S100 Family: 3.30.1490.20.15.1.1.1

Representative domain: 2nu8B02

Classification Lineage (3.30.1490.20.15.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.30	2-Layer Sandwich
3.30.1490	Dna Ligase; domain 1
3.30.1490.20	ATP-grasp fold, A domain	Gene3D
3.30.1490.20.15
3.30.1490.20.15.1
3.30.1490.20.15.1.1
3.30.1490.20.15.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	24

Non-Redundant Representatives (24)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.30.1490.20.15.1.1.1 (24)

CATH code	Domain ID	Keywords
3.30.1490.20.15.1.1.1.1	2nu8B02	Propanoate metabolism, cytoplasm, Succinate--CoA ligase (ADP-forming)., C5-Branched dibasic acid metabolism, tricarboxylic acid cycle, Succinyl-CoA ligase [ADP-forming] subunit beta, Metabolic pathways, succinyl-CoA synthetase beta subunit [EC:6.2.1.5], Escherichia coli K-12, Citrate cycle (TCA cycle)
3.30.1490.20.15.1.1.1.2	2nu8E02	Propanoate metabolism, cytoplasm, Succinate--CoA ligase (ADP-forming)., C5-Branched dibasic acid metabolism, tricarboxylic acid cycle, Succinyl-CoA ligase [ADP-forming] subunit beta, Metabolic pathways, Escherichia coli K-12, succinyl-CoA synthetase beta subunit [EC:6.2.1.5], Citrate cycle (TCA cycle)
3.30.1490.20.15.1.1.1.3	2nu7B02	Propanoate metabolism, cytoplasm, C5-Branched dibasic acid metabolism, tricarboxylic acid cycle, Succinate--CoA ligase (ADP-forming)., Escherichia coli K-12, succinyl-CoA synthetase beta subunit [EC:6.2.1.5], Metabolic pathways, Succinyl-CoA ligase [ADP-forming] subunit beta, Citrate cycle (TCA cycle)
3.30.1490.20.15.1.1.1.4	2nu7E02	Citrate cycle (TCA cycle), Escherichia coli K-12, succinyl-CoA synthetase beta subunit [EC:6.2.1.5], Metabolic pathways, Succinyl-CoA ligase [ADP-forming] subunit beta, C5-Branched dibasic acid metabolism, tricarboxylic acid cycle, Succinate--CoA ligase (ADP-forming)., Propanoate metabolism, cytoplasm
3.30.1490.20.15.1.1.1.5	2scuB02	Propanoate metabolism, cytoplasm, C5-Branched dibasic acid metabolism, tricarboxylic acid cycle, Succinate--CoA ligase (ADP-forming)., succinyl-CoA synthetase beta subunit [EC:6.2.1.5], Escherichia coli K-12, Succinyl-CoA ligase [ADP-forming] subunit beta, Metabolic pathways, Citrate cycle (TCA cycle)
3.30.1490.20.15.1.1.1.6	2scuE02	Escherichia coli K-12, succinyl-CoA synthetase beta subunit [EC:6.2.1.5], Metabolic pathways, Succinyl-CoA ligase [ADP-forming] subunit beta, Citrate cycle (TCA cycle), Propanoate metabolism, cytoplasm, C5-Branched dibasic acid metabolism, tricarboxylic acid cycle, Succinate--CoA ligase (ADP-forming).
3.30.1490.20.15.1.1.1.7	1jkjB02	Citrate cycle (TCA cycle), succinyl-CoA synthetase beta subunit [EC:6.2.1.5], Escherichia coli K-12, Succinyl-CoA ligase [ADP-forming] subunit beta, Metabolic pathways, C5-Branched dibasic acid metabolism, tricarboxylic acid cycle, Succinate--CoA ligase (ADP-forming)., Propanoate metabolism, cytoplasm
3.30.1490.20.15.1.1.1.8	1jkjE02	Succinate--CoA ligase (ADP-forming)., C5-Branched dibasic acid metabolism, tricarboxylic acid cycle, Propanoate metabolism, cytoplasm, Citrate cycle (TCA cycle), Metabolic pathways, Succinyl-CoA ligase [ADP-forming] subunit beta, Escherichia coli K-12, succinyl-CoA synthetase beta subunit [EC:6.2.1.5]
3.30.1490.20.15.1.1.1.9	1scuB02	C5-Branched dibasic acid metabolism, tricarboxylic acid cycle, Succinate--CoA ligase (ADP-forming)., Propanoate metabolism, cytoplasm, Citrate cycle (TCA cycle), Escherichia coli K-12, succinyl-CoA synthetase beta subunit [EC:6.2.1.5], Succinyl-CoA ligase [ADP-forming] subunit beta, Metabolic pathways
3.30.1490.20.15.1.1.1.10	1scuE02	Succinate--CoA ligase (ADP-forming)., C5-Branched dibasic acid metabolism, tricarboxylic acid cycle, Propanoate metabolism, cytoplasm, Citrate cycle (TCA cycle), Metabolic pathways, Succinyl-CoA ligase [ADP-forming] subunit beta, Escherichia coli K-12, succinyl-CoA synthetase beta subunit [EC:6.2.1.5]
3.30.1490.20.15.1.1.1.11	2nu6B02	Propanoate metabolism, cytoplasm, Succinate--CoA ligase (ADP-forming)., C5-Branched dibasic acid metabolism, tricarboxylic acid cycle, Metabolic pathways, Succinyl-CoA ligase [ADP-forming] subunit beta, Escherichia coli K-12, succinyl-CoA synthetase beta subunit [EC:6.2.1.5], Citrate cycle (TCA cycle)
3.30.1490.20.15.1.1.1.12	2nu6E02	C5-Branched dibasic acid metabolism, tricarboxylic acid cycle, Succinate--CoA ligase (ADP-forming)., Propanoate metabolism, cytoplasm, Citrate cycle (TCA cycle), succinyl-CoA synthetase beta subunit [EC:6.2.1.5], Escherichia coli K-12, Succinyl-CoA ligase [ADP-forming] subunit beta, Metabolic pathways
3.30.1490.20.15.1.1.1.13	1jllB02	Metabolic pathways, Succinyl-CoA ligase [ADP-forming] subunit beta, succinyl-CoA synthetase beta subunit [EC:6.2.1.5], Escherichia coli K-12, Citrate cycle (TCA cycle), Propanoate metabolism, cytoplasm, Succinate--CoA ligase (ADP-forming)., C5-Branched dibasic acid metabolism, tricarboxylic acid cycle
3.30.1490.20.15.1.1.1.14	1jllE02	Escherichia coli K-12, succinyl-CoA synthetase beta subunit [EC:6.2.1.5], Succinyl-CoA ligase [ADP-forming] subunit beta, Metabolic pathways, Citrate cycle (TCA cycle), Propanoate metabolism, cytoplasm, C5-Branched dibasic acid metabolism, tricarboxylic acid cycle, Succinate--CoA ligase (ADP-forming).
3.30.1490.20.15.1.1.1.15	1cqjB02	Citrate cycle (TCA cycle), Escherichia coli K-12, succinyl-CoA synthetase beta subunit [EC:6.2.1.5], Metabolic pathways, Succinyl-CoA ligase [ADP-forming] subunit beta, C5-Branched dibasic acid metabolism, tricarboxylic acid cycle, Succinate--CoA ligase (ADP-forming)., Propanoate metabolism, cytoplasm
3.30.1490.20.15.1.1.1.16	1cqjE02	Succinate--CoA ligase (ADP-forming)., C5-Branched dibasic acid metabolism, tricarboxylic acid cycle, Propanoate metabolism, cytoplasm, Citrate cycle (TCA cycle), Succinyl-CoA ligase [ADP-forming] subunit beta, Metabolic pathways, Escherichia coli K-12, succinyl-CoA synthetase beta subunit [EC:6.2.1.5]
3.30.1490.20.15.1.1.1.17	2nu9B02	Metabolic pathways, Succinyl-CoA ligase [ADP-forming] subunit beta, succinyl-CoA synthetase beta subunit [EC:6.2.1.5], Escherichia coli K-12, Citrate cycle (TCA cycle), Propanoate metabolism, cytoplasm, Succinate--CoA ligase (ADP-forming)., C5-Branched dibasic acid metabolism, tricarboxylic acid cycle
3.30.1490.20.15.1.1.1.18	2nu9E02	Citrate cycle (TCA cycle), Metabolic pathways, Succinyl-CoA ligase [ADP-forming] subunit beta, Escherichia coli K-12, succinyl-CoA synthetase beta subunit [EC:6.2.1.5], Succinate--CoA ligase (ADP-forming)., C5-Branched dibasic acid metabolism, tricarboxylic acid cycle, Propanoate metabolism, cytoplasm
3.30.1490.20.15.1.1.1.19	2nu9G02	Metabolic pathways, Succinyl-CoA ligase [ADP-forming] subunit beta, succinyl-CoA synthetase beta subunit [EC:6.2.1.5], Escherichia coli K-12, Citrate cycle (TCA cycle), Propanoate metabolism, cytoplasm, Succinate--CoA ligase (ADP-forming)., C5-Branched dibasic acid metabolism, tricarboxylic acid cycle
3.30.1490.20.15.1.1.1.20	2nu9I02	Citrate cycle (TCA cycle), succinyl-CoA synthetase beta subunit [EC:6.2.1.5], Escherichia coli K-12, Metabolic pathways, Succinyl-CoA ligase [ADP-forming] subunit beta, C5-Branched dibasic acid metabolism, tricarboxylic acid cycle, Succinate--CoA ligase (ADP-forming)., Propanoate metabolism, cytoplasm
3.30.1490.20.15.1.1.1.21	2nuaB02	C5-Branched dibasic acid metabolism, tricarboxylic acid cycle, Succinate--CoA ligase (ADP-forming)., Propanoate metabolism, cytoplasm, Citrate cycle (TCA cycle), Escherichia coli K-12, succinyl-CoA synthetase beta subunit [EC:6.2.1.5], Succinyl-CoA ligase [ADP-forming] subunit beta, Metabolic pathways
3.30.1490.20.15.1.1.1.22	2nuaE02	C5-Branched dibasic acid metabolism, tricarboxylic acid cycle, Succinate--CoA ligase (ADP-forming)., Propanoate metabolism, cytoplasm, Citrate cycle (TCA cycle), succinyl-CoA synthetase beta subunit [EC:6.2.1.5], Escherichia coli K-12, Succinyl-CoA ligase [ADP-forming] subunit beta, Metabolic pathways
3.30.1490.20.15.1.1.1.23	1cqiB02	Propanoate metabolism, cytoplasm, Succinate--CoA ligase (ADP-forming)., C5-Branched dibasic acid metabolism, tricarboxylic acid cycle, Succinyl-CoA ligase [ADP-forming] subunit beta, Metabolic pathways, Escherichia coli K-12, succinyl-CoA synthetase beta subunit [EC:6.2.1.5], Citrate cycle (TCA cycle)
3.30.1490.20.15.1.1.1.24	1cqiE02	succinyl-CoA synthetase beta subunit [EC:6.2.1.5], Escherichia coli K-12, Metabolic pathways, Succinyl-CoA ligase [ADP-forming] subunit beta, Citrate cycle (TCA cycle), Propanoate metabolism, cytoplasm, C5-Branched dibasic acid metabolism, tricarboxylic acid cycle, Succinate--CoA ligase (ADP-forming).

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.30.1490.20.15.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.30.1490.20.15.1.1.1

Classification Lineage (3.30.1490.20.15.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.30.1490.20.15.1.1.1 (24)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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