S95 Family: 3.10.200.10.1.1.1

Representative domain: 3ks3A00

Classification Lineage (3.10.200.10.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.10	Roll
3.10.200	Carbonic Anhydrase II
3.10.200.10	Carbonic Anhydrase II	Gene3D
3.10.200.10.1
3.10.200.10.1.1
3.10.200.10.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	83	295

Non-Redundant Representatives (83)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Family Entries in S95 Family 3.10.200.10.1.1.1 (83)

CATH code	Representative Domain	Representative Keywords	Number of Domains
3.10.200.10.1.1.1.1	3ks3A00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	161
3.10.200.10.1.1.1.2	2fouA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.3	2nnoA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.4	1mooA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	3
3.10.200.10.1.1.1.5	2nnsA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.6	2fosA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.7	2nnvA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.8	2fovA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.9	2nxtA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	3
3.10.200.10.1.1.1.10	2nngA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.11	2foqA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.12	1fr7A00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	8
3.10.200.10.1.1.1.13	3dcwA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	6
3.10.200.10.1.1.1.14	2cbaA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.15	1fr4A00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	4
3.10.200.10.1.1.1.16	2povA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.17	3dvcA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.18	3dvdA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.19	1th9A00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	2
3.10.200.10.1.1.1.20	2nwyA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	2
3.10.200.10.1.1.1.21	2cbbA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.22	2cbdA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.23	1muaA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.24	1zh9A00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.25	1camA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	2
3.10.200.10.1.1.1.26	1yo1A00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	3
3.10.200.10.1.1.1.27	2nwoA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	2
3.10.200.10.1.1.1.28	3dv7A00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.29	3dvbA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.30	1lg5A00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	3
3.10.200.10.1.1.1.31	1cniA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.32	1cnjA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.33	1zscA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	3
3.10.200.10.1.1.1.34	1caiA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.35	1i9qA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	12
3.10.200.10.1.1.1.36	1tg3A00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	2
3.10.200.10.1.1.1.37	2fnkA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.38	2fnmA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	2
3.10.200.10.1.1.1.39	2cbeA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.40	1h9nA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.41	2cbcA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.42	1cngA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.43	2h4nA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	2
3.10.200.10.1.1.1.44	1ydbA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	2
3.10.200.10.1.1.1.45	1bicA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.46	1cajA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.47	1cakA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	2
3.10.200.10.1.1.1.48	1ugeA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.49	1canA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.50	1caoA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.51	1craA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.52	1fqlA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.53	1heaA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	2
3.10.200.10.1.1.1.54	1hecA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.55	1hebA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	2
3.10.200.10.1.1.1.56	1hedA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.57	1ugaA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.58	1ugbA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.59	1ugcA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.60	1ugdA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	2
3.10.200.10.1.1.1.61	1ugfA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.62	1cnhA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.63	1dcbA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	2
3.10.200.10.1.1.1.64	5ca2A00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.65	1cnkA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.66	1cctA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.67	1cncA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	3
3.10.200.10.1.1.1.68	1cvdA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.69	1h9qA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.70	1ccuA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.71	1cvaA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	2
3.10.200.10.1.1.1.72	1cveA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.73	1cvfA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.74	1lzvA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.75	1cvcA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.76	1cvhA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.77	1ccsA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.78	12caA00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.79	7ca2A00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.80	8ca2A00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.81	6ca2A00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.82	9ca2A00	Nitrogen metabolismZinc ion bindingNucleusCarbonic anhydrase [EC:4.2.1.1]Proximal tubule bicarbonate reclamation	1
3.10.200.10.1.1.1.83	1cac000		1

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.10.200.10.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S95 Family: 3.10.200.10.1.1.1

Classification Lineage (3.10.200.10.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Family Entries in S95 Family 3.10.200.10.1.1.1 (83)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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