S100 Family: 3.30.200.20.10.1.1.1

Representative domain: 1ia8A01

Classification Lineage (3.30.200.20.10.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.30	2-Layer Sandwich
3.30.200	Phosphorylase Kinase; domain 1
3.30.200.20	Phosphorylase Kinase; domain 1	Gene3D
3.30.200.20.10
3.30.200.20.10.1
3.30.200.20.10.1.1
3.30.200.20.10.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	52

Non-Redundant Representatives (52)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.30.200.20.10.1.1.1 (52)

CATH code	Domain ID	Keywords
3.30.200.20.10.1.1.1.1	1ia8A01	DNA damage checkpoint, condensed nuclear chromosome, Homo sapiens, protein binding, gamete generation, Non-specific serine/threonine protein kinase., senescence, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, DNA repair
3.30.200.20.10.1.1.1.2	1zltA01	DNA repair, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, senescence, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, gamete generation, protein binding, Non-specific serine/threonine protein kinase., DNA damage checkpoint, condensed nuclear chromosome, Homo sapiens
3.30.200.20.10.1.1.1.3	2hxlA01	DNA damage checkpoint, Homo sapiens, condensed nuclear chromosome, gamete generation, protein binding, Non-specific serine/threonine protein kinase., regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, senescence, Serine/threonine-protein kinase Chk1, negative regulation of cell proliferation, DNA repair
3.30.200.20.10.1.1.1.4	2hy0A01	Serine/threonine-protein kinase Chk1, negative regulation of cell proliferation, regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, senescence, DNA repair, Homo sapiens, condensed nuclear chromosome, DNA damage checkpoint, Non-specific serine/threonine protein kinase., gamete generation, protein binding
3.30.200.20.10.1.1.1.5	2x8dA01	DNA repair, senescence, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, Serine/threonine-protein kinase Chk1, negative regulation of cell proliferation, protein binding, gamete generation, Non-specific serine/threonine protein kinase., DNA damage checkpoint, Homo sapiens, condensed nuclear chromosome
3.30.200.20.10.1.1.1.6	1nvrA01	negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, senescence, regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, DNA repair, condensed nuclear chromosome, Homo sapiens, DNA damage checkpoint, Non-specific serine/threonine protein kinase., protein binding, gamete generation
3.30.200.20.10.1.1.1.7	1nvsA01	senescence, regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, DNA repair, DNA damage checkpoint, condensed nuclear chromosome, Homo sapiens, gamete generation, protein binding, Non-specific serine/threonine protein kinase.
3.30.200.20.10.1.1.1.8	2qhnA01	DNA repair, senescence, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, gamete generation, protein binding, Non-specific serine/threonine protein kinase., DNA damage checkpoint, condensed nuclear chromosome, Homo sapiens
3.30.200.20.10.1.1.1.9	2br1A01	Serine/threonine-protein kinase Chk1, negative regulation of cell proliferation, regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, senescence, DNA repair, Homo sapiens, condensed nuclear chromosome, DNA damage checkpoint, Non-specific serine/threonine protein kinase., protein binding, gamete generation
3.30.200.20.10.1.1.1.10	2hxqA01	Non-specific serine/threonine protein kinase., protein binding, gamete generation, Homo sapiens, condensed nuclear chromosome, DNA damage checkpoint, DNA repair, Serine/threonine-protein kinase Chk1, negative regulation of cell proliferation, senescence, regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination
3.30.200.20.10.1.1.1.11	2hogA01	DNA repair, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, senescence, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, Non-specific serine/threonine protein kinase., protein binding, gamete generation, condensed nuclear chromosome, Homo sapiens, DNA damage checkpoint
3.30.200.20.10.1.1.1.12	2x8iA01	Homo sapiens, condensed nuclear chromosome, DNA damage checkpoint, Non-specific serine/threonine protein kinase., protein binding, gamete generation, Serine/threonine-protein kinase Chk1, negative regulation of cell proliferation, senescence, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, DNA repair
3.30.200.20.10.1.1.1.13	2e9uA01	DNA repair, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, senescence, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, protein binding, gamete generation, Non-specific serine/threonine protein kinase., DNA damage checkpoint, condensed nuclear chromosome, Homo sapiens
3.30.200.20.10.1.1.1.14	2e9vA01	DNA repair, senescence, regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, gamete generation, protein binding, Non-specific serine/threonine protein kinase., DNA damage checkpoint, condensed nuclear chromosome, Homo sapiens
3.30.200.20.10.1.1.1.15	2e9vB01	DNA damage checkpoint, Homo sapiens, condensed nuclear chromosome, protein binding, gamete generation, Non-specific serine/threonine protein kinase., regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, senescence, Serine/threonine-protein kinase Chk1, negative regulation of cell proliferation, DNA repair
3.30.200.20.10.1.1.1.16	2brbA01	condensed nuclear chromosome, Homo sapiens, DNA damage checkpoint, Non-specific serine/threonine protein kinase., gamete generation, protein binding, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, senescence, DNA repair
3.30.200.20.10.1.1.1.17	2r0uA01	protein binding, gamete generation, Non-specific serine/threonine protein kinase., DNA damage checkpoint, Homo sapiens, condensed nuclear chromosome, DNA repair, senescence, regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, Serine/threonine-protein kinase Chk1, negative regulation of cell proliferation
3.30.200.20.10.1.1.1.18	2e9oA01	gamete generation, protein binding, Non-specific serine/threonine protein kinase., DNA damage checkpoint, condensed nuclear chromosome, Homo sapiens, DNA repair, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, senescence, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1
3.30.200.20.10.1.1.1.19	1nvqA01	DNA repair, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, senescence, Non-specific serine/threonine protein kinase., protein binding, gamete generation, condensed nuclear chromosome, Homo sapiens, DNA damage checkpoint
3.30.200.20.10.1.1.1.20	2broA01	DNA repair, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, senescence, Non-specific serine/threonine protein kinase., gamete generation, protein binding, condensed nuclear chromosome, Homo sapiens, DNA damage checkpoint
3.30.200.20.10.1.1.1.21	2qhmA01	gamete generation, protein binding, Non-specific serine/threonine protein kinase., DNA damage checkpoint, condensed nuclear chromosome, Homo sapiens, DNA repair, regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, senescence, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1
3.30.200.20.10.1.1.1.22	2cgxA01	Serine/threonine-protein kinase Chk1, negative regulation of cell proliferation, senescence, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, DNA repair, Homo sapiens, condensed nuclear chromosome, DNA damage checkpoint, Non-specific serine/threonine protein kinase., protein binding, gamete generation
3.30.200.20.10.1.1.1.23	3f9nA01	protein binding, gamete generation, Non-specific serine/threonine protein kinase., DNA damage checkpoint, condensed nuclear chromosome, Homo sapiens, DNA repair, senescence, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1
3.30.200.20.10.1.1.1.24	2cgwA01	reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, senescence, Serine/threonine-protein kinase Chk1, negative regulation of cell proliferation, DNA repair, DNA damage checkpoint, Homo sapiens, condensed nuclear chromosome, protein binding, gamete generation, Non-specific serine/threonine protein kinase.
3.30.200.20.10.1.1.1.25	2brgA01	DNA damage checkpoint, Homo sapiens, condensed nuclear chromosome, gamete generation, protein binding, Non-specific serine/threonine protein kinase., senescence, regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, Serine/threonine-protein kinase Chk1, negative regulation of cell proliferation, DNA repair
3.30.200.20.10.1.1.1.26	2c3jA01	DNA repair, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, senescence, regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, Non-specific serine/threonine protein kinase., gamete generation, protein binding, condensed nuclear chromosome, Homo sapiens, DNA damage checkpoint
3.30.200.20.10.1.1.1.27	2brmA01	DNA repair, senescence, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, Serine/threonine-protein kinase Chk1, negative regulation of cell proliferation, protein binding, gamete generation, Non-specific serine/threonine protein kinase., DNA damage checkpoint, Homo sapiens, condensed nuclear chromosome
3.30.200.20.10.1.1.1.28	2brhA01	DNA damage checkpoint, Homo sapiens, condensed nuclear chromosome, protein binding, gamete generation, Non-specific serine/threonine protein kinase., reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, senescence, Serine/threonine-protein kinase Chk1, negative regulation of cell proliferation, DNA repair
3.30.200.20.10.1.1.1.29	2c3lA01	DNA damage checkpoint, condensed nuclear chromosome, Homo sapiens, protein binding, gamete generation, Non-specific serine/threonine protein kinase., regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, senescence, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, DNA repair
3.30.200.20.10.1.1.1.30	2wmvA01	senescence, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, Serine/threonine-protein kinase Chk1, negative regulation of cell proliferation, DNA repair, DNA damage checkpoint, Homo sapiens, condensed nuclear chromosome, gamete generation, protein binding, Non-specific serine/threonine protein kinase.
3.30.200.20.10.1.1.1.31	2e9nA01	DNA damage checkpoint, condensed nuclear chromosome, Homo sapiens, gamete generation, protein binding, Non-specific serine/threonine protein kinase., senescence, regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, DNA repair
3.30.200.20.10.1.1.1.32	2cguA01	DNA repair, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, senescence, Non-specific serine/threonine protein kinase., gamete generation, protein binding, condensed nuclear chromosome, Homo sapiens, DNA damage checkpoint
3.30.200.20.10.1.1.1.33	2e9pA01	condensed nuclear chromosome, Homo sapiens, DNA damage checkpoint, Non-specific serine/threonine protein kinase., protein binding, gamete generation, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, senescence, DNA repair
3.30.200.20.10.1.1.1.34	2c3kA01	gamete generation, protein binding, Non-specific serine/threonine protein kinase., DNA damage checkpoint, Homo sapiens, condensed nuclear chromosome, DNA repair, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, senescence, Serine/threonine-protein kinase Chk1, negative regulation of cell proliferation
3.30.200.20.10.1.1.1.35	2cgvA01	DNA repair, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, senescence, Non-specific serine/threonine protein kinase., protein binding, gamete generation, condensed nuclear chromosome, Homo sapiens, DNA damage checkpoint
3.30.200.20.10.1.1.1.36	2x8eA01	DNA damage checkpoint, Homo sapiens, condensed nuclear chromosome, gamete generation, protein binding, Non-specific serine/threonine protein kinase., reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, senescence, Serine/threonine-protein kinase Chk1, negative regulation of cell proliferation, DNA repair
3.30.200.20.10.1.1.1.37	2xezA01	protein binding, gamete generation, Non-specific serine/threonine protein kinase., DNA damage checkpoint, condensed nuclear chromosome, Homo sapiens, DNA repair, senescence, regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1
3.30.200.20.10.1.1.1.38	2wmrA01	negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, senescence, DNA repair, condensed nuclear chromosome, Homo sapiens, DNA damage checkpoint, Non-specific serine/threonine protein kinase., gamete generation, protein binding
3.30.200.20.10.1.1.1.39	2xf0A01	DNA repair, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, senescence, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, Non-specific serine/threonine protein kinase., gamete generation, protein binding, condensed nuclear chromosome, Homo sapiens, DNA damage checkpoint
3.30.200.20.10.1.1.1.40	2brnA01	condensed nuclear chromosome, Homo sapiens, DNA damage checkpoint, Non-specific serine/threonine protein kinase., protein binding, gamete generation, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, senescence, DNA repair
3.30.200.20.10.1.1.1.41	2aypA01	reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, senescence, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, DNA repair, DNA damage checkpoint, condensed nuclear chromosome, Homo sapiens, gamete generation, protein binding, Non-specific serine/threonine protein kinase.
3.30.200.20.10.1.1.1.42	2ywpA01	senescence, regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, Serine/threonine-protein kinase Chk1, negative regulation of cell proliferation, DNA repair, DNA damage checkpoint, Homo sapiens, condensed nuclear chromosome, gamete generation, protein binding, Non-specific serine/threonine protein kinase.
3.30.200.20.10.1.1.1.43	2gdoA01	Homo sapiens, condensed nuclear chromosome, DNA damage checkpoint, Non-specific serine/threonine protein kinase., gamete generation, protein binding, Serine/threonine-protein kinase Chk1, negative regulation of cell proliferation, regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, senescence, DNA repair
3.30.200.20.10.1.1.1.44	2wmxA01	DNA repair, senescence, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, protein binding, gamete generation, Non-specific serine/threonine protein kinase., DNA damage checkpoint, condensed nuclear chromosome, Homo sapiens
3.30.200.20.10.1.1.1.45	2wmwA01	Non-specific serine/threonine protein kinase., protein binding, gamete generation, Homo sapiens, condensed nuclear chromosome, DNA damage checkpoint, DNA repair, Serine/threonine-protein kinase Chk1, negative regulation of cell proliferation, senescence, regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination
3.30.200.20.10.1.1.1.46	2wmqA01	reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, senescence, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, DNA repair, DNA damage checkpoint, condensed nuclear chromosome, Homo sapiens, protein binding, gamete generation, Non-specific serine/threonine protein kinase.
3.30.200.20.10.1.1.1.47	2xeyA01	DNA repair, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, senescence, regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, Non-specific serine/threonine protein kinase., protein binding, gamete generation, condensed nuclear chromosome, Homo sapiens, DNA damage checkpoint
3.30.200.20.10.1.1.1.48	2wmtA01	protein binding, gamete generation, Non-specific serine/threonine protein kinase., DNA damage checkpoint, condensed nuclear chromosome, Homo sapiens, DNA repair, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, senescence, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1
3.30.200.20.10.1.1.1.49	2wmuA01	Non-specific serine/threonine protein kinase., gamete generation, protein binding, condensed nuclear chromosome, Homo sapiens, DNA damage checkpoint, DNA repair, negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, senescence
3.30.200.20.10.1.1.1.50	2wmsA01	protein binding, gamete generation, Non-specific serine/threonine protein kinase., DNA damage checkpoint, Homo sapiens, condensed nuclear chromosome, DNA repair, reciprocal meiotic recombination, regulation of cyclin-dependent protein kinase activity, senescence, Serine/threonine-protein kinase Chk1, negative regulation of cell proliferation
3.30.200.20.10.1.1.1.51	2ghgA01	negative regulation of cell proliferation, Serine/threonine-protein kinase Chk1, regulation of cyclin-dependent protein kinase activity, reciprocal meiotic recombination, senescence, DNA repair, condensed nuclear chromosome, Homo sapiens, DNA damage checkpoint, Non-specific serine/threonine protein kinase., gamete generation, protein binding
3.30.200.20.10.1.1.1.52	2fgaA01

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.30.200.20.10.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.30.200.20.10.1.1.1

Classification Lineage (3.30.200.20.10.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.30.200.20.10.1.1.1 (52)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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