficiency, protein phosphorylation, glycoprotein binding, Tyrosine-protein kinase Lck, induction of apoptosis, activation of caspase activity, Natural killer cell mediated cytotoxicity | |
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3.30.200.20.19.1.1.1.20 | 2of4A01 | T cell receptor signaling pathway, ATPase binding, membrane raft, T cell differentiation, Homo sapiens, SH2 domain binding, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], pericentriolar material, cellular zinc ion homeostasis, positive regulation of T cell activation, CD4 receptor binding, protein kinase binding, CD8 receptor binding, protein C-terminus binding, Golgi apparatus, Non-specific protein-tyrosine kinase., response to drug, phosphoinositide 3-kinase binding, Primary immunodeficiency, protein phosphorylation, protein serine/threonine phosphatase activity, Tyrosine-protein kinase Lck, induction of apoptosis, glycoprotein binding, Natural killer cell mediated cytotoxicity, activation of caspase activity | |
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3.30.200.20.19.1.1.1.21 | 2zm4A01 | protein serine/threonine phosphatase activity, protein phosphorylation, Primary immunodeficiency, phosphoinositide 3-kinase binding, activation of caspase activity, Natural killer cell mediated cytotoxicity, glycoprotein binding, induction of apoptosis, Tyrosine-protein kinase Lck, cellular zinc ion homeostasis, pericentriolar material, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], Homo sapiens, SH2 domain binding, T cell differentiation, membrane raft, ATPase binding, T cell receptor signaling pathway, response to drug, Non-specific protein-tyrosine kinase., Golgi apparatus, protein C-terminus binding, CD8 receptor binding, protein kinase binding, CD4 receptor binding, positive regulation of T cell activation | |
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3.30.200.20.19.1.1.1.22 | 3ac4A01 | pericentriolar material, lymphocyte-specific protein tyrosine kinase [EC:2.7.10.2], cellular zinc ion homeostasis, T cell receptor signaling pathway, ATPase binding, T cell differentiation, membrane raft, Homo sapiens, SH2 domain binding, Golgi apparatus, Non-specific protein-tyrosine kinase., response to drug, positive regulation of T cell activation, protein kinase binding, CD4 receptor binding, CD8 receptor binding, protein C-terminus binding, phosphoinositide 3-kinase binding, protein phosphorylation, Primary immunodeficiency, protein serine/threonine phosphatase activity, Natural killer cell mediated cytotoxicity, activation of caspase activity, Tyrosine-protein kinase Lck, induction of apoptosis, glycoprotein binding |
The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:
- Multiple alignments for each functional family
- Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
- Detailed functional information on diversity and conservation within Functional families
- Multi-domain architectures