S100 Family: 3.30.1490.20.5.1.1.1

Representative domain: 3g8dB03

Classification Lineage (3.30.1490.20.5.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.30	2-Layer Sandwich
3.30.1490	Dna Ligase; domain 1
3.30.1490.20	ATP-grasp fold, A domain	Gene3D
3.30.1490.20.5
3.30.1490.20.5.1
3.30.1490.20.5.1.1
3.30.1490.20.5.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	25

Non-Redundant Representatives (25)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.30.1490.20.5.1.1.1 (25)

CATH code	Domain ID	Keywords
3.30.1490.20.5.1.1.1.1	3g8dB03	biotin carboxylase [EC:6.3.4.14], Metabolic pathways, Biotin carboxylase, Fatty acid biosynthesis, Escherichia coli K-12, Biotin carboxylase., acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], Acetyl-CoA carboxylase., fatty acid biosynthetic process, Pyruvate metabolism, Propanoate metabolism
3.30.1490.20.5.1.1.1.2	2j9gA03	Fatty acid biosynthesis, Escherichia coli K-12, Metabolic pathways, Biotin carboxylase, biotin carboxylase [EC:6.3.4.14], Propanoate metabolism, Acetyl-CoA carboxylase., fatty acid biosynthetic process, Pyruvate metabolism, Biotin carboxylase., acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2]
3.30.1490.20.5.1.1.1.3	3g8cA03	fatty acid biosynthetic process, Acetyl-CoA carboxylase., Pyruvate metabolism, Biotin carboxylase., acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], Propanoate metabolism, biotin carboxylase [EC:6.3.4.14], Fatty acid biosynthesis, Escherichia coli K-12, Metabolic pathways, Biotin carboxylase
3.30.1490.20.5.1.1.1.4	3g8cB03	biotin carboxylase [EC:6.3.4.14], Fatty acid biosynthesis, Escherichia coli K-12, Metabolic pathways, Biotin carboxylase, Acetyl-CoA carboxylase., fatty acid biosynthetic process, Pyruvate metabolism, Biotin carboxylase., acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], Propanoate metabolism
3.30.1490.20.5.1.1.1.5	2j9gB03	Escherichia coli K-12, Fatty acid biosynthesis, Biotin carboxylase, Metabolic pathways, biotin carboxylase [EC:6.3.4.14], Propanoate metabolism, Pyruvate metabolism, fatty acid biosynthetic process, Acetyl-CoA carboxylase., acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], Biotin carboxylase.
3.30.1490.20.5.1.1.1.6	2v58A03	Pyruvate metabolism, fatty acid biosynthetic process, Acetyl-CoA carboxylase., acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], Biotin carboxylase., Propanoate metabolism, biotin carboxylase [EC:6.3.4.14], Escherichia coli K-12, Fatty acid biosynthesis, Biotin carboxylase, Metabolic pathways
3.30.1490.20.5.1.1.1.7	2v58B03	biotin carboxylase [EC:6.3.4.14], Fatty acid biosynthesis, Escherichia coli K-12, Metabolic pathways, Biotin carboxylase, fatty acid biosynthetic process, Acetyl-CoA carboxylase., Pyruvate metabolism, Biotin carboxylase., acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], Propanoate metabolism
3.30.1490.20.5.1.1.1.8	2gpwC03	Pyruvate metabolism, Acetyl-CoA carboxylase., fatty acid biosynthetic process, acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], Biotin carboxylase., Propanoate metabolism, biotin carboxylase [EC:6.3.4.14], Escherichia coli K-12, Fatty acid biosynthesis, Biotin carboxylase, Metabolic pathways
3.30.1490.20.5.1.1.1.9	2gpwD03	Biotin carboxylase, Metabolic pathways, Escherichia coli K-12, Fatty acid biosynthesis, biotin carboxylase [EC:6.3.4.14], Propanoate metabolism, acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], Biotin carboxylase., Pyruvate metabolism, fatty acid biosynthetic process, Acetyl-CoA carboxylase.
3.30.1490.20.5.1.1.1.10	1dv1A03	Escherichia coli K-12, Fatty acid biosynthesis, Biotin carboxylase, Metabolic pathways, biotin carboxylase [EC:6.3.4.14], Propanoate metabolism, Pyruvate metabolism, fatty acid biosynthetic process, Acetyl-CoA carboxylase., acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], Biotin carboxylase.
3.30.1490.20.5.1.1.1.11	2gpwA03	Biotin carboxylase, Metabolic pathways, Escherichia coli K-12, Fatty acid biosynthesis, biotin carboxylase [EC:6.3.4.14], Propanoate metabolism, acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], Biotin carboxylase., Pyruvate metabolism, Acetyl-CoA carboxylase., fatty acid biosynthetic process
3.30.1490.20.5.1.1.1.12	2v5aA03	Propanoate metabolism, Acetyl-CoA carboxylase., fatty acid biosynthetic process, Pyruvate metabolism, Biotin carboxylase., acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], Fatty acid biosynthesis, Escherichia coli K-12, Metabolic pathways, Biotin carboxylase, biotin carboxylase [EC:6.3.4.14]
3.30.1490.20.5.1.1.1.13	2v5aB03	acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], Biotin carboxylase., Pyruvate metabolism, Acetyl-CoA carboxylase., fatty acid biosynthetic process, Propanoate metabolism, biotin carboxylase [EC:6.3.4.14], Biotin carboxylase, Metabolic pathways, Escherichia coli K-12, Fatty acid biosynthesis
3.30.1490.20.5.1.1.1.14	2v59A03	Propanoate metabolism, Acetyl-CoA carboxylase., fatty acid biosynthetic process, Pyruvate metabolism, Biotin carboxylase., acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], Fatty acid biosynthesis, Escherichia coli K-12, Metabolic pathways, Biotin carboxylase, biotin carboxylase [EC:6.3.4.14]
3.30.1490.20.5.1.1.1.15	2v59B03	Propanoate metabolism, Biotin carboxylase., acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], Acetyl-CoA carboxylase., fatty acid biosynthetic process, Pyruvate metabolism, Metabolic pathways, Biotin carboxylase, Fatty acid biosynthesis, Escherichia coli K-12, biotin carboxylase [EC:6.3.4.14]
3.30.1490.20.5.1.1.1.16	2gpwB03	biotin carboxylase [EC:6.3.4.14], Metabolic pathways, Biotin carboxylase, Fatty acid biosynthesis, Escherichia coli K-12, Biotin carboxylase., acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], fatty acid biosynthetic process, Acetyl-CoA carboxylase., Pyruvate metabolism, Propanoate metabolism
3.30.1490.20.5.1.1.1.17	1dv2A03	biotin carboxylase [EC:6.3.4.14], Fatty acid biosynthesis, Escherichia coli K-12, Metabolic pathways, Biotin carboxylase, Acetyl-CoA carboxylase., fatty acid biosynthetic process, Pyruvate metabolism, Biotin carboxylase., acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], Propanoate metabolism
3.30.1490.20.5.1.1.1.18	1dv2B03	Propanoate metabolism, Acetyl-CoA carboxylase., fatty acid biosynthetic process, Pyruvate metabolism, Biotin carboxylase., acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], Fatty acid biosynthesis, Escherichia coli K-12, Metabolic pathways, Biotin carboxylase, biotin carboxylase [EC:6.3.4.14]
3.30.1490.20.5.1.1.1.19	2vr1A03	Biotin carboxylase, Metabolic pathways, Escherichia coli K-12, Fatty acid biosynthesis, biotin carboxylase [EC:6.3.4.14], Propanoate metabolism, acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], Biotin carboxylase., Pyruvate metabolism, fatty acid biosynthetic process, Acetyl-CoA carboxylase.
3.30.1490.20.5.1.1.1.20	1dv1B03	Fatty acid biosynthesis, Escherichia coli K-12, Metabolic pathways, Biotin carboxylase, biotin carboxylase [EC:6.3.4.14], Propanoate metabolism, Acetyl-CoA carboxylase., fatty acid biosynthetic process, Pyruvate metabolism, Biotin carboxylase., acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2]
3.30.1490.20.5.1.1.1.21	2gpsA03	Metabolic pathways, Biotin carboxylase, Fatty acid biosynthesis, Escherichia coli K-12, biotin carboxylase [EC:6.3.4.14], Propanoate metabolism, Biotin carboxylase., acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], fatty acid biosynthetic process, Acetyl-CoA carboxylase., Pyruvate metabolism
3.30.1490.20.5.1.1.1.22	1bncA03	Escherichia coli K-12, Fatty acid biosynthesis, Biotin carboxylase, Metabolic pathways, biotin carboxylase [EC:6.3.4.14], Propanoate metabolism, Pyruvate metabolism, Acetyl-CoA carboxylase., fatty acid biosynthetic process, acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], Biotin carboxylase.
3.30.1490.20.5.1.1.1.23	2gpsB03	Propanoate metabolism, Acetyl-CoA carboxylase., fatty acid biosynthetic process, Pyruvate metabolism, Biotin carboxylase., acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], Fatty acid biosynthesis, Escherichia coli K-12, Metabolic pathways, Biotin carboxylase, biotin carboxylase [EC:6.3.4.14]
3.30.1490.20.5.1.1.1.24	2vr1B03	Biotin carboxylase, Metabolic pathways, Escherichia coli K-12, Fatty acid biosynthesis, biotin carboxylase [EC:6.3.4.14], Propanoate metabolism, acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], Biotin carboxylase., Pyruvate metabolism, Acetyl-CoA carboxylase., fatty acid biosynthetic process
3.30.1490.20.5.1.1.1.25	1bncB03	biotin carboxylase [EC:6.3.4.14], Metabolic pathways, Biotin carboxylase, Fatty acid biosynthesis, Escherichia coli K-12, Biotin carboxylase., acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2], Acetyl-CoA carboxylase., fatty acid biosynthetic process, Pyruvate metabolism, Propanoate metabolism

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.30.1490.20.5.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.30.1490.20.5.1.1.1

Classification Lineage (3.30.1490.20.5.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.30.1490.20.5.1.1.1 (25)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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