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CATH Superfamily 3.30.160.380

Dicer dimerisation domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Dicer dimerisation domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Dicer dimerisation domain

This superfamily includes the dimerisation domain found in members of the Dicer or Dicer-like (DCL) proteins, involved in microRNA (miRNA) or small interference RNA (siRNA) pathway, an evolutionarily conserved mechanism for gene silencing using double-stranded RNA (dsRNA) molecules. The dimerisation domain is essential for the activity of Dicer PMID:16424907,PMID:17666393. The N-terminal alpha helix of this domain is in a different orientation to that found in canonical dsRNA-binding domains. This results in a change of charge distribution at the potential dsRNA-binding surface and in the N- and C-termini of the domain being in close proximity PMID:20106953. This domain has weak dsRNA-binding activity. It mediates heterodimerisation of Dicer proteins with their respective protein partners PMID:20106953.

PFAM:PF03368,INTERPRO:IPR005034

GO Diversity

Unique GO annotations
169 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
1219 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 1
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 20
Function
Unique EC: 1
Unique GO: 169
Taxonomy
Unique Species: 1219
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