S100 Family: 3.10.450.40.10.1.1.1

Representative domain: 1oacA04

Classification Lineage (3.10.450.40.10.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.10	Roll
3.10.450	Nuclear Transport Factor 2; Chain: A,
3.10.450.40		Gene3D
3.10.450.40.10
3.10.450.40.10.1
3.10.450.40.10.1.1
3.10.450.40.10.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	32

Non-Redundant Representatives (32)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.10.450.40.10.1.1.1 (32)

CATH code	Domain ID	Keywords
3.10.450.40.10.1.1.1.1	1oacA04	beta-Alanine metabolism, Primary amine oxidase, Escherichia coli K-12, Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism, Primary-amine oxidase., Phenylalanine metabolism, primary-amine oxidase [EC:1.4.3.21]
3.10.450.40.10.1.1.1.2	1oacB04	Primary amine oxidase, beta-Alanine metabolism, Glycine, serine and threonine metabolism, Tyrosine metabolism, Metabolic pathways, Escherichia coli K-12, Phenylalanine metabolism, Primary-amine oxidase., primary-amine oxidase [EC:1.4.3.21]
3.10.450.40.10.1.1.1.3	1qakA04	beta-Alanine metabolism, Primary amine oxidase, Escherichia coli K-12, Metabolic pathways, Tyrosine metabolism, Glycine, serine and threonine metabolism, Phenylalanine metabolism, Primary-amine oxidase., primary-amine oxidase [EC:1.4.3.21]
3.10.450.40.10.1.1.1.4	1qakB04	Tyrosine metabolism, Glycine, serine and threonine metabolism, Metabolic pathways, Escherichia coli K-12, Primary amine oxidase, beta-Alanine metabolism, primary-amine oxidase [EC:1.4.3.21], Primary-amine oxidase., Phenylalanine metabolism
3.10.450.40.10.1.1.1.5	1spuA04	beta-Alanine metabolism, Primary amine oxidase, Escherichia coli K-12, Metabolic pathways, Tyrosine metabolism, Glycine, serine and threonine metabolism, Phenylalanine metabolism, Primary-amine oxidase., primary-amine oxidase [EC:1.4.3.21]
3.10.450.40.10.1.1.1.6	1spuB04	Primary amine oxidase, beta-Alanine metabolism, Escherichia coli K-12, Glycine, serine and threonine metabolism, Tyrosine metabolism, Metabolic pathways, Primary-amine oxidase., Phenylalanine metabolism, primary-amine oxidase [EC:1.4.3.21]
3.10.450.40.10.1.1.1.7	1dyuA04	primary-amine oxidase [EC:1.4.3.21], Primary-amine oxidase., Phenylalanine metabolism, Glycine, serine and threonine metabolism, Tyrosine metabolism, Metabolic pathways, Escherichia coli K-12, Primary amine oxidase, beta-Alanine metabolism
3.10.450.40.10.1.1.1.8	1dyuB04	beta-Alanine metabolism, Primary amine oxidase, Metabolic pathways, Tyrosine metabolism, Glycine, serine and threonine metabolism, Escherichia coli K-12, Phenylalanine metabolism, Primary-amine oxidase., primary-amine oxidase [EC:1.4.3.21]
3.10.450.40.10.1.1.1.9	1d6zA04	Tyrosine metabolism, Glycine, serine and threonine metabolism, Metabolic pathways, Escherichia coli K-12, Primary amine oxidase, beta-Alanine metabolism, primary-amine oxidase [EC:1.4.3.21], Phenylalanine metabolism, Primary-amine oxidase.
3.10.450.40.10.1.1.1.10	1d6zB04	Escherichia coli K-12, Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism, beta-Alanine metabolism, Primary amine oxidase, primary-amine oxidase [EC:1.4.3.21], Primary-amine oxidase., Phenylalanine metabolism
3.10.450.40.10.1.1.1.11	1jrqA04	primary-amine oxidase [EC:1.4.3.21], Phenylalanine metabolism, Primary-amine oxidase., Glycine, serine and threonine metabolism, Tyrosine metabolism, Metabolic pathways, Escherichia coli K-12, Primary amine oxidase, beta-Alanine metabolism
3.10.450.40.10.1.1.1.12	1jrqB04	Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism, Escherichia coli K-12, beta-Alanine metabolism, Primary amine oxidase, primary-amine oxidase [EC:1.4.3.21], Primary-amine oxidase., Phenylalanine metabolism
3.10.450.40.10.1.1.1.13	1qafA04	primary-amine oxidase [EC:1.4.3.21], Primary-amine oxidase., Phenylalanine metabolism, Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism, Escherichia coli K-12, beta-Alanine metabolism, Primary amine oxidase
3.10.450.40.10.1.1.1.14	1qafB04	Escherichia coli K-12, Metabolic pathways, Tyrosine metabolism, Glycine, serine and threonine metabolism, beta-Alanine metabolism, Primary amine oxidase, primary-amine oxidase [EC:1.4.3.21], Phenylalanine metabolism, Primary-amine oxidase.
3.10.450.40.10.1.1.1.15	1qalA04	Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism, Escherichia coli K-12, beta-Alanine metabolism, Primary amine oxidase, primary-amine oxidase [EC:1.4.3.21], Phenylalanine metabolism, Primary-amine oxidase.
3.10.450.40.10.1.1.1.16	1qalB04	primary-amine oxidase [EC:1.4.3.21], Primary-amine oxidase., Phenylalanine metabolism, Tyrosine metabolism, Glycine, serine and threonine metabolism, Metabolic pathways, Escherichia coli K-12, Primary amine oxidase, beta-Alanine metabolism
3.10.450.40.10.1.1.1.17	2wofA03	primary-amine oxidase [EC:1.4.3.21], Phenylalanine metabolism, Primary-amine oxidase., Escherichia coli K-12, Tyrosine metabolism, Glycine, serine and threonine metabolism, Metabolic pathways, Primary amine oxidase, beta-Alanine metabolism
3.10.450.40.10.1.1.1.18	2wofB03	Phenylalanine metabolism, Primary-amine oxidase., primary-amine oxidase [EC:1.4.3.21], Primary amine oxidase, beta-Alanine metabolism, Tyrosine metabolism, Glycine, serine and threonine metabolism, Metabolic pathways, Escherichia coli K-12
3.10.450.40.10.1.1.1.19	1d6uA04	primary-amine oxidase [EC:1.4.3.21], Phenylalanine metabolism, Primary-amine oxidase., Glycine, serine and threonine metabolism, Tyrosine metabolism, Metabolic pathways, Escherichia coli K-12, Primary amine oxidase, beta-Alanine metabolism
3.10.450.40.10.1.1.1.20	1d6uB04	primary-amine oxidase [EC:1.4.3.21], Primary-amine oxidase., Phenylalanine metabolism, Escherichia coli K-12, Metabolic pathways, Tyrosine metabolism, Glycine, serine and threonine metabolism, beta-Alanine metabolism, Primary amine oxidase
3.10.450.40.10.1.1.1.21	1d6yA04	primary-amine oxidase [EC:1.4.3.21], Primary-amine oxidase., Phenylalanine metabolism, Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism, Escherichia coli K-12, beta-Alanine metabolism, Primary amine oxidase
3.10.450.40.10.1.1.1.22	1d6yB04	Primary amine oxidase, beta-Alanine metabolism, Escherichia coli K-12, Tyrosine metabolism, Glycine, serine and threonine metabolism, Metabolic pathways, Phenylalanine metabolism, Primary-amine oxidase., primary-amine oxidase [EC:1.4.3.21]
3.10.450.40.10.1.1.1.23	1lvnA04	Phenylalanine metabolism, Primary-amine oxidase., primary-amine oxidase [EC:1.4.3.21], beta-Alanine metabolism, Primary amine oxidase, Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism, Escherichia coli K-12
3.10.450.40.10.1.1.1.24	1lvnB04	Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism, Escherichia coli K-12, beta-Alanine metabolism, Primary amine oxidase, primary-amine oxidase [EC:1.4.3.21], Primary-amine oxidase., Phenylalanine metabolism
3.10.450.40.10.1.1.1.25	2w0qA03	beta-Alanine metabolism, Primary amine oxidase, Escherichia coli K-12, Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism, Phenylalanine metabolism, Primary-amine oxidase., primary-amine oxidase [EC:1.4.3.21]
3.10.450.40.10.1.1.1.26	2w0qB03	Primary amine oxidase, beta-Alanine metabolism, Glycine, serine and threonine metabolism, Tyrosine metabolism, Metabolic pathways, Escherichia coli K-12, Phenylalanine metabolism, Primary-amine oxidase., primary-amine oxidase [EC:1.4.3.21]
3.10.450.40.10.1.1.1.27	2wgqA03	primary-amine oxidase [EC:1.4.3.21], Phenylalanine metabolism, Primary-amine oxidase., Glycine, serine and threonine metabolism, Tyrosine metabolism, Metabolic pathways, Escherichia coli K-12, Primary amine oxidase, beta-Alanine metabolism
3.10.450.40.10.1.1.1.28	2wgqB03	Escherichia coli K-12, Metabolic pathways, Glycine, serine and threonine metabolism, Tyrosine metabolism, beta-Alanine metabolism, Primary amine oxidase, primary-amine oxidase [EC:1.4.3.21], Phenylalanine metabolism, Primary-amine oxidase.
3.10.450.40.10.1.1.1.29	2wo0A03	Metabolic pathways, Tyrosine metabolism, Glycine, serine and threonine metabolism, Escherichia coli K-12, beta-Alanine metabolism, Primary amine oxidase, primary-amine oxidase [EC:1.4.3.21], Phenylalanine metabolism, Primary-amine oxidase.
3.10.450.40.10.1.1.1.30	2wo0B03	primary-amine oxidase [EC:1.4.3.21], Phenylalanine metabolism, Primary-amine oxidase., Escherichia coli K-12, Metabolic pathways, Tyrosine metabolism, Glycine, serine and threonine metabolism, beta-Alanine metabolism, Primary amine oxidase
3.10.450.40.10.1.1.1.31	2wohA03	beta-Alanine metabolism, Primary amine oxidase, Escherichia coli K-12, Metabolic pathways, Tyrosine metabolism, Glycine, serine and threonine metabolism, Phenylalanine metabolism, Primary-amine oxidase., primary-amine oxidase [EC:1.4.3.21]
3.10.450.40.10.1.1.1.32	2wohB03	Primary amine oxidase, beta-Alanine metabolism, Glycine, serine and threonine metabolism, Tyrosine metabolism, Metabolic pathways, Escherichia coli K-12, Primary-amine oxidase., Phenylalanine metabolism, primary-amine oxidase [EC:1.4.3.21]

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.10.450.40.10.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.10.450.40.10.1.1.1

Classification Lineage (3.10.450.40.10.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.10.450.40.10.1.1.1 (32)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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