S100 Family: 3.10.100.10.17.1.1.1

Representative domain: 1rtm100

Classification Lineage (3.10.100.10.17.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.10	Roll
3.10.100	Mannose-Binding Protein A; Chain A
3.10.100.10	Mannose-Binding Protein A, subunit A	Gene3D
3.10.100.10.17
3.10.100.10.17.1
3.10.100.10.17.1.1
3.10.100.10.17.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	28

Non-Redundant Representatives (28)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.10.100.10.17.1.1.1 (28)

CATH code	Domain ID	Keywords
3.10.100.10.17.1.1.1.1	1rtm100	Complement and coagulation cascades, Rattus norvegicus, calcium ion binding, extracellular space, calcium-dependent protein binding, polysaccharide binding, mannose-binding lectin, mannose binding, Mannose-binding protein A, complement activation, lectin pathway, protein homodimerization activity
3.10.100.10.17.1.1.1.2	1rtm200	extracellular space, calcium-dependent protein binding, mannose-binding lectin, polysaccharide binding, mannose binding, Mannose-binding protein A, complement activation, lectin pathway, protein homodimerization activity, Rattus norvegicus, Complement and coagulation cascades, calcium ion binding
3.10.100.10.17.1.1.1.3	1rtm300	Complement and coagulation cascades, Rattus norvegicus, calcium ion binding, mannose binding, polysaccharide binding, mannose-binding lectin, protein homodimerization activity, Mannose-binding protein A, complement activation, lectin pathway, extracellular space, calcium-dependent protein binding
3.10.100.10.17.1.1.1.4	1buuA00	calcium-dependent protein binding, extracellular space, polysaccharide binding, mannose-binding lectin, mannose binding, Mannose-binding protein A, complement activation, lectin pathway, protein homodimerization activity, Complement and coagulation cascades, Rattus norvegicus, calcium ion binding
3.10.100.10.17.1.1.1.5	1kwwA00	calcium ion binding, Rattus norvegicus, Complement and coagulation cascades, extracellular space, calcium-dependent protein binding, Mannose-binding protein A, complement activation, lectin pathway, protein homodimerization activity, mannose-binding lectin, polysaccharide binding, mannose binding
3.10.100.10.17.1.1.1.6	1kwwB00	calcium-dependent protein binding, extracellular space, Mannose-binding protein A, complement activation, lectin pathway, protein homodimerization activity, polysaccharide binding, mannose-binding lectin, mannose binding, calcium ion binding, Complement and coagulation cascades, Rattus norvegicus
3.10.100.10.17.1.1.1.7	1kwwC00	Complement and coagulation cascades, Rattus norvegicus, calcium ion binding, polysaccharide binding, mannose-binding lectin, mannose binding, Mannose-binding protein A, complement activation, lectin pathway, protein homodimerization activity, calcium-dependent protein binding, extracellular space
3.10.100.10.17.1.1.1.8	1kwtA00	protein homodimerization activity, Mannose-binding protein A, complement activation, lectin pathway, mannose binding, polysaccharide binding, mannose-binding lectin, calcium-dependent protein binding, extracellular space, calcium ion binding, Complement and coagulation cascades, Rattus norvegicus
3.10.100.10.17.1.1.1.9	1kwtB00	Complement and coagulation cascades, Rattus norvegicus, calcium ion binding, extracellular space, calcium-dependent protein binding, mannose binding, polysaccharide binding, mannose-binding lectin, protein homodimerization activity, Mannose-binding protein A, complement activation, lectin pathway
3.10.100.10.17.1.1.1.10	1kwtC00	calcium-dependent protein binding, extracellular space, mannose binding, polysaccharide binding, mannose-binding lectin, protein homodimerization activity, Mannose-binding protein A, complement activation, lectin pathway, Complement and coagulation cascades, Rattus norvegicus, calcium ion binding
3.10.100.10.17.1.1.1.11	1kwuA00	protein homodimerization activity, Mannose-binding protein A, complement activation, lectin pathway, mannose binding, polysaccharide binding, mannose-binding lectin, extracellular space, calcium-dependent protein binding, calcium ion binding, Complement and coagulation cascades, Rattus norvegicus
3.10.100.10.17.1.1.1.12	1kwuB00	Rattus norvegicus, Complement and coagulation cascades, calcium ion binding, extracellular space, calcium-dependent protein binding, mannose-binding lectin, polysaccharide binding, mannose binding, Mannose-binding protein A, complement activation, lectin pathway, protein homodimerization activity
3.10.100.10.17.1.1.1.13	1kwuC00	Complement and coagulation cascades, Rattus norvegicus, calcium ion binding, calcium-dependent protein binding, extracellular space, mannose binding, polysaccharide binding, mannose-binding lectin, protein homodimerization activity, Mannose-binding protein A, complement activation, lectin pathway
3.10.100.10.17.1.1.1.14	1kwvA00	extracellular space, calcium-dependent protein binding, mannose binding, polysaccharide binding, mannose-binding lectin, protein homodimerization activity, Mannose-binding protein A, complement activation, lectin pathway, Complement and coagulation cascades, Rattus norvegicus, calcium ion binding
3.10.100.10.17.1.1.1.15	1kwvB00	Mannose-binding protein A, complement activation, lectin pathway, protein homodimerization activity, mannose-binding lectin, polysaccharide binding, mannose binding, extracellular space, calcium-dependent protein binding, calcium ion binding, Rattus norvegicus, Complement and coagulation cascades
3.10.100.10.17.1.1.1.16	1kwvC00	calcium ion binding, Complement and coagulation cascades, Rattus norvegicus, protein homodimerization activity, Mannose-binding protein A, complement activation, lectin pathway, mannose binding, polysaccharide binding, mannose-binding lectin, calcium-dependent protein binding, extracellular space
3.10.100.10.17.1.1.1.17	1kwxA00	extracellular space, calcium-dependent protein binding, polysaccharide binding, mannose-binding lectin, mannose binding, Mannose-binding protein A, complement activation, lectin pathway, protein homodimerization activity, Complement and coagulation cascades, Rattus norvegicus, calcium ion binding
3.10.100.10.17.1.1.1.18	1kwxB00	Rattus norvegicus, Complement and coagulation cascades, calcium ion binding, mannose-binding lectin, polysaccharide binding, mannose binding, Mannose-binding protein A, complement activation, lectin pathway, protein homodimerization activity, calcium-dependent protein binding, extracellular space
3.10.100.10.17.1.1.1.19	1kwxC00	polysaccharide binding, mannose-binding lectin, mannose binding, Mannose-binding protein A, complement activation, lectin pathway, protein homodimerization activity, calcium-dependent protein binding, extracellular space, Complement and coagulation cascades, Rattus norvegicus, calcium ion binding
3.10.100.10.17.1.1.1.20	1kwyA00	Complement and coagulation cascades, Rattus norvegicus, calcium ion binding, mannose binding, polysaccharide binding, mannose-binding lectin, protein homodimerization activity, Mannose-binding protein A, complement activation, lectin pathway, calcium-dependent protein binding, extracellular space
3.10.100.10.17.1.1.1.21	1kwyB00	mannose binding, polysaccharide binding, mannose-binding lectin, protein homodimerization activity, Mannose-binding protein A, complement activation, lectin pathway, extracellular space, calcium-dependent protein binding, Complement and coagulation cascades, Rattus norvegicus, calcium ion binding
3.10.100.10.17.1.1.1.22	1kwyC00	Complement and coagulation cascades, Rattus norvegicus, calcium ion binding, calcium-dependent protein binding, extracellular space, polysaccharide binding, mannose-binding lectin, mannose binding, Mannose-binding protein A, complement activation, lectin pathway, protein homodimerization activity
3.10.100.10.17.1.1.1.23	1kx1A00	Complement and coagulation cascades, Rattus norvegicus, calcium ion binding, polysaccharide binding, mannose-binding lectin, mannose binding, Mannose-binding protein A, complement activation, lectin pathway, protein homodimerization activity, extracellular space, calcium-dependent protein binding
3.10.100.10.17.1.1.1.24	1kx1B00	calcium ion binding, Rattus norvegicus, Complement and coagulation cascades, protein homodimerization activity, Mannose-binding protein A, complement activation, lectin pathway, mannose binding, mannose-binding lectin, polysaccharide binding, calcium-dependent protein binding, extracellular space
3.10.100.10.17.1.1.1.25	1kx1C00	calcium ion binding, Rattus norvegicus, Complement and coagulation cascades, Mannose-binding protein A, complement activation, lectin pathway, protein homodimerization activity, mannose-binding lectin, polysaccharide binding, mannose binding, calcium-dependent protein binding, extracellular space
3.10.100.10.17.1.1.1.26	1kx1D00	extracellular space, calcium-dependent protein binding, mannose-binding lectin, polysaccharide binding, mannose binding, Mannose-binding protein A, complement activation, lectin pathway, protein homodimerization activity, Rattus norvegicus, Complement and coagulation cascades, calcium ion binding
3.10.100.10.17.1.1.1.27	1kx1E00	calcium ion binding, Rattus norvegicus, Complement and coagulation cascades, extracellular space, calcium-dependent protein binding, Mannose-binding protein A, complement activation, lectin pathway, protein homodimerization activity, mannose-binding lectin, polysaccharide binding, mannose binding
3.10.100.10.17.1.1.1.28	1kx1F00	calcium ion binding, Rattus norvegicus, Complement and coagulation cascades, protein homodimerization activity, Mannose-binding protein A, complement activation, lectin pathway, mannose binding, mannose-binding lectin, polysaccharide binding, calcium-dependent protein binding, extracellular space

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.10.100.10.17.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.10.100.10.17.1.1.1

Classification Lineage (3.10.100.10.17.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.10.100.10.17.1.1.1 (28)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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