S100 Family: 3.10.450.40.7.1.1.1

Representative domain: 1oacA02

Classification Lineage (3.10.450.40.7.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.10	Roll
3.10.450	Nuclear Transport Factor 2; Chain: A,
3.10.450.40		Gene3D
3.10.450.40.7
3.10.450.40.7.1
3.10.450.40.7.1.1
3.10.450.40.7.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	32

Non-Redundant Representatives (32)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.10.450.40.7.1.1.1 (32)

CATH code	Domain ID	Keywords
3.10.450.40.7.1.1.1.1	1oacA02	beta-Alanine metabolism, Primary amine oxidase, Metabolic pathways, Tyrosine metabolism, Glycine, serine and threonine metabolism, Escherichia coli K-12, Phenylalanine metabolism, Primary-amine oxidase., primary-amine oxidase [EC:1.4.3.21]
3.10.450.40.7.1.1.1.2	1oacB02	Escherichia coli K-12, Metabolic pathways, Tyrosine metabolism, Glycine, serine and threonine metabolism, beta-Alanine metabolism, Primary amine oxidase, primary-amine oxidase [EC:1.4.3.21], Phenylalanine metabolism, Primary-amine oxidase.
3.10.450.40.7.1.1.1.3	1qakA02	Primary-amine oxidase., Phenylalanine metabolism, primary-amine oxidase [EC:1.4.3.21], beta-Alanine metabolism, Primary amine oxidase, Metabolic pathways, Tyrosine metabolism, Glycine, serine and threonine metabolism, Escherichia coli K-12
3.10.450.40.7.1.1.1.4	1qakB02	primary-amine oxidase [EC:1.4.3.21], Phenylalanine metabolism, Primary-amine oxidase., Escherichia coli K-12, Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism, beta-Alanine metabolism, Primary amine oxidase
3.10.450.40.7.1.1.1.5	1spuA02	Primary amine oxidase, beta-Alanine metabolism, Glycine, serine and threonine metabolism, Tyrosine metabolism, Metabolic pathways, Escherichia coli K-12, Phenylalanine metabolism, Primary-amine oxidase., primary-amine oxidase [EC:1.4.3.21]
3.10.450.40.7.1.1.1.6	1spuB02	beta-Alanine metabolism, Primary amine oxidase, Escherichia coli K-12, Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism, Phenylalanine metabolism, Primary-amine oxidase., primary-amine oxidase [EC:1.4.3.21]
3.10.450.40.7.1.1.1.7	1dyuA02	beta-Alanine metabolism, Primary amine oxidase, Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism, Escherichia coli K-12, Primary-amine oxidase., Phenylalanine metabolism, primary-amine oxidase [EC:1.4.3.21]
3.10.450.40.7.1.1.1.8	1dyuB02	Escherichia coli K-12, Glycine, serine and threonine metabolism, Tyrosine metabolism, Metabolic pathways, Primary amine oxidase, beta-Alanine metabolism, primary-amine oxidase [EC:1.4.3.21], Primary-amine oxidase., Phenylalanine metabolism
3.10.450.40.7.1.1.1.9	1d6zA02	Phenylalanine metabolism, Primary-amine oxidase., primary-amine oxidase [EC:1.4.3.21], Primary amine oxidase, beta-Alanine metabolism, Escherichia coli K-12, Tyrosine metabolism, Glycine, serine and threonine metabolism, Metabolic pathways
3.10.450.40.7.1.1.1.10	1d6zB02	primary-amine oxidase [EC:1.4.3.21], Phenylalanine metabolism, Primary-amine oxidase., Escherichia coli K-12, Tyrosine metabolism, Glycine, serine and threonine metabolism, Metabolic pathways, Primary amine oxidase, beta-Alanine metabolism
3.10.450.40.7.1.1.1.11	1jrqA02	Primary amine oxidase, beta-Alanine metabolism, Tyrosine metabolism, Glycine, serine and threonine metabolism, Metabolic pathways, Escherichia coli K-12, Phenylalanine metabolism, Primary-amine oxidase., primary-amine oxidase [EC:1.4.3.21]
3.10.450.40.7.1.1.1.12	1jrqB02	Primary-amine oxidase., Phenylalanine metabolism, primary-amine oxidase [EC:1.4.3.21], beta-Alanine metabolism, Primary amine oxidase, Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism, Escherichia coli K-12
3.10.450.40.7.1.1.1.13	1qafA02	primary-amine oxidase [EC:1.4.3.21], Phenylalanine metabolism, Primary-amine oxidase., Tyrosine metabolism, Glycine, serine and threonine metabolism, Metabolic pathways, Escherichia coli K-12, Primary amine oxidase, beta-Alanine metabolism
3.10.450.40.7.1.1.1.14	1qafB02	Metabolic pathways, Tyrosine metabolism, Glycine, serine and threonine metabolism, Escherichia coli K-12, beta-Alanine metabolism, Primary amine oxidase, primary-amine oxidase [EC:1.4.3.21], Phenylalanine metabolism, Primary-amine oxidase.
3.10.450.40.7.1.1.1.15	1qalA02	primary-amine oxidase [EC:1.4.3.21], Primary-amine oxidase., Phenylalanine metabolism, Tyrosine metabolism, Glycine, serine and threonine metabolism, Metabolic pathways, Escherichia coli K-12, Primary amine oxidase, beta-Alanine metabolism
3.10.450.40.7.1.1.1.16	1qalB02	Primary amine oxidase, beta-Alanine metabolism, Tyrosine metabolism, Glycine, serine and threonine metabolism, Metabolic pathways, Escherichia coli K-12, Primary-amine oxidase., Phenylalanine metabolism, primary-amine oxidase [EC:1.4.3.21]
3.10.450.40.7.1.1.1.17	2wofA02	Primary-amine oxidase., Phenylalanine metabolism, primary-amine oxidase [EC:1.4.3.21], beta-Alanine metabolism, Primary amine oxidase, Escherichia coli K-12, Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism
3.10.450.40.7.1.1.1.18	2wofB02	primary-amine oxidase [EC:1.4.3.21], Phenylalanine metabolism, Primary-amine oxidase., Escherichia coli K-12, Glycine, serine and threonine metabolism, Tyrosine metabolism, Metabolic pathways, Primary amine oxidase, beta-Alanine metabolism
3.10.450.40.7.1.1.1.19	1d6uA02	Primary-amine oxidase., Phenylalanine metabolism, primary-amine oxidase [EC:1.4.3.21], Primary amine oxidase, beta-Alanine metabolism, Glycine, serine and threonine metabolism, Tyrosine metabolism, Metabolic pathways, Escherichia coli K-12
3.10.450.40.7.1.1.1.20	1d6uB02	Phenylalanine metabolism, Primary-amine oxidase., primary-amine oxidase [EC:1.4.3.21], beta-Alanine metabolism, Primary amine oxidase, Metabolic pathways, Tyrosine metabolism, Glycine, serine and threonine metabolism, Escherichia coli K-12
3.10.450.40.7.1.1.1.21	1d6yA02	Primary amine oxidase, beta-Alanine metabolism, Glycine, serine and threonine metabolism, Tyrosine metabolism, Metabolic pathways, Escherichia coli K-12, Primary-amine oxidase., Phenylalanine metabolism, primary-amine oxidase [EC:1.4.3.21]
3.10.450.40.7.1.1.1.22	1d6yB02	primary-amine oxidase [EC:1.4.3.21], Primary-amine oxidase., Phenylalanine metabolism, Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism, Escherichia coli K-12, beta-Alanine metabolism, Primary amine oxidase
3.10.450.40.7.1.1.1.23	1lvnA02	Phenylalanine metabolism, Primary-amine oxidase., primary-amine oxidase [EC:1.4.3.21], beta-Alanine metabolism, Primary amine oxidase, Escherichia coli K-12, Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism
3.10.450.40.7.1.1.1.24	1lvnB02	Primary amine oxidase, beta-Alanine metabolism, Tyrosine metabolism, Glycine, serine and threonine metabolism, Metabolic pathways, Escherichia coli K-12, Primary-amine oxidase., Phenylalanine metabolism, primary-amine oxidase [EC:1.4.3.21]
3.10.450.40.7.1.1.1.25	2w0qA02	Escherichia coli K-12, Tyrosine metabolism, Glycine, serine and threonine metabolism, Metabolic pathways, Primary amine oxidase, beta-Alanine metabolism, primary-amine oxidase [EC:1.4.3.21], Phenylalanine metabolism, Primary-amine oxidase.
3.10.450.40.7.1.1.1.26	2w0qB02	Primary amine oxidase, beta-Alanine metabolism, Tyrosine metabolism, Glycine, serine and threonine metabolism, Metabolic pathways, Escherichia coli K-12, Phenylalanine metabolism, Primary-amine oxidase., primary-amine oxidase [EC:1.4.3.21]
3.10.450.40.7.1.1.1.27	2wgqA02	primary-amine oxidase [EC:1.4.3.21], Primary-amine oxidase., Phenylalanine metabolism, Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism, Escherichia coli K-12, beta-Alanine metabolism, Primary amine oxidase
3.10.450.40.7.1.1.1.28	2wgqB02	Primary-amine oxidase., Phenylalanine metabolism, primary-amine oxidase [EC:1.4.3.21], beta-Alanine metabolism, Primary amine oxidase, Escherichia coli K-12, Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism
3.10.450.40.7.1.1.1.29	2wo0A02	Phenylalanine metabolism, Primary-amine oxidase., primary-amine oxidase [EC:1.4.3.21], beta-Alanine metabolism, Primary amine oxidase, Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism, Escherichia coli K-12
3.10.450.40.7.1.1.1.30	2wo0B02	Escherichia coli K-12, Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism, beta-Alanine metabolism, Primary amine oxidase, primary-amine oxidase [EC:1.4.3.21], Phenylalanine metabolism, Primary-amine oxidase.
3.10.450.40.7.1.1.1.31	2wohA02	Primary amine oxidase, beta-Alanine metabolism, Glycine, serine and threonine metabolism, Tyrosine metabolism, Metabolic pathways, Escherichia coli K-12, Phenylalanine metabolism, Primary-amine oxidase., primary-amine oxidase [EC:1.4.3.21]
3.10.450.40.7.1.1.1.32	2wohB02	Escherichia coli K-12, Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism, beta-Alanine metabolism, Primary amine oxidase, primary-amine oxidase [EC:1.4.3.21], Phenylalanine metabolism, Primary-amine oxidase.

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.10.450.40.7.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.10.450.40.7.1.1.1

Classification Lineage (3.10.450.40.7.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.10.450.40.7.1.1.1 (32)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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